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Retina May 2025

A Simple and Rapid Method for Simultaneous Isolation of Mouse Retina and RPE Wholemounts

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Jialiang Yang; Haiping Wu; Qi Li; Jiaxin Guo; Jialin Yao; Shengliu Pan; Xiawei Wu; Haotian Huang; Runfang Chen; Junnian Chen; Yubin Wang; Yue Peng; Fuhua Wu; Jing Hu
TAGS: mice, patient isolation, retina, social isolation, phosphate-buffered saline, personal integrity
Trans. Vis. Sci. Tech.. 2025; 14(5):14. https://doi.org/10.1167/tvst.14.5.14

Includes: Multimedia, Supplemental Content

Retina May 2025

Complement C3/C3aR Signaling Pathway Inhibition Ameliorates Retinal Damage in Experimental Retinal Vein Occlusion

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Yanying Zhao; Zhengwei Ge; Tingting Guo; Hengwei Liu; Yufan Zhou; Juan Chen; Heping Xu; Zhongping Chen
TAGS: complement 3, lasers, mice, retinal vein occlusion, signal pathway, signal transduction pathways, complement system proteins, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):2. https://doi.org/10.1167/iovs.66.5.2

Includes: Supplemental Content

Refractive Intervention May 2025

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

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Yue Xu; Xing-Xuan Dong; Yun Wang; Xin-Yu Zhuang; Ying-Jie Chen; Xiao-Feng Zhang; Chen-Wei Pan
TAGS: cytokine, mendelian randomization analysis, refractive errors, ciliary motility disorders
Trans. Vis. Sci. Tech.. 2025; 14(5):1. https://doi.org/10.1167/tvst.14.5.1

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

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Zi Xuan Lin; Xiu Juan Zhang; Fang Yao Tang; Yuzhou Zhang; Ka Wai Kam; Alvin L. Young; Patrick Ip; Carol Y. Cheung; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Kyoko Ohno-Matsui; Jason C. Yam
TAGS: child, eye, myopia, retinal vasculature, hong kong
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):64. https://doi.org/10.1167/iovs.66.4.64

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank

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Yu Peng; Yuzhou Zhang; Ka Wai Kam; Gavin Wong; Mary Ho; Simon Sezto; Sunny Au; Xiujuan Zhang; Mandy P. H. Ng; Patrick Ip; Alvin Young; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Jason C. Yam
TAGS: health, macular disorders, uk biobank, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):63. https://doi.org/10.1167/iovs.66.4.63

Includes: Supplemental Content

Retina April 2025

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

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Kao-Jung Chang; Ching-Yun Wang; Hsin-Yu Wu; Pei-Yu Weng; Chia-Hsin Lu; Wei Chiu; Wei-Chieh Fang; Chong-En Kao; Cheng-Yi Li; Yi-Ting Chung; Yu-Chun Chen; Ai-Ru Hsieh; Shih-Hwa Chiou; Chih-Chien Hsu; Tai-Chi Lin; Shih-Jen Chen; De-Kuang Hwang
TAGS: biological markers, polygenic risk score, retinal detachment, screening, ultrasonography, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(4):16. https://doi.org/10.1167/tvst.14.4.16

Includes: Supplemental Content

Retina April 2025

Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis

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Shanshan Zhu; Lusi Zhang; Ping Tong; Jiawei Chen; Cong Wang; Zewei Wang; Jingyuan Liu; Peiyun Duan; Qian Jiang; Yubing Zhou; Guangshuang Tan; Xian Zhang; Bing Jiang
TAGS: dna, niacinamide, pyroptosis, retinal degeneration, retina, light exposure, mice, neuroinflammatory diseases, photoreceptors, microglia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):14. https://doi.org/10.1167/iovs.66.4.14

Includes: Supplemental Content

Refractive Intervention April 2025

Assessment of Corneal Biomechanical Changes After Discontinuation of Long-Term Orthokeratology: A 2-Year Prospective Study

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Hou-Ren Tsai; Jeng-Hung Wang; Cheng-Jen Chiu
TAGS: cornea, orthokeratology, prospective studies, lens (device), lens, crystalline
Trans. Vis. Sci. Tech.. 2025; 14(4):5. https://doi.org/10.1167/tvst.14.4.5

Includes: Supplemental Content

Cornea March 2025

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

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Shiding Li; Hao Sun; Fei Fang; Siyi Zhang; Junzhao Chen; Chunyi Shao; Yao Fu; Liangbo Chen
TAGS: body tissue, cell communication, cornea, epithelial stem cells, epithelium, fluorescent antibody technique, genes, rna, small cytoplasmic, transcriptomics, melanocytes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):52. https://doi.org/10.1167/iovs.66.3.52

Includes: Supplemental Content

Pediatric Ophthalmology & Strabismus March 2025

The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children

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Wenyan Xu; Xiaoman Li; Jianing Zhang; Hongyi Li; Xuewen Ding; Xiaoyue Hu; Xinyue Quan; Yue Su; Fan Lu; Jie Chen
TAGS: astigmatism, child, lens (device), lens, crystalline, myopia, refractive errors
Trans. Vis. Sci. Tech.. 2025; 14(3):8. https://doi.org/10.1167/tvst.14.3.8

Includes: Supplemental Content

Retina March 2025

Fibronectin Mediates Endothelial-to-Mesenchymal Transition in Retina Angiogenesis

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Dan Liu; Zhishang Meng; Chen Jin; Fang Chen; Li Pu; Ze Wu; Qi Zeng; Jing Luo; Wenyi Wu
TAGS: angiogenesis, fibronectins, retina, genes, endothelium, vascular endothelial growth factor a, epithelial to mesenchymal transition, rna, small interfering, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):10. https://doi.org/10.1167/iovs.66.3.10

Includes: Supplemental Content

Glaucoma February 2025

Lung Function as a Biomarker for Glaucoma: The UK Biobank Study

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Jun Yu; Yuzhou Zhang; Ka Wai Kam; Mary Ho; Alvin L. Young; Chi Pui Pang; Clement C. Tham; Jason C. Yam; Li Jia Chen
TAGS: glaucoma, pulmonary function, pulmonary function tests, respiratory physiology, uk biobank, biological markers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):48. https://doi.org/10.1167/iovs.66.2.48

Includes: Supplemental Content

Public Health February 2025

Associations Between Diabetic Retinopathy and Frailty: Insights From the National Health and Nutrition Examination Survey and Mendelian Randomization

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Jianqi Chen; Xuhao Chen; Xu Cao; Xiaohua Zhuo; Yuwen Wen; Guitong Ye; Yuan Zhang; Jinan Zhan; Hongmei Tan; Yingting Zhu; Yehong Zhuo
TAGS: frailty, national health and nutrition examination survey, diabetic retinopathy, mendelian randomization analysis
Trans. Vis. Sci. Tech.. 2025; 14(2):2. https://doi.org/10.1167/tvst.14.2.2

Includes: Supplemental Content

Retinal Cell Biology January 2025

Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells

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Qi Liu; Ling-Xiao Xia; Wan-Zhao Yi; Ya-Ni Wu; Shuo-Shuo Gu; Jian-Ying Chen; Ting-Ting Liu; Ying-Hui Lu; Yu-Hong Cui; Jing Meng; Hong-Wei Pan
TAGS: cyclin d1, endothelial cells, proto-oncogene proteins c-akt, retinal neovascularization, cell cycle, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):66. https://doi.org/10.1167/iovs.66.1.66

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2025

The Value of Orbital Exenteration for Eyelid Sebaceous Carcinoma in Stages II to IV: A Cohort Study of 78 Patients

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Jie Chen; Tianyu Zhu; Ziyue Huang; Renbing Jia; Shiqiong Xu
TAGS: cohort studies, eye, orbit evisceration, sebaceous adenocarcinoma, sebaceous adenocarcinoma of eyelid, neoplasm metastasis, surgical procedures, operative, recurrence, selenocysteine, cerebral arterial thrombosis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):40. https://doi.org/10.1167/iovs.66.1.40

Includes: Supplemental Content

Retina December 2024

Association of Metabolomics With Incidence of Age-Related Macular Degeneration: The UK Biobank Study

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Jun Yu; Yuzhou Zhang; Mary Ho; Xiu Juan Zhang; Ka Wai Kam; Alvin L. Young; Chi Pui Pang; Clement C. Tham; Jason C. Yam; Li Jia Chen
TAGS: age-related macular degeneration, incidence, metabolites, metabolomics, uk biobank, biological markers, polygenic risk score, lipids
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):43. https://doi.org/10.1167/iovs.65.14.43

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics December 2024

Serial Dependence in Smooth Pursuit Eye Movements of Preadolescent Children and Adults

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Bao Hong; Jing Chen; Wenjun Huang; Li Li
TAGS: adult, anisotropy, child, motion, pursuit, smooth, pre-teen, precision
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):37. https://doi.org/10.1167/iovs.65.14.37

Includes: Supplemental Content

Immunology and Microbiology December 2024

Itaconate Ameliorates Experimental Autoimmune Uveitis by Modulating Teff/Treg Cell Imbalance Via the DNAJA1/CDC45 Axis

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Qi Jiang; Zhaohuai Li; Yao Huang; Zhaohao Huang; Junjie Chen; Xiuxing Liu; Chun Zhang; Chenyang Gu; Tianfu Wang; He Li; Yingqi Li; Wenru Su
TAGS: autoimmunity, flow cytometry, imbalance, itaconate, mice, regulatory t-lymphocytes, t-lymphocytes, uveitis, inflammation, th17 cells
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):23. https://doi.org/10.1167/iovs.65.14.23

Includes: Supplemental Content

Retina December 2024

Effects of Physical Activity and Inactivity on Microvasculature in Children: The Hong Kong Children Eye Study

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Xiu Juan Zhang; Vincent L. Yuen; Yuzhou Zhang; Ka Wai Kam; Jason Wong; Fang Yao Tang; Alvin Young; Patrick Ip; Li Jia Chen; Tien Y. Wong; Chi Pui Pang; Clement C. Tham; Carol Y. Cheung; Jason C. Yam
TAGS: child, eye, hong kong, lack of exercise, microvascular network, physical activity
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):7. https://doi.org/10.1167/iovs.65.14.7

Includes: Supplemental Content

Data Science December 2024

Development of an Open-Source Dataset of Flat-Mounted Images for the Murine Oxygen–Induced Retinopathy Model of Ischemic Retinopathy

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Kyle V. Marra; Jimmy S. Chen; Hailey K. Robles-Holmes; Kristine B. Ly; Joseph Miller; Guoqin Wei; Edith Aguilar; Felicitas Bucher; Yoichi Ideguchi; Fritz Gerald P. Kalaw; Andrew C. Lin; Napoleone Ferrara; J. Peter Campbell; Martin Friedlander; Eric Nudleman
TAGS: datasets, ischemia, mice, oxygen, retinal diseases
Trans. Vis. Sci. Tech.. 2024; 13(12):4. https://doi.org/10.1167/tvst.13.12.4

Includes: Supplemental Content

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A Simple and Rapid Method for Simultaneous Isolation of Mouse Retina and RPE Wholemounts

Complement C3/C3aR Signaling Pathway Inhibition Ameliorates Retinal Damage in Experimental Retinal Vein Occlusion

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis

Assessment of Corneal Biomechanical Changes After Discontinuation of Long-Term Orthokeratology: A 2-Year Prospective Study

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children

Fibronectin Mediates Endothelial-to-Mesenchymal Transition in Retina Angiogenesis

Lung Function as a Biomarker for Glaucoma: The UK Biobank Study

Associations Between Diabetic Retinopathy and Frailty: Insights From the National Health and Nutrition Examination Survey and Mendelian Randomization

Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells

The Value of Orbital Exenteration for Eyelid Sebaceous Carcinoma in Stages II to IV: A Cohort Study of 78 Patients

Association of Metabolomics With Incidence of Age-Related Macular Degeneration: The UK Biobank Study

Serial Dependence in Smooth Pursuit Eye Movements of Preadolescent Children and Adults

Itaconate Ameliorates Experimental Autoimmune Uveitis by Modulating Teff/Treg Cell Imbalance Via the DNAJA1/CDC45 Axis

Effects of Physical Activity and Inactivity on Microvasculature in Children: The Hong Kong Children Eye Study

Development of an Open-Source Dataset of Flat-Mounted Images for the Murine Oxygen–Induced Retinopathy Model of Ischemic Retinopathy

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