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Visual Neuroscience April 2025

TUT7-Mediated Uridine Degradation of MCPIP1 in the Pterygium to Regulate TRAF6-Mediated Autophagy

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Juanjuan Li; Hao Ji; Yanze Xu; Weijia Zhang; Yuru Yin; Yubing Zhao; Yan Du; Anni He; Dandan Zhao
TAGS: autophagy, pterygium, fibroblasts, rna, messenger, proteins, uridine, rna, catabolism
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):41. https://doi.org/10.1167/iovs.66.4.41

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2025

Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice

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Senmao Li; Jingbin Xie; Jiayan Xiang; Ruyu Yan; Jiangman Liu; Qiwei Fan; Liyuan Lu; Jiaxin Wu; Jun Liu; Yunxia Xue; Ting Fu; Zhijie Li
TAGS: cornea, lacrimal gland, nerve injuries, neurons, rhythm, circadian rhythms, nerve supply, mice, wounds and injuries, sensory nerves
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):40. https://doi.org/10.1167/iovs.66.4.40

Includes: Supplemental Content

Letters to the Editor April 2025

Comments on Xie et al.’s Study on Artificial Intelligence–Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy

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James Lin; Ting-Wan Kao
TAGS: artificial intelligence, biological markers, diabetic nephropathy, perfusion, screening
Trans. Vis. Sci. Tech.. 2025; 14(4):11. https://doi.org/10.1167/tvst.14.4.11

Retina April 2025

Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis

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Shanshan Zhu; Lusi Zhang; Ping Tong; Jiawei Chen; Cong Wang; Zewei Wang; Jingyuan Liu; Peiyun Duan; Qian Jiang; Yubing Zhou; Guangshuang Tan; Xian Zhang; Bing Jiang
TAGS: dna, niacinamide, pyroptosis, retinal degeneration, retina, light exposure, mice, neuroinflammatory diseases, photoreceptors, microglia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):14. https://doi.org/10.1167/iovs.66.4.14

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract April 2025

Poster Session: Increasing the luminance of primary colors increases the perception of warmth

Colin Gardner; Lisa Renzi-Hammond; Cassandra Mesh; Jessica Lin; Randy Hammond
TAGS: color, luminance, perception, posters
Journal of Vision. 2025; 25(5):44. https://doi.org/10.1167/jov.25.5.44

Cornea & External Disease March 2025

Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography

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Sunny Kwok; Xueliang Pan; Manqi Pan; Zihao Chen; Madison Ammon; Andrew Hendershot; Jun Liu
TAGS: cornea, keratoconus, ultrasound elastography, ultrasonography, eye
Trans. Vis. Sci. Tech.. 2025; 14(3):22. https://doi.org/10.1167/tvst.14.3.22

Cornea March 2025

Evodiamine Promotes Autophagy and Alleviates Oxidative Stress in Dry Eye Disease Through the p53/mTOR Pathway

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Boda Li; Junpeng Liu; Di Zhang; Yiran Chu; Zeying Chen; Jiaruei Tsao; Taige Chen; Jiaxuan Jiang; Kai Hu
TAGS: autophagy, dry eye syndromes, mice, mtor serine-threonine kinases, oxidative stress, western blotting, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):44. https://doi.org/10.1167/iovs.66.3.44

Includes: Supplemental Content

Lens March 2025

Changes in Lens Thickness and Power Before and After Myopia Onset

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Jiaqing Zhang; Ling Jin; Qianyun Chen; Decai Wang; Xiang Chen; Yuting Li; Yabin Qu; Rong Lin; Mingguang He; Ian G. Morgan; Lixia Luo; Yangfa Zeng; Xiaotong Han
TAGS: lens, crystalline, myopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):36. https://doi.org/10.1167/iovs.66.3.36

Includes: Supplemental Content

Retina March 2025

The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke

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Zhifan Chen; Shuoxin Liao; Guangzhong Chen; Changmao Li; Chunling Liu; Junbin Liu; Guangyu Wu; Zheng Lyu; Mengya Liu; Xiyu Wu; Guixian Ma; Qianli Meng
TAGS: carotid stenosis, ischemic stroke
Trans. Vis. Sci. Tech.. 2025; 14(3):14. https://doi.org/10.1167/tvst.14.3.14

Includes: Supplemental Content

Glaucoma March 2025

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

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Jiayong Li; Yuncheng Ma; Lingling Xie; Kaichen Zhuo; Yuxian He; Xin Ma; Shufen Zheng; Shicheng Guo; Yizhen Tang; Guzainuer Muhetaer; Mireayi Aizezi; Dan Zhang; Aizezi Wumaier; Xu Zhang; Chao Tang; Wei Wang; Wenyong Huang; Xinbo Gao
TAGS: biological markers, exfoliation syndrome, mass spectrometry, mendelian randomization analysis, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):19. https://doi.org/10.1167/iovs.66.3.19

Includes: Supplemental Content

Cornea March 2025

Single-Cell Multiomics Analysis of Early Wound Response Programs in the Mouse Corneal Epithelium

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Zhao-Jing Lu; Jin-Guo Ye; Jing-Ni Li; Jiang-Bo Liang; Ming Zhou; Qiu-Ling Hu; Qi-Kai Zhang; Yu-Heng Lin; Ying-Feng Zheng
TAGS: corneal epithelium, genes, mice, wounds and injuries, chromatin, cornea, wound healing, multiomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):9. https://doi.org/10.1167/iovs.66.3.9

Includes: Supplemental Content

Glaucoma February 2025

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma

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Jonathan B. Lin; Hani El Helwe; Henisk Falah; Bruno L. Hammerschlag; Stephanie A. Schultz; George Baldwin; Yixi Xue; Ryan A. Vasan; Christian Song; Kristine Lo; Austin Meeker; Silas L. Wang; Pia Kivisäkk; David Solá-Del Valle; Milica A. Margeta
TAGS: aqueous humor, glaucoma, nerve degeneration, neurofilament protein l, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(2):24. https://doi.org/10.1167/tvst.14.2.24

Includes: Supplemental Content

Glaucoma February 2025

Lung Function as a Biomarker for Glaucoma: The UK Biobank Study

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Jun Yu; Yuzhou Zhang; Ka Wai Kam; Mary Ho; Alvin L. Young; Chi Pui Pang; Clement C. Tham; Jason C. Yam; Li Jia Chen
TAGS: glaucoma, pulmonary function, pulmonary function tests, respiratory physiology, uk biobank, biological markers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):48. https://doi.org/10.1167/iovs.66.2.48

Includes: Supplemental Content

Immunology and Microbiology February 2025

kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis

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Jiamin Liu; Min Kang; Yuan Wei; Zijun Zhang; Jinding Pang; Qiankun Chen; Xizhan Xu; Zhenyu Wei; Yang Zhang; Kexin Chen; Zhiqun Wang; Xinxin Lu; Qingfeng Liang
TAGS: genes, genome, keratitis, virulence, aspergillus flavus, cornea, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):42. https://doi.org/10.1167/iovs.66.2.42

Includes: Supplemental Content

Retinal Cell Biology February 2025

Remote Preconditioning Provides Protection Against Retinal Cell Death From Retinal Detachment

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Bruna Miglioranza Scavuzzi; Sumathi Shanmugam; Mengling Yang; Jingyu Yao; Heather Hager; Bhavneet Kaur; Lin Jia; Steven F. Abcouwer; David N. Zacks
TAGS: cell death, eye, retinal detachment, rna, messenger, retina, mice, dna fragmentation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):34. https://doi.org/10.1167/iovs.66.2.34

Includes: Supplemental Content

Cornea February 2025

Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways

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Fang Han; Leyi Wang; Jiayin Wu; Lin Shen; Yangyang Li; Hui Guo; Jianqiao Li
TAGS: keratitis, leucine-rich repeat serine/threonine-protein kinase 2, lrrk2 gene, signal pathway, signal transduction pathways, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):13. https://doi.org/10.1167/iovs.66.2.13

Includes: Supplemental Content

Cornea February 2025

HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis

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Xiaojuan Hu; Jiayao Feng; Chengjie Pan; Zhenzhen Sun; Jiechen Liu; Shuang Xie; Decheng Xiao; Xiaoyin Ma; Qinxiang Zheng; Wei Chen
TAGS: dry eye syndromes, hmgb1 protein, lysosomes, borderline neoplasms, apoptosis, homeostasis, cell death, stress, date of last normal period, cytoplasm
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):5. https://doi.org/10.1167/iovs.66.2.5

Perspective January 2025

The Landscape of Vascular Endothelial Growth Factor Inhibition in Retinal Diseases

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Joseph B. Lin; Rajendra S. Apte
TAGS: retinal diseases, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):47. https://doi.org/10.1167/iovs.66.1.47

Review January 2025

New Directions for Ophthalmic OCT – Handhelds, Surgery, and Robotics

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Julia Foust; Morgan McCloud; Amit Narawane; Robert M. Trout; Xi Chen; Al-Hafeez Dhalla; Jianwei D. Li; Christian Viehland; Mark Draelos; Lejla Vajzovic; Ryan P. McNabb; Anthony N. Kuo; Cynthia A. Toth
TAGS: eye, intraoperative care, robotics, surgical procedures, operative, diagnostic imaging, mobile devices
Trans. Vis. Sci. Tech.. 2025; 14(1):14. https://doi.org/10.1167/tvst.14.1.14

Public Health January 2025

Social Determinants of Uncorrected Distance and Near Visual Impairment in an Older Adult Population

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Po-Jen Lin; Alison G. Abraham; Pradeep Ramulu; Aleks Mihailovic; Anna Kucharska-Newton; Xinxing Guo
TAGS: community, eye, older adult, social determinants of health, visual impairment, physicians, aric trial, health, income
Trans. Vis. Sci. Tech.. 2025; 14(1):8. https://doi.org/10.1167/tvst.14.1.8

Includes: Supplemental Content

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TUT7-Mediated Uridine Degradation of MCPIP1 in the Pterygium to Regulate TRAF6-Mediated Autophagy

Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice

Comments on Xie et al.’s Study on Artificial Intelligence–Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy

Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis

Poster Session: Increasing the luminance of primary colors increases the perception of warmth

Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography

Evodiamine Promotes Autophagy and Alleviates Oxidative Stress in Dry Eye Disease Through the p53/mTOR Pathway

Changes in Lens Thickness and Power Before and After Myopia Onset

The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

Single-Cell Multiomics Analysis of Early Wound Response Programs in the Mouse Corneal Epithelium

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma

Lung Function as a Biomarker for Glaucoma: The UK Biobank Study

kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis

Remote Preconditioning Provides Protection Against Retinal Cell Death From Retinal Detachment

Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways

HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis

The Landscape of Vascular Endothelial Growth Factor Inhibition in Retinal Diseases

New Directions for Ophthalmic OCT – Handhelds, Surgery, and Robotics

Social Determinants of Uncorrected Distance and Near Visual Impairment in an Older Adult Population

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