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Genetics July 2020

Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4

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Milica A. Margeta; Sophia M. Letcher; Robert P. Igo, Jr.; Jessica N. Cooke Bailey; Louis R. Pasquale; Jonathan L. Haines; Oleg Butovsky; Janey L. Wiggs; for the NEIGHBORHOOD consortium
TAGS: apolipoprotein e, glaucoma, open-angle glaucoma, trem2 gene, alleles
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):3. doi: https://doi.org/10.1167/iovs.61.8.3

ARVO Annual Meeting Abstract June 2020

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma, and shows a genetic link to Alzheimer’s disease.

Janey Wiggs; Puya Gharahkhani; Eric Jorgenson; Pirro G Hysi; Anthony Khawaja; Sarah Pendergrass; Xikun Han; David Mackey; Christopher Hammond; Michael A Hauser; Louis R Pasquale; Caroline Klaver; Michiaki Kubo; Tin Aung; Jamie E Craig; Stuart MacGregor

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1890. doi:

ARVO Annual Meeting Abstract June 2020

Evidence for a causal link between pseudoexfoliation syndrome and myocardial infarction using Mendelian randomization

Marianne T Kennedy Neary; Oliver J Kennedy; George Davey Smith; Pirro G Hysi; Louis R Pasquale; Janey Wiggs; Anthony P Khawaja

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2738. doi:

ARVO Annual Meeting Abstract June 2020

Calcium Channel Blocker Use and Risk of Glaucoma in a Large United Kingdom Population

Alan Kastner; Giovanni Montesano; C Gustavo De Moraes; Jae H. Kang; Janey Wiggs; Louis Pasquale; Pirro G Hysi; Sharon Chua; Praveen J Patel; Paul J Foster; Sir Peng T. Khaw; Anthony Khawaja

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2739. doi:

ARVO Annual Meeting Abstract June 2020

Association of coffee, tea, and caffeine consumption with intraocular pressure and interaction with genetic risk: findings from the UK Biobank

Jihye Kim; Hugues Aschard; Jae H. Kang; Marleen AH Lentjes; Janey Wiggs; Anthony Khawaja; Louis R Pasquale

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):52. doi:

ARVO Annual Meeting Abstract June 2020

Genome-Wide Gene-Environment Interaction Analysis of Body Mass Index and Vertical Cup-Disc Ratio in a Latino Population

Yingjie Li; Janey Wiggs; Xiaoyi Raymond Gao

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):68. doi:

ARVO Annual Meeting Abstract June 2020

Integrative Prioritization of IOP-associated Genes Using High Throughput Genomic Data

Yutao Liu; Emily Parker; Hannah Youngblood; Jingwen Cai; Kristin Marie Perkumas; Janey Wiggs; Louis R Pasquale; Michael A Hauser; Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):990. doi:

ARVO Annual Meeting Abstract June 2020

Analysis of ATXN2 trinucleotide repeats in primary open angle glaucoma patients

Shi Song Rong; Robert Igo; Jessica Cooke Bailey; Jonathan L Haines; Louis Pasquale; Janey Wiggs

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1247. doi:

ARVO Annual Meeting Abstract June 2020

Glaucoma Examination in the Amish of Holmes County, Ohio

Jonathan Mikal Skarie; Tyler G Kinzy; Jane Sewell; Yeunjoo E Song; Renee Laux; Denise Fuzzell; Sarada Fuzzell; Sherri Hochstetler; Louis R Pasquale; Janey Wiggs; Jonathan L Haines; Jessica Cooke Bailey

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1252. doi:

ARVO Annual Meeting Abstract June 2020

Genetic Correlation between Corneal Hysteresis and Vertical Cup-disc Ratio in South Indian Consanguineous Pedigrees

Baojian Fan; P Ferdina Marie Sharmila; N Soumittra; Sripriya Sarangapani; Xiaoyi Gao; David S Friedman; L Vijaya; Jonathan L Haines; Ronnie J George; Janey Wiggs

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1253. doi:

ARVO Annual Meeting Abstract June 2020

A prospective study of the natural history of MYOC -associated juvenile open-angle glaucoma

Edward Ryan Collantes; Baojian Fan; Manuel Jr. Delfin; Janey Wiggs

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1254. doi:

ARVO Annual Meeting Abstract June 2020

Glucocorticoid receptor binding sites are enriched for genetic associations with intraocular pressure variation

John Rouhana; Andrew R Hamel; Allison van den Hout; Janey Wiggs; Lucia Sobrin; Ayellet Segre

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1256. doi:

ARVO Annual Meeting Abstract June 2020

The Prevalence of Primary Open-Angle Glaucoma-Like Features in a Rhesus Macaque Colony from Southern China

Louis R Pasquale; Li Gong; Janey Wiggs; Lingzhen Pan; Zhenyan Yang; Mingling Wu; Dongfeng Chen; Wen Zeng

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1436. doi:

ARVO Annual Meeting Abstract July 2019

Glaucoma Examination in the Amish of Holmes County, Ohio

Jonathan Mikal Skarie; Tyler Kinzy; Jane Sewell; Yeunjoo E. Song; Renee Laux; Denise Fuzzell; Sarada Fuzzell; Erika Trapl; Farren BS Briggs; Louis R Pasquale; Janey L Wiggs; Jonathan L Haines; Jessica Cooke Bailey

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1602. doi:

ARVO Annual Meeting Abstract July 2019

Whole exome sequencing identifies GPC6 as a candidate early-onset glaucoma gene

Shiming Li; Baojian Fan; Anna Larson; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1609. doi:

ARVO Annual Meeting Abstract July 2019

APEX1 as a new candidate gene for glaucoma

Paulo Vinicius Svidnicki; Monica B Melo; Jose Paulo C Vasconcellos; Shi Song Rong; Anna Larson; John Simmons Borchert; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1614. doi:

ARVO Annual Meeting Abstract July 2019

Family-based Genome-wide Association Study in South Indian Consanguineous Pedigrees Identifies an Association between LPHN3 and Vertical Cup-disc Ratio

Baojian Fan; P Ferdina Marie Sharmila; N Soumittra; S Sripriya; X. Raymond Gao; David S Friedman; L Vijaya; Jonathan L Haines; Ronnie J George; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1618. doi:

ARVO Annual Meeting Abstract July 2019

A glaucoma polygenic risk score strongly associated with disease prediction and treatment intensity.

Jamie E Craig; Ayub Qassim; Xikun Han; Mark Hassall; Robert James Casson; Stuart L Graham; David A Mackey; Colin Willoughby; Kathryn P Burdon; John Landers; Emmanuelle Souzeau; Janey L Wiggs; Alex W Hewitt; Stuart MacGregor

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1619. doi:

ARVO Annual Meeting Abstract July 2019

Association of APOE with POAG suggests a protective effect for APOE4

Sophia M Letcher; Milica Margeta; Robert P. Igo; Jessica Cooke Bailey; Jonathan L Haines; Oleg Butovsky; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1627. doi:

ARVO Annual Meeting Abstract July 2019

Integrative analysis of GWAS and eQTLs proposes new genetic associations and causal genes for Primary Open Angle Glaucoma

Ayellet Segre; Andrew Hamel; John Rouhana; Anthony P Khawaja; Mark James Simcoe; Christopher J Hammond; Pirro G Hysi; GTEx consortium; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4252. doi:

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Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma, and shows a genetic link to Alzheimer’s disease.

Evidence for a causal link between pseudoexfoliation syndrome and myocardial infarction using Mendelian randomization

Calcium Channel Blocker Use and Risk of Glaucoma in a Large United Kingdom Population

Association of coffee, tea, and caffeine consumption with intraocular pressure and interaction with genetic risk: findings from the UK Biobank

Genome-Wide Gene-Environment Interaction Analysis of Body Mass Index and Vertical Cup-Disc Ratio in a Latino Population

Integrative Prioritization of IOP-associated Genes Using High Throughput Genomic Data

Analysis of ATXN2 trinucleotide repeats in primary open angle glaucoma patients

Glaucoma Examination in the Amish of Holmes County, Ohio

Genetic Correlation between Corneal Hysteresis and Vertical Cup-disc Ratio in South Indian Consanguineous Pedigrees

A prospective study of the natural history of MYOC -associated juvenile open-angle glaucoma

Glucocorticoid receptor binding sites are enriched for genetic associations with intraocular pressure variation

The Prevalence of Primary Open-Angle Glaucoma-Like Features in a Rhesus Macaque Colony from Southern China

Glaucoma Examination in the Amish of Holmes County, Ohio

Whole exome sequencing identifies GPC6 as a candidate early-onset glaucoma gene

APEX1 as a new candidate gene for glaucoma

Family-based Genome-wide Association Study in South Indian Consanguineous Pedigrees Identifies an Association between LPHN3 and Vertical Cup-disc Ratio

A glaucoma polygenic risk score strongly associated with disease prediction and treatment intensity.

Association of APOE with POAG suggests a protective effect for APOE4

Integrative analysis of GWAS and eQTLs proposes new genetic associations and causal genes for Primary Open Angle Glaucoma

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