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ARVO Annual Meeting Abstract June 2024

DJ-1 mitigates hypoxic stress in oxygen-induced retinopathy mouse model

Mala Upadhyay; Paul Freedman; George Hoppe; Jonathan E Sears; Vera L Bonilha

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):295.

ARVO Annual Meeting Abstract June 2024

A/J Mice Protection from OIR is Associated with Aryl Hydrocarbon Receptor Activity

Kevin Fung; George Hoppe; Demiana Hanna; Ke Jiang; Andrew Dale Benos; Jonathan E Sears

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):294.

ARVO Annual Meeting Abstract June 2024

HIF stabilization by Roxadustat may condition retinal cells to withstand hyperoxic insult via metabolic adaptation.

Andrew Dale Benos; George Hoppe; Jonathan E Sears

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):271.

ARVO Annual Meeting Abstract June 2024

Assistive artificial intelligence for improved clinical diagnosis of retinopathy of prematurity

Aaron S Coyner; Benjamin Young; Susan R Ostmo; Florin Grigorian; Anna Ells; Baker Hubbard; Sarah Rodriguez; Pukhraj Rishi; Aaron Miller; Amit R Bhatt; Swati Agarwal-Sinha; Jonathan E Sears; Robison Vernon Paul Chan; Jayashree Kalpathy-Cramer; John Peter Campbell

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4289.

ARVO Annual Meeting Abstract June 2023

Hepatic HIF Stabilization by Novel Carbonyl Glycine Derivatives Protects Against Oxygen-Induced Retinopathy

Christie Kay Campla; George Hoppe; Demiana Hanna; Andrew Dale Benos; Vara Prasad Josyula; Shaun Stauffer; Juliana Woda; Jonathan E Sears

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):579.

ARVO Annual Meeting Abstract June 2023

HIF Stabilization Induces Reductive Carboxylation

Andrew Dale Benos; George Hoppe; Demiana Hanna; Christie Kay Campla; Jonathan E Sears

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1607.

ARVO Annual Meeting Abstract June 2022

A unified model of hyperoxia of prematurity: systemic HIF stabilization protects developing vasculature of the eye and brain

Weilin Song; Demiana Hanna; Andrew Benos; George Hoppe; Tara DeSilva; Jonathan Sears

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):277 – F0322.

ARVO Annual Meeting Abstract June 2022

Hepatic HIF-1 stabilization increases retinal and brain serine/1-carbon metabolism

Andrew Dale Benos; George Hoppe; Demiana Hanna; Weilin Song; Allison B Grenell; Bela Anand-Apte; Jonathan Sears

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4142 – F0379.

ARVO Annual Meeting Abstract June 2022

Near infrared photobiomodulation prevents neovascularization in oxygen-induced retinopathy in mouse

Rupesh Singh; George Hoppe; Demiana Hanna; Zoe Miller; Paul Freedman; Vera L Bonilha; Bela Anand-Apte; Jonathan Sears

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4133 – F0370.

ARVO Annual Meeting Abstract June 2021

A two-step model of PVL and ROP

Weilin Song; George Hoppe; Demiana Hanna; Jonathan E Sears

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3001.

ARVO Annual Meeting Abstract June 2020

Foveal capillary perfusion density decreases in diabetics with DME treated on a fixed regimen of intravitreal aflibercept injections over 24 months

Brittney Statler; Thais Conti; Felipe Ferreira Conti; Fabiana Q Silva; Aleksandra Rachitskaya; Alex Yuan; Andrew Schachat; Justis P Ehlers; Jonathan E Sears; Sunil K Srivastava; Rishi P Singh; Amy Babiuch

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4360.

ARVO Annual Meeting Abstract June 2020

Presentation and outcomes of patients with post-injection endophthalmitis at a large academic center

Michael Ramos; Srinidhi Singuri; Lucy Xu; Julio Castillo; Justis P Ehlers; Peter M Kaiser; Rishi P Singh; Aleksandra Rachitskaya; Sunil K Srivastava; Jonathan E Sears; Andrew Schachat; Amy Babiuch; Sumit Sharma; Daniel F Martin; Careen Y Lowder; Alex Yuan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4410.

ARVO Annual Meeting Abstract June 2020

Retinal metabolic remodeling and hepatic nitrogen imbalance in oxygen induced retinopathy (OIR)

Charandeep Singh; Andrew Benos; Vincent Tran; Leah McCollum; Youstina Bolok; Hanna Demiana; Kristin Allan; Alex Yuan; George Hoppe; Henri Brunengraber; Jonathan E Sears

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5405.

ARVO Annual Meeting Abstract July 2019

Müller Cell HIF-2 is Not Required for Protection Against Oxygen Induced Retinopathy by Prolyl Hydroxylase Inhibition

George Hoppe; Youstina Bolok; Leah McCollum; Charandeep Singh; Jonathan E Sears

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1655.

ARVO Annual Meeting Abstract July 2019

Novel mutation in CTNNB1 causing familial exudative vitreoretinopathy and microcephaly

Razek Georges Coussa; Yue Zhao; Meghan J DeBenedictis; Allison Babiuch; Jonathan E Sears; Elias I Traboulsi

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2947.

ARVO Annual Meeting Abstract July 2018

FEVR-like Phenotype of Zone 1 Type 1 Infants Treated with anti-VEGF Therapy

Christine Sonnie; Jonathan E Sears

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3769.

ARVO Annual Meeting Abstract July 2018

3-Hydroxypyruvate accumulates in the retina of newborn mice exposed to hyperoxia and may contribute to angiostasis

Amit Sharma; Charandeep Singh; Weilin Song; Youstina Bolok; Jin Zhang; George Hoppe; Jonathan E Sears

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5462.

ARVO Annual Meeting Abstract July 2018

Serine metabolism is a key pathway involved in the prevention of oxygen-induced retinopathy by Roxadustat

Charandeep Singh; Amit Sharma; George Hoppe; Henri Brunengraber; Jonathan E Sears

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5464.

Retina July 2018

3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis

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Charandeep Singh; Amit Sharma; George Hoppe; Weilin Song; Youstina Bolok; Jonathan E. Sears
TAGS: hypoxia, metabolites, pyruvates
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3440-3448. https://doi.org/10.1167/iovs.18-24120

ARVO Annual Meeting Abstract June 2017

Development of geographic atrophy in age-related macular degeneration treated with long term intravitreal injections of anti-vascular endothelial growth factor.

Ang Li; Fabiana Queiroga de Paula Araujo Silva; Jonathan E Sears; Sunil K Srivastava; Justis Ehlers; Andrew Schachat; Peter K Kaiser; Daniel F Martin; Rishi P Singh

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):897.

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DJ-1 mitigates hypoxic stress in oxygen-induced retinopathy mouse model

A/J Mice Protection from OIR is Associated with Aryl Hydrocarbon Receptor Activity

HIF stabilization by Roxadustat may condition retinal cells to withstand hyperoxic insult via metabolic adaptation.

Assistive artificial intelligence for improved clinical diagnosis of retinopathy of prematurity

Hepatic HIF Stabilization by Novel Carbonyl Glycine Derivatives Protects Against Oxygen-Induced Retinopathy

HIF Stabilization Induces Reductive Carboxylation

A unified model of hyperoxia of prematurity: systemic HIF stabilization protects developing vasculature of the eye and brain

Hepatic HIF-1 stabilization increases retinal and brain serine/1-carbon metabolism

Near infrared photobiomodulation prevents neovascularization in oxygen-induced retinopathy in mouse

A two-step model of PVL and ROP

Foveal capillary perfusion density decreases in diabetics with DME treated on a fixed regimen of intravitreal aflibercept injections over 24 months

Presentation and outcomes of patients with post-injection endophthalmitis at a large academic center

Retinal metabolic remodeling and hepatic nitrogen imbalance in oxygen induced retinopathy (OIR)

Müller Cell HIF-2 is Not Required for Protection Against Oxygen Induced Retinopathy by Prolyl Hydroxylase Inhibition

Novel mutation in CTNNB1 causing familial exudative vitreoretinopathy and microcephaly

FEVR-like Phenotype of Zone 1 Type 1 Infants Treated with anti-VEGF Therapy

3-Hydroxypyruvate accumulates in the retina of newborn mice exposed to hyperoxia and may contribute to angiostasis

Serine metabolism is a key pathway involved in the prevention of oxygen-induced retinopathy by Roxadustat

3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis

Development of geographic atrophy in age-related macular degeneration treated with long term intravitreal injections of anti-vascular endothelial growth factor.

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