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ARVO Annual Meeting Abstract June 2022

Ex vivo analysis of mast cell degranulation in human donor choroids

Imran Ahmed Bhutto; Tomohiro Niizawa; Alexandra Pado; Erin McDonnell; Gerard A Lutty; Malia Michelle Edwards

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3029 – F0400. doi:

ARVO Annual Meeting Abstract June 2022

Improved generation and long-term engraftment of retinal organoids from Tankyrase/PARP-Inhibitor-Regulated Naïve human pluripotent stem cells (TIRN-hPSC)

Ludovic Zimmerlin; Imran Ahmed Bhutto; Riya Kanherkar; Tea Soon Park; Michael Barbato; Michael Koldobskiy; Ying Liu; Mandeep Singh; Gerard A Lutty; Elias T Zambidis

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3725 – F0331. doi:

ARVO Annual Meeting Abstract June 2021

Topical Ketotifen fumarate inhibits mast cell degranulation and loss of retinal pigment epithelial cells in rat model for geographic atrophy

Tomohiro Niizawa; Imran Ahmed Bhutto; Anupama Tiwari; Rhonda R. Grebe; Jesse Alt; Rana Rais; Malia Michelle Edwards; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):252. doi:

ARVO Annual Meeting Abstract June 2020

Visualization of choroidal vasculature in pigmented mouse eyes

Imran Ahmed Bhutto; Anupama Tiwari; Benjamin R Thomson; Malia Michelle Edwards; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2235. doi:

ARVO Annual Meeting Abstract June 2020

Increased expression of epithelial-to-mesenchymal transition markers in geographic atrophy

Anupama Tiwari; Imran Ahmed Bhutto; Malia Michelle Edwards; Rhonda Grebe; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2273. doi:

ARVO Annual Meeting Abstract June 2020

Long-term engraftment of mature human photoreceptors following subretinal transplantation of naïve hPSC-derived retinal organoids

Elias Zambidis; Imran Ahmed Bhutto; Riya T Kanherkar; Tea Soon Park; Rebecca T Moses; Ludovic T Zimmerlin; Ying T Liu; Mandeep S Singh; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5203. doi:

ARVO Annual Meeting Abstract June 2020

Targeted intravenous dendrimer-drug therapies for AMD

Kannan Rangaramanujam; Siva Pramodh Pramodh Kambhampati; Imran Ahmed Bhutto; Tony Wu; Scott McLeod; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4929. doi:

ARVO Annual Meeting Abstract July 2019

Autophagy is required for maintaining of oligodendrocyte precursor cells in optic nerve

Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; Joseph Weiss; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6388. doi:

ARVO Annual Meeting Abstract July 2019

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Stacey L Hose; Sayan Ghosh; Nadezda A. Stepicheva; Sara Jabalameli; Imran Ahmed Bhutto; Peng Shang; Meysam Yazdankhah; Joseph Weiss; Gerard A Lutty; J Samuel Zigler, Jr; Leah Byrne; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1238. doi:

ARVO Annual Meeting Abstract July 2019

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

Sayan Ghosh; Peng Shang; Meysam Yazdankhah; Imran Ahmed Bhutto; Nadezda A. Stepicheva; Joseph Weiss; Stacey L Hose; Gerard A Lutty; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1345. doi:

ARVO Annual Meeting Abstract July 2019

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

Peng Shang; Nadezda A. Stepicheva; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Joseph Weiss; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1918. doi:

ARVO Annual Meeting Abstract July 2019

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Imran Ahmed Bhutto; Tanuja Vaidya; Sayan Ghosh; Archana Padmanabhan; Meysam Yazdankhah; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; J Samuel Zigler, Jr; Santosh GopiKrishna; Thirumalesh MB; Gerard A Lutty; Arkasubhra Ghosh; Swaminathan Sethu; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2683. doi:

ARVO Annual Meeting Abstract July 2019

Naïve pluripotency improves human diabetic iPSC derived-vascular progenitor cell engraftment and migration in an ischemic retinopathy mouse model

Tea Soon Park; Ludovic Zimmerlin; Imran Ahmed Bhutto; Riya Kanherkar; Rebecca Evans-Moses; Gerard A Lutty; Elias T Zambidis

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2792. doi:

ARVO Annual Meeting Abstract July 2019

Lysosomal distribution and function may be affected by the cell type and spatial localization of the cell within the tissue

Nadezda A. Stepicheva; Joseph Weiss; Peng Shang; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5981. doi:

ARVO Annual Meeting Abstract July 2018

βA3/A1-crystallin is necessary for intracellular protein trafficking in mature RPE cells

Peng Shang; Meysam Yazdankhah; Nadezda Stepicheva; Stacey L Hose; Sayan Ghosh; Imran Ahmed Bhutto; J Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3994. doi:

ARVO Annual Meeting Abstract July 2018

βA3/A1-crystallin affects circadian rhythm of the retinal pigmented epithelium through regulation of GSK3β expression

Nadezda Stepicheva; Peng Shang; Imran Ahmed Bhutto; J Samuel Zigler; Stacey L Hose; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3996. doi:

ARVO Annual Meeting Abstract July 2018

Systemic dendrimer-triamcinolone therapy for age-related macular degeneration

Kannan Rangaramanujam; Siva Pramodh Kambhampati; Imran Ahmed Bhutto; Tony P Wu; Scott McLeod; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):770. doi:

ARVO Annual Meeting Abstract July 2018

Loss of functional βA3/A1-crystallin upregulates the expression of colony stimulating factor 1 receptor (CSF-1R) and activates inflammation in Nuc1 rat retina

Stacey L Hose; Sayan Ghosh; Meysam Yazdankhah; Imran Ahmed Bhutto; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4594. doi:

ARVO Annual Meeting Abstract July 2018

Understanding the role of glial cells (astrocytes and oligodendrocytes) in maintaining the homeostasis of the optic nerve

Meysam Yazdankhah; Rhonda Grebe; Emily G Baxi; Imran Ahmed Bhutto; Stacey L Hose; Amanda N. FairchildBaranowski; Peter Calabresi; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):311. doi:

ARVO Annual Meeting Abstract July 2018

A potent LXR (liver X receptor) agonist can restore lysosome-mediated clearance in RPE cells from a mouse model with AMD-like phenotype

Debasish Sinha; Meysam Yazdankhah; Peng Shang; Cyrille Maugeais; Hasane Ratni; Stacey L Hose; Imran Ahmed Bhutto; Ashwath Jayagopal

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2448. doi:

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