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Retina June 2022

The Association of Fluid Volatility With Subretinal Hyperreflective Material and Ellipsoid Zone Integrity in Neovascular AMD

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Justis P. Ehlers; Nikhil Patel; Peter K. Kaiser; Jeffrey S. Heier; David M. Brown; Xiangyi Meng; Jamie Reese; Leina Lunasco; Thuy K. Le; Ming Hu; Sunil K. Srivastava
TAGS: exudative age-related macular degeneration, eye, personal integrity, volume, attenuation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):17. doi: https://doi.org/10.1167/iovs.63.6.17

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Assessing Inhibition of HUVEC Migration by a Novel VEGF-A and Angiopoietin-2 Bispecific Protein (RO-634)

John Kunzeman; Jeffrey L Olson; Anthony Jones; Josh Morgenstern; Anne Strong; Steven Droho; Shaun Bevers; Niklaus Mueller; Michael Huvard; Li Xu; Peter K Kaiser; Arshad M. Khanani; Jeffrey S Heier; Nikhil Gupta; Alina Sinha; Ramanath Bhandari

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1325 – F0159. doi:

ARVO Annual Meeting Abstract June 2022

Preliminary Results from a First-in-human Phase I/II Gene Therapy Study (FOCUS) of Subretinally Delivered GT005, an Investigational AAV2 Vector, in Patients with Geographic Atrophy Secondary to Age-related Macular Degeneration

Jared Nielsen; Robert E MacLaren; Jeffrey S Heier; David Steel; Tsveta Ivanova; Sobha Sivaprasad; Paulo Stanga; Clare Bailey; Peter Charbel Issa; Luisa Mendonca; James Francis; Darin Curtiss; Jane Hughes; Nadia K Waheed

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1504. doi:

ARVO Annual Meeting Abstract June 2022

Impact of baseline imbalances on the efficacy of pegcetacoplan for the treatment of geographic atrophy (GA): A post hoc analysis of OAKS, DERBY, and FILLY

Sunir Garg; Charles Clifton Wykoff; Nathan Steinle; Giovanni Staurenghi; Debra Morris; Allen Chiang; Caleb Bliss; Daniel Jones; Ramiro Ribeiro; Allen C Ho; Jeffrey S Heier

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1501. doi:

ARVO Annual Meeting Abstract June 2022

Prospective, longitudinal feasibility study: daily self-imaging with home OCT in neovascular age-related macular degeneration

Yingna Liu; Nancy M Holekamp; Jeffrey S Heier

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2320. doi:

ARVO Annual Meeting Abstract June 2022

Determining the Ocular Biocompatibility of a Novel VEGF-A and Ang-2 Bispecific Protein (RO-634) Through Histological Analysis

Evan Sembell; Jeffrey L Olson; Anthony Jones; Josh Morgenstern; Anne Strong; Steven Droho; Niklaus Mueller; Michael Huvard; Shaun Bevers; Li Xu; Peter K Kaiser; Arshad M. Khanani; Jeffrey S Heier; Nikhil Gupta; John M Kunzeman; Ramanath Bhandari

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):305 – F0108. doi:

ARVO Annual Meeting Abstract June 2022

Preclinical Animal Model for Functional Biocompatibility of a Novel VEGF and Ang-2 Bispecific Protein (RO-634) Using ERG Analysis

Nikhil Gupta; Jeffrey L Olson; Anthony Jones; Josh Morgenstern; Anne Strong; Steven Droho; Shaun Bevers; Niklaus Mueller; Michael Huvard; Li Xu; Peter K Kaiser; Arshad M. Khanani; Jeffrey S Heier; Alina Sinha; Evan Sembell; Ramanath Bhandari

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):286 – F0089. doi:

ARVO Annual Meeting Abstract June 2022

The Half Maximal Effective Concentration (EC50) of a Novel VEGF-A and Ang-2 Bispecific Protein (RO-634) for Back of the Eye Disease

Alina Sinha; Jeffrey L Olson; Anthony Jones; Josh Morgenstern; Anne Strong; Steven Droho; Shaun Bevers; Niklaus Mueller; Michael Huvard; Li Xu; Peter K Kaiser; Arshad M. Khanani; Jeffrey S Heier; John M Kunzeman; Evan Sembell; Ramanath Bhandari

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1316 – F0150. doi:

ARVO Annual Meeting Abstract June 2022

Characterizing a Novel Bispecific Platform (Surrobody) for use in Back of the Eye Disease

Ramanath Bhandari; Li Xu; Evan Sembell; Jeffrey L Olson; Peter M Kaiser; Arshad M. Khanani; Jeffrey S Heier; Alina Sinha; John M Kunzeman; Nikhil Gupta; Ramesh Bhatt

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):302 – F0105. doi:

ARVO Annual Meeting Abstract June 2022

Efficacy of intravitreal pegcetacoplan in patients with geographic atrophy (GA): 12-month results from the phase 3 OAKS and DERBY studies.

Roger Goldberg; Jeffrey S Heier; Charles Clifton Wykoff; Giovanni Staurenghi; Rishi P Singh; Nathan Steinle; David S Boyer; Jordi Mones; Frank G Holz; Caleb Bliss; Federico Grossi; Ravi Metlapally; Ramiro Ribeiro

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1500. doi:

ARVO Annual Meeting Abstract June 2020

Disease Activity Assessments with Brolucizumab vs Aflibercept in Patients with nAMD in HAWK and HARRIER

Rishi P Singh; Robin Hamilton; Jeffrey S Heier; Carl Regillo; Mark C Gillies; Georges Weissgerber; Jahangir Alam; Pravin U Dugel

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1158. doi:

ARVO Annual Meeting Abstract June 2020

Safety and Efficacy of Risuteganib in Intermediate Non-exudative Age-Related Macular Degeneration

Raj Maturi; Glenn J Jaffe; Justis P Ehlers; Peter K Kaiser; David S Boyer; Jeffrey S Heier; Julia A Kornfield; Baruch D Kuppermann; Hugo Quiroz-Mercado; Janine Aubel; Lisa Karageozian; Vicken H Karageozian; Melvin Sarayba

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1944. doi:

ARVO Annual Meeting Abstract June 2020

Analysis of choriocapillaris flow impairment in intermediate age-related macular degeneration as a predictor of progression to exudative choroidal neovascularization

Luísa Salles de Moura Mendonca; Jeffrey S Heier; David S Boyer; David M Brown; Sumit P Shah; A. Yasin Alibhai; Namrata Saroj; Sabin Dang; Nadia K Waheed

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4092. doi:

ARVO Annual Meeting Abstract July 2019

Detection of choroidal neovascular membranes using OCT Angiography: Learnings from the PROCON Study

Sabin Dang; Nadia K Waheed; David S Boyer; David M Brown; Sumit Shah; Jeffrey S. Heier

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3482. doi:

ARVO Annual Meeting Abstract July 2019

Sustained neuroprotective effect of novel Aβ aggregation modulator GAL-101 shown in dry AMD and glaucoma models with transient peak concentrations using eye drops

Hermann Russ; Christopher Parsons; Yaniv Barkana; Andrew L. Pearlman; Jeffrey S. Heier; Leonard A Levin; Robert N Weinreb; Jeffrey M Liebmann

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5393. doi:

ARVO Annual Meeting Abstract July 2019

Treatment and Management of Neovascular AMD: Impact on Patients

Vincent W Li; Isaac R. Gabriel; Madeleine M Li; Andrew N Antoszyk; Carl W Baker; Pravin U Dugel; Roger A. Goldberg; Jeffrey S. Heier; Allen C Ho; John S Pollack; Charles Clifton Wykoff; Demetrios Vavvas; William W Li

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):136. doi:

ARVO Annual Meeting Abstract July 2018

Incidence of Vascularized Drusen in Non-Exudative Age-related Macular Degeneration using Spectral Domain Optical Coherence Tomography (OCT) Angiography

Chris Or; Jeffrey S. Heier; Namrata Saroj; A. Yasin Alibhai; Nadia K Waheed

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3229. doi:

ARVO Annual Meeting Abstract July 2018

Lampalizumab for geographic atrophy (GA) in age-related macular degeneration (AMD): pooled results of the Chroma and Spectri phase 3 randomized clinical trials (RCTs)

Dante Joseph Pieramici; Frank Holz; Jeffrey S. Heier; Srinivas R. Sadda; Brandon G Busbee; Emily Y. Chew; Paul Mitchell; Adnan Tufail; Christopher Brittain; Daniela Ferrara; Sarah Gray; Lee Honigberg; Jillian Martin; Barbara Tong; Jason Ehrlich; Neil M Bressler

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4948. doi:

ARVO Annual Meeting Abstract July 2018

Randomized, Prospective, Double-Masked, Controlled Phase 2b Trial to Evaluate the Safety & Efficacy of ALG-1001 (Luminate®) in Diabetic Macular Edema

Hugo Quiroz-Mercado; David S Boyer; Peter A Campochiaro; Jeffrey S. Heier; Peter K Kaiser; Julie Kornfield; Baruch D Kuppermann; Vicken H Karageozian; Hampar L Karageozian; Lisa Karageozian; John Y Park; Melvin Sarayba

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1960. doi:

ARVO Annual Meeting Abstract July 2018

First-in human study of SF0166 Topical Ophthalmic Solution in patients with diabetic macular edema

D. Edwards; David S Boyer; Peter K Kaiser; Jeffrey S. Heier; Ben Askew

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1961. doi:

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The Association of Fluid Volatility With Subretinal Hyperreflective Material and Ellipsoid Zone Integrity in Neovascular AMD

Assessing Inhibition of HUVEC Migration by a Novel VEGF-A and Angiopoietin-2 Bispecific Protein (RO-634)

Preliminary Results from a First-in-human Phase I/II Gene Therapy Study (FOCUS) of Subretinally Delivered GT005, an Investigational AAV2 Vector, in Patients with Geographic Atrophy Secondary to Age-related Macular Degeneration

Impact of baseline imbalances on the efficacy of pegcetacoplan for the treatment of geographic atrophy (GA): A post hoc analysis of OAKS, DERBY, and FILLY

Prospective, longitudinal feasibility study: daily self-imaging with home OCT in neovascular age-related macular degeneration

Determining the Ocular Biocompatibility of a Novel VEGF-A and Ang-2 Bispecific Protein (RO-634) Through Histological Analysis

Preclinical Animal Model for Functional Biocompatibility of a Novel VEGF and Ang-2 Bispecific Protein (RO-634) Using ERG Analysis

The Half Maximal Effective Concentration (EC50) of a Novel VEGF-A and Ang-2 Bispecific Protein (RO-634) for Back of the Eye Disease

Characterizing a Novel Bispecific Platform (Surrobody) for use in Back of the Eye Disease

Efficacy of intravitreal pegcetacoplan in patients with geographic atrophy (GA): 12-month results from the phase 3 OAKS and DERBY studies.

Disease Activity Assessments with Brolucizumab vs Aflibercept in Patients with nAMD in HAWK and HARRIER

Safety and Efficacy of Risuteganib in Intermediate Non-exudative Age-Related Macular Degeneration

Analysis of choriocapillaris flow impairment in intermediate age-related macular degeneration as a predictor of progression to exudative choroidal neovascularization

Detection of choroidal neovascular membranes using OCT Angiography: Learnings from the PROCON Study

Sustained neuroprotective effect of novel Aβ aggregation modulator GAL-101 shown in dry AMD and glaucoma models with transient peak concentrations using eye drops

Treatment and Management of Neovascular AMD: Impact on Patients

Incidence of Vascularized Drusen in Non-Exudative Age-related Macular Degeneration using Spectral Domain Optical Coherence Tomography (OCT) Angiography

Lampalizumab for geographic atrophy (GA) in age-related macular degeneration (AMD): pooled results of the Chroma and Spectri phase 3 randomized clinical trials (RCTs)

Randomized, Prospective, Double-Masked, Controlled Phase 2b Trial to Evaluate the Safety & Efficacy of ALG-1001 (Luminate®) in Diabetic Macular Edema

First-in human study of SF0166 Topical Ophthalmic Solution in patients with diabetic macular edema

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