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Cornea & External Disease March 2025

Artificial Intelligence–Driven Detection of LASIK Using Corneal Optical Coherence Tomography Maps

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Jiachi Hong; Afshan A. Nanji; Richard D. Stutzman; Winston D. Chamberlain; Xubo Song; David Huang; Yan Li
TAGS: artificial intelligence, cornea, keratomileusis, laser in situ, maps, optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(3):17. https://doi.org/10.1167/tvst.14.3.17

Includes: Supplemental Content

Glaucoma March 2025

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

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Jing Wang; Yang Zhang; Huimin Zhong; Yumeng Zhang; Ruiqi Han; Yanzhi Guo; Shouyue Huang; Huan Yu; Yisheng Zhong
TAGS: ferroptosis, fibrosis, nadph oxidase 4, silicone oils, smad3 gene, trabecular meshwork, glaucoma, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):25. https://doi.org/10.1167/iovs.66.3.25

Review March 2025

Advances in OCT Angiography

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Tristan T. Hormel; David Huang; Yali Jia
TAGS: angiogram, artifacts, diagnostic imaging, deep learning, fluid flow, body tissue
Trans. Vis. Sci. Tech.. 2025; 14(3):6. https://doi.org/10.1167/tvst.14.3.6

Glaucoma March 2025

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

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Jiayong Li; Yuncheng Ma; Lingling Xie; Kaichen Zhuo; Yuxian He; Xin Ma; Shufen Zheng; Shicheng Guo; Yizhen Tang; Guzainuer Muhetaer; Mireayi Aizezi; Dan Zhang; Aizezi Wumaier; Xu Zhang; Chao Tang; Wei Wang; Wenyong Huang; Xinbo Gao
TAGS: biological markers, exfoliation syndrome, mass spectrometry, mendelian randomization analysis, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):19. https://doi.org/10.1167/iovs.66.3.19

Includes: Supplemental Content

Immunology and Microbiology March 2025

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

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Zhuang Li; Xiuxing Liu; Zuoyi Li; Zhiqiang Xiao; Guanyu Chen; Yangyang Li; Jun Huang; Yunwei Hu; Haixiang Huang; Wenjie Zhu; Yuxun Shi; Minzhen Wang; Yanyan Xie; Wenru Su; Xiaoqing Chen; Dan Liang
TAGS: autoimmunity, flow cytometry, interleukin-17, mice, rna, small cytoplasmic, t follicular helper cells, uveitis, genes, t-lymphocytes, phenotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):8. https://doi.org/10.1167/iovs.66.3.8

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology March 2025

One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old Rabbits

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Jiangtao Lou; Hailu Huang; Yiyi Peng; Chunxiao Wang; Meiping Xu; Xinping Yu
TAGS: muscle of orbit, oryctolagus cuniculus, postoperative care, surgical procedures, operative, embryo, russell-silver syndrome, surgery specialty, somatostatin receptor scintigraphy, preoperative care
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):12. https://doi.org/10.1167/iovs.66.3.12

Includes: Supplemental Content

Glaucoma February 2025

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

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Raymond Fang; Pengpeng Zhang; Daniel Kim; Junghun Kweon; Cheng Sun; Alex S. Huang; Hao F. Zhang
TAGS: optical coherence tomography, pilocarpine, schlemm's canal, visible light, eye, diagnostic imaging, vaccine information sheets, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):47. https://doi.org/10.1167/iovs.66.2.47

Cornea February 2025

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation

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Xiao Zhou; Lingjuan Xu; Yongyao Tan; Wei Wang; Xiaoyu Huang; Guigang Li
TAGS: language morphology, morphology, phenotype, translocation (genetics), diffuse idiopathic skeletal hyperostosis, cornea, stem cells, proteins, western blotting, patient isolation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):43. https://doi.org/10.1167/iovs.66.2.43

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2025

Peripheral Refraction and Axial Growth Rate After Multifocal or Monofocal Intraocular Lens Implantation in Chinese Pediatric Cataract Patients

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Qiuxuan Du; Ying Zhang; Yusen Huang
TAGS: cataract, cataract, childhood, chinese (other dialects), chinese people, eye, growth rate, intraocular lens implantation procedure, multifocal intraocular lenses, refraction, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):33. https://doi.org/10.1167/iovs.66.2.33

Clinical and Epidemiologic Research February 2025

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

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Ying-Yi Chen; Chung-May Yang; Chang-Hao Yang; Tzyy-Chang Ho; Yi-Ting Hsieh; Tso-Ting Lai; Tzu-Hsun Tsai; Shu-Yi Huang
TAGS: ceramides, vitreous body, diabetic retinopathy, proliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):28. https://doi.org/10.1167/iovs.66.2.28

Glaucoma January 2025

SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression

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Qian Ying; Hongdou Luo; Zhi Xie; Yi Huang; Haijian Hu; Ming Jin; Ke Xu; Yulian Pang; Yuning Song; Xu Zhang
TAGS: glutamate, glutamates, mitochondria, neuroglia, optic atrophy, autosomal dominant, proteins, retina, wounds and injuries, n-methylaspartate, retinal injuries
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):62. https://doi.org/10.1167/iovs.66.1.62

Retina January 2025

Perfusion Capacity as a Predictive Index for Assessing Visual Functional Recovery in Patients With Idiopathic Epiretinal Membrane

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Jinlian Zhan; Chen Chen; Tong Wang; Qi Zhang; Xia Huang; Lin Lu; Xiujuan Zhao
TAGS: epiretinal membrane, perfusion, postoperative care, preoperative care, recovery of function, retinal vasculature, vision, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(1):19. https://doi.org/10.1167/tvst.14.1.19

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2025

The Value of Orbital Exenteration for Eyelid Sebaceous Carcinoma in Stages II to IV: A Cohort Study of 78 Patients

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Jie Chen; Tianyu Zhu; Ziyue Huang; Renbing Jia; Shiqiong Xu
TAGS: cohort studies, eye, orbit evisceration, sebaceous adenocarcinoma, sebaceous adenocarcinoma of eyelid, neoplasm metastasis, surgical procedures, operative, recurrence, selenocysteine, cerebral arterial thrombosis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):40. https://doi.org/10.1167/iovs.66.1.40

Includes: Supplemental Content

Cornea January 2025

Recombinant Thrombomodulin Domain 1 Modulates Macrophage Polarization and Enhances Healing in Corneal Alkali Burns

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Chun-Hsiang Chang; I-Chen Peng; Yi-Hsun Huang
TAGS: alkalies, burns, cornea, macrophage activation, thrombomodulin, wound healing
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):21. https://doi.org/10.1167/iovs.66.1.21

Anatomy and Pathology/Oncology January 2025

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

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Xiaoting Pei; Mengru Ba; Tingting Yang; Shuting Xuan; Duliurui Huang; Di Qi; Dingli Lu; Shenzhen Huang; Zhijie Li
TAGS: diabetes mellitus, diabetes mellitus, type 2, insulin, mice, langer-giedion syndrome, circadian rhythms, dry eye syndromes, gene expression
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):19. https://doi.org/10.1167/iovs.66.1.19

Includes: Supplemental Content

Pediatric Ophthalmology & Strabismus January 2025

The Associations Between Myopia and Fundus Tessellation in School Children: A Comparative Analysis of Macular and Peripapillary Regions Using Deep Learning

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Dan Huang; Xiao Lin; Hui Zhu; Saiguang Ling; Zhou Dong; Xin Ke; Tengfei Long; Yingxiao Qian; Qi Yan; Rui Li; Hua Zhong; Hu Liu
TAGS: deep learning, frontotemporal dementia, myopia, school-age child
Trans. Vis. Sci. Tech.. 2025; 14(1):4. https://doi.org/10.1167/tvst.14.1.4

Includes: Supplemental Content

Physiology and Pharmacology January 2025

Chronic Jet Lag Disrupts Circadian Rhythms and Induces Hyperproliferation in Murine Lacrimal Glands via ROS Accumulation

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Shenzhen Huang; Wenxiao Zhang; Mengru Ba; Shuting Xuan; Duliurui Huang; Di Qi; Xiaoting Pei; Dingli Lu; Zhijie Li
TAGS: circadian rhythm disorders, circadian rhythms, jet lag syndrome, mice, gene expression, rhythm, genes, cell proliferation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):12. https://doi.org/10.1167/iovs.66.1.12

Includes: Supplemental Content

Anatomy and Pathology/Oncology January 2025

Metabolic Atlas of Human Eyelid Infiltrative Basal Cell Carcinoma

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Yanjing Huang; Chengjie He; Qiuling Hu; Zhong Liu; Xingyi Li; Wuyou Gao; Xuanwei Liang; Rongxin Chen; Zhen Mao; Xianchai Lin
TAGS: basal cell carcinoma, eyelid, genes, infiltrative basal cell carcinoma, metabolites, neoplasms, metabolic disturbance, tumor microenvironment, up-regulation (physiology), spectrometry, mass, matrix-assisted laser desorption-ionization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):11. https://doi.org/10.1167/iovs.66.1.11

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2025

Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults

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Yanping Chen; Ruilin Xiong; Jian Zhang; Shaopeng Yang; Huangdong Li; Ziyu Zhu; Peiyuan Wang; Mingguang He; Yingfeng Zheng; Wei Wang
TAGS: adult, child, eye, incidence, myopia, vision, visual impairment, blindness, world health organization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):2. https://doi.org/10.1167/iovs.66.1.2

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics December 2024

Serial Dependence in Smooth Pursuit Eye Movements of Preadolescent Children and Adults

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Bao Hong; Jing Chen; Wenjun Huang; Li Li
TAGS: adult, anisotropy, child, motion, pursuit, smooth, pre-teen, precision
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):37. https://doi.org/10.1167/iovs.65.14.37

Includes: Supplemental Content

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Artificial Intelligence–Driven Detection of LASIK Using Corneal Optical Coherence Tomography Maps

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

Advances in OCT Angiography

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old Rabbits

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation

Peripheral Refraction and Axial Growth Rate After Multifocal or Monofocal Intraocular Lens Implantation in Chinese Pediatric Cataract Patients

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression

Perfusion Capacity as a Predictive Index for Assessing Visual Functional Recovery in Patients With Idiopathic Epiretinal Membrane

The Value of Orbital Exenteration for Eyelid Sebaceous Carcinoma in Stages II to IV: A Cohort Study of 78 Patients

Recombinant Thrombomodulin Domain 1 Modulates Macrophage Polarization and Enhances Healing in Corneal Alkali Burns

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

The Associations Between Myopia and Fundus Tessellation in School Children: A Comparative Analysis of Macular and Peripapillary Regions Using Deep Learning

Chronic Jet Lag Disrupts Circadian Rhythms and Induces Hyperproliferation in Murine Lacrimal Glands via ROS Accumulation

Metabolic Atlas of Human Eyelid Infiltrative Basal Cell Carcinoma

Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults

Serial Dependence in Smooth Pursuit Eye Movements of Preadolescent Children and Adults

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