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Letters to the Editor April 2025

Comments on Xie et al.’s Study on Artificial Intelligence–Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy

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James Lin; Ting-Wan Kao
TAGS: artificial intelligence, biological markers, diabetic nephropathy, perfusion, screening
Trans. Vis. Sci. Tech.. 2025; 14(4):11. https://doi.org/10.1167/tvst.14.4.11

Optica Fall Vision Meeting Abstract April 2025

Invited Session III: Machine Learning and AI Approaches to Retinal Diagnostics: Towards more robust AI models in ophthalmology

Adam M Dubis; Mustafa Arikan; James Willoughby; Watjana Lilaonitkul
TAGS: machine learning, ophthalmology
Journal of Vision. 2025; 25(5):29. https://doi.org/10.1167/jov.25.5.29

Cornea & External Disease March 2025

Enhanced Riboflavin Stromal Delivery Using Microchannel-Assisted Iontophoresis for Corneal Crosslinking

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Rohan Joshi; Samantha Bradford; Shangbang Luo; Emily Farrah; Yilu Xie; Donald J. Brown; Tibor Juhasz; James V. Jester
TAGS: corneal collagen cross-linking, iontophoresis, riboflavin, mass or substance concentration per volume, eye, oryctolagus cuniculus, cornea
Trans. Vis. Sci. Tech.. 2025; 14(3):18. https://doi.org/10.1167/tvst.14.3.18

Clinical and Epidemiologic Research March 2025

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

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Joseph Magagnoli; Tammy Cummings; James W. Hardin; S. Scott Sutton; Jayakrishna Ambati
TAGS: age-related macular degeneration, bisphosphonates, nlr family, pyrin domain-containing 3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):32. https://doi.org/10.1167/iovs.66.3.32

Includes: Supplemental Content

Retina February 2025

Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA

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Hiroyuki Takahashi; Yunchan Hwang; Jungeun Won; Muhammad Usman Jamil; Antonio Yaghy; Michelle C. Liang; Caroline R. Baumal; Andre J. Witkin; Kyoko Ohno-Matsui; Jay S. Duker; James G. Fujimoto; Nadia K. Waheed
TAGS: diabetic retinal microaneurysm, diabetic retinopathy, fluid flow, macrophage activation syndrome, meconium aspiration syndrome, retinal microaneurysm, vascular flow, blood capillaries
Trans. Vis. Sci. Tech.. 2025; 14(2):27. https://doi.org/10.1167/tvst.14.2.27

Cornea February 2025

Ultrastructural Aspects of Corneal Functional Recovery in Rats Following Intrastromal Keratocyte Injection

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Qian Ma; Andri K. Riau; Robert D. Young; James S. Bell; Olga Shebanova; Nicholas J. Terrill; Gary H. F. Yam; Evelina Han; Keith M. Meek; Jodhbir S. Mehta; Craig Boote
TAGS: cornea, injections, keratocytes, rats, recovery of function, collagen, phosphatidylglycerols, digestion, corneal injuries
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):45. https://doi.org/10.1167/iovs.66.2.45

Clinical Trials February 2025

A Single-Center Sham and Active-Controlled Double-Blind Randomized Crossover Trial of the Magnetic Levator Prosthesis for Severe Blepharoptosis

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Kevin E. Houston; Shrinivas Pundlik; Prerana Shivshanker; Alex R. Bowers; Sarah LaRosa; Mara Robinson; James Chodosh; Lynn Brandes; Patrick Lee; Eleftherios I. Paschalis
TAGS: eyelid ptosis, prostheses, safety, adverse event
Trans. Vis. Sci. Tech.. 2025; 14(2):15. https://doi.org/10.1167/tvst.14.2.15

Includes: Supplemental Content

Retina January 2025

ABCA4 Deep Intronic Variants Contributed to Nearly Half of Unsolved Stargardt Cases With a Milder Phenotype

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Yingwei Wang; Pangfeng Wang; Zhen Yi; Jiamin Ouyang; Yi Jiang; Shiqiang Li; Xiaoyun Jia; Xueshan Xiao; James Fielding Hejtmancik; Wenmin Sun; Qingjiong Zhang
TAGS: abca4 gene, introns, phenotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):65. https://doi.org/10.1167/iovs.66.1.65

Includes: Supplemental Content

Retina January 2025

High-Resolution OCT Reveals Age-Associated Variation in the Region Posterior to the External Limiting Membrane

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Muhammad Usman Jamil; Jungeun Won; Stefan B. Ploner; Anna Marmalidou; Hiroyuki Takahashi; Stephanie Kaiser; Yunchan Hwang; Omar Abu-Qamar; Antonio Yaghy; Andre J. Witkin; Peter Y. Zhao; Shilpa Desai; Jay S. Duker; Andreas Maier; James G. Fujimoto; Nadia K. Waheed
TAGS: embryonic lethal mutation, tissue membrane, diagnostic imaging, volume, motion
Trans. Vis. Sci. Tech.. 2025; 14(1):16. https://doi.org/10.1167/tvst.14.1.16

Includes: Supplemental Content

Perspective December 2024

Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs

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Jacque L. Duncan; Angela Bowman; Amy Laster; Claire Gelfman; David G. Birch; Shannon E. Boye; Stephen P. Daiger; Lucian del Priore; Donald J. Zack; James T. Handa; the Foundation Fighting Blindness Scientific Advisory Board
TAGS: age-related macular degeneration, genes, genetics, retinal degeneration, disease progression, gene therapy, vision, medical management, blindness
Trans. Vis. Sci. Tech.. 2024; 13(12):28. https://doi.org/10.1167/tvst.13.12.28

Retina December 2024

Sterile Caliper Anterior Chamber Decompression Mitigates Intraocular Pressure Spikes in Intravitreal Injections

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Mahsaw Mansoor; Noor-Us-Sabah Ahmad; S. Bilal Ahmed; Samuel Tadros; James Folk; Michael D. Abramoff
TAGS: anterior chamber of eye, decompression, external, decompressive incision, intraocular pressure, intravitreal injections, injections, arm
Trans. Vis. Sci. Tech.. 2024; 13(12):13. https://doi.org/10.1167/tvst.13.12.13

Anatomy and Pathology/Oncology November 2024

Novel Uveal Melanoma Patient-Derived Organoid Models Recapitulate Human Disease to Support Translational Research

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Lauren A. Dalvin; Cynthia M. Andrews-Pfannkoch; David R. Miley; Tara L. Hogenson; Samantha A. Erickson; Shivani Malpotra; Kjersten J. Anderson; Mohammed E. Omer; Luciana L. Almada; Cheng Zhang; Hu Li; Diva R. Salomao; Carol L. Shields; Sara E. Lally; Rachel M. Malsch; James A. Armitage; Heather L. Holmes; Michael F. Romero; Michael P. Fautsch; Svetomir N. Markovic; Martin E. Fernandez-Zapico
TAGS: intraocular melanoma, neoplasms, organoids, translational research, immunohistochemistry, bap1 gene, transplantation, heterologous, atac trial
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):60. https://doi.org/10.1167/iovs.65.13.60

Includes: Supplemental Content

Retina November 2024

Patient-Reported Outcomes in RLBP1 Retinal Dystrophy: Longitudinal Assessment in a Prospective Natural History Study

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James Whelan; Jane Green; Marie Burstedt; Erin Greco; Xiao Ni; Claudio Spera; Anmol Mullins; Jean-Yves Deslandes; Zhenzhong Su; Michael Wald; Cynthia L. Grosskreutz; Guillaume Normand; Arnaud Charil; Darlene Lu; Kalliopi Stasi; Karen Holopigian
TAGS: natural history, patient self-report, pik3ca-related overgrowth spectrum, questionnaires, rasch model, retinal dystrophies, vision, significance
Trans. Vis. Sci. Tech.. 2024; 13(11):16. https://doi.org/10.1167/tvst.13.11.16

Includes: Supplemental Content

Cornea November 2024

Determining the Relationship Between Corneal Stiffening and Tissue Dehydration After Corneal Cross-Linking

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Raymundo Rodríguez-López; Joshua N. Webb; Metecan Erdi; Peter Kofinas; Walfre Franco; Hongyuan Zhang; James Bradley Randleman; Giuliano Scarcelli
TAGS: body tissue, cornea, corneal collagen cross-linking, cross-linking, dehydration, dehydration of tissue specimen
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):14. https://doi.org/10.1167/iovs.65.13.14

Includes: Supplemental Content

Retina November 2024

Retinal Function in Advanced Multiple Sclerosis

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James V. M. Hanson; Sara Single; Rahel B. Eberle; Veronika Kana; Benjamin V. Ineichen; Christina Gerth-Kahlert
TAGS: electroretinography, multiple sclerosis, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):2. https://doi.org/10.1167/iovs.65.13.2

Includes: Supplemental Content

Cornea & External Disease October 2024

In Vivo Femtosecond Laser Machined Transepithelial Nonlinear Optical Corneal Crosslinking Compared to Ultraviolet Corneal Crosslinking

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Samantha Bradford; Rohan Joshi; Shangbang Luo; Emily Farrah; Yilu Xie; Donald J. Brown; Tibor Juhasz; James V. Jester
TAGS: corneal collagen cross-linking, ultraviolet a radiation, epithelium, cornea, femtosecond pulsed lasers, optics, riboflavin
Trans. Vis. Sci. Tech.. 2024; 13(10):9. https://doi.org/10.1167/tvst.13.10.9

Glaucoma September 2024

Lamina Cribrosa Microstructure in Nonhuman Primates With Naturally Occurring Peripapillary Retinal Nerve Fiber Layer Thinning

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Palaiologos Alexopoulos; Arthur G. Fernandes; Zeinab Ghassabi; Ronald Zambrano; Anse Vellappally; Eitan Shemuelian; TingFang Lee; Jiyuan Hu; Armando Burgos-Rodriguez; Melween I. Martinez; Joel S. Schuman; Amanda D. Melin; James P. Higham; John Danias; Gadi Wollstein
TAGS: cribriform plate, eye, glaucoma, primates, retinal nerve fiber layer
Trans. Vis. Sci. Tech.. 2024; 13(9):23. https://doi.org/10.1167/tvst.13.9.23

Vision Sciences Society Annual Meeting Abstract September 2024

Remapping in LIP takes time

Yelda Alkan; Alanna Morris; James W. Bisley

Journal of Vision. 2024; 24(10):710. https://doi.org/10.1167/jov.24.10.710

Vision Sciences Society Annual Meeting Abstract September 2024

Facilitation of visual and haptic recognition after multisensory active control of real 3D objects.

Hellen Kyler; Karin James

Journal of Vision. 2024; 24(10):661. https://doi.org/10.1167/jov.24.10.661

Vision Sciences Society Annual Meeting Abstract September 2024

The left eye and upper eye biases are largely not face-specific.

Nicolas Davidenko; Mika Peer Shalem; Monique Crouse; James Pedroff

Journal of Vision. 2024; 24(10):635. https://doi.org/10.1167/jov.24.10.635

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Comments on Xie et al.’s Study on Artificial Intelligence–Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy

Invited Session III: Machine Learning and AI Approaches to Retinal Diagnostics: Towards more robust AI models in ophthalmology

Enhanced Riboflavin Stromal Delivery Using Microchannel-Assisted Iontophoresis for Corneal Crosslinking

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA

Ultrastructural Aspects of Corneal Functional Recovery in Rats Following Intrastromal Keratocyte Injection

A Single-Center Sham and Active-Controlled Double-Blind Randomized Crossover Trial of the Magnetic Levator Prosthesis for Severe Blepharoptosis

ABCA4 Deep Intronic Variants Contributed to Nearly Half of Unsolved Stargardt Cases With a Milder Phenotype

High-Resolution OCT Reveals Age-Associated Variation in the Region Posterior to the External Limiting Membrane

Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs

Sterile Caliper Anterior Chamber Decompression Mitigates Intraocular Pressure Spikes in Intravitreal Injections

Novel Uveal Melanoma Patient-Derived Organoid Models Recapitulate Human Disease to Support Translational Research

Patient-Reported Outcomes in RLBP1 Retinal Dystrophy: Longitudinal Assessment in a Prospective Natural History Study

Determining the Relationship Between Corneal Stiffening and Tissue Dehydration After Corneal Cross-Linking

Retinal Function in Advanced Multiple Sclerosis

In Vivo Femtosecond Laser Machined Transepithelial Nonlinear Optical Corneal Crosslinking Compared to Ultraviolet Corneal Crosslinking

Lamina Cribrosa Microstructure in Nonhuman Primates With Naturally Occurring Peripapillary Retinal Nerve Fiber Layer Thinning

Remapping in LIP takes time

Facilitation of visual and haptic recognition after multisensory active control of real 3D objects.

The left eye and upper eye biases are largely not face-specific.

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