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ARVO Annual Meeting Abstract June 2021

Investigation of Ataluren (PTC124) as a potential therapeutic for LCA4 in a patient-derived iPS-retinal organoid model

Amy Leung; Almudena Sacristan-Reviriego; Pedro Perdigao; James W B Bainbridge; Michel Michaelides; Jacqueline van der Spuy

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1671. doi:

ARVO Annual Meeting Abstract June 2021

Quantification of color vision impairment in RPGR -associated Retinitis Pigmentosa

Yesa Yang; Caterina Ripamonti; Neruban Kumaran; Angelos Kalitzeos; Navjit Singh; James Tee; James W B Bainbridge; Michel Michaelides

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2805. doi:

Articles September 2020

Validation of a Vision-Guided Mobility Assessment for RPE65 -Associated Retinal Dystrophy

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Neruban Kumaran; Robin R. Ali; Nick A. Tyler; James W. B. Bainbridge; Michel Michaelides; Gary S. Rubin
TAGS: mobility, retinal dystrophies, rpe65 protein, vision, walking speed
Trans. Vis. Sci. Tech.. 2020; 9(10):5. doi: https://doi.org/10.1167/tvst.9.10.5

Includes: Supplemental Content

Review June 2020

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium

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Debra A. Thompson; Alessandro Iannaccone; Robin R. Ali; Vadim Y. Arshavsky; Isabelle Audo; James W. B. Bainbridge; Cagri G. Besirli; David G. Birch; Kari E. Branham; Artur V. Cideciyan; Steven P. Daiger; Deniz Dalkara; Jacque L. Duncan; Abigail T. Fahim; John G. Flannery; Roberto Gattegna; John R. Heckenlively; Elise Heon; K. Thiran Jayasundera; Naheed W. Khan; Henry Klassen; Bart P. Leroy; Robert S. Molday; David C. Musch; Mark E. Pennesi; Simon M. Petersen-Jones; Eric A. Pierce; Rajesh C. Rao; Thomas A. Reh; Jose A. Sahel; Dror Sharon; Paul A. Sieving; Enrica Strettoi; Paul Yang; David N. Zacks; The Monaciano Consortium
TAGS: outcome measures, retinal diseases, surrogate endpoints, genetics, vision, natural history, ethics, gene therapy
Trans. Vis. Sci. Tech.. 2020; 9(7):2. doi: https://doi.org/10.1167/tvst.9.7.2

Genetics April 2020

Retinal Structure in RPE65 -Associated Retinal Dystrophy

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Neruban Kumaran; Michalis Georgiou; James W. B. Bainbridge; Mette Bertelsen; Michael Larsen; Fiona Blanco-Kelly; Carmen Ayuso; Hoai Viet Tran; Francis L. Munier; Angelos Kalitzeos; Michel Michaelides
TAGS: retina, retinal dystrophies, rpe65 protein, spectral domain-optical coherence tomography, eye, fundus autofluorescence imaging
Invest. Ophthalmol. Vis. Sci.. 2020; 61(4):47. doi: https://doi.org/10.1167/iovs.61.4.47

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Development and efficacy assessment of AAV2/8-hG1.7p.coCNGA3, a CNGA3 gene therapy vector

Tassos Georgiadis; Takaaki Matsuki; Justin Hoke; Matteo Rizzi; Anai Gonzalez-Cordero; Robert Sampson; James WB Bainbridge; Alexander Smith; Robin R Ali

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3426. doi:

ARVO Annual Meeting Abstract July 2019

Early phase clinical trial of human embryonic stem cell-derived retinal pigmented epithelium transplantation in Stargardt disease: 5-year results

Manjit Singh Singh Mehat; James WB Bainbridge

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3940. doi:

ARVO Annual Meeting Abstract July 2019

Vitreous and plasma cytokine levels in subjects with advanced proliferative diabetic retinopathy in the Ranibizumab in Diabetic Vitrectomy (RaDiVit) Study

Oliver Comyn; Clemens Lange; James WB Bainbridge

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5362. doi:

ARVO Annual Meeting Abstract July 2019

Pharmacokinetics of the Anti-angiogenic Glycoprotein Opticin in Preclinical Studies

Eva Maria del Amo Páez; John R. Griffiths; Izabela P Klaska; Anne White; Leon Aarons; James WB Bainbridge; Richard J Unwin; Paul N Bishop

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2716. doi:

Retina May 2019

The Relationship Between Retinal Vessel Oxygenation and Spatial Distribution of Retinal Nonperfusion in Retinal Vascular Diseases

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Luke Nicholson; Clara Vazquez-Alfageme; Philip G. Hykin; James W. Bainbridge; Sobha Sivaprasad
TAGS: alveolar ventilation function, cell respiration, oximetry, retinal vascular disorders, retinal vessels
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2083-2087. doi: https://doi.org/10.1167/iovs.18-24917

Genetics December 2018

Longitudinal Assessment of Retinal Structure in Achromatopsia Patients With Long-Term Follow-up

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Nashila Hirji; Michalis Georgiou; Angelos Kalitzeos; James W. Bainbridge; Neruban Kumaran; Jonathan Aboshiha; Joseph Carroll; Michel Michaelides
TAGS: achromatopsia, follow-up, retina, spectral domain-optical coherence tomography, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5735-5744. doi: https://doi.org/10.1167/iovs.18-25452

Includes: Supplemental Content

Retina August 2018

Mechanistic Evaluation of Panretinal Photocoagulation Versus Aflibercept in Proliferative Diabetic Retinopathy: CLARITY Substudy

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Luke Nicholson; Roxanne Crosby-Nwaobi; Joana C. Vasconcelos; A. Toby Prevost; Jayashree Ramu; Amy Riddell; James W. Bainbridge; Philip G. Hykin; Sobha Sivaprasad
TAGS: aflibercept, panretinal photocoagulation, proliferative diabetic retinopathy, eye, oximetry
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4277-4284. doi: https://doi.org/10.1167/iovs.17-23509

Includes: Supplemental Content

Clinical and Epidemiologic Research July 2018

A Cross-Sectional and Longitudinal Study of Retinal Sensitivity in RPE65 -Associated Leber Congenital Amaurosis

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Neruban Kumaran; Gary S. Rubin; Angelos Kalitzeos; Kaoru Fujinami; James W. B. Bainbridge; Richard G. Weleber; Michel Michaelides
TAGS: contrast sensitivity, eye, genotype, leber's amaurosis, longitudinal studies, perimetry, vision, visual acuity, visual fields, reliability
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3330-3339. doi: https://doi.org/10.1167/iovs.18-23873

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2018

Severe Loss of Tritan Color Discrimination in RPE65 Associated Leber Congenital Amaurosis

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Neruban Kumaran; Caterina Ripamonti; Angelos Kalitzeos; Gary S. Rubin; James W. B. Bainbridge; Michel Michaelides
TAGS: color, color vision, leber's amaurosis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):85-93. doi: https://doi.org/10.1167/iovs.17-22905

Retina June 2017

Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs

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Freya M. Mowat; Kristen J. Gervais; Laurence M. Occelli; Matthew J. Annear; Janice Querubin; James W. Bainbridge; Alexander J. Smith; Robin R. Ali; Simon M. Petersen-Jones
TAGS: dog, domestic, retina, retinal cone, tissue degeneration, photoreceptors, rod photoreceptors, opsin, eye
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3268-3277. doi: https://doi.org/10.1167/iovs.17-21930

ARVO Annual Meeting Abstract June 2017

Human opticin reduces pathological preretinal neovascularization in the mouse model of oxygen-induced retinopathy.

Izabela Paulina Klaska; Catherine Orr; Anne White; Pilar Villacampa Alcubierre; Laura Abelleira Hervás; Justin Hoke; Catey V Bunce; Richard Unwin; Garth Cooper; Paul N Bishop; James W B Bainbridge

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4063. doi:

ARVO Annual Meeting Abstract June 2017

Severe Loss of Tritan Colour Discrimination in RPE65 Associated Leber Congenital Amaurosis

Neruban Kumaran; Caterina Ripamonti; Angelos Kalitzeos; James W B Bainbridge; Michel Michaelides

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4297. doi:

ARVO Annual Meeting Abstract September 2016

Myeloid-derived VEGF and HIF are dispensable for ocular neovascularisation

Sidath Liyanage; Alessandro Fantin; Pilar Villacampa; Clemens Lange; Laura Denti; Enrico Cristante; Alexander J Smith; Robin R Ali; Ulrich F O Luhmann; James W B Bainbridge; Christiana Ruhrberg

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Impact of vitrectomy on outcomes of treatment for diabetic macular oedema with intravitreal ranibizumab

Sheelah Antao; Mark Fajgenbaum; Namritha Valerie Patrao; Roger Wong; Lyndon da Cruz; James W B Bainbridge; Ranjan Rajendram

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2091. doi:

ARVO Annual Meeting Abstract September 2016

Treatment outcomes of intravitreal ranibizumab for diabetic macular oedema in vitrectomised eyes

Vicky Hsin-Ju Lu; Sheelah Antao; Mark Fajgenbaum; Roger Wong; James W B Bainbridge; Lyndon da Cruz; Robin D Hamilton; Ranjan Rajendram

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2095. doi:

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Investigation of Ataluren (PTC124) as a potential therapeutic for LCA4 in a patient-derived iPS-retinal organoid model

Quantification of color vision impairment in RPGR -associated Retinitis Pigmentosa

Validation of a Vision-Guided Mobility Assessment for RPE65 -Associated Retinal Dystrophy

Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium

Retinal Structure in RPE65 -Associated Retinal Dystrophy

Development and efficacy assessment of AAV2/8-hG1.7p.coCNGA3, a CNGA3 gene therapy vector

Early phase clinical trial of human embryonic stem cell-derived retinal pigmented epithelium transplantation in Stargardt disease: 5-year results

Vitreous and plasma cytokine levels in subjects with advanced proliferative diabetic retinopathy in the Ranibizumab in Diabetic Vitrectomy (RaDiVit) Study

Pharmacokinetics of the Anti-angiogenic Glycoprotein Opticin in Preclinical Studies

The Relationship Between Retinal Vessel Oxygenation and Spatial Distribution of Retinal Nonperfusion in Retinal Vascular Diseases

Longitudinal Assessment of Retinal Structure in Achromatopsia Patients With Long-Term Follow-up

Mechanistic Evaluation of Panretinal Photocoagulation Versus Aflibercept in Proliferative Diabetic Retinopathy: CLARITY Substudy

A Cross-Sectional and Longitudinal Study of Retinal Sensitivity in RPE65 -Associated Leber Congenital Amaurosis

Severe Loss of Tritan Color Discrimination in RPE65 Associated Leber Congenital Amaurosis

Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs

Human opticin reduces pathological preretinal neovascularization in the mouse model of oxygen-induced retinopathy.

Severe Loss of Tritan Colour Discrimination in RPE65 Associated Leber Congenital Amaurosis

Myeloid-derived VEGF and HIF are dispensable for ocular neovascularisation

Impact of vitrectomy on outcomes of treatment for diabetic macular oedema with intravitreal ranibizumab

Treatment outcomes of intravitreal ranibizumab for diabetic macular oedema in vitrectomised eyes

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