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ARVO Annual Meeting Abstract June 2024

Targeting depletion of glutathione (GSH) by menadione leads to reduced cell viability: Implications for posterior capsular opacification following cataract surgery.

Preeya Ganger; Ian Michael Wormstone

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5045.

Lens December 2021

GSH Levels Serve As a Biological Redox Switch Regulating Sulforaphane-Induced Cell Fate in Human Lens Cells

PDF

Thao Phuong Ngoc Huynh; Richard P. Bowater; Federico Bernuzzi; Shikha Saha; I. Michael Wormstone
TAGS: cell death, cytotoxicity, lens, crystalline, oxidation-reduction, sulforaphane, proteins, glutathione disulfide, mitochondria, mass or substance concentration per volume, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2021; 62(15):2. https://doi.org/10.1167/iovs.62.15.2

Includes: Supplemental Content

Lens September 2019

Resveratrol Inhibits Wound Healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification Prevention

PDF

Andrew J. O. Smith; Julie A. Eldred; I. Michael Wormstone
TAGS: lens, crystalline, resveratrol, wound healing, lens (device), after-cataract, prevention, fibrosis, epithelial to mesenchymal transition
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3863-3877. https://doi.org/10.1167/iovs.18-26248

Lens January 2019

An In Vitro Human Lens Capsular Bag Model Adopting a Graded Culture Regime to Assess Putative Impact of IOLs on PCO Formation

PDF

Julie A. Eldred; Jiyun Zheng; Sulin Chen; I. Michael Wormstone
TAGS: cell growth, lens, crystalline, cataract surgery, surgical procedures, operative, donors, immunocytochemistry, optics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):113-122. https://doi.org/10.1167/iovs.18-25930

Lens December 2015

Ku80 Counters Oxidative Stress–Induced DNA Damage and Cataract Formation in the Human Lens

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Andrew John Oliver Smith; Simon Sidney Robert Ball; Kamal Manzar; Richard Peter Bowater; Ian Michael Wormstone
TAGS: cataract, dna damage, lens, crystalline, oxidative stress
Invest. Ophthalmol. Vis. Sci.. 2015; 56(13):7868-7874. https://doi.org/10.1167/iovs.15-18309

Lens November 2014

An In Vitro Evaluation of the Anew Zephyr Open-Bag IOL in the Prevention of Posterior Capsule Opacification Using a Human Capsular Bag Model

PDF

Julie A. Eldred; David J. Spalton; I. Michael Wormstone
TAGS: after-cataract, prevention, eye
Invest. Ophthalmol. Vis. Sci.. 2014; 55(11):7057-7064. https://doi.org/10.1167/iovs.14-15302

Lens August 2013

Sulforaphane Can Protect Lens Cells Against Oxidative Stress: Implications for Cataract Prevention

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Hanruo Liu; Andrew J. O. Smith; Martin C. Lott; Yongping Bao; Richard P. Bowater; John R. Reddan; Ian Michael Wormstone
TAGS: cataract, lens (device), lens cell, lens, crystalline, oxidative stress, prevention, sulforaphane, cytotoxicity, mohr-tranebjaerg syndrome, cell survival
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5236-5248. https://doi.org/10.1167/iovs.13-11664

Cornea July 2013

Serum Deprivation Can Suppress Receptor-Mediated Calcium Signaling in Pterygial-Derived Fibroblasts

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Chunlai Fang; Christopher D. Illingworth; Limin Qian; I. Michael Wormstone
TAGS: calcium signaling, fibroblasts, thapsigargin, cell growth, calcium, calcium level result, pterygium, mohr-tranebjaerg syndrome
Invest. Ophthalmol. Vis. Sci.. 2013; 54(7):4563-4570. https://doi.org/10.1167/iovs.13-11604

Lens January 2013

Age-Related Differences in Signaling Efficiency of Human Lens Cells Underpin Differential Wound Healing Response Rates following Cataract Surgery

PDF

Lucy Jean Dawes; George Duncan; Ian Michael Wormstone
TAGS: cataract surgery, cytokine, donors, frequency of responses, lens, crystalline, signal transduction, wound healing, culture media, proteins, fibroblast growth factor 2
Invest. Ophthalmol. Vis. Sci.. 2013; 54(1):333-342. https://doi.org/10.1167/iovs.12-10425

Lens June 2012

MMP2 Activity is Critical for TGFβ2-Induced Matrix Contraction—Implications for Fibrosis

PDF

Julie A. Eldred; Lisa M. Hodgkinson; Lucy J. Dawes; John R. Reddan; Dylan R. Edwards; I. Michael Wormstone
TAGS: gelatinase a
Invest. Ophthalmol. Vis. Sci.. 2012; 53(7):4085-4098. https://doi.org/10.1167/iovs.12-9457

ARVO Annual Meeting Abstract March 2012

Serum Deprivation Can Suppress Receptor Mediated Calcium Signalling In Pterygial-derived Fibroblasts

Chunlai FANG; Christopher D. Illingworth; Limin Qian; I M. Wormstone

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4023.

ARVO Annual Meeting Abstract March 2012

A Putative Role for Histamine Releasing Factor in Posterior Capsule Opacification

I M. Wormstone; Jevneet K. Kular; John R. Reddan; Lucy J. Dawes

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6910.

ARVO Annual Meeting Abstract March 2012

Sulforaphane Can Protect Human Lens Cells Against Oxidative Stress

Hanruo Liu; Andrew J. Smith; Martin C. Lott; Yongping Bao; Richard P. Bowater; John R. Reddan; I M. Wormstone

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1066.

Lens January 2012

A Fully Human In Vitro Capsular Bag Model to Permit Intraocular Lens Evaluation

PDF

Lucy J. Dawes; Christopher D. Illingworth; I. Michael Wormstone
TAGS: intraocular lens implant device, lens, crystalline, cataract surgery, lens (device), polymethyl methacrylate, bromodeoxyuridine, epithelium
Invest. Ophthalmol. Vis. Sci.. 2012; 53(1):23-29. https://doi.org/10.1167/iovs.11-8851

ARVO Annual Meeting Abstract April 2011

17β-estradiol Can Suppress TGFβ2-induced Transdifferentiation And Collagen Production, But Does Not Inhibit Matrix Contraction

Ian M. Wormstone; Chris D. Illingworth; John R. Reddan; Lucy J. Dawes

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4779.

ARVO Annual Meeting Abstract April 2010

Sigma-1 Receptor Stimulation Provides Protection Against Oxidative Damage Through Suppression of ER Stress Responses in the Human Lens

L. Wang; J. R. Reddan; I. M. Wormstone

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):1184.

ARVO Annual Meeting Abstract April 2010

Histamine Stimulates Multiple Signalling Pathways in Human Lens Cells Leading to Accelerated Growth Rate

I. M. Wormstone; M. Johnston; L. J. Dawes; J. A. Maidment; L. Wang; L. M. Hodgkinson; J. Hadfield; J. R. Reddan

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):1597.

Lens November 2009

TGFβ/Smad4-Dependent and -Independent Regulation of Human Lens Epithelial Cells

PDF

Lucy Jean Dawes; Matthew Alexander Sleeman; Ian Keith Anderson; John R. Reddan; Ian Michael Wormstone
TAGS: rna, small interfering, smad4 gene, lens, crystalline, epithelial cells, regulation
Invest. Ophthalmol. Vis. Sci.. 2009; 50(11):5318-5327. https://doi.org/10.1167/iovs.08-3223

Lens September 2009

Regional Differences in Store-Operated Ca 2+ Entry in the Epithelium of the Intact Human Lens

PDF

Jeremy D. Rhodes; Sarah L. Russell; Christopher D. Illingworth; George Duncan; I. Michael Wormstone
TAGS: epithelium, geographic difference, lens, crystalline, lens epithelial cell, epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2009; 50(9):4330-4336. https://doi.org/10.1167/iovs.08-3222

ARVO Annual Meeting Abstract April 2009

Age-Related Signaling Capacities of Human Lens Cells

L. J. Dawes; G. Duncan; I. M. Wormstone

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):2119.

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Targeting depletion of glutathione (GSH) by menadione leads to reduced cell viability: Implications for posterior capsular opacification following cataract surgery.

GSH Levels Serve As a Biological Redox Switch Regulating Sulforaphane-Induced Cell Fate in Human Lens Cells

Resveratrol Inhibits Wound Healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification Prevention

An In Vitro Human Lens Capsular Bag Model Adopting a Graded Culture Regime to Assess Putative Impact of IOLs on PCO Formation

Ku80 Counters Oxidative Stress–Induced DNA Damage and Cataract Formation in the Human Lens

An In Vitro Evaluation of the Anew Zephyr Open-Bag IOL in the Prevention of Posterior Capsule Opacification Using a Human Capsular Bag Model

Sulforaphane Can Protect Lens Cells Against Oxidative Stress: Implications for Cataract Prevention

Serum Deprivation Can Suppress Receptor-Mediated Calcium Signaling in Pterygial-Derived Fibroblasts

Age-Related Differences in Signaling Efficiency of Human Lens Cells Underpin Differential Wound Healing Response Rates following Cataract Surgery

MMP2 Activity is Critical for TGFβ2-Induced Matrix Contraction—Implications for Fibrosis

Serum Deprivation Can Suppress Receptor Mediated Calcium Signalling In Pterygial-derived Fibroblasts

A Putative Role for Histamine Releasing Factor in Posterior Capsule Opacification

Sulforaphane Can Protect Human Lens Cells Against Oxidative Stress

A Fully Human In Vitro Capsular Bag Model to Permit Intraocular Lens Evaluation

17β-estradiol Can Suppress TGFβ2-induced Transdifferentiation And Collagen Production, But Does Not Inhibit Matrix Contraction

Sigma-1 Receptor Stimulation Provides Protection Against Oxidative Damage Through Suppression of ER Stress Responses in the Human Lens

Histamine Stimulates Multiple Signalling Pathways in Human Lens Cells Leading to Accelerated Growth Rate

TGFβ/Smad4-Dependent and -Independent Regulation of Human Lens Epithelial Cells

Regional Differences in Store-Operated Ca 2+ Entry in the Epithelium of the Intact Human Lens

Age-Related Signaling Capacities of Human Lens Cells

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