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ARVO Imaging in the Eye Conference Abstract August 2019

Real-time measurement of lamina cribrosa and sclera collagen architecture and mechanics at sub-micron resolution

Ian A Sigal; PoYi Lee; Bryn Brazile; Po Lam; Ziyi Zhu; Yi Hua; Bin Yang

Invest. Ophthalmol. Vis. Sci.. 2019; 60(11):011. doi:

ARVO Imaging in the Eye Conference Abstract August 2019

Reproducibility of Lamina Cribrosa Microstructure Measurements in Varying Intraocular and Intracranial Pressure Settings

Katie Lucy; Ravneet Singh Rai; Yoav Glidai; Mengfei Wu; Bo Wang; Ian A Sigal; Matthew Smith; Hiroshi Ishikawa; Joel S Schuman; Gadi Wollstein

Invest. Ophthalmol. Vis. Sci.. 2019; 60(11):PB0180. doi:

ARVO Annual Meeting Abstract July 2019

Translaminar Pressure Effect on the Lamina Cribrosa of Non-Human Primate Eyes as a Function of Depth

Katie Lucy; Bo Wang; Hiroshi Ishikawa; Joel S Schuman; Mengfei Wu; Ian A Sigal; Matthew A Smith; Gadi Wollstein

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2248. doi:

ARVO Annual Meeting Abstract July 2019

One beam-one vessel is not true: lamina cribrosa vessel and collagen beam networks have distinct topologies

Bryn Brazile; Bin Yang; Alexandra Gogola; Po Lam; Andrew Voorhees; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4275. doi:

ARVO Annual Meeting Abstract July 2019

Collagen fiber interweaving strongly influences sclera stiffness, and likely plays a central role in globe mechanics

Ian A Sigal; Bingrui Wang; Bin Yang; Po-Yi Lee; Tian Yong Foong; Bryn Brazile; Yi Hua

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6177. doi:

Glaucoma October 2018

Radial and Circumferential Collagen Fibers Are a Feature of the Peripapillary Sclera of Human, Monkey, Pig, Cow, Goat, and Sheep

PDF

Alexandra Gogola; Ning-Jiun Jan; Kira L. Lathrop; Ian A. Sigal
TAGS: cattle, cercopithecidae, collagen, mammals, sheep, eye, sclera, galveston orientation and amnesia test
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4763-4774. doi: 10.1167/iovs.18-25025

Includes: Supplemental Content

Glaucoma September 2018

Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams

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Bryn L. Brazile; Yi Hua; Ning-Jiun Jan; Jacob Wallace; Alexandra Gogola; Ian A. Sigal
TAGS: collagen, eye, cribriform plate
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4653-4661. doi: 10.1167/iovs.18-24763

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Don’t judge a beam by its width; thin lamina cribrosa beams have different collagen microstructure than thick beams

Ian A Sigal; Bryn Brazile; Ning-Jiun Jan; Alexandra Gogola; James Russell Constantin; Andrew Voorhees

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1216. doi:

ARVO Annual Meeting Abstract July 2018

In-Vivo Macro and Micro-Structure Optic Nerve Head Deformations Due to Gaze and Intracranial Pressure Changes

Jenna Tauber; Katie Lucy; Ian A Sigal; Junchao Wei; Samantha Schmitt; Zach Nadler; Hiroshi Ishikawa; Joel S Schuman; Matthew A Smith; Gadi Wollstein

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2096. doi:

ARVO Annual Meeting Abstract July 2018

Simultaneous in-situ visualization and quantification of lamina cribrosa collagen beams and capillaries at normal and elevated IOPs

Bryn Brazile; Bin Yang; Andrew Voorhees; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1220. doi:

Glaucoma June 2018

Spatial Patterns and Age-Related Changes of the Collagen Crimp in the Human Cornea and Sclera

PDF

Alexandra Gogola; Ning-Jiun Jan; Bryn Brazile; Po Lam; Kira L. Lathrop; Kevin C. Chan; Ian A. Sigal
TAGS: collagen, cornea, eye, sclera
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2987-2998. doi: 10.1167/iovs.17-23474

Includes: Supplemental Content

Glaucoma May 2018

Seeing the Hidden Lamina: Effects of Exsanguination on the Optic Nerve Head

PDF

Huong Tran; Jacob Wallace; Ziyi Zhu; Katie A. Lucy; Andrew P. Voorhees; Samantha E. Schmitt; Richard A. Bilonick; Joel S. Schuman; Matthew A. Smith; Gadi Wollstein; Ian A. Sigal
TAGS: optic disk, eye, sclera, shape
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2564-2575. doi: 10.1167/iovs.17-23356

Glaucoma January 2018

Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics

PDF

Yi Hua; Andrew P. Voorhees; Ian A. Sigal
TAGS: biomechanics, cerebrospinal fluid pressure, optic disk, intraocular pressure, sclera
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):154-165. doi: 10.1167/iovs.17-22488

Includes: Supplemental Content

Glaucoma October 2017

Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult

PDF

Andrew P. Voorhees; Ning-Jiun Jan; Morgan E. Austin; John G. Flanagan; Jeremy M. Sivak; Richard A. Bilonick; Ian A. Sigal
TAGS: nerve tissue, intraocular pressure, stress, cribriform plate, shape
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5336-5346. doi: 10.1167/iovs.17-22015

Glaucoma July 2017

Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers

PDF

Ning-Jiun Jan; Celeste Gomez; Saundria Moed; Andrew P. Voorhees; Joel S. Schuman; Richard A. Bilonick; Ian A. Sigal
TAGS: collagen, sclera
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3378-3388. doi: 10.1167/iovs.17-21811

ARVO Annual Meeting Abstract June 2017

Lamina Cribrosa Pore Convexity Predicts Neural Tissue Mechanical Insult

Andrew P Voorhees; Ning-Jiun Jan; Morgan Austin; John G Flanagan; Jeremy M Sivak; Richard Anthony Bilonick; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3159. doi:

ARVO Annual Meeting Abstract June 2017

Stretch-Induced Collagen Bundle Uncrimping and Recruitment are Independent of Depth in Equatorial Sclera

Jacob Wallace; Ning-Jiun Jan; Alexandra Gogola; Michael Iasella; Kira L Lathrop; Andrew P Voorhees; Huong Tran; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3162. doi:

ARVO Annual Meeting Abstract June 2017

Lamina cribrosa shape is different between humans and monkeys at baseline IOP and is changed differently with IOP elevations

Huong Tran; Jacob Wallace; Andrew P Voorhees; Ziyi Zhu; Bo Wang; Katie A. Lucy; Joel S Schuman; Matthew Smith; Gadi Wollstein; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3157. doi:

ARVO Annual Meeting Abstract June 2017

Cerebrospinal Fluid Pressure (CSFP) and the Constraints on the Optic Nerve at the Orbit Exit (CON) Can Influence Optic Nerve Head (ONH) Biomechanics

Yi Hua; Andrew P Voorhees; Jonathan L Grimm; Bin Yang; Joel S Schuman; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3172. doi:

ARVO Annual Meeting Abstract June 2017

Collagen architecture in the third dimension:3D polarized light microscopy (3DPLM) for mapping in-plane (IP) and out-of-plane (OOP) collagen fiber architecture

Bin Yang; Ning-Jiun Jan; Po Lam; Kira L Lathrop; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4825. doi:

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Real-time measurement of lamina cribrosa and sclera collagen architecture and mechanics at sub-micron resolution

Reproducibility of Lamina Cribrosa Microstructure Measurements in Varying Intraocular and Intracranial Pressure Settings

Translaminar Pressure Effect on the Lamina Cribrosa of Non-Human Primate Eyes as a Function of Depth

One beam-one vessel is not true: lamina cribrosa vessel and collagen beam networks have distinct topologies

Collagen fiber interweaving strongly influences sclera stiffness, and likely plays a central role in globe mechanics

Radial and Circumferential Collagen Fibers Are a Feature of the Peripapillary Sclera of Human, Monkey, Pig, Cow, Goat, and Sheep

Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams

Don’t judge a beam by its width; thin lamina cribrosa beams have different collagen microstructure than thick beams

In-Vivo Macro and Micro-Structure Optic Nerve Head Deformations Due to Gaze and Intracranial Pressure Changes

Simultaneous in-situ visualization and quantification of lamina cribrosa collagen beams and capillaries at normal and elevated IOPs

Spatial Patterns and Age-Related Changes of the Collagen Crimp in the Human Cornea and Sclera

Seeing the Hidden Lamina: Effects of Exsanguination on the Optic Nerve Head

Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics

Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult

Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers

Lamina Cribrosa Pore Convexity Predicts Neural Tissue Mechanical Insult

Stretch-Induced Collagen Bundle Uncrimping and Recruitment are Independent of Depth in Equatorial Sclera

Lamina cribrosa shape is different between humans and monkeys at baseline IOP and is changed differently with IOP elevations

Cerebrospinal Fluid Pressure (CSFP) and the Constraints on the Optic Nerve at the Orbit Exit (CON) Can Influence Optic Nerve Head (ONH) Biomechanics

Collagen architecture in the third dimension:3D polarized light microscopy (3DPLM) for mapping in-plane (IP) and out-of-plane (OOP) collagen fiber architecture

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