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ARVO Annual Meeting Abstract April 2014

PARP-1 in the human lens: a story of life and death

Andrew J O Smith; Richard P Bowater; John R Reddan; Michael Wormstone

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):728. doi:

Lens August 2013

Sulforaphane Can Protect Lens Cells Against Oxidative Stress: Implications for Cataract Prevention

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Hanruo Liu; Andrew J. O. Smith; Martin C. Lott; Yongping Bao; Richard P. Bowater; John R. Reddan; Ian Michael Wormstone
TAGS: cataract, lens (device), lens cell, lens, crystalline, oxidative stress, prevention, sulforaphane, cytotoxicity, mohr-tranebjaerg syndrome, cell survival
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5236-5248. doi: https://doi.org/10.1167/iovs.13-11664

ARVO Annual Meeting Abstract June 2013

Non-Homologous End Joining Repair in the Lens

Andrew Smith; Kamal Manzar; Meghan Betts; Richard Bowater; John Reddan; Michael Wormstone

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2974. doi:

Lens June 2012

MMP2 Activity is Critical for TGFβ2-Induced Matrix Contraction—Implications for Fibrosis

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Julie A. Eldred; Lisa M. Hodgkinson; Lucy J. Dawes; John R. Reddan; Dylan R. Edwards; I. Michael Wormstone
TAGS: gelatinase a
Invest. Ophthalmol. Vis. Sci.. 2012; 53(7):4085-4098. doi: https://doi.org/10.1167/iovs.12-9457

ARVO Annual Meeting Abstract March 2012

Sulforaphane Can Protect Human Lens Cells Against Oxidative Stress

Hanruo Liu; Andrew J. Smith; Martin C. Lott; Yongping Bao; Richard P. Bowater; John R. Reddan; I M. Wormstone

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1066. doi:

ARVO Annual Meeting Abstract March 2012

A Putative Role for Histamine Releasing Factor in Posterior Capsule Opacification

I M. Wormstone; Jevneet K. Kular; John R. Reddan; Lucy J. Dawes

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6910. doi:

ARVO Annual Meeting Abstract April 2011

17β-estradiol Can Suppress TGFβ2-induced Transdifferentiation And Collagen Production, But Does Not Inhibit Matrix Contraction

Ian M. Wormstone; Chris D. Illingworth; John R. Reddan; Lucy J. Dawes

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4779. doi:

ARVO Annual Meeting Abstract April 2010

Sigma-1 Receptor Stimulation Provides Protection Against Oxidative Damage Through Suppression of ER Stress Responses in the Human Lens

L. Wang; J. R. Reddan; I. M. Wormstone

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):1184. doi:

ARVO Annual Meeting Abstract April 2010

Histamine Stimulates Multiple Signalling Pathways in Human Lens Cells Leading to Accelerated Growth Rate

I. M. Wormstone; M. Johnston; L. J. Dawes; J. A. Maidment; L. Wang; L. M. Hodgkinson; J. Hadfield; J. R. Reddan

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):1597. doi:

Lens November 2009

TGFβ/Smad4-Dependent and -Independent Regulation of Human Lens Epithelial Cells

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Lucy Jean Dawes; Matthew Alexander Sleeman; Ian Keith Anderson; John R. Reddan; Ian Michael Wormstone
TAGS: rna, small interfering, smad4 gene, lens, crystalline, epithelial cells, regulation
Invest. Ophthalmol. Vis. Sci.. 2009; 50(11):5318-5327. doi: https://doi.org/10.1167/iovs.08-3223

ARVO Annual Meeting Abstract April 2009

A Key Role for Myosin in TGFbeta Mediated Matrix Contraction by Human Lens Cells

I. M. Wormstone; L. Wang; J. A. Eldred; L. J. Dawes; J. R. Reddan

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):4763. doi:

ARVO Annual Meeting Abstract April 2009

MMP2 Plays a Critical Role in TGFβ Mediated Matrix Contraction by Human Lens Cells Independent of MT1-MMP

J. A. Eldred; L. M. Hodgkinson; J. R. Reddan; D. R. Edwards; I. M. Wormstone

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):4356. doi:

ARVO Annual Meeting Abstract May 2008

FGF Promotes TGFbeta-Induced Matrix Contraction and Suppresses Expression of the Transdifferentiation Marker alphaSMA

I. M. Wormstone; L. J. Dawes; M. Sleeman; I. K. Anderson; J. R. Reddan

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):3726. doi:

Lens February 2008

TGFβ-Induced Contraction Is Not Promoted by Fibronectin-Fibronectin Receptor Interaction, or αSMA Expression

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Lucy Jean Dawes; Julie Ann Eldred; Ian Kevin Anderson; Matthew Sleeman; John R. Reddan; George Duncan; Ian Michael Wormstone
TAGS: fibronectins, proteins, rna, small interfering, gene expression, integrins
Invest. Ophthalmol. Vis. Sci.. 2008; 49(2):650-661. doi: https://doi.org/10.1167/iovs.07-0586

ARVO Annual Meeting Abstract May 2007

Smad4 Is Critical for TGFß Induced Transdifferentiation but Does Not Mediate Matrix Contraction by Human Lens Epithelial Cells

L. J. Dawes; I. K. Anderson; M. Sleeman; J. R. Reddan; I. M. Wormstone

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):5641. doi:

Lens March 2007

Transcytotic Passage of Albumin through Lens Epithelial Cells

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Judith R. Sabah; Bruce D. Schultz; Zach W. Brown; Annelise T. Nguyen; John Reddan; Larry J. Takemoto
TAGS: albumins, lens epithelial cell, oryctolagus cuniculus, lens (device), lens, crystalline
Invest. Ophthalmol. Vis. Sci.. 2007; 48(3):1237-1244. doi: https://doi.org/10.1167/iovs.06-0620

ARVO Annual Meeting Abstract May 2006

Silencing of Sigma–1 Receptor Induces Cell Death in Human Lens Cells

L. Wang; G. Duncan; M. Handsley; J.R. Reddan

Invest. Ophthalmol. Vis. Sci.. 2006; 47(13):3517. doi:

ARVO Annual Meeting Abstract May 2006

Transcytotic Passage of Albumin Through Lens Epithelial Cells

J.R. Sabah; B.D. Schultz; Z.W. Brown; J. Reddan; L.J. Takemoto

Invest. Ophthalmol. Vis. Sci.. 2006; 47(13):4102. doi:

ARVO Annual Meeting Abstract May 2006

TGFß Induced Matrix Contraction Is Not Promoted by Fibronectin/Fibronectin Receptor Interaction or Alpha Smooth Muscle Actin Expression

M. Wormstone; L.J. Dawes; J.A. Eldred; J.R. Reddan; I.K. Anderson; M. Sleeman; G. Duncan

Invest. Ophthalmol. Vis. Sci.. 2006; 47(13):4741. doi:

ARVO Annual Meeting Abstract May 2005

Transfection of the Human Sodium Dependentvitamin C Transporter (hSCVT2) Corrects the Impaired Uptake in Rodent Lens

M.E. M. Obrenovich; X.X. Fan; S.M. Jarvis; L. Reneker; J.R. Reddan; V.M. Monnier

Invest. Ophthalmol. Vis. Sci.. 2005; 46(13):1860. doi:

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PARP-1 in the human lens: a story of life and death

Sulforaphane Can Protect Lens Cells Against Oxidative Stress: Implications for Cataract Prevention

Non-Homologous End Joining Repair in the Lens

MMP2 Activity is Critical for TGFβ2-Induced Matrix Contraction—Implications for Fibrosis

Sulforaphane Can Protect Human Lens Cells Against Oxidative Stress

A Putative Role for Histamine Releasing Factor in Posterior Capsule Opacification

17β-estradiol Can Suppress TGFβ2-induced Transdifferentiation And Collagen Production, But Does Not Inhibit Matrix Contraction

Sigma-1 Receptor Stimulation Provides Protection Against Oxidative Damage Through Suppression of ER Stress Responses in the Human Lens

Histamine Stimulates Multiple Signalling Pathways in Human Lens Cells Leading to Accelerated Growth Rate

TGFβ/Smad4-Dependent and -Independent Regulation of Human Lens Epithelial Cells

A Key Role for Myosin in TGFbeta Mediated Matrix Contraction by Human Lens Cells

MMP2 Plays a Critical Role in TGFβ Mediated Matrix Contraction by Human Lens Cells Independent of MT1-MMP

FGF Promotes TGFbeta-Induced Matrix Contraction and Suppresses Expression of the Transdifferentiation Marker alphaSMA

TGFβ-Induced Contraction Is Not Promoted by Fibronectin-Fibronectin Receptor Interaction, or αSMA Expression

Smad4 Is Critical for TGFß Induced Transdifferentiation but Does Not Mediate Matrix Contraction by Human Lens Epithelial Cells

Transcytotic Passage of Albumin through Lens Epithelial Cells

Silencing of Sigma–1 Receptor Induces Cell Death in Human Lens Cells

Transcytotic Passage of Albumin Through Lens Epithelial Cells

TGFß Induced Matrix Contraction Is Not Promoted by Fibronectin/Fibronectin Receptor Interaction or Alpha Smooth Muscle Actin Expression

Transfection of the Human Sodium Dependentvitamin C Transporter (hSCVT2) Corrects the Impaired Uptake in Rodent Lens

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