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ARVO Annual Meeting Abstract June 2020

Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Meysam Yazdankhah; Emily G. Boxi; Stacey L Hose; Nadezda A Stepicheva; Joseph Weiss; Sayan Ghosh; Peng Shang; Haitao Liu; Christopher Scott Fitting; Ming-Wen Hu; Jiang Qian; Peter Calabresi; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2791. doi:

ARVO Annual Meeting Abstract June 2020

Akt2 overexpression in RPE cells drives retinal degeneration: a novel model to study inflammation in atrophic AMD

Sayan Ghosh; Hai Tao Liu; Peng Shang; Meysam Yazdankhah; Nadezda A Stepicheva; Joseph Weiss; Christopher Scott Fitting; Stacey L Hose; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2794. doi:

ARVO Annual Meeting Abstract June 2020

A possible role of βA3/A1-crystallin in clathrin-mediated endocytosis and maintenance of microvilli of RPE cells

Peng Shang; Christopher Scott Fitting; Meysam Yazdankhah; Nadezda A Stepicheva; Sayan Ghosh; Haitao Liu; Joseph Weiss; Stacey L Hose; J. Samuel Zigler; Simon Watkins; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4152. doi:

ARVO Annual Meeting Abstract June 2020

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Haitao Liu; J. Samuel Zigler; Ashwath Jayagopal; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4157. doi:

ARVO Annual Meeting Abstract July 2019

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Stacey L Hose; Sayan Ghosh; Nadezda A. Stepicheva; Sara Jabalameli; Imran Ahmed Bhutto; Peng Shang; Meysam Yazdankhah; Joseph Weiss; Gerard A Lutty; J Samuel Zigler, Jr; Leah Byrne; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1238. doi:

ARVO Annual Meeting Abstract July 2019

Autophagy is required for maintaining of oligodendrocyte precursor cells in optic nerve

Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; Joseph Weiss; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6388. doi:

ARVO Annual Meeting Abstract July 2019

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

Sayan Ghosh; Peng Shang; Meysam Yazdankhah; Imran Ahmed Bhutto; Nadezda A. Stepicheva; Joseph Weiss; Stacey L Hose; Gerard A Lutty; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1345. doi:

ARVO Annual Meeting Abstract July 2019

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

Peng Shang; Nadezda A. Stepicheva; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Joseph Weiss; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1918. doi:

ARVO Annual Meeting Abstract July 2019

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Imran Ahmed Bhutto; Tanuja Vaidya; Sayan Ghosh; Archana Padmanabhan; Meysam Yazdankhah; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; J Samuel Zigler, Jr; Santosh GopiKrishna; Thirumalesh MB; Gerard A Lutty; Arkasubhra Ghosh; Swaminathan Sethu; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2683. doi:

ARVO Annual Meeting Abstract July 2019

Lysosomal distribution and function may be affected by the cell type and spatial localization of the cell within the tissue

Nadezda A. Stepicheva; Joseph Weiss; Peng Shang; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5981. doi:

Special Issue July 2018

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

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Sayan Ghosh; Peng Shang; Hiroto Terasaki; Nadezda Stepicheva; Stacey Hose; Meysam Yazdankhah; Joseph Weiss; Taiji Sakamoto; Imran A. Bhutto; Shuli Xia; J. Samuel Zigler, Jr; Ram Kannan; Jiang Qian; James T. Handa; Debasish Sinha
TAGS: crystallins, epithelial to mesenchymal transition, retinal pigment cell, age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD104-AMD113. doi: https://doi.org/10.1167/iovs.18-24132

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Targeting neutrophils as a novel approach for AMD therapy

Sayan Ghosh; Peng Shang; Meysam Yazdankhah; Imran Ahmed Bhutto; Stacey L Hose; Gerard A Lutty; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3472. doi:

ARVO Annual Meeting Abstract July 2018

βA3/A1-crystallin is necessary for intracellular protein trafficking in mature RPE cells

Peng Shang; Meysam Yazdankhah; Nadezda Stepicheva; Stacey L Hose; Sayan Ghosh; Imran Ahmed Bhutto; J Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3994. doi:

ARVO Annual Meeting Abstract July 2018

βA3/A1-crystallin affects circadian rhythm of the retinal pigmented epithelium through regulation of GSK3β expression

Nadezda Stepicheva; Peng Shang; Imran Ahmed Bhutto; J Samuel Zigler; Stacey L Hose; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3996. doi:

ARVO Annual Meeting Abstract July 2018

Loss of functional βA3/A1-crystallin upregulates the expression of colony stimulating factor 1 receptor (CSF-1R) and activates inflammation in Nuc1 rat retina

Stacey L Hose; Sayan Ghosh; Meysam Yazdankhah; Imran Ahmed Bhutto; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4594. doi:

ARVO Annual Meeting Abstract July 2018

Understanding the role of glial cells (astrocytes and oligodendrocytes) in maintaining the homeostasis of the optic nerve

Meysam Yazdankhah; Rhonda Grebe; Emily G Baxi; Imran Ahmed Bhutto; Stacey L Hose; Amanda N. FairchildBaranowski; Peter Calabresi; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):311. doi:

ARVO Annual Meeting Abstract June 2017

Loss of βA3/A1-crystallin in astrocytes lead to persistent fetal vasculature (PFV) by activating EGFR/mTORC1 signaling and inhibiting autophagy

Meysam Yazdankhah; Tianqi Luo; Imran Ahmed Bhutto; Peng Shang; Subrata Mishra; Gerard A Lutty; Stacey L Hose; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1210. doi:

ARVO Annual Meeting Abstract June 2017

βA3/A1-Crystallin/SLC36A4/V-ATPase complex in the RPE is a novel therapeutic target for AMD

Peng Shang; Mallika Valapala; Stacey L Hose; Jun Wan; Jiang Qian; Yuri V Sergeev; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3384. doi:

ARVO Annual Meeting Abstract June 2017

βA3/A1-crystallin modulates endolysosomal acidification in astrocytes by preventing phosphorylation of the V 0 a1 subunit of V-ATPase

Subrata H Mishra; Meysam Yazdankhah; Peng Shang; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5243. doi:

ARVO Annual Meeting Abstract June 2017

Cryba1 : Do its two gene products (βA3- and βA1-crystallin) have distinct functions?

J Samuel Zigler; Eric F Wawrousek; Lixia Lu; Guo-Tong Xu; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5307. doi:

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Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Akt2 overexpression in RPE cells drives retinal degeneration: a novel model to study inflammation in atrophic AMD

A possible role of βA3/A1-crystallin in clathrin-mediated endocytosis and maintenance of microvilli of RPE cells

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Autophagy is required for maintaining of oligodendrocyte precursor cells in optic nerve

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Lysosomal distribution and function may be affected by the cell type and spatial localization of the cell within the tissue

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

Targeting neutrophils as a novel approach for AMD therapy

βA3/A1-crystallin is necessary for intracellular protein trafficking in mature RPE cells

βA3/A1-crystallin affects circadian rhythm of the retinal pigmented epithelium through regulation of GSK3β expression

Loss of functional βA3/A1-crystallin upregulates the expression of colony stimulating factor 1 receptor (CSF-1R) and activates inflammation in Nuc1 rat retina

Understanding the role of glial cells (astrocytes and oligodendrocytes) in maintaining the homeostasis of the optic nerve

Loss of βA3/A1-crystallin in astrocytes lead to persistent fetal vasculature (PFV) by activating EGFR/mTORC1 signaling and inhibiting autophagy

βA3/A1-Crystallin/SLC36A4/V-ATPase complex in the RPE is a novel therapeutic target for AMD

βA3/A1-crystallin modulates endolysosomal acidification in astrocytes by preventing phosphorylation of the V 0 a1 subunit of V-ATPase

Cryba1 : Do its two gene products (βA3- and βA1-crystallin) have distinct functions?

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