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Biochemistry and Molecular Biology June 2025

Machine Learning Identifies Key Gene Markers Related to Fetal Retina Development at Single-Cell Transcription Level

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Jiyu Zhang; Tong Du; Yiqing Jin; Yusheng Bao; Qinglan Ma; Yu-Dong Cai; Jian Zhang
TAGS: fetus, genes, retina, machine learning, rod photoreceptors, retinal cone, retinal diseases, classification algorithms
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):60. https://doi.org/10.1167/iovs.66.6.60

Includes: Supplemental Content

Cornea June 2025

Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice

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Ning Wang; Yizhou Li; Xiaolei Wang; Lingling Yang; Jing Zhang; Jun Cheng; Xiaoyue Jiang; Xia Qi; Chao Wei; Qingjun Zhou; Ya Li; Suxia Li

Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):28. https://doi.org/10.1167/iovs.66.6.28

Includes: Supplemental Content

Low Vision June 2025

The Efficiency and Safety of Oxygen-Supplemented Accelerated Scleral Cross-Linking in Rabbits

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Lingling Yan; Ce Wu; Xiaona Liu; Pengfei Han; Jie Zhang; Zhipeng Gao; Xiaona Li; Weiyi Chen
TAGS: cross-linking, oryctolagus cuniculus, oxygen, sclera, safety
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):10. https://doi.org/10.1167/iovs.66.6.10

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2025

Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia

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Binyu Wen; Hangyu Li; Hui Tao; Hong Ren; Bosheng Ma; Mengdi Shi; Shen Chen; Jiaqi Du; Ziyi Cai; Jing Zhang; Dongshi Guan; Zhihong Deng
TAGS: caviidae, collagen, gelatinase a, myopia, sclera, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):19. https://doi.org/10.1167/iovs.66.5.19

Includes: Supplemental Content

Lens April 2025

Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

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Dongzhe Zhang; Junwei Qu; Cuncun Ke; Xiumei Kong; Mengyun Liu; Iqbal Nawaz Khan; Shuxin Huang; Haijiao Tian; Tong Xie; Ke Qiu; Jing Li; Mingli Wang; Hui Li; Fengling Yuan; Weikai Guo; Mingya Cao; Jing Zhang; Keke Zhu; Jin Luo; Fengyan Zhang; Xiukun Cui; Hongmei Mu; Yanzhong Hu
TAGS: body tissue, cataract, epithelium, infections, lens (device), macrophages, risk factors, porphyromonas gingivalis, hypertension, lens, crystalline
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):68. https://doi.org/10.1167/iovs.66.4.68

Includes: Supplemental Content

Cornea April 2025

Enhanced Therapeutic Effect of IL-10-ADSCs on Rabbit Autoimmune Dacryoadenitis By Suppressing T Follicular Helper Cell Responses Via miR-142-5p/RC3H1 Axis

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Lu Zhao; Na Li; Xinrui Shi; Jiachen Zhang; Min Gao; Yankai Wei; Xuejia Li; Bei Du; Deming Sun; Hong Nian; Ruihua Wei
TAGS: autoimmunity, dacryoadenitis, dry eye syndromes, oryctolagus cuniculus, t follicular helper cells, attenuation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):66. https://doi.org/10.1167/iovs.66.4.66

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

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Zi Xuan Lin; Xiu Juan Zhang; Fang Yao Tang; Yuzhou Zhang; Ka Wai Kam; Alvin L. Young; Patrick Ip; Carol Y. Cheung; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Kyoko Ohno-Matsui; Jason C. Yam
TAGS: child, eye, myopia, retinal vasculature, hong kong
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):64. https://doi.org/10.1167/iovs.66.4.64

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics April 2025

Temporal Contour Integration Deficits in Children With Amblyopia

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Yan-Ru Chen; Shu-Qi Jiang; Xiang-Yun Liu; Jun-Yun Zhang
TAGS: amblyopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):27. https://doi.org/10.1167/iovs.66.4.27

Lens March 2025

Changes in Lens Thickness and Power Before and After Myopia Onset

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Jiaqing Zhang; Ling Jin; Qianyun Chen; Decai Wang; Xiang Chen; Yuting Li; Yabin Qu; Rong Lin; Mingguang He; Ian G. Morgan; Lixia Luo; Yangfa Zeng; Xiaotong Han
TAGS: lens, crystalline, myopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):36. https://doi.org/10.1167/iovs.66.3.36

Includes: Supplemental Content

Pediatric Ophthalmology & Strabismus March 2025

The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children

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Wenyan Xu; Xiaoman Li; Jianing Zhang; Hongyi Li; Xuewen Ding; Xiaoyue Hu; Xinyue Quan; Yue Su; Fan Lu; Jie Chen
TAGS: astigmatism, child, lens (device), lens, crystalline, myopia, refractive errors
Trans. Vis. Sci. Tech.. 2025; 14(3):8. https://doi.org/10.1167/tvst.14.3.8

Includes: Supplemental Content

Retina February 2025

Topography of Slowed Dark Adaptation in Pseudoxanthoma Elasticum: PROPXE Study Report 1

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Kristina Pfau; Georg Ansari; Stephan Michels; Chantal Dysli; Sandra Liakopoulos; Jana Burghaus-Zhang; Mayss Al-Sheikh; Justus G. Garweg; Mathieu Quinodoz; Karolina Kaminska; Francesca Cancellieri; Carlo Rivolta; Sharon F. Terry; Nicolas Feltgen; Maximilian Pfau
TAGS: dark adaptation, pseudoxanthoma elasticum, study report, rod photoreceptors, calcification, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):17. https://doi.org/10.1167/iovs.66.2.17

Includes: Supplemental Content

Cornea January 2025

Posterior Limbal Mesenchymal Stromal Cells Promote Proliferation and Stemness of Transition Zone Cells: A Novel Insight Into Corneal Endothelial Rejuvenation

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Yuting Xiao; Charles N. J. McGhee; Jie Zhang
TAGS: cornea, endothelium, rejuvenation, mesenchymal stem cells, mice, wounds and injuries, proteins, culture media, conditioned, coculture techniques
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):44. https://doi.org/10.1167/iovs.66.1.44

Includes: Supplemental Content

Immunology and Microbiology January 2025

Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate Fungal Keratitis

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Jiahui Yang; Jing Zhong; Zhenyuan Fu; Dalian He; Jing Zhang; Jin Yuan
TAGS: cornea, fungal keratitis, infections, macrophages, marenostrin, mice, phagocytosis, proteins, mycoses, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):33. https://doi.org/10.1167/iovs.66.1.33

Includes: Supplemental Content

Cornea January 2025

RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway

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Yan Shen; Jiajia Wang; Yiqin Dai; Xichen Wan; Jing Zhang; Qihua Le
TAGS: corneal epithelium, epithelial stem cells, signal pathway, signal transduction pathways, wounds and injuries, proteins, mice, wound healing, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):8. https://doi.org/10.1167/iovs.66.1.8

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2025

Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults

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Yanping Chen; Ruilin Xiong; Jian Zhang; Shaopeng Yang; Huangdong Li; Ziyu Zhu; Peiyuan Wang; Mingguang He; Yingfeng Zheng; Wei Wang
TAGS: adult, child, eye, incidence, myopia, vision, visual impairment, blindness, world health organization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):2. https://doi.org/10.1167/iovs.66.1.2

Includes: Supplemental Content

Retina December 2024

Association of Metabolomics With Incidence of Age-Related Macular Degeneration: The UK Biobank Study

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Jun Yu; Yuzhou Zhang; Mary Ho; Xiu Juan Zhang; Ka Wai Kam; Alvin L. Young; Chi Pui Pang; Clement C. Tham; Jason C. Yam; Li Jia Chen
TAGS: age-related macular degeneration, incidence, metabolites, metabolomics, uk biobank, biological markers, polygenic risk score, lipids
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):43. https://doi.org/10.1167/iovs.65.14.43

Includes: Supplemental Content

Retina December 2024

Early Diabetic Retinopathy Evaluation With OCTA: A Study on Vascular Branching and Fragmentation

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Yao Yu; Shiwei Cui; Yang He; Jiahao Zhang; Nan Lu; Yanqiu Yang; Jian Liu; Yi Wang; Zhenhe Ma
TAGS: diabetic retinopathy, human placental lactogen, embolic protection devices, diabetes mellitus, fovea centralis
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):21. https://doi.org/10.1167/iovs.65.14.21

Includes: Supplemental Content

Retina December 2024

Effects of Physical Activity and Inactivity on Microvasculature in Children: The Hong Kong Children Eye Study

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Xiu Juan Zhang; Vincent L. Yuen; Yuzhou Zhang; Ka Wai Kam; Jason Wong; Fang Yao Tang; Alvin Young; Patrick Ip; Li Jia Chen; Tien Y. Wong; Chi Pui Pang; Clement C. Tham; Carol Y. Cheung; Jason C. Yam
TAGS: child, eye, hong kong, lack of exercise, microvascular network, physical activity
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):7. https://doi.org/10.1167/iovs.65.14.7

Includes: Supplemental Content

Retina November 2024

Midperipheral Microvascular Defects and Their Associations With Vitreoretinal Abnormalities in Early-Stage Familial Exudative Vitreoretinopathy

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Juan Zhang; Lu Ruan; Chen Jiang; Qian Yang; Qing Chang; Xin Huang
TAGS: familial exudative vitreoretinopathies
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):4. https://doi.org/10.1167/iovs.65.13.4

Includes: Supplemental Content

Retinal Cell Biology October 2024

Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs

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Mei-Ling Gao; Tong-Yu Wang; Xin Lin; Chun Tang; Mengyao Li; Zhan-Pei Bai; Zhi-Cong Liu; Li-Jun Chen; Qing-Ran Kong; Shao-Hui Pan; Shan-Shan Zeng; Ya Guo; Jian-Qi Cai; Xiu-Feng Huang; Jun Zhang
TAGS: foreign medical graduates, microglia, organoids, coculture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):19. https://doi.org/10.1167/iovs.65.12.19

Includes: Supplemental Content

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Machine Learning Identifies Key Gene Markers Related to Fetal Retina Development at Single-Cell Transcription Level

Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice

The Efficiency and Safety of Oxygen-Supplemented Accelerated Scleral Cross-Linking in Rabbits

Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia

Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

Enhanced Therapeutic Effect of IL-10-ADSCs on Rabbit Autoimmune Dacryoadenitis By Suppressing T Follicular Helper Cell Responses Via miR-142-5p/RC3H1 Axis

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

Temporal Contour Integration Deficits in Children With Amblyopia

Changes in Lens Thickness and Power Before and After Myopia Onset

The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children

Topography of Slowed Dark Adaptation in Pseudoxanthoma Elasticum: PROPXE Study Report 1

Posterior Limbal Mesenchymal Stromal Cells Promote Proliferation and Stemness of Transition Zone Cells: A Novel Insight Into Corneal Endothelial Rejuvenation

Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate Fungal Keratitis

RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway

Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults

Association of Metabolomics With Incidence of Age-Related Macular Degeneration: The UK Biobank Study

Early Diabetic Retinopathy Evaluation With OCTA: A Study on Vascular Branching and Fragmentation

Effects of Physical Activity and Inactivity on Microvasculature in Children: The Hong Kong Children Eye Study

Midperipheral Microvascular Defects and Their Associations With Vitreoretinal Abnormalities in Early-Stage Familial Exudative Vitreoretinopathy

Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs

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