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Perspective April 2021

Tackling the Challenges of Product Development Through a Collaborative Rare Disease Network: The Foundation Fighting Blindness Consortium

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Todd A. Durham; Jacque L. Duncan; Allison R. Ayala; David G. Birch; Janet K. Cheetham; Frederick L. Ferris, III; Carel B. Hoyng; Mark E. Pennesi; José-Alain Sahel; for the Foundation Fighting Blindness Consortium Investigator Group
TAGS: blindness, rare diseases
Trans. Vis. Sci. Tech.. 2021; 10(4):23. doi: https://doi.org/10.1167/tvst.10.4.23

Retina January 2021

Biometrics, Impact, and Significance of Basal Linear Deposit and Subretinal Drusenoid Deposit in Age-Related Macular Degeneration

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Ling Chen; Jeffrey D. Messinger; Deepayan Kar; Jacque L. Duncan; Christine A. Curcio
TAGS: age-related macular degeneration, biometry, blinded, drusen, eye, lipids, visually impaired persons, volume
Invest. Ophthalmol. Vis. Sci.. 2021; 62(1):33. doi: https://doi.org/10.1167/iovs.62.1.33

Includes: Supplemental Content

Articles October 2020

The RUSH2A Study: Best-Corrected Visual Acuity, Full-Field Electroretinography Amplitudes, and Full-Field Stimulus Thresholds at Baseline

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David G. Birch; Peiyao Cheng; Jacque L. Duncan; Allison R. Ayala; Maureen G. Maguire; Isabelle Audo; Janet K. Cheetham; Todd A. Durham; Abigail T. Fahim; Frederick L. Ferris, III; Elise Heon; Rachel M. Huckfeldt; Alessandro Iannaccone; Naheed W. Khan; Eleonora M. Lad; Michel Michaelides; Mark E. Pennesi; Katarina Stingl; Ajoy Vincent; Christina Y. Weng; for the Foundation Fighting Blindness Consortium Investigator Group
TAGS: electroretinography, visual acuity
Trans. Vis. Sci. Tech.. 2020; 9(11):9. doi: https://doi.org/10.1167/tvst.9.11.9

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Photoreceptor imaging in USH2A -related non-syndromic retinitis pigmentosa and Usher Syndrome type 2A patients

Lesley Everett; Jessica Wong; Jenna Cava; Travis Proco; Austin Roorda; Joseph Carroll; Jacque L Duncan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):209. doi:

ARVO Annual Meeting Abstract June 2020

Multimodal imaging in patients with MYO7A- related Usher syndrome

Leslie Small; Jessica Wong; Mark E Pennesi; Hao Zhou; Ruikang K Wang; Abhishek Chadha; David S Williams; Austin Roorda; Travis Proco; Jacque L Duncan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):228. doi:

ARVO Annual Meeting Abstract June 2020

RUSH2A: systematic cohort variant modeling reveals phenotypic correlates

Robert B. Hufnagel; Bin Guan; Ehsan Ullah; Wendi Liang; Carmen Brewer; Stephen P Daiger; Kari E Branham; Jacque L Duncan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):836. doi:

ARVO Annual Meeting Abstract June 2020

Natural history study of visual function in patients with BBS1 and BBS10 -related Bardet-Biedl syndrome.

Monika Grudzinska Pechhacker; Samuel G Jacobson; Ine Strubbe; Jacque L Duncan; Arlene V Drack; Andrea L Vincent; Tomas Aleman; Caroline Van Cauwenbergh; Elfride De Baere; Helene Dollfus; Nathalie Goetz; Bart Peter Leroy; Ajoy Vincent; Elise Heon

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4463. doi:

ARVO Annual Meeting Abstract June 2020

Creating an in vitro Leber congenital amaurosis model to investigate disease mechanisms

Kathleen R Chirco; Shereen Chew; Jacque L Duncan; Anthony Moore; Deepak A Lamba

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3803. doi:

ARVO Annual Meeting Abstract June 2020

Test-retest variability of static perimetry and microperimetry results from the RUSH2A study

Allison Ayala; Wendi Liang; David G Birch; Janet K Cheetham; Elvira N Chegarnov; Jacque L Duncan; Todd Durham; Frederick L Ferris; Eleonora M Lad; Maureen Maguire; Mark E Pennesi

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3342. doi:

ARVO Annual Meeting Abstract June 2020

Accelerating research in rare inherited retinal disorders (IRDs) through an international consortium

Janet K Cheetham; Allison Ayala; David G Birch; Jacque L Duncan; Todd Durham; Frederick L Ferris; Maureen Maguire; Mark E Pennesi

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3356. doi:

ARVO Annual Meeting Abstract June 2020

Baseline visual fields in the RUSH2A study: Associated factors and correlation with measures of disease severity

Jacque L Duncan; Wendi Liang; Isabelle S Audo; David G Birch; Joseph Carroll; Janet K. Cheetham; Laura R Erker; Frederick L Ferris; Elise Heon; Robert Hufnagel; Alessandro Iannaccone; Glenn J Jaffe; Christine N Kay; Maureen Maguire; Michel Michaelides; Mark E Pennesi

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3364. doi:

ARVO Annual Meeting Abstract June 2020

Deep learning-based automatic segmentation of intact ellipsoid zone area on optical coherence tomography images of USH2A-related retinal degeneration

Sina Farsiu; Jessica Loo; Jacque L Duncan; David G Birch; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):485. doi:

ARVO Annual Meeting Abstract June 2020

Meta-learning approach to automatically register multivendor retinal images

Ali Hasan; Zengtian Deng; Jessica Loo; Dibyendu Mukherjee; Jacque L Duncan; David G Birch; Glenn J Jaffe; Sina Farsiu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1634. doi:

Articles June 2020

OCT Angiography to Predict Geographic Atrophy Progression using Choriocapillaris Flow Void as a Biomarker

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Khashayar Nattagh; Hao Zhou; Nicholas Rinella; Qinqin Zhang; Yining Dai; Katharina G. Foote; Cathrine Keiner; Michael Deiner; Jacque L. Duncan; Travis C. Porco; Ruikang K. Wang; Daniel M. Schwartz
TAGS: angiogram, atrophy, biological markers, chief complaint, fluid flow
Trans. Vis. Sci. Tech.. 2020; 9(7):6. doi: https://doi.org/10.1167/tvst.9.7.6

Review June 2020

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium

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Debra A. Thompson; Alessandro Iannaccone; Robin R. Ali; Vadim Y. Arshavsky; Isabelle Audo; James W. B. Bainbridge; Cagri G. Besirli; David G. Birch; Kari E. Branham; Artur V. Cideciyan; Steven P. Daiger; Deniz Dalkara; Jacque L. Duncan; Abigail T. Fahim; John G. Flannery; Roberto Gattegna; John R. Heckenlively; Elise Heon; K. Thiran Jayasundera; Naheed W. Khan; Henry Klassen; Bart P. Leroy; Robert S. Molday; David C. Musch; Mark E. Pennesi; Simon M. Petersen-Jones; Eric A. Pierce; Rajesh C. Rao; Thomas A. Reh; Jose A. Sahel; Dror Sharon; Paul A. Sieving; Enrica Strettoi; Paul Yang; David N. Zacks; The Monaciano Consortium
TAGS: outcome measures, retinal diseases, surrogate endpoints, genetics, vision, natural history, ethics, gene therapy
Trans. Vis. Sci. Tech.. 2020; 9(7):2. doi: https://doi.org/10.1167/tvst.9.7.2

Retina April 2020

Comparing Cone Structure and Function in RHO- and RPGR- Associated Retinitis Pigmentosa

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Katharina G. Foote; Jessica J. Wong; Alexandra E. Boehm; Ethan Bensinger; Travis C. Porco; Austin Roorda; Jacque L. Duncan
TAGS: mutation, retinal cone, retinitis pigmentosa
Invest. Ophthalmol. Vis. Sci.. 2020; 61(4):42. doi: https://doi.org/10.1167/iovs.61.4.42

Perspective February 2020

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

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Ian M. MacDonald; Christopher Moen; Jacque L. Duncan; Stephen H. Tsang; Jasmina Cehajic-Kapetanovic; Tomas S. Aleman
TAGS: choroideremia, gene therapy, retinal degeneration, spatial vectors
Trans. Vis. Sci. Tech.. 2020; 9(3):17. doi: https://doi.org/10.1167/tvst.9.3.17

Retina November 2019

Cone Structure Persists Beyond Margins of Short-Wavelength Autofluorescence in Choroideremia

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Katharina G. Foote; Nicholas Rinella; Janette Tang; Nicolas Bensaid; Hao Zhou; Qinqin Zhang; Ruikang K. Wang; Travis C. Porco; Austin Roorda; Jacque L. Duncan
TAGS: autofluorescence, chief complaint, choroideremia, diagnostic imaging, photoreceptors, retinal cone, perfusion
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4931-4942. doi: https://doi.org/10.1167/iovs.19-27979

Retina July 2019

Loss of Foveal Cone Structure Precedes Loss of Visual Acuity in Patients With Rod-Cone Degeneration

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Ethan Bensinger; Nicholas Rinella; Asma Saud; Panagiota Loumou; Kavitha Ratnam; Shane Griffin; Jia Qin; Travis C. Porco; Austin Roorda; Jacque L. Duncan
TAGS: blindness, retinal cone, retinitis pigmentosa, tissue degeneration, rod photoreceptors, visual acuity, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3187-3196. doi: https://doi.org/10.1167/iovs.18-26245

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Gene therapy trials for hereditary retinal degenerations

Jacque L Duncan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):992. doi:

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Tackling the Challenges of Product Development Through a Collaborative Rare Disease Network: The Foundation Fighting Blindness Consortium

Biometrics, Impact, and Significance of Basal Linear Deposit and Subretinal Drusenoid Deposit in Age-Related Macular Degeneration

The RUSH2A Study: Best-Corrected Visual Acuity, Full-Field Electroretinography Amplitudes, and Full-Field Stimulus Thresholds at Baseline

Photoreceptor imaging in USH2A -related non-syndromic retinitis pigmentosa and Usher Syndrome type 2A patients

Multimodal imaging in patients with MYO7A- related Usher syndrome

RUSH2A: systematic cohort variant modeling reveals phenotypic correlates

Natural history study of visual function in patients with BBS1 and BBS10 -related Bardet-Biedl syndrome.

Creating an in vitro Leber congenital amaurosis model to investigate disease mechanisms

Test-retest variability of static perimetry and microperimetry results from the RUSH2A study

Accelerating research in rare inherited retinal disorders (IRDs) through an international consortium

Baseline visual fields in the RUSH2A study: Associated factors and correlation with measures of disease severity

Deep learning-based automatic segmentation of intact ellipsoid zone area on optical coherence tomography images of USH2A-related retinal degeneration

Meta-learning approach to automatically register multivendor retinal images

OCT Angiography to Predict Geographic Atrophy Progression using Choriocapillaris Flow Void as a Biomarker

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium

Comparing Cone Structure and Function in RHO- and RPGR- Associated Retinitis Pigmentosa

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

Cone Structure Persists Beyond Margins of Short-Wavelength Autofluorescence in Choroideremia

Loss of Foveal Cone Structure Precedes Loss of Visual Acuity in Patients With Rod-Cone Degeneration

Gene therapy trials for hereditary retinal degenerations

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