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ARVO Annual Meeting Abstract June 2022

Depletion of GSDMD by AAV-Mediated Crispr/SaCas9 Rescues Hyperoxia-induced Cell Death in Vitro

Huijun Yuan; Shaoyi Chen; Matthew R Duncan; Pingping Chen; Merline Benny; Augusto Schmidt; Karen Young; Shu Wu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1743 – F0203.

ARVO Annual Meeting Abstract July 2019

Photoreceptor damage caused by human mutant T8993G ATP6 in a transgenic mouse model of Leigh syndrome and NARP

Huijun Yuan; John Guy

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):456.

ARVO Annual Meeting Abstract July 2019

Gene Therapy for Leber Hereditary Optic NeuropathY An update of Where We Stand (Clinicaltrials.gov number: NCT02161380)

John Guy; William Feuer; Janet L Davis; Vittorio Porciatti; Philip Gonzalez; Rajeshwari D Koilkonda; Huijun Yuan; Byron L Lam

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3602.

ARVO Annual Meeting Abstract July 2018

Novel NDUFV1 mutations with optic nerve atrophy

Zhike Zhang; Huijun Yuan; John Guy

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4140.

ARVO Annual Meeting Abstract September 2016

Rescue of a mutant T8993G ATP6 mouse model of NARP and MILS with Mito-Targeted AAV9 Containing Normal ATP6

Huijun Yuan; Hong Yu; John Guy

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):754.

ARVO Annual Meeting Abstract September 2016

LHON Gene Therapy Clinical Trial: Year 2 Results

John Guy; William J Feuer; Janet L Davis; Vittorio Porciatti; Rajeshwari D Koilkonda; Huijun Yuan; Byron L Lam; William Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5086.

ARVO Annual Meeting Abstract June 2015

A Mutant Human T8993G ATP6 Transgenic Mouse Model With Visual Loss, Paralysis and Death

Huijun Yuan; Hong Yu; John Guy

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):247.

ARVO Annual Meeting Abstract June 2015

Leber Hereditary Optic Neuropathy Gene Therapy (LHON) Clinical Trial: Initial Results

John Guy; William J Feuer; Vittorio Porciatti; William W Hauswirth; Janet L Davis; Byron L Lam; Rajeshwari D Koilkonda; Huijun Yuan; Phillip Gonzalez; Anil Lalwani

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2608.

ARVO Annual Meeting Abstract April 2014

A Single Mito-targeted AAV Containing Multiple Mitochondrial Genes: Expression and Rescue Studies In Mice and LHON Cells.

Hong Yu; Huijun Yuan; Gabriel S Gaidosh; John Guy

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3308.

ARVO Annual Meeting Abstract April 2014

Mutant Human T8993G ATP6 Expression by a Mitochondrial Targeting Sequence Modification of AAV Capsid VP2 in Transgenic Mice

Huijun Yuan; John Guy

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3311.

ARVO Annual Meeting Abstract April 2014

Gene Therapy For Mitochondrial Disease: Are We Ready?

Rajeshwari D Koilkonda; Hong Yu; Huijun Yuan; Vittorio Porciatti; William W Hauswirth; Thomas J Conlon; Lauren Renner; Martha Neuringer; Carol Detrisac; John Guy

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):836.

ARVO Annual Meeting Abstract June 2013

Gene Delivery of ATP6 by A Mitochondrial Targeting Sequence Modification of AAV Capsid VP2 Rescues Cells with Mutated T8993G MtDNA Responsible for Neuropathy Ataxia and Retinitis Pigmentosa

Huijun Yuan; Hong Yu; John Guy

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2724.

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