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Glaucoma May 2025

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

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Huiwen Ye; Yanlin Feng; Wu Xiang; Zihao Lin; Yue Li; Wen Hu; Keyu Liu; Shuya Tao; Qinmeng Shu; Jiawei Wang; Fan Xu; Yue Xu; Yantao Wei; Jingjing Huang
TAGS: ferroptosis, mice, glutamate, glutamates, excitotoxicity, low tension glaucoma, lipid peroxidation, retina, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):26. https://doi.org/10.1167/iovs.66.5.26

Includes: Supplemental Content

Retina April 2025

Use of SGLT2 Inhibitors Versus DPP-4 Inhibitors and Age-Related Macular Degeneration in Patients WithType 2 Diabetes: A Multinational Cohort Study

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Ssu-Yu Pan; Chien-Hsiang Weng; Shang-Feng Tsai; Hui-Ju Lin; Jun-Fu Lin; Ching-Heng Lin; I-Jong Wang; Chien-Chih Chou
TAGS: age-related macular degeneration, diabetes mellitus, type 2, dipeptidyl-peptidase iv inhibitors, sodium-glucose transporter 2 inhibitors, diabetes mellitus, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):58. https://doi.org/10.1167/iovs.66.4.58

Includes: Supplemental Content

Glaucoma April 2025

Vitamin K1 Alleviates Retinal Inflammation Following Acute Ocular Hypertension by Modulating Microglial Ferroptosis

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Xi Chen; Yan Rong; Yuxian Jiang; Qiuxiang Zhang; Sifei Xiang; Zhiqi Chen; Wei Chen; Hong Zhang; Chaohua Deng; Junming Wang
TAGS: retinitis, vitamin k 1, wounds and injuries, ocular hypertension, ferroptosis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):46. https://doi.org/10.1167/iovs.66.4.46

Cornea April 2025

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

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Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang
TAGS: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome, fenofibrate, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):36. https://doi.org/10.1167/iovs.66.4.36

Includes: Supplemental Content

Retina April 2025

Nonperfused Retinal Capillaries—A New Method Developed on OCT and OCTA

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Min Gao; Yukun Guo; Tristan T. Hormel; Jie Wang; Elizabeth White; Dong-Wouk Park; Thomas S. Hwang; Steven T. Bailey; Yali Jia
TAGS: biological markers, blood capillaries, diagnostic imaging, eye, face, noise, angiogram
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):22. https://doi.org/10.1167/iovs.66.4.22

Lens April 2025

In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation

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Le Chang; Fen Song; Shijia Qu; Huazheng Cao; Yanan Wu; Lulu Xu; Jing Wang; Ruirui Zhang; Chao Xue; Yan Wang
TAGS: cell nucleus, eye, lens (device), lens, crystalline, myopia, visual accommodation, adult, regression analysis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):6. https://doi.org/10.1167/iovs.66.4.6

Includes: Supplemental Content

Refractive Intervention April 2025

Assessment of Corneal Biomechanical Changes After Discontinuation of Long-Term Orthokeratology: A 2-Year Prospective Study

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Hou-Ren Tsai; Jeng-Hung Wang; Cheng-Jen Chiu
TAGS: cornea, orthokeratology, prospective studies, lens (device), lens, crystalline
Trans. Vis. Sci. Tech.. 2025; 14(4):5. https://doi.org/10.1167/tvst.14.4.5

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2025

Epigenetic ALYREF/UHRF1/RHOB Axis in Corneal Wound Healing and Implications for Epithelial Tumorigenesis

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Hua Zhang; Shuning Lan; Disuo Ren; Xiaoyan Chen; Yong Lin; Qiongjie Cao; Weiwei Xu; Jiao Wang; Peter Sol Reinach; Dongsheng Yan; Guangying Luo
TAGS: cornea, dna methylation, epigenetics, epithelium, genes, rna, tumorigenesis, wound healing, neoplasms, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):54. https://doi.org/10.1167/iovs.66.3.54

Includes: Supplemental Content

Glaucoma March 2025

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

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Jing Wang; Yang Zhang; Huimin Zhong; Yumeng Zhang; Ruiqi Han; Yanzhi Guo; Shouyue Huang; Huan Yu; Yisheng Zhong
TAGS: ferroptosis, fibrosis, nadph oxidase 4, silicone oils, smad3 gene, trabecular meshwork, glaucoma, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):25. https://doi.org/10.1167/iovs.66.3.25

Retina March 2025

Artificial Intelligence Versus Rules-Based Approach for Segmenting NonPerfusion Area in a DRCR Retina Network Optical Coherence Tomography Angiography Dataset

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Tristan T. Hormel; Wesley T. Beaulieu; Jie Wang; Jennifer K. Sun; Yali Jia
TAGS: nasopharyngeal aspirate, retina, angiogram, optical coherence tomography, datasets, artificial intelligence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):22. https://doi.org/10.1167/iovs.66.3.22

Includes: Supplemental Content

Retina March 2025

Photoreceptor Outer Segment Reflectivity With Ultrahigh-Resolution Visible-Light Optical Coherence Tomography in Systemic Hydroxychloroquine Use

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Anupam K. Garg; Jingyu Wang; Bailee Alonzo; Ji Yi; Amir H. Kashani
TAGS: hydroxychloroquine, optical coherence tomography, photoreceptors, vaccine information sheets, visible light, diagnostic imaging, toxic effect
Trans. Vis. Sci. Tech.. 2025; 14(3):2. https://doi.org/10.1167/tvst.14.3.2

Includes: Supplemental Content

Cornea February 2025

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

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Chao Wang; Yu-Zhi Li; Huan Guo; Shi-Rui Zhou; Xi Peng; Jia-Song Wang; Hua-Tao Xie; Ming-Chang Zhang
TAGS: lacrimal gland, nlr family, pyrin domain-containing 3 protein, sirt1 gene, melatonin, pathophysiology, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):51. https://doi.org/10.1167/iovs.66.2.51

Includes: Supplemental Content

Glaucoma February 2025

Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study

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Jingyu Wang; Natalie Sadlak; Marissa G. Fiorello; Manishi Desai; Ji Yi
TAGS: glaucoma, optical coherence tomography, oximetry, oxygen saturation measurement, pilot projects, somalia, visible light, eye, antistreptolysin o, arteriosclerosis obliterans
Trans. Vis. Sci. Tech.. 2025; 14(2):12. https://doi.org/10.1167/tvst.14.2.12

Includes: Supplemental Content

Retina February 2025

Design, Fabrication, and Surgical Testing of the 3D-Printed Large-Array Port-System for the Implantation of Large Epiretinal Stimulators

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Frederic Kuba Balcewicz; Sabine Baumgarten; Kim Schaffrath; Jiayun Wang; Sandra Johnen; Peter Walter; Tibor Lohmann
TAGS: implantation procedure, printing, three-dimensional, surgical procedures, operative, eye
Trans. Vis. Sci. Tech.. 2025; 14(2):8. https://doi.org/10.1167/tvst.14.2.8

Biochemistry and Molecular Biology January 2025

ENO2-Regulated Glycolysis in Endothelial Cells Contributes to FGF2-Induced Retinal Neovascularization

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Dan Liao; Jie Wang; Xiaoyu Zhang; Rong Li; Xiaoli Yang
TAGS: angiogenesis, endothelial cells, fibroblast growth factor 2, glycolysis, retinal neovascularization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):58. https://doi.org/10.1167/iovs.66.1.58

Includes: Supplemental Content

Cornea January 2025

ROCK Inhibitor Enhances Resilience Against Metabolic Stress Through Increasing Bioenergetic Capacity in Corneal Endothelial Cells

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Wei-Ting Ho; Jung-Shen Chang; Chia-Jen Lei; Tsan-Chi Chen; Jia-Kang Wang; Shu-Wen Chang; Muh-Hwa Yang; Tzuu-Shuh Jou; I-Jong Wang
TAGS: cornea, endothelial cells, metabolic stress, monensin, sodium, stress, chronic exertional compartment syndrome, apoptosis, glycolysis, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):51. https://doi.org/10.1167/iovs.66.1.51

Includes: Supplemental Content

Cornea January 2025

Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus

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Loren Moon; Pritpal Kaur; Jiangxia Wang; Akrit Sodhi; Charles Eberhart; Uri Soiberman
TAGS: collagen, corneal epithelial cells, corneal epithelium, keratoconus, wnt10a gene, genes, proteins, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):52. https://doi.org/10.1167/iovs.66.1.52

Includes: Supplemental Content

Retinal Cell Biology January 2025

DNA-Dependent Protein Kinase Catalytic Subunit Prevents Ferroptosis in Retinal Pigment Epithelial Cells

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Xueying Wang; Xi Wang; Zhenzhen Zhao; Qian Wang; Xiaoman Zhu; Qingjian Ou; Jing-Ying Xu; Lixia Lu; Furong Gao; Juan Wang; Yanlong Bi; Guo-Tong Xu; Caixia Jin; Haibin Tian
TAGS: ferroptosis, prkdc gene, retinal pigment cell, catalytic domain, dna damage, phosphorylation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):50. https://doi.org/10.1167/iovs.66.1.50

Includes: Supplemental Content

Retina January 2025

Slab-Specific Projection-Resolved Optical Coherence Tomography Angiography for Enhancing En Face Polyp Detection in Polypoidal Choroidal Vasculopathy

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Nida Wongchaisuwat; Jie Wang; Tristan T. Hormel; Yali Jia; Elizabeth S. White; Nuttawut Rodanant; Nopasak Phasukkijwatana
TAGS: angiogram, face, polypoidal choroidal vasculopathy, polyps, optical coherence tomography, fluid flow
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):9. https://doi.org/10.1167/iovs.66.1.9

Cornea January 2025

RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway

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Yan Shen; Jiajia Wang; Yiqin Dai; Xichen Wan; Jing Zhang; Qihua Le
TAGS: corneal epithelium, epithelial stem cells, signal pathway, signal transduction pathways, wounds and injuries, proteins, mice, wound healing, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):8. https://doi.org/10.1167/iovs.66.1.8

Includes: Supplemental Content

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Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

Use of SGLT2 Inhibitors Versus DPP-4 Inhibitors and Age-Related Macular Degeneration in Patients WithType 2 Diabetes: A Multinational Cohort Study

Vitamin K1 Alleviates Retinal Inflammation Following Acute Ocular Hypertension by Modulating Microglial Ferroptosis

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

Nonperfused Retinal Capillaries—A New Method Developed on OCT and OCTA

In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation

Assessment of Corneal Biomechanical Changes After Discontinuation of Long-Term Orthokeratology: A 2-Year Prospective Study

Epigenetic ALYREF/UHRF1/RHOB Axis in Corneal Wound Healing and Implications for Epithelial Tumorigenesis

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

Artificial Intelligence Versus Rules-Based Approach for Segmenting NonPerfusion Area in a DRCR Retina Network Optical Coherence Tomography Angiography Dataset

Photoreceptor Outer Segment Reflectivity With Ultrahigh-Resolution Visible-Light Optical Coherence Tomography in Systemic Hydroxychloroquine Use

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study

Design, Fabrication, and Surgical Testing of the 3D-Printed Large-Array Port-System for the Implantation of Large Epiretinal Stimulators

ENO2-Regulated Glycolysis in Endothelial Cells Contributes to FGF2-Induced Retinal Neovascularization

ROCK Inhibitor Enhances Resilience Against Metabolic Stress Through Increasing Bioenergetic Capacity in Corneal Endothelial Cells

Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus

DNA-Dependent Protein Kinase Catalytic Subunit Prevents Ferroptosis in Retinal Pigment Epithelial Cells

Slab-Specific Projection-Resolved Optical Coherence Tomography Angiography for Enhancing En Face Polyp Detection in Polypoidal Choroidal Vasculopathy

RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway

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