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ARVO Annual Meeting Abstract June 2024

A tale of two substrates: Glucose and Lactate feed retina and RPE glycogen

Daniel Hass; Lan Wang; Yiyi Chen; LuLu Callies; Timothy Joel Cherry; Nancy Philp; Francois Paquet-Durand; James Hurley

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):434.

ARVO Annual Meeting Abstract June 2024

Do RPE cells have a preferred ketogenic substrate?

Kriti Pandey; Daniel Hass; Gillian Autterson; Jason Matthew Lewis Miller; James Hurley

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):187.

ARVO Annual Meeting Abstract June 2024

Modeling AMD-Relevant Metabolism in RPE Cultures Using a Novel Device for Measuring Long-Term Oxygen Consumption Rates

Jason Matthew Lewis Miller; Qitao Zhang; Gillian Autterson; Daniel Hass; James Hurley; Richard Bryant; Daisy Y Shu; Kaitlyn Digsby; John Yeong Se Han

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):184.

Optica Fall Vision Meeting Abstract December 2023

Poster Session II: Can a drug for liver disease be used to treat Age-Related Macular Degeneration?

Kriti Pandey; Daniel T Hass; Rayne R Lim; Noah Horton; Jennifer R Chao; James B Hurley
TAGS: age-related macular degeneration, liver diseases, posters
Journal of Vision. 2023; 23(15):67. https://doi.org/10.1167/jov.23.15.67

Retinal Cell Biology November 2023

Medium Depth Influences O 2 Availability and Metabolism in Human RPE Cultures

PDF

Daniel T. Hass; Qitao Zhang; Gillian A. Autterson; Richard A. Bryan; James B. Hurley; Jason M. L. Miller
TAGS: glucose, hypoxia, lactates, metabolism, metabolites, volume, cell culture techniques, induced pluripotent stem cells, lipids, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):4. https://doi.org/10.1167/iovs.64.14.4

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Mitochondrial respiration by the RPE-choroid does not require external fuels

Brian Robbings; Daniel Hass; Ian Sweet; James Bryant Hurley

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2981.

ARVO Annual Meeting Abstract June 2023

Aerobic glycolysis in the outer retina is not essential for supporting metabolic homeostasis in the RPE

John Yeong Se Han; Daniel Hass; Ivy S Samuels; Nicklaus Newman; Neal S Peachey; James Bryant Hurley; Nancy Philp

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3517.

ARVO Annual Meeting Abstract June 2023

Retina and RPE-choroid – what fuels do they prefer in vivo?

Daniel Hass; Elizabeth Giering; James Bryant Hurley

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3511.

Retina December 2022

Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers

PDF

Bruce A. Berkowitz; Robert H. Podolsky; Karen Lins Childers; Robin Roberts; Ryan Katz; Rida Waseem; Brian M. Robbings; Daniel T. Hass; James B. Hurley; Ian R. Sweet; Cole Goodman; Haohua Qian; Bruno Alvisio; Sam Heaps
TAGS: biological markers, mice, mitochondria, rod photoreceptors, transducin, optical coherence tomography, oxygen consumption, retina
Invest. Ophthalmol. Vis. Sci.. 2022; 63(13):22. https://doi.org/10.1167/iovs.63.13.22

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Metabolic ecosystems exist between retina and RPE in vivo

Daniel Hass; Elizabeth Giering; Celia Bisbach; James B Hurley

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):868.

ARVO Annual Meeting Abstract June 2022

Rod photoreceptor-specific deletion of MPC1 impairs visual function with age-dependent retinal degeneration

Rong Xu; Jiancheng Huang; Yekai Wang; Siyan Zhu; James B Hurley; Jianhai Du

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1788 – F0337.

ARVO Annual Meeting Abstract June 2022

Probing the Contribution of Retinal Pigment Epithelium to Eyecup Metabolism

Collin Chiu; Daniel Hass; James B Hurley

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2477 – F0184.

Retina April 2022

Monocarboxylate Transporter 1 (MCT1) Mediates Succinate Export in the Retina

PDF

Celia M. Bisbach; Daniel T. Hass; Eric D. Thomas; Timothy J. Cherry; James B. Hurley
TAGS: retina, succinates, monocarboxylic acid transporters
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):1. https://doi.org/10.1167/iovs.63.4.1

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2021

An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice

PDF

Kristine A. Tsantilas; Whitney M. Cleghorn; Celia M. Bisbach; Jeremy A. Whitson; Daniel T. Hass; Brian M. Robbings; Martin Sadilek; Jonathan D. Linton; Austin M. Rountree; Ana P. Valencia; Mariya T. Sweetwyne; Matthew D. Campbell; Huiliang Zhang; Connor S. R. Jankowski; Ian R. Sweet; David J. Marcinek; Peter S. Rabinovitch; James B. Hurley
TAGS: aging, choroid, glucose, metabolic disturbance, mice, retina, retinal pigment epithelium, electroretinography, body tissue
Invest. Ophthalmol. Vis. Sci.. 2021; 62(14):20. https://doi.org/10.1167/iovs.62.14.20

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

In vivo 13 C-succinate infusion reveals gluconeogenesis in the mouse retina and eyecup

Daniel Hass; Celia Bisbach; Elizabeth Giering; Thomas Mundinger; James Hurley

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2228.

ARVO Annual Meeting Abstract June 2021

Monocarboxylate Transporters Facilitate Succinate Export, but not Import, in Ocular Tissues

Celia Bisbach; Daniel Hass; James Hurley

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2215.

ARVO Annual Meeting Abstract June 2020

Non-photopic and photopic visual cycles enable different phases of cone photoreceptor-mediated visual behaviour

Rebecca Ward; Joanna J Kaylor; Susan E Brockerhoff; James Hurley; Gabriel H Travis; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4978.

ARVO Annual Meeting Abstract July 2019

Cone mitochondria shape cytosolic Ca 2+ transients and recovery of the photoresponse

Rachel Hutto; Fatima Abbas; Celia Bisbach; James Hurley; Frans Vinberg; Susan Brockerhoff

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):565.

ARVO Annual Meeting Abstract July 2019

Increasing mitochondrial Ca 2+ in cones stimulates α-ketoglutarate dehydrogenase

Celia Bisbach; Rachel Hutto; Susan Brockerhoff; James Hurley

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1680.

ARVO Annual Meeting Abstract July 2018

Sorsby Fundus Dystrophy patient-derived RPE form abnormal extracellular matrices and demonstrate large basal laminar drusen

Abbi L. Engel; Kaitlen Knight; Thomas Khuu; Emily Worral; Megan Manson; Jianhai Du; James Hurley; Jennifer R Chao

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4507.

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A tale of two substrates: Glucose and Lactate feed retina and RPE glycogen

Do RPE cells have a preferred ketogenic substrate?

Modeling AMD-Relevant Metabolism in RPE Cultures Using a Novel Device for Measuring Long-Term Oxygen Consumption Rates

Poster Session II: Can a drug for liver disease be used to treat Age-Related Macular Degeneration?

Medium Depth Influences O 2 Availability and Metabolism in Human RPE Cultures

Mitochondrial respiration by the RPE-choroid does not require external fuels

Aerobic glycolysis in the outer retina is not essential for supporting metabolic homeostasis in the RPE

Retina and RPE-choroid – what fuels do they prefer in vivo?

Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers

Metabolic ecosystems exist between retina and RPE in vivo

Rod photoreceptor-specific deletion of MPC1 impairs visual function with age-dependent retinal degeneration

Probing the Contribution of Retinal Pigment Epithelium to Eyecup Metabolism

Monocarboxylate Transporter 1 (MCT1) Mediates Succinate Export in the Retina

An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice

In vivo 13 C-succinate infusion reveals gluconeogenesis in the mouse retina and eyecup

Monocarboxylate Transporters Facilitate Succinate Export, but not Import, in Ocular Tissues

Non-photopic and photopic visual cycles enable different phases of cone photoreceptor-mediated visual behaviour

Cone mitochondria shape cytosolic Ca 2+ transients and recovery of the photoresponse

Increasing mitochondrial Ca 2+ in cones stimulates α-ketoglutarate dehydrogenase

Sorsby Fundus Dystrophy patient-derived RPE form abnormal extracellular matrices and demonstrate large basal laminar drusen

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