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Retina August 2020

A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration

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Siddharth Narendran; Felipe Pereira; Praveen Yerramothu; Ivana Apicella; Shao-bin Wang; Akhil Varshney; Kirstie L. Baker; Kenneth M. Marion; Meenakshi Ambati; Vidya L. Ambati; Kameshwari Ambati; Srinivas R. Sadda; Bradley D. Gelfand; Jayakrishna Ambati
TAGS: atrophy, choroidal neovascularization, metabolites, rna, tissue degeneration, zidovudine, epithelium, lasers
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):4. doi: https://doi.org/10.1167/iovs.61.10.4

ARVO Annual Meeting Abstract June 2020

PAD4 in the Accelerated Mouse Model of AMD and Human AMD

Sarah Ilona Palko; Nicholas Saba; Humza Zaidi; Benjamin Nicholas; Yosuke Nagasaka; Jayakrishna Ambati; Bradley Gelfand; Paola Bargagna-Mohan; Royce Mohan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3689. doi:

ARVO Annual Meeting Abstract June 2020

Sex determines the off-target effects of Bevacizumab (Avastin) in mouse models

Dionne Argyle; Felipe Pereira; Ivana Apicella; Nagaraj Kerur; Jayakrishna Ambati; Bradley Gelfand

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4346. doi:

ARVO Annual Meeting Abstract June 2020

Voluntary exercise attenuates choroidal neovascularization in mice

Ryan Daniel Makin; Dionne Argyle; Yosuke Nagasaka; Shuichiro Hirahara; Nagaraj Kerur; Jayakrishna Ambati; Bradley Gelfand

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5392. doi:

ARVO Annual Meeting Abstract June 2020

Alu RNA exacerbates experimental choroidal neovascularization via an inflammasome-dependent pathway

Felipe Pereira; Ivana Apicella; Ryan Makin; Younghee Kim; Charles Wright; Tetsuhiro Yasuma; Reo Yasuma; Shuichiro Hirahara; Shinichi Fukuda; Siddharth Narendran; Romulo Albuquerque; Benjamin Fowler; Nagaraj Kerur; Jayakrishna Ambati; Bradley Gelfand

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5394. doi:

Retinal Cell Biology May 2020

Voluntary Exercise Suppresses Choroidal Neovascularization in Mice

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Ryan D. Makin; Dionne Argyle; Shuichiro Hirahara; Yosuke Nagasaka; Mei Zhang; Zhen Yan; Nagaraj Kerur; Jayakrishna Ambati; Bradley D. Gelfand
TAGS: choroidal neovascularization, exercise, mice
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):52. doi: https://doi.org/10.1167/iovs.61.5.52

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Multifarious evidence for NLRP3 inflammasome expression and activation in retinal pigment epithelium

Ivana Apicella; Shinichi Fukuda; Shuichiro Hirahara; Shaobin Wang; Siddharth Narendran; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):765. doi:

ARVO Annual Meeting Abstract July 2019

Title: Soluble oligomeric Amyloid-β induced retinal pigment epithelial degeneration requires non-canonical inflammsome activation

Siddharth Narendran; DAIPAYAN BANERJEE; Ivana Apicella; Shaobin Wang; Akhil Varshney; Shinichi Fukuda; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):990. doi:

ARVO Annual Meeting Abstract July 2019

TELOMERASE IN CHOROIDAL NEOVASCULARIZATION

Nagaraj Kerur; Jayakrishna Ambati; Shaobin Wang; DAIPAYAN BANERJEE; Shuichiro Hirahara; Eric Odermatt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4319. doi:

Retinal Cell Biology December 2018

RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes

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Ryan D. Makin; Ivana Apicella; Yosuke Nagasaka; Hiroki Kaneko; Stephen D. Turner; Nagaraj Kerur; Jayakrishna Ambati; Bradley D. Gelfand
TAGS: endothelial cells, endothelium, phenotype
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5795-5802. doi: https://doi.org/10.1167/iovs.18-25215

ARVO Annual Meeting Abstract July 2018

Non-integrated, reverse transcribed Alu complementary DNAs in Geographic Atrophy cause RPE toxicity

Shinichi Fukuda; Benjamin J Fowler; Tetsuhiro Yasuma; Akhil Varshney; Kameshwari Ambati; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2456. doi:

ARVO Annual Meeting Abstract July 2018

Nucleoside reverse transcriptase inhibitors are broad-spectrum RPE protectants

Shuichiro Hirahara; Shinichi Fukuda; Younghee Kim; Reo Yasuma; Kameshwari Ambati; Junichi Fukuhara; Dongxu Fu; DAIPAYAN BANERJEE; Benjamin J Fowler; Tetsuhiro Yasuma; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2459. doi:

ARVO Annual Meeting Abstract July 2018

Nucleoside reverse transcriptase inhibitors (NRTI) prevent inflammasome activation in retinal pigmented epithelium cells.

DAIPAYAN BANERJEE; Junichi Fukuhara; Dongxu Fu; Shinichi Fukuda; Shuichiro Hirahara; Younghee Kim; Benjamin J Fowler; Tetsuhiro Yasuma; Reo Yasuma; Kameshwari Ambati; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2475. doi:

ARVO Annual Meeting Abstract July 2018

Hemodynamic shear stress in the inner choroid primes endothelium for complement damage

Bradley Gelfand; Jayakrishna Ambati; Senyou An; Rou Chen; Whitney H Yu; Jun Yao

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3473. doi:

Review January 2018

Pharmacology of Corticosteroids for Diabetic Macular Edema

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Scott M. Whitcup; John A. Cidlowski; Karl G. Csaky; Jayakrishna Ambati
TAGS: adrenal corticosteroids, glucocorticoids, mineralocorticoids, diabetic macular edema
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):1-12. doi: https://doi.org/10.1167/iovs.17-22259

ARVO Annual Meeting Abstract June 2017

Shear stress governs choroidal endothelial cell proliferation and homeostasis

Bradley D Gelfand; Senyou An; Whitney Yu; Rou Chen; Jun Yao; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1102. doi:

ARVO Annual Meeting Abstract June 2017

Endogenous complementary DNA in age-related macular degeneration

Shinichi Fukuda; Tetsuhiro Yasuma; Benjamin J Fowler; Bradley D Gelfand; Nagaraj Kerur; Reo Yasuma; Brian Werner; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5262. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Junichi Fukuhara; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Benjamin Fowler; Shinichi Fukuda; Takako Fukuhara; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5005. doi:

ARVO Annual Meeting Abstract September 2016

Hypoxia signaling pathways in retinal pigment epithelium require Alu RNA

Charles B Wright; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5813. doi:

ARVO Annual Meeting Abstract September 2016

Dicer1 deficiency in atrophic and neovascular age-related macular degeneration

Bradley D Gelfand; Charles B Wright; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

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A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration

PAD4 in the Accelerated Mouse Model of AMD and Human AMD

Sex determines the off-target effects of Bevacizumab (Avastin) in mouse models

Voluntary exercise attenuates choroidal neovascularization in mice

Alu RNA exacerbates experimental choroidal neovascularization via an inflammasome-dependent pathway

Voluntary Exercise Suppresses Choroidal Neovascularization in Mice

Multifarious evidence for NLRP3 inflammasome expression and activation in retinal pigment epithelium

Title: Soluble oligomeric Amyloid-β induced retinal pigment epithelial degeneration requires non-canonical inflammsome activation

TELOMERASE IN CHOROIDAL NEOVASCULARIZATION

RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes

Non-integrated, reverse transcribed Alu complementary DNAs in Geographic Atrophy cause RPE toxicity

Nucleoside reverse transcriptase inhibitors are broad-spectrum RPE protectants

Nucleoside reverse transcriptase inhibitors (NRTI) prevent inflammasome activation in retinal pigmented epithelium cells.

Hemodynamic shear stress in the inner choroid primes endothelium for complement damage

Pharmacology of Corticosteroids for Diabetic Macular Edema

Shear stress governs choroidal endothelial cell proliferation and homeostasis

Endogenous complementary DNA in age-related macular degeneration

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Hypoxia signaling pathways in retinal pigment epithelium require Alu RNA

Dicer1 deficiency in atrophic and neovascular age-related macular degeneration

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