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Glaucoma November 2020

So-Called Lamina Cribrosa Defects May Mitigate IOP-Induced Neural Tissue Insult

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Andrew P. Voorhees; Yi Hua; Bryn L. Brazile; Bingrui Wang; Susannah Waxman; Joel S. Schuman; Ian A. Sigal

Invest. Ophthalmol. Vis. Sci.. 2020; 61(13):15. doi: https://doi.org/10.1167/iovs.61.13.15

Glaucoma October 2020

Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases

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Bryn L. Brazile; Bin Yang; Susannah Waxman; Po Lam; Andrew P. Voorhees; Yi Hua; Ralitsa T. Loewen; Nils A. Loewen; Joseph F. Rizzo, III; Tatjana Jakobs; Ian A. Sigal
TAGS: blood capillaries, cribriform plate, intraocular pressure, vasculature, eye
Invest. Ophthalmol. Vis. Sci.. 2020; 61(12):2. doi: https://doi.org/10.1167/iovs.61.12.2

ARVO Imaging in the Eye Conference Abstract July 2020

Real-time structured polarized light imaging (rtSPLI) for thick ocular tissue dynamics

Bin Yang; Po-Yi Lee; Melissa Echard; Ziyi Zhu; Fengting Ji; Benjamin Bernarding; Ian A. Sigal

Invest. Ophthalmol. Vis. Sci.. 2020; 61(9):PB0022. doi:

ARVO Imaging in the Eye Conference Abstract July 2020

In-Vivo 3D Lamina Cribrosa Microstructure Characterization of Healthy Non-Human Primates

Yoav Glidai; Anoop Sainulabdeen; Mengfei Wu; Matthew A. Smith; Ian A. Sigal; Hiroshi Ishikawa; Joel Schuman; Gadi Wollstein

Invest. Ophthalmol. Vis. Sci.. 2020; 61(9):PP004. doi:

ARVO Annual Meeting Abstract June 2020

Under the Surface: Deformations in the Deep Lamina Cribrosa

Yoav Glidai; Mengfei Wu; Joel S Schuman; Katie Lucy; Ian A Sigal; Matthew A Smith; Hiroshi Ishikawa; Gadi Wollstein

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3529. doi:

ARVO Annual Meeting Abstract June 2020

Local decreases in lamina cribrosa oxygen concentration under elevated IOP are not correlated with the degree of IOP-induced compression

Yi Hua; Haiden McDonald; Jason Walker; Pedro Pallares; Bryn Brazile; Ian A. Sigal

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3532. doi:

ARVO Annual Meeting Abstract June 2020

Characterization of lamina cribrosa beam insertion into the sclera canal in sheep, pig, monkey, and human

Fengting Ji; Bin Yang; Yi Hua; Po-Yi Lee; Ziyi Zhu; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4782. doi:

ARVO Annual Meeting Abstract June 2020

Microstructural evidence that lamina cribrosa beams (LC), peripapillary sclera (PPS) and central retinal artery (CRA) have distinct mechanical behaviors when stretched

Po-Yi Lee; Bin Yang; Ziyi Zhu; Fengting Ji; Yi Hua; Ian A. Sigal

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4783. doi:

ARVO Annual Meeting Abstract June 2020

Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo

Ian A Sigal; Huong Tran; Ziyi Zhu; Bo Wang; Elizabeth Tyler-Kabara; Hiroshi Ishikawa; Joel S Schuman; Matthew A Smith; Gadi Wollstein

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4785. doi:

ARVO Annual Meeting Abstract June 2020

Factors influencing oxygen concentration in the lamina cribrosa

Jason Arthur Walker; Yi Hua; Haiden McDonald; Pedro Pallares; Bryn Brazile; Ian A. Sigal

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):632. doi:

ARVO Imaging in the Eye Conference Abstract August 2019

Real-time measurement of lamina cribrosa and sclera collagen architecture and mechanics at sub-micron resolution

Ian A Sigal; PoYi Lee; Bryn Brazile; Po Lam; Ziyi Zhu; Yi Hua; Bin Yang

Invest. Ophthalmol. Vis. Sci.. 2019; 60(11):011. doi:

ARVO Imaging in the Eye Conference Abstract August 2019

Reproducibility of Lamina Cribrosa Microstructure Measurements in Varying Intraocular and Intracranial Pressure Settings

Katie Lucy; Ravneet Singh Rai; Yoav Glidai; Mengfei Wu; Bo Wang; Ian A Sigal; Matthew Smith; Hiroshi Ishikawa; Joel S Schuman; Gadi Wollstein

Invest. Ophthalmol. Vis. Sci.. 2019; 60(11):PB0180. doi:

ARVO Annual Meeting Abstract July 2019

One beam-one vessel is not true: lamina cribrosa vessel and collagen beam networks have distinct topologies

Bryn Brazile; Bin Yang; Alexandra Gogola; Po Lam; Andrew Voorhees; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4275. doi:

ARVO Annual Meeting Abstract July 2019

Collagen fiber interweaving strongly influences sclera stiffness, and likely plays a central role in globe mechanics

Ian A Sigal; Bingrui Wang; Bin Yang; Po-Yi Lee; Tian Yong Foong; Bryn Brazile; Yi Hua

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6177. doi:

ARVO Annual Meeting Abstract July 2019

Translaminar Pressure Effect on the Lamina Cribrosa of Non-Human Primate Eyes as a Function of Depth

Katie Lucy; Bo Wang; Hiroshi Ishikawa; Joel S Schuman; Mengfei Wu; Ian A Sigal; Matthew A Smith; Gadi Wollstein

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2248. doi:

Glaucoma October 2018

Radial and Circumferential Collagen Fibers Are a Feature of the Peripapillary Sclera of Human, Monkey, Pig, Cow, Goat, and Sheep

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Alexandra Gogola; Ning-Jiun Jan; Kira L. Lathrop; Ian A. Sigal
TAGS: cattle, cercopithecidae, collagen, eye, galveston orientation and amnesia test, mammals, sclera, sheep
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4763-4774. doi: https://doi.org/10.1167/iovs.18-25025

Includes: Supplemental Content

Glaucoma September 2018

Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams

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Bryn L. Brazile; Yi Hua; Ning-Jiun Jan; Jacob Wallace; Alexandra Gogola; Ian A. Sigal
TAGS: collagen, cribriform plate, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4653-4661. doi: https://doi.org/10.1167/iovs.18-24763

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Simultaneous in-situ visualization and quantification of lamina cribrosa collagen beams and capillaries at normal and elevated IOPs

Bryn Brazile; Bin Yang; Andrew Voorhees; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1220. doi:

ARVO Annual Meeting Abstract July 2018

Don’t judge a beam by its width; thin lamina cribrosa beams have different collagen microstructure than thick beams

Ian A Sigal; Bryn Brazile; Ning-Jiun Jan; Alexandra Gogola; James Russell Constantin; Andrew Voorhees

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1216. doi:

ARVO Annual Meeting Abstract July 2018

In-Vivo Macro and Micro-Structure Optic Nerve Head Deformations Due to Gaze and Intracranial Pressure Changes

Jenna Tauber; Katie Lucy; Ian A Sigal; Junchao Wei; Samantha Schmitt; Zach Nadler; Hiroshi Ishikawa; Joel S Schuman; Matthew A Smith; Gadi Wollstein

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2096. doi:

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So-Called Lamina Cribrosa Defects May Mitigate IOP-Induced Neural Tissue Insult

Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases

Real-time structured polarized light imaging (rtSPLI) for thick ocular tissue dynamics

In-Vivo 3D Lamina Cribrosa Microstructure Characterization of Healthy Non-Human Primates

Under the Surface: Deformations in the Deep Lamina Cribrosa

Local decreases in lamina cribrosa oxygen concentration under elevated IOP are not correlated with the degree of IOP-induced compression

Characterization of lamina cribrosa beam insertion into the sclera canal in sheep, pig, monkey, and human

Microstructural evidence that lamina cribrosa beams (LC), peripapillary sclera (PPS) and central retinal artery (CRA) have distinct mechanical behaviors when stretched

Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo

Factors influencing oxygen concentration in the lamina cribrosa

Real-time measurement of lamina cribrosa and sclera collagen architecture and mechanics at sub-micron resolution

Reproducibility of Lamina Cribrosa Microstructure Measurements in Varying Intraocular and Intracranial Pressure Settings

One beam-one vessel is not true: lamina cribrosa vessel and collagen beam networks have distinct topologies

Collagen fiber interweaving strongly influences sclera stiffness, and likely plays a central role in globe mechanics

Translaminar Pressure Effect on the Lamina Cribrosa of Non-Human Primate Eyes as a Function of Depth

Radial and Circumferential Collagen Fibers Are a Feature of the Peripapillary Sclera of Human, Monkey, Pig, Cow, Goat, and Sheep

Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams

Simultaneous in-situ visualization and quantification of lamina cribrosa collagen beams and capillaries at normal and elevated IOPs

Don’t judge a beam by its width; thin lamina cribrosa beams have different collagen microstructure than thick beams

In-Vivo Macro and Micro-Structure Optic Nerve Head Deformations Due to Gaze and Intracranial Pressure Changes

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