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Glaucoma November 2020

Effect of Timolol on Optineurin Aggregation in Transformed Induced Pluripotent Stem Cells Derived From Patient With Familial Glaucoma

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Satoshi Inagaki; Kazuhide Kawase; Michinori Funato; Junko Seki; Chizuru Kawase; Kazuki Ohuchi; Tsubasa Kameyama; Shiori Ando; Arisu Sato; Wataru Morozumi; Shinsuke Nakamura; Masamitsu Shimazawa; Daisuke Iejima; Takeshi Iwata; Tetsuya Yamamoto; Hideo Kaneko; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2020; 59(6):2293-2304. doi: https://doi.org/10.1167/iovs.17-22975

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

The effect of GDF15 on the neurite outgrowth in retinal ganglion cells.

Yuki Iwata; Satoshi Inagaki; Wataru Morozumi; Shinsuke Nakamura; Masamitsu Shimazawa; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):624. doi:

ARVO Annual Meeting Abstract July 2019

Donepezil, an anti-Alzheimer's disease drug has the neuroprotective effect on RGCs derived from familial glaucoma patients’ iPS cells.

Satoshi Inagaki; Michinori Funato; Shinsuke Nakamura; Masamitsu Shimazawa; Hideo Kaneko; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):626. doi:

ARVO Annual Meeting Abstract July 2019

Progranulin knockout mice show the outer retinal abnormalities similar to advanced AMD

Kei Takahashi; Miruto Tanaka; Shinsuke Nakamura; Masamitsu Shimazawa; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1236. doi:

ARVO Annual Meeting Abstract July 2019

Development of a macaque model of dry, nonexudative form age-related macular degeneration with geographic atropy

Nobuyuki Takahashi; Chinatsu Kitazawa; Takahiro Natsume; Wakana Sotoyama; Yoshitaka Itani; Aldric Hama; Ikuo Hayashi; Masamitsu Shimazawa; Hiroyuki Takamatsu; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1237. doi:

ARVO Annual Meeting Abstract July 2019

Mitochondria fission by Drp1 as the potential therapeutic target for retinal pigmented epithelial cell death

Tomohiro Yako; Maho Nakamura; Shinsuke Nakamura; Masamitsu Shimazawa; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1948. doi:

ARVO Annual Meeting Abstract July 2019

The potential therapeutic targets for the macular edema in murine retinal vein occlusion model

Anri Nishinaka; Shinsuke Nakamura; Tomomi Masuda; Masamitsu Shimazawa; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4066. doi:

ARVO Annual Meeting Abstract July 2019

The involvement of G protein-coupled receptor 35 on pathology of non-exudative age-related macular degeneration

Masamitsu Shimazawa; Mayu Moriguchi; Shinsuke Nakamura; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5386. doi:

ARVO Annual Meeting Abstract July 2019

Tracking of disease progression over time with optic nerve diffusion tensor imaging and retinal nerve fiber layer thickness in macaques with experimental glaucoma

Aldric Hama; Nobuyuki Takahashi; Takahiro Natsume; Chinatsu Kitazawa; Yoshitaka Itani; Ikuo Hayashi; Masamitsu Shimazawa; Hideaki Hara; Hiroyuki Takamatsu

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5583. doi:

Retina May 2019

Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability

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Shinsuke Nakamura; Tetsuro Noguchi; Yuki Inoue; Shuji Sakurai; Anri Nishinaka; Yoshifumi Hida; Tomomi Masuda; Yasuhiro Nakagami; Naoto Horai; Hideshi Tsusaki; Hideaki Hara; Masamitsu Shimazawa
TAGS: angiogenesis, cercopithecidae, choroidal neovascularization, lasers, mice, neovascularization, pathologic, proteins, transcriptional activation, vascular diseases, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):1943-1952. doi: https://doi.org/10.1167/iovs.18-25745

Includes: Supplemental Content

Retinal Cell Biology December 2018

Granulin 1 Promotes Retinal Regeneration in Zebrafish

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Kazuhiro Tsuruma; Yuichi Saito; Hiroyuki Okuyoshi; Akihiro Yamaguchi; Masamitsu Shimazawa; Daniel Goldman; Hideaki Hara
TAGS: bromodeoxyuridine, grn gene, retina, zebrafish, genes, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6057-6066. doi: https://doi.org/10.1167/iovs.18-24828

Includes: Supplemental Content

Retina September 2018

Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion

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Anri Nishinaka; Yuki Inoue; Shinichiro Fuma; Yoshifumi Hida; Shinsuke Nakamura; Masamitsu Shimazawa; Hideaki Hara
TAGS: antibodies, anti-vascular endothelial growth factor therapy, edema, eye, mice, retinal vein occlusion, vascular endothelial growth factor a, injections, lasers
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4701-4713. doi: https://doi.org/10.1167/iovs.18-23994

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

The pathophysiological roles of vascular endothelial growth factor (VEGF) on retinal edema and nonperfusion areas in retinal vein occlusion murine model

Anri Nishinaka; Yuki Inoue; Shinichiro Fuma; Yoshifumi Hida; Shinsuke Nakamura; Masamitsu Shimazawa; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5430. doi:

ARVO Annual Meeting Abstract July 2018

The effect of VGF nerve growth factor inducible on retinal ganglion cell injury after optic nerve crush in mice

Masamitsu Shimazawa; Hiroto Takeuchi; Satoshi Inagaki; Wataru Morozumi; Yukimichi Nakano; Yuki Inoue; Yoshiki Kuse; Takahiro Mizoguchi; Michinori Funato; Hideo Kaneko; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6129. doi:

ARVO Annual Meeting Abstract July 2018

The oligodendrocyte derived from familial glaucoma patients-iPSCs decreases neuroprotective action for retinal ganglion cells

Satoshi Inagaki; Kazuhide Kawase; Michinori Funato; Kazuki Ohuchi; Shiori Ando; Arisu Sato; Wataru Morozumi; Masamitsu Shimazawa; Daisuke Iejima; Takeshi Iwata; Tetsuya Yamamoto; Hideo Kaneko; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3751. doi:

Retina July 2018

Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation

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Mayu Moriguchi; Shinsuke Nakamura; Yuki Inoue; Anri Nishinaka; Maho Nakamura; Masamitsu Shimazawa; Hideaki Hara
TAGS: injections, iodates, macrophages, mice, photoreceptors, retinal pigment cell, sodium, retina, immunohistochemistry
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3476-3487. doi: https://doi.org/10.1167/iovs.17-23532

Retina December 2017

Platelet-Derived Growth Factor-BB Lessens Light-Induced Rod Photoreceptor Damage in Mice

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Kei Takahashi; Masamitsu Shimazawa; Hiroshi Izawa; Yuki Inoue; Yoshiki Kuse; Hideaki Hara
TAGS: mice, platelet-derived growth factor, platelet-derived growth factor receptor, rod photoreceptors, light exposure
Invest. Ophthalmol. Vis. Sci.. 2017; 58(14):6299-6307. doi: https://doi.org/10.1167/iovs.17-22556

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Low concentrations of levofloxacin can decrease UV-induced cellular damage

takashi nishida; Yoshiki Kuse; Kiyofumi Mochizuki; Tetsuya Yamamoto; Masamitsu Shimazawa; Hideaki Hara

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5779. doi:

Biochemistry and Molecular Biology February 2017

Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization

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Tomomi Masuda; Masamitsu Shimazawa; Yuhei Hashimoto; Atsushi Kojima; Shinsuke Nakamura; Shinsuke Suemori; Kiyofumi Mochizuki; Hideaki Kawakami; Kazuhide Kawase; Hideaki Hara
TAGS: angiogenesis, apolipoprotein e, apolipoprotein e2, neovascularization, pathologic, vascular endothelial growth factor a, mice, retinal neovascularization, vitreous body, retina, apolipoprotein e4
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):1208-1217. doi: https://doi.org/10.1167/iovs.16-20539

Includes: Supplemental Content

Retina October 2015

Protective Effects of Antiplacental Growth Factor Antibody Against Light-Induced Retinal Damage in Mice

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Hiroshi Izawa; Yuki Inoue; Yuta Ohno; Kazuki Ojino; Kazuhiro Tsuruma; Masamitsu Shimazawa; Hideaki Hara
TAGS: antibodies, mice, placenta growth factor, retina, light exposure, growth factor
Invest. Ophthalmol. Vis. Sci.. 2015; 56(11):6914-6924. doi: https://doi.org/10.1167/iovs.15-16748

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Effect of Timolol on Optineurin Aggregation in Transformed Induced Pluripotent Stem Cells Derived From Patient With Familial Glaucoma

The effect of GDF15 on the neurite outgrowth in retinal ganglion cells.

Donepezil, an anti-Alzheimer's disease drug has the neuroprotective effect on RGCs derived from familial glaucoma patients’ iPS cells.

Progranulin knockout mice show the outer retinal abnormalities similar to advanced AMD

Development of a macaque model of dry, nonexudative form age-related macular degeneration with geographic atropy

Mitochondria fission by Drp1 as the potential therapeutic target for retinal pigmented epithelial cell death

The potential therapeutic targets for the macular edema in murine retinal vein occlusion model

The involvement of G protein-coupled receptor 35 on pathology of non-exudative age-related macular degeneration

Tracking of disease progression over time with optic nerve diffusion tensor imaging and retinal nerve fiber layer thickness in macaques with experimental glaucoma

Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability

Granulin 1 Promotes Retinal Regeneration in Zebrafish

Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion

The pathophysiological roles of vascular endothelial growth factor (VEGF) on retinal edema and nonperfusion areas in retinal vein occlusion murine model

The effect of VGF nerve growth factor inducible on retinal ganglion cell injury after optic nerve crush in mice

The oligodendrocyte derived from familial glaucoma patients-iPSCs decreases neuroprotective action for retinal ganglion cells

Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation

Platelet-Derived Growth Factor-BB Lessens Light-Induced Rod Photoreceptor Damage in Mice

Low concentrations of levofloxacin can decrease UV-induced cellular damage

Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization

Protective Effects of Antiplacental Growth Factor Antibody Against Light-Induced Retinal Damage in Mice

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