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Glaucoma June 2018

YAP/TAZ Are Essential for TGF-β2–Mediated Conjunctival Fibrosis

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Akiko Futakuchi; Toshihiro Inoue; Fan-Yan Wei; Miyuki Inoue-Mochita; Tomokazu Fujimoto; Kazuhito Tomizawa; Hidenobu Tanihara
TAGS: conjunctiva, fibroblasts, fibrosis, proteins, signal transduction, verteporfin
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3069-3078. doi: https://doi.org/10.1167/iovs.18-24258

Includes: Supplemental Content

Glaucoma April 2018

Interaction Between Pilocarpine and Ripasudil on Intraocular Pressure, Pupil Diameter, and the Aqueous-Outflow Pathway

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Reiko Yamagishi-Kimura; Megumi Honjo; Takashi Komizo; Takashi Ono; Akiko Yagi; Jinhee Lee; Kazunori Miyata; Tomokazu Fujimoto; Toshihiro Inoue; Hidenobu Tanihara; Junko Nishida; Takatoshi Uchida; Yuka Araki; Makoto Aihara
TAGS: pilocarpine, intraocular pressure, pupil
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1844-1854. doi: https://doi.org/10.1167/iovs.18-23900

Glaucoma August 2017

Determinants and Characteristics of Bruch's Membrane Opening and Bruch's Membrane Opening–Minimum Rim Width in a Normal Japanese Population

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Makoto Araie; Aiko Iwase; Kazuhisa Sugiyama; Toru Nakazawa; Goji Tomita; Masanori Hangai; Yasuo Yanagi; Hiroshi Murata; Hidenobu Tanihara; Claude F. Burgoyne; Balwantray C. Chauhan
TAGS: bruch's basal membrane, japanese, optic disk, eye, glaucoma, spectral domain-optical coherence tomography, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4106-4113. doi: https://doi.org/10.1167/iovs.17-22057

Glaucoma April 2017

Molecular Mechanisms Underlying the Filtration Bleb-Maintaining Effects of Suberoylanilide Hydroxamic Acid (SAHA)

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Akiko Futakuchi; Toshihiro Inoue; Tomokazu Fujimoto; Utako Kuroda; Miyuki Inoue-Mochita; Eri Takahashi; Saori Ohira; Hidenobu Tanihara
TAGS: vorinostat, blister, filtration
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2421-2429. doi: https://doi.org/10.1167/iovs.16-21403

Glaucoma November 2016

Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity

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Takayuki Tsutsumi; Keiichiro Iwao; Hideki Hayashi; Tomoko Kirihara; Takahiro Kawaji; Toshihiro Inoue; Shinjiro Hino; Mitsuyoshi Nakao; Hidenobu Tanihara
TAGS: neuroprotective effect, tranylcypromine, mitogen-activated protein kinase p38, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2016; 57(14):6461-6473. doi: https://doi.org/10.1167/iovs.16-19494

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Vascular Endothelial Growth Factor-A Increases Aqueous humor Outflow Fcility

Tomokazu Fujimoto; Toshihiro Inoue; KEI MAKI; Miyuki Mochita Inoue; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4689. doi:

ARVO Annual Meeting Abstract September 2016

Effects of interleukin-6 signaling activity on fibrogenic activity of human trabecular meshwork cells

Toshihiro Inoue; Miyuki Mochita Inoue; Tomokazu Fujimoto; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4693. doi:

ARVO Annual Meeting Abstract September 2016

Four-dimensional imaging revealed influences of monocyte chemoattractant protein-1 on immune cell dynamics in the subconjunctival tissue.

Sachi Kojima; Toshihiro Inoue; Tomokazu Fujimoto; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5148. doi:

ARVO Annual Meeting Abstract September 2016

Increasing the population of retinal ganglion-like cells among retinal cells differentiated from mouse ES cells using 3D culture method

Satoshi Iraha; Michiko Mandai; Hidenobu Tanihara; Masayo Takahashi

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6073. doi:

ARVO Annual Meeting Abstract September 2016

Effects of ripasudil (K-115), a Rho kinase inhibitor, on the activation of human conjunctival fibroblasts

Akiko Futakuchi; Toshihiro Inoue; Tomokazu Fujimoto; Miyuki Mochita Inoue; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2929. doi:

ARVO Annual Meeting Abstract September 2016

Trabeculectomy in Both Eyes; the First-Operated Versus the Second-Operated Eyes: A Comparative, Multicenter Study.

Kentaro Iwasaki; Yoshihiro Takamura; Takashi Nishida; Akira Sawada; Keiichiro Iwao; Ayano Shinmura; Shiho Kunimatsu-Sanuki; Hidenobu Tanihara; Kazuhisa Sugiyama; Toru Nakazawa; Masaru Inatani

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2949. doi:

ARVO Annual Meeting Abstract September 2016

Specific clinical features of intraocular pressure-lowering effect in ripasudil (K-115): insights from 52-week phase 3 study

Hidenobu Tanihara; Toshihiro Inoue; Tetsuya Yamamoto; Yasuaki Kuwayama; Haruki Abe; Atsuki Fukushima; Hideki Suganami; Makoto Araie

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3033. doi:

Immunology and Microbiology May 2016

Differentiated Expression Patterns and Phagocytic Activities of Type 1 and 2 Microglia

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Akira Haga; Eri Takahashi; Yasuya Inomata; Koichi Kawahara; Hidenobu Tanihara
TAGS: interleukin-4, microglia
Invest. Ophthalmol. Vis. Sci.. 2016; 57(6):2814-2823. doi: https://doi.org/10.1167/iovs.15-18509

Multidisciplinary Ophthalmic Imaging March 2016

Visualization of Intravital Immune Cell Dynamics After Conjunctival Surgery Using Multiphoton Microscopy

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Sachi Kojima; Toshihiro Inoue; Junichi Kikuta; Masayuki Furuya; Ayaka Koga; Tomokazu Fujimoto; Mayumi Ueta; Shigeru Kinoshita; Masaru Ishii; Hidenobu, Tanihara
TAGS: conjunctiva, diagnostic imaging, surgical procedures, operative, wounds and injuries, mice, body tissue
Invest. Ophthalmol. Vis. Sci.. 2016; 57(3):1207-1212. doi: https://doi.org/10.1167/iovs.15-18507

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Bruch’s Membrane Opening-Based Neuroretinal Rim Width and Retinal Nerve Fibre Layer Thickness in a Normal Japanese Population. A Multi-Centre Study

Balwantray C Chauhan; Masanori Hangai; Aiko Iwase; Toru Nakazawa; Kazuhisa Sugiyama; Hidenobu Tanihara; Goji Tomita; Yasuo Yanagi; Claude F Burgoyne; Makoto Araie

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1014. doi:

ARVO Annual Meeting Abstract June 2015

The Effect of VEGF-A on Trabecular Meshwork and Schlemm’s Canal Endothelial Cells Permeability

Tomokazu Fujimoto; Toshihiro Inoue; Kei Maki; Sachi Kojima; Miyuki Inoue-Mochita; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2008. doi:

ARVO Annual Meeting Abstract June 2015

Histone deacetylase inhibitor attenuates TGF-β2 induced human conjunctival fibroblast activation

Akiko Futakuchi; Toshihiro Inoue; Tomokazu Fujimoto; Utako Kuroda; Miyuki Mochita Inoue; Eri Takahashi; Kohei Shobayashi; Saori Ohira; Sachi Kojima; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2678. doi:

ARVO Annual Meeting Abstract June 2015

Totally organized mitochondrial axonal transport patterns in retinal ganglion cells of old mice in vivo

Yuji Takihara; Masaru Inatani; Toshihiro Inoue; Keiichiro Iwao; Yoshihiro Takamura; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3661. doi:

ARVO Annual Meeting Abstract June 2015

Merlin regulates hyaluronan endocytosis and epithelial mesenchymal transition in ARPE-19 cells

Eri Takahashi; Akira Haga; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4239. doi:

ARVO Annual Meeting Abstract June 2015

TGF-β-activated kinase 1 is essential for tumor necrosis factor-α-induced epithelial mesenchymal transition in ARPE-19 cells

KOKI MATSUBARA; Eri Takahashi; Akira Haga; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4240. doi:

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YAP/TAZ Are Essential for TGF-β2–Mediated Conjunctival Fibrosis

Interaction Between Pilocarpine and Ripasudil on Intraocular Pressure, Pupil Diameter, and the Aqueous-Outflow Pathway

Determinants and Characteristics of Bruch's Membrane Opening and Bruch's Membrane Opening–Minimum Rim Width in a Normal Japanese Population

Molecular Mechanisms Underlying the Filtration Bleb-Maintaining Effects of Suberoylanilide Hydroxamic Acid (SAHA)

Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity

Vascular Endothelial Growth Factor-A Increases Aqueous humor Outflow Fcility

Effects of interleukin-6 signaling activity on fibrogenic activity of human trabecular meshwork cells

Four-dimensional imaging revealed influences of monocyte chemoattractant protein-1 on immune cell dynamics in the subconjunctival tissue.

Increasing the population of retinal ganglion-like cells among retinal cells differentiated from mouse ES cells using 3D culture method

Effects of ripasudil (K-115), a Rho kinase inhibitor, on the activation of human conjunctival fibroblasts

Trabeculectomy in Both Eyes; the First-Operated Versus the Second-Operated Eyes: A Comparative, Multicenter Study.

Specific clinical features of intraocular pressure-lowering effect in ripasudil (K-115): insights from 52-week phase 3 study

Differentiated Expression Patterns and Phagocytic Activities of Type 1 and 2 Microglia

Visualization of Intravital Immune Cell Dynamics After Conjunctival Surgery Using Multiphoton Microscopy

Bruch’s Membrane Opening-Based Neuroretinal Rim Width and Retinal Nerve Fibre Layer Thickness in a Normal Japanese Population. A Multi-Centre Study

The Effect of VEGF-A on Trabecular Meshwork and Schlemm’s Canal Endothelial Cells Permeability

Histone deacetylase inhibitor attenuates TGF-β2 induced human conjunctival fibroblast activation

Totally organized mitochondrial axonal transport patterns in retinal ganglion cells of old mice in vivo

Merlin regulates hyaluronan endocytosis and epithelial mesenchymal transition in ARPE-19 cells

TGF-β-activated kinase 1 is essential for tumor necrosis factor-α-induced epithelial mesenchymal transition in ARPE-19 cells

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