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ARVO Annual Meeting Abstract June 2017

PGC-1α is required to maintain RPE metabolism, integrity and function.

Mariana Aparecida Brunini Rosales; Sarah Melissa Jacobo; Jared Iacovelli; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3014.

ARVO Annual Meeting Abstract June 2017

PGC-1beta promotes oxidative damage and dysfunction of the retinal pigment epithelium

Magali Saint-Geniez; Quincy Charles; Mariana Rosales; Arogya Khadka; Gopalan Gnanaguru; Jared Iacovelli

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3381.

Retinal Cell Biology March 2016

PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity

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Jared Iacovelli; Glenn C. Rowe; Arogya Khadka; Daniel Diaz-Aguilar; Carrie Spencer; Zoltan Arany; Magali Saint-Geniez
TAGS: antioxidants, cell respiration, gene expression, metabolism, proteins, oxidants, cell death, mitochondria, fatty acids, genes
Invest. Ophthalmol. Vis. Sci.. 2016; 57(3):1038-1051. https://doi.org/10.1167/iovs.15-17758

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Control of human RPE differentiation and metabolism by PGC-1α: implications for AMD

Magali Saint-Geniez; Jared Iacovelli; Glenn Rowe; Zoltan Arany

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):830.

ARVO Annual Meeting Abstract April 2014

PGC-1 alpha regulates human RPE oxidative metabolism and anti-oxidant capacity

Jared Iacovelli; Glenn C Rowe; Zoltan Arany; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1740.

Retina March 2014

Direct Effect of Sodium Iodate on Neurosensory Retina

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Jinmei Wang; Jared Iacovelli; Carrie Spencer; Magali Saint-Geniez
TAGS: genes, iodates, mice, oxidative stress, phototransduction, retina, sodium, toxic effect, retinal pigment cell, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2014; 55(3):1941-1953. https://doi.org/10.1167/iovs.13-13075

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2013

PGC-1 isoforms regulate photoreceptor response to photo-oxidative stress: relevance to retinal degenerative diseases

Jared Iacovelli; Zoltan Arany; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1796.

ARVO Annual Meeting Abstract June 2013

Sodium Iodate Induces Rapid Neuroretinal Dysfunction Prior To RPE Changes

Jinmei Wang; Jared Iacovelli; Carrie Spencer; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):723.

ARVO Annual Meeting Abstract June 2013

Transcriptional and post-transcriptional regulation links RPE65, RLBP1, and RGR in the RPE

Noriko Esumi; Tomohiro Masuda; Jun Wan; Karl Wahlin; Jared Iacovelli; Natalie Wolkow; Joshua Dunaief; Donald Zack; Jiang Qian

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2612.

ARVO Annual Meeting Abstract June 2013

Iron Upregulates Melanogenesis Genes in the RPE

Natalie Wolkow; Arvydas Maminishkis; Jared Iacovelli; Jennifer Lee; Sheldon Miller; Joshua Dunaief

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):6071.

Articles October 2012

The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms

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Majda Hadziahmetovic; Miroslav Pajic; Steven Grieco; Ying Song; Delu Song; Yafeng Li; Alyssa Cwanger; Jared Iacovelli; Sally Chu; Gui-shuang Ying; John Connelly; Michael Spino; Joshua L Dunaief
TAGS: deferiprone, iron chelating agents, retinal degeneration, mice, photoreceptors, retina
Trans. Vis. Sci. Tech.. 2012; 1(3):2. https://doi.org/10.1167/tvst.1.3.2

ARVO Annual Meeting Abstract April 2011

Role Of Ferroportin In Rpe Iron Export

Jared Iacovelli; Majda Hadziahmetovic; Ying Song; Steven Grieco; Irene Zohn; Joshua L. Dunaief

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):925.

ARVO Annual Meeting Abstract April 2011

Potential Role of BMP6-induced Iron Dysregulation in Age-Related Macular Degeneration Suggested by Analysis of Mouse Models and Post Mortem Human Retinas

Majda Hadziahmetovic; Ying Song; Jared Iacovelli; Natalie Wolkow; Leon Kautz; Marie-Paule Roth; Joshua L. Dunaief

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1830.

Retina March 2011

Generation of Cre Transgenic Mice with Postnatal RPE-Specific Ocular Expression

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Jared Iacovelli; Chen Zhao; Natalie Wolkow; Peter Veldman; Kandace Gollomp; Pallavi Ojha; Nina Lukinova; Ayala King; Leonard Feiner; Noriko Esumi; Donald J. Zack; Eric A. Pierce; Douglas Vollrath; Joshua L. Dunaief
TAGS: mice, mice, transgenic, eye, polymerase chain reaction, fluorescent antibody technique, dna, retina, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2011; 52(3):1378-1383. https://doi.org/10.1167/iovs.10-6347

Retina February 2011

The Oral Iron Chelator Deferiprone Protects against Iron Overload–Induced Retinal Degeneration

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Majda Hadziahmetovic; Ying Song; Natalie Wolkow; Jared Iacovelli; Steven Grieco; Jennifer Lee; Arkady Lyubarsky; Domenico Pratico; John Connelly; Michael Spino; Z. Leah Harris; Joshua L. Dunaief
TAGS: deferiprone, iron, iron chelating agents, iron overload, mice, retinal degeneration, retina, oxidative stress, did not receive therapy or drug, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2011; 52(2):959-968. https://doi.org/10.1167/iovs.10-6207

Retina January 2011

Age-Dependent Retinal Iron Accumulation and Degeneration in Hepcidin Knockout Mice

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Majda Hadziahmetovic; Ying Song; Padmavathi Ponnuru; Jared Iacovelli; Allan Hunter; Nadine Haddad; John Beard; James R. Connor; Sophie Vaulont; Joshua L. Dunaief
TAGS: iron, mice, retina, hepcidin, tissue degeneration
Invest. Ophthalmol. Vis. Sci.. 2011; 52(1):109-118. https://doi.org/10.1167/iovs.10-6113

ARVO Annual Meeting Abstract April 2010

Peptide Hormone Hepcidin Regulates Retinal Iron Homeostasis

Y. Song; M. Hadziahmetovic; A. Hunter; J. Iacovelli; N. Haddad; S. Vaulont; J. L. Dunaief

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):3504.

ARVO Annual Meeting Abstract April 2009

Hepcidin Dependent Ferroportin Degradation in Cultured Human Retinal Pigment Epithelium

J. Iacovelli; I. De Domenico; S. S. Miller; J. L. Dunaief

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):1862.

Retinal Cell Biology March 2009

Iron Chelation Protects the Retinal Pigment Epithelial Cell Line ARPE-19 against Cell Death Triggered by Diverse Stimuli

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Nina Lukinova; Jared Iacovelli; Tzvete Dentchev; Natalie Wolkow; Allan Hunter; Defne Amado; Gui-Shuang Ying; Janet R. Sparrow; Joshua L. Dunaief
TAGS: cell death, iron chelation therapy, retinal pigment cell, staurosporine, blue light
Invest. Ophthalmol. Vis. Sci.. 2009; 50(3):1440-1447. https://doi.org/10.1167/iovs.08-2545

ARVO Annual Meeting Abstract May 2008

The Iron Exporter Ferroportin Plays A Role in Retinal Iron Homeostasis

J. Iacovelli; P. Veldman; P. Ojha; P. Hahn; A. Donovan; N. Andrews; J. L. Dunaief

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):214.

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PGC-1α is required to maintain RPE metabolism, integrity and function.

PGC-1beta promotes oxidative damage and dysfunction of the retinal pigment epithelium

PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity

Control of human RPE differentiation and metabolism by PGC-1α: implications for AMD

PGC-1 alpha regulates human RPE oxidative metabolism and anti-oxidant capacity

Direct Effect of Sodium Iodate on Neurosensory Retina

PGC-1 isoforms regulate photoreceptor response to photo-oxidative stress: relevance to retinal degenerative diseases

Sodium Iodate Induces Rapid Neuroretinal Dysfunction Prior To RPE Changes

Transcriptional and post-transcriptional regulation links RPE65, RLBP1, and RGR in the RPE

Iron Upregulates Melanogenesis Genes in the RPE

The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms

Role Of Ferroportin In Rpe Iron Export

Potential Role of BMP6-induced Iron Dysregulation in Age-Related Macular Degeneration Suggested by Analysis of Mouse Models and Post Mortem Human Retinas

Generation of Cre Transgenic Mice with Postnatal RPE-Specific Ocular Expression

The Oral Iron Chelator Deferiprone Protects against Iron Overload–Induced Retinal Degeneration

Age-Dependent Retinal Iron Accumulation and Degeneration in Hepcidin Knockout Mice

Peptide Hormone Hepcidin Regulates Retinal Iron Homeostasis

Hepcidin Dependent Ferroportin Degradation in Cultured Human Retinal Pigment Epithelium

Iron Chelation Protects the Retinal Pigment Epithelial Cell Line ARPE-19 against Cell Death Triggered by Diverse Stimuli

The Iron Exporter Ferroportin Plays A Role in Retinal Iron Homeostasis

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