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ARVO Annual Meeting Abstract June 2022

The differential role of distinct astrocyte populations in Persistent Fetal Vasculature (PFV) disease

Victoria Koontz; Sayan Ghosh; Nadezda A Stepicheva; Haitao Liu; PENG SHANG; Olivia Chowdhury; Anastasiia Strizhakova; Rachel Daley; Stacey L Hose; J. Samuel Zigler; Meysam Yazdankhah; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):266 – F0311. doi:

ARVO Annual Meeting Abstract June 2022

βA3/A1-crystallin may link lysosomal clearance and the circadian rhythm in the RPE

Anastasiia Strizhakova; Adithya Sreenivas; Victoria Koontz; Peng Shang; Haitao Liu; Sayan Ghosh; Olivia Chowdhury; Stacey L Hose; J. Samuel Zigler; Nadezda A Stepicheva; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):778 – F0337. doi:

ARVO Annual Meeting Abstract June 2022

PITPβ/βA3/A1-crystallin complex is critical for PIP metabolism in retinal pigment epithelium (RPE)

Emma Rose Mahally; Rachel Daley; Kenneth Teel; Austin McCauley; Nadezda A Stepicheva; Sayan Ghosh; Haitao Liu; Olivia Chowdhury; Anastasiia Strizhakova; Victoria Koontz; Stacey L Hose; J. Samuel Zigler; Raju V S Rajala; Debasish Sinha; PENG SHANG

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2473 – F0180. doi:

ARVO Annual Meeting Abstract June 2022

Looking for hidden cues: can the function of the moonlighting ocular protein βA3/A1-crystallin be regulated by the signals hidden in its coding sequence?

Nadezda A Stepicheva; Ekaterina Volkova; Victoria Koontz; PENG SHANG; Haitao Liu; Sayan Ghosh; Anastasiia Strizhakova; Olivia Chowdhury; Rachel Daley; J. Samuel Zigler; Stacey L Hose; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2300. doi:

ARVO Annual Meeting Abstract June 2022

Inhibiting mTOR-independent TFEB activity in RPE alleviates the early AMD-like phenotype in a mouse model

Mihir Nemani; Haitao Liu; PENG SHANG; Olivia Chowdhury; Victoria Koontz; Nadezda A Stepicheva; Anastasiia Strizhakova; Rachel Daley; Stacey L Hose; J. Samuel Zigler; Debasish Sinha; Sayan Ghosh

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3038 – F0409. doi:

ARVO Annual Meeting Abstract June 2022

Activation of mTOR signaling in the RPE cells induces alterations in melanogenesis thereby triggering oxidative stress

Olivia Chowdhury; Vishnu Maddipatla; Sayan Ghosh; Haitao Liu; PENG SHANG; Victoria Koontz; Nadezda A Stepicheva; Anastasiia Strizhakova; Rachel Daley; Stacey L Hose; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3033 – F0404. doi:

ARVO Annual Meeting Abstract June 2022

Akt2 signaling in diabetes-induced dysfunction of the outer blood retina barrier

Rachel Daley; Sayan Ghosh; PENG SHANG; Nadezda A Stepicheva; Anastasiia Strizhakova; Olivia Chowdhury; Victoria Koontz; Stacey L Hose; J. Samuel Zigler; Debasish Sinha; Haitao Liu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3599 – A0054. doi:

ARVO Annual Meeting Abstract June 2022

HDAC11 is a crucial regulator for visual cycle genes and retinal function

Peng Shang; Rachel Daley; Emma Rose Mahally; Nadezda A Stepicheva; Sayan Ghosh; Haitao Liu; Anastasiia Strizhakova; Olivia Chowdhury; Victoria Koontz; Stacey L Hose; J. Samuel Zigler; Jiang Qian; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4115 – F0352. doi:

ARVO Annual Meeting Abstract June 2022

Crosstalk between metabolism and inflammation in dry age-related macular degeneration

Sayan Ghosh; PENG SHANG; Nadezda A Stepicheva; Haitao Liu; Olivia Chowdhury; Victoria Koontz; Anastasiia Strizhakova; Rachel Daley; Stacey L Hose; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4625 – F0417. doi:

ARVO Annual Meeting Abstract June 2022

Lipocalin-2 homodimer variant: Role in dry age-related macular degeneration

Urvi Gupta; Sayan Ghosh; PENG SHANG; Haitao Liu; Anastasiia Strizhakova; Stacey L Hose; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4602 – F0394. doi:

ARVO Annual Meeting Abstract June 2020

Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Meysam Yazdankhah; Emily G. Boxi; Stacey L Hose; Nadezda A Stepicheva; Joseph Weiss; Sayan Ghosh; Peng Shang; Haitao Liu; Christopher Scott Fitting; Ming-Wen Hu; Jiang Qian; Peter Calabresi; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2791. doi:

ARVO Annual Meeting Abstract June 2020

Akt2 overexpression in RPE cells drives retinal degeneration: a novel model to study inflammation in atrophic AMD

Sayan Ghosh; Hai Tao Liu; Peng Shang; Meysam Yazdankhah; Nadezda A Stepicheva; Joseph Weiss; Christopher Scott Fitting; Stacey L Hose; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2794. doi:

ARVO Annual Meeting Abstract June 2020

A possible role of βA3/A1-crystallin in clathrin-mediated endocytosis and maintenance of microvilli of RPE cells

Peng Shang; Christopher Scott Fitting; Meysam Yazdankhah; Nadezda A Stepicheva; Sayan Ghosh; Haitao Liu; Joseph Weiss; Stacey L Hose; J. Samuel Zigler; Simon Watkins; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4152. doi:

ARVO Annual Meeting Abstract June 2020

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Haitao Liu; J. Samuel Zigler; Ashwath Jayagopal; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4157. doi:

ARVO Annual Meeting Abstract July 2019

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Stacey L Hose; Sayan Ghosh; Nadezda A. Stepicheva; Sara Jabalameli; Imran Ahmed Bhutto; Peng Shang; Meysam Yazdankhah; Joseph Weiss; Gerard A Lutty; J Samuel Zigler, Jr; Leah Byrne; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1238. doi:

ARVO Annual Meeting Abstract July 2019

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

Sayan Ghosh; Peng Shang; Meysam Yazdankhah; Imran Ahmed Bhutto; Nadezda A. Stepicheva; Joseph Weiss; Stacey L Hose; Gerard A Lutty; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1345. doi:

ARVO Annual Meeting Abstract July 2019

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

Peng Shang; Nadezda A. Stepicheva; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Joseph Weiss; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1918. doi:

ARVO Annual Meeting Abstract July 2019

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Imran Ahmed Bhutto; Tanuja Vaidya; Sayan Ghosh; Archana Padmanabhan; Meysam Yazdankhah; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; J Samuel Zigler, Jr; Santosh GopiKrishna; Thirumalesh MB; Gerard A Lutty; Arkasubhra Ghosh; Swaminathan Sethu; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2683. doi:

ARVO Annual Meeting Abstract July 2019

Lysosomal distribution and function may be affected by the cell type and spatial localization of the cell within the tissue

Nadezda A. Stepicheva; Joseph Weiss; Peng Shang; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5981. doi:

ARVO Annual Meeting Abstract July 2019

Autophagy is required for maintaining of oligodendrocyte precursor cells in optic nerve

Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; Joseph Weiss; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6388. doi:

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The differential role of distinct astrocyte populations in Persistent Fetal Vasculature (PFV) disease

βA3/A1-crystallin may link lysosomal clearance and the circadian rhythm in the RPE

PITPβ/βA3/A1-crystallin complex is critical for PIP metabolism in retinal pigment epithelium (RPE)

Looking for hidden cues: can the function of the moonlighting ocular protein βA3/A1-crystallin be regulated by the signals hidden in its coding sequence?

Inhibiting mTOR-independent TFEB activity in RPE alleviates the early AMD-like phenotype in a mouse model

Activation of mTOR signaling in the RPE cells induces alterations in melanogenesis thereby triggering oxidative stress

Akt2 signaling in diabetes-induced dysfunction of the outer blood retina barrier

HDAC11 is a crucial regulator for visual cycle genes and retinal function

Crosstalk between metabolism and inflammation in dry age-related macular degeneration

Lipocalin-2 homodimer variant: Role in dry age-related macular degeneration

Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Akt2 overexpression in RPE cells drives retinal degeneration: a novel model to study inflammation in atrophic AMD

A possible role of βA3/A1-crystallin in clathrin-mediated endocytosis and maintenance of microvilli of RPE cells

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Lysosomal distribution and function may be affected by the cell type and spatial localization of the cell within the tissue

Autophagy is required for maintaining of oligodendrocyte precursor cells in optic nerve

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