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Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. doi: https://doi.org/10.1167/iovs.63.2.12

ARVO Annual Meeting Abstract June 2021

Knockout of the mechanotransducer, Integrin-α7, in trabecular meshwork cells affects signaling through Akt and mTOR

Julia Staverosky; VijayKrishna Raghunathan; Janice A Vranka

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):490. doi:

ARVO Annual Meeting Abstract June 2021

Decreased levels of Notch signaling in human trabecular meshwork cells cultured on rigid substrate

Kamesh Dhamodaran; Julia Staverosky; Janice A Vranka; VijayKrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):481. doi:

ARVO Annual Meeting Abstract June 2021

Substrate stiffness modulates gene expression and phagocytosis in segmental human trabecular meshwork cells

Andrews Nartey; Kamesh Dhamodaran; Julia Staverosky; Janice A Vranka; VijayKrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1632. doi:

ARVO Annual Meeting Abstract June 2020

Crosslinked ECM modulates β-Catenin and YAP/TAZ pathways in human trabecular meshwork cells

Felix Yemanyi; Janice A Vranka; Vijaykrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1434. doi:

ARVO Annual Meeting Abstract June 2020

Expression of Notch signal in primary human trabecular meshwork segmental flow cells

Kamesh Dhamodaran; Janice A Vranka; Vijaykrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3443. doi:

ARVO Annual Meeting Abstract June 2020

Molecular Differences in Segmental Flow Cells from Human Trabecular Meshwork

Janice A Vranka; Julia Staverosky; Kamesh Dhamodaran; Vijaykrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3469. doi:

ARVO Annual Meeting Abstract July 2019

A new method for en Face confocal imaging of Schlemm’s canal inner wall and juxtacanalicular trabecular meshwork

Mini Aga; John Bradley; Janice A Vranka; Ted S Acott

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5123. doi:

ARVO Annual Meeting Abstract July 2019

New Tools for Understanding Segmental Flow: Generation and Characterization of Trabecular Meshwork High Flow and Low Flow Cell Lines

Julia Staverosky; Raghunathan VijayKrishna; Janice A Vranka

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5130. doi:

ARVO Annual Meeting Abstract July 2019

Cell derived matrices modulate TGFβ2 signaling in human trabecular meshwork cells

Felix Yemanyi; Janice A Vranka; VijayKrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5146. doi:

ARVO Annual Meeting Abstract July 2018

Substrate stiffness triggers an extracellular matrix response in human trabecular meshwork cells and tissues

Janice A Vranka; Julia Staverosky; Ying Ying Sun; Yong-Feng Yang; John Bradley; Kate E Keller; Ted S Acott

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4722. doi:

ARVO Annual Meeting Abstract July 2018

Homeostatic Role for GPR158 in Modulating Intraocular Pressure (IOP)

Tatsuo Itakura; Andrew Webster; Jose M Gonzalez; James C H Tan; Maria Sibug-Saber; Cheryl Mae Craft; Janice A Vranka; Ted S Acott; W Daniel Stamer; Kirill A Martemyanov; M Elizabeth Fini

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4724. doi:

ARVO Annual Meeting Abstract July 2018

Integrin α7-β1 heterodimer as a mechanosensor in the trabecular meshwork

Julia A Staverosky; Ted S Acott; Janice A Vranka

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4725. doi:

Biochemistry and Molecular Biology January 2018

Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures

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Janice A. Vranka; Julia A. Staverosky; Ashok P. Reddy; Phillip A. Wilmarth; Larry L. David; Ted S. Acott; Paul Russell; Vijay Krishna Raghunathan
TAGS: biomechanics, body tissue, fluid flow, heart failure, muscle rigidity, pressure-physical agent, proteins, proteomics, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):246-259. doi: https://doi.org/10.1167/iovs.17-22759

Includes: Supplemental Content

Glaucoma September 2017

Estimating Human Trabecular Meshwork Stiffness by Numerical Modeling and Advanced OCT Imaging

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Ke Wang; Murray A. Johnstone; Chen Xin; Shaozhen Song; Steven Padilla; Janice A. Vranka; Ted S. Acott; Kai Zhou; Stephen A. Schwaner; Ruikang K. Wang; Todd Sulchek; C. Ross Ethier
TAGS: body tissue, diagnostic imaging, eye, glaucoma, trabecular meshwork, orthopedic footwear, wedges, sclera
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4809-4817. doi: https://doi.org/10.1167/iovs.17-22175

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract September 2016

Biomechanical Rigidity and Proteomics Analyses of Segmental Outflow Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures

Janice A Vranka; Vijaykrishna Raghunathan; Paul Russell; Kate E Keller; Ashok Reddy; Phillip Wilmarth; John Klimek; Larry L. David; Ted S Acott

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4702. doi:

Glaucoma August 2013

The Effects of Tenascin C Knockdown on Trabecular Meshwork Outflow Resistance

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Kate E. Keller; Janice A. Vranka; Ramez I. Haddadin; Min-Hyung Kang; Dong-Jin Oh; Douglas J. Rhee; Yong-feng Yang; Ying Ying Sun; Mary J. Kelley; Ted S. Acott
TAGS: tenascin, trabecular meshwork, proteins, rna, messenger, eye
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5613-5623. doi: https://doi.org/10.1167/iovs.13-11620

Includes: Supplemental Content

ARVO Annual Meeting Abstract March 2012

Cell-Matrix and Cell-Cell Interactions and the Aqueous Humor Outflow In Trabecular Meshwork (TM) Cells

Xinbo li; Diala W. Abu-Hassan; Janice A. Vranka; Ted S. Acott; Mary J. Kelley

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3230. doi:

ARVO Annual Meeting Abstract March 2012

Structural Consequences of Versican Silencing on the Outflow Resistance Pathway and in Human Trabecular Meshwork Cells

Janice A. Vranka; Kate E. Keller; Ted S. Acott

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3263. doi:

Glaucoma July 2011

Segmental Versican Expression in the Trabecular Meshwork and Involvement in Outflow Facility

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Kate E. Keller; John M. Bradley; Janice A. Vranka; Ted S. Acott
TAGS: biosynthesis, eye, fluid flow, immunohistochemistry, infections, lentivirus, perfusion, proteins, quantitative real-time polymerase chain reaction, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2011; 52(8):5049-5057. doi: https://doi.org/10.1167/iovs.10-6948

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Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Knockout of the mechanotransducer, Integrin-α7, in trabecular meshwork cells affects signaling through Akt and mTOR

Decreased levels of Notch signaling in human trabecular meshwork cells cultured on rigid substrate

Substrate stiffness modulates gene expression and phagocytosis in segmental human trabecular meshwork cells

Crosslinked ECM modulates β-Catenin and YAP/TAZ pathways in human trabecular meshwork cells

Expression of Notch signal in primary human trabecular meshwork segmental flow cells

Molecular Differences in Segmental Flow Cells from Human Trabecular Meshwork

A new method for en Face confocal imaging of Schlemm’s canal inner wall and juxtacanalicular trabecular meshwork

New Tools for Understanding Segmental Flow: Generation and Characterization of Trabecular Meshwork High Flow and Low Flow Cell Lines

Cell derived matrices modulate TGFβ2 signaling in human trabecular meshwork cells

Substrate stiffness triggers an extracellular matrix response in human trabecular meshwork cells and tissues

Homeostatic Role for GPR158 in Modulating Intraocular Pressure (IOP)

Integrin α7-β1 heterodimer as a mechanosensor in the trabecular meshwork

Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures

Estimating Human Trabecular Meshwork Stiffness by Numerical Modeling and Advanced OCT Imaging

Biomechanical Rigidity and Proteomics Analyses of Segmental Outflow Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures

The Effects of Tenascin C Knockdown on Trabecular Meshwork Outflow Resistance

Cell-Matrix and Cell-Cell Interactions and the Aqueous Humor Outflow In Trabecular Meshwork (TM) Cells

Structural Consequences of Versican Silencing on the Outflow Resistance Pathway and in Human Trabecular Meshwork Cells

Segmental Versican Expression in the Trabecular Meshwork and Involvement in Outflow Facility

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