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ARVO Annual Meeting Abstract July 2019

Depletion of ocular surface CD11c+ dendritic cells prevents the generation of contrasuppressor cells and restores immune privilege of corneal allografts

Sudha neelam; Jessamee Mellon; Jerry Y Niederkorn

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1347.

Immunology and Microbiology September 2018

Induction of Contrasuppressor Cells and Loss of Immune Privilege Produced by Corneal Nerve Ablation

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Sudha Neelam; Jessamee Mellon; Amber Wilkerson; Jerry Y. Niederkorn
TAGS: cornea, eye, immune privilege, mice, nerve ablation, injections, adoptive transfer, patient isolation, spleen, immunization
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4738-4747. https://doi.org/10.1167/iovs.18-24894

ARVO Annual Meeting Abstract July 2018

Severing corneal nerves induces the release of substance P which converts ocular surface CD11c+ cells to contrasuppressor cells that abolish ocular immune privilege.

Sudha Neelam; Amber Wilkerson; Jessamee Mellon; Jerry Y Niederkorn

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2576.

ARVO Annual Meeting Abstract June 2017

Corneal nerve ablation in one eye induces Langerhans cell infiltration into both eyes and abolishes immune privilege in both eyes

Jerry Y Niederkorn; Juan Mo; Sudha neelam; jessamee Mellon; amber Wilkerson

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5731.

Immunology and Microbiology January 2017

Effect of Corneal Nerve Ablation on Immune Tolerance Induced by Corneal Allografts, Oral Immunization, or Anterior Chamber Injection of Antigens

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Juan Mo; Sudha Neelam; Jessamee Mellon; Joseph R. Brown; Jerry Y. Niederkorn
TAGS: allografting, antigens, cornea, immunization, injections, nerve ablation, burr hole procedure, immune tolerance, keratoplasty, eye
Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):137-148. https://doi.org/10.1167/iovs.16-20601

ARVO Annual Meeting Abstract September 2016

Effect of severing corneal nerves on the induction of immune tolerance during corneal transplantation

Juan Mo; Jessamee Mellon; Jerry Y Niederkorn

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1444.

ARVO Annual Meeting Abstract June 2015

Second corneal allografts ablate T regulatory cells that are induced by first corneal allografts and produce a permanent loss of immune privilege in both eyes

Jerry Y Niederkorn; Kathryn Joy Paunicka; jessamee Mellon; joseph R brown

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4874.

ARVO Annual Meeting Abstract June 2013

Penetrating keratoplasty to one eye abolishes immune privilege and promotes corneal allograft rejection in the opposite eye, even to grafts from unrelated donors

Jerry Niederkorn; Kathryn Paunicka; Jessamee Mellon

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2160.

Anatomy and Pathology/Oncology January 2013

Epigenetic Regulation of CXCR4 Expression by the Ocular Microenvironment

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Haochuan Li; Jerry Y. Niederkorn; Leila Sadegh; Jessamee Mellon; Peter W. Chen
TAGS: cxcr4 receptors, tumor cells, epigenetics, methylation, histone deacetylase, regulation
Invest. Ophthalmol. Vis. Sci.. 2013; 54(1):234-243. https://doi.org/10.1167/iovs.12-10643

ARVO Annual Meeting Abstract March 2012

Epigenetic Regulation of Corneal Endothelial Cell Proliferation

Peter W. Chen; Lauren Tien; Jessamee Mellon

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5121.

Immunology and Microbiology May 2011

NKT Cell Exacerbation of Liver Metastases Arising from Melanomas Transplanted into Either the Eyes or Spleens of Mice

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Wanhua Yang; Haochuan Li; Elizabeth Mayhew; Jessamee Mellon; Peter W. Chen; Jerry Y. Niederkorn
TAGS: liver, liver metastases, melanoma, mice, natural killer cells, natural killer t-cells, interleukin-10, eye, spleen, neoplasms
Invest. Ophthalmol. Vis. Sci.. 2011; 52(6):3094-3102. https://doi.org/10.1167/iovs.10-7067

Anatomy and Pathology/Oncology December 2004

Expression and Possible Function of IL-2 and IL-15 Receptors on Human Uveal Melanoma Cells

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Yu-Guang He; Elizabeth Mayhew; Jessamee Mellon; Jerry Y. Niederkorn
TAGS: aldesleukin, interleukin-15, intraocular melanoma, melanoma, apoptosis, disease susceptibility
Invest. Ophthalmol. Vis. Sci.. 2004; 45(12):4240-4246. https://doi.org/10.1167/iovs.04-0599

Immunology and Microbiology August 2004

Role of Tumor Necrosis Factor Receptor Expression in Anterior Chamber-Associated Immune Deviation (ACAID) and Corneal Allograft Survival

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Jerry Y. Niederkorn; Elizabeth Mayhew; Jessamee Mellon; Sushma Hegde
TAGS: allografting, cornea, receptors, tumor necrosis factor, type ii, tumor necrosis factor receptor
Invest. Ophthalmol. Vis. Sci.. 2004; 45(8):2674-2681. https://doi.org/10.1167/iovs.04-0144

Immunology and Microbiology April 2004

Fate of MHC-Matched Corneal Allografts in Th1-Deficient Hosts

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Sylvia L. Hargrave; Christina Hay; Jessamee Mellon; Elizabeth Mayhew; Jerry Y. Niederkorn
TAGS: allografting, cornea, rejection (psychology), keratoplasty, mice
Invest. Ophthalmol. Vis. Sci.. 2004; 45(4):1188-1193. https://doi.org/10.1167/iovs.03-0515

Cornea April 2002

Effect of Alloantibodies on Corneal Allograft Survival

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Sushma Hegde; Jessamee K. Mellon; Sylvia L. Hargrave; Jerry Y. Niederkorn
TAGS: allografting, complement system proteins, cornea, isoantibodies, donors, keratoplasty, antibodies, rejection (psychology)
Invest. Ophthalmol. Vis. Sci.. 2002; 43(4):1012-1018.

Physiology and Pharmacology August 1999

Inhibition of Intraocular Tumor Growth by Topical Application of the Angiostatic Steroid Anecortave Acetate

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Abbot F. Clark; Jessamee Mellon; Xiao–Yan Li; Ding Ma; Henry Leher; Rajendra Apte; Hassan Alizadeh; Sushma Hegde; Amanda McLenaghan; Elizabeth Mayhew; Thomas J. D’Orazio; Jerry Y. Niederkorn
TAGS: administration, topical, anecortave, eye neoplasms, steroids, tumor cells, neoplasms
Invest. Ophthalmol. Vis. Sci.. 1999; 40(9):2158-2162.

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Depletion of ocular surface CD11c+ dendritic cells prevents the generation of contrasuppressor cells and restores immune privilege of corneal allografts

Induction of Contrasuppressor Cells and Loss of Immune Privilege Produced by Corneal Nerve Ablation

Severing corneal nerves induces the release of substance P which converts ocular surface CD11c+ cells to contrasuppressor cells that abolish ocular immune privilege.

Corneal nerve ablation in one eye induces Langerhans cell infiltration into both eyes and abolishes immune privilege in both eyes

Effect of Corneal Nerve Ablation on Immune Tolerance Induced by Corneal Allografts, Oral Immunization, or Anterior Chamber Injection of Antigens

Effect of severing corneal nerves on the induction of immune tolerance during corneal transplantation

Second corneal allografts ablate T regulatory cells that are induced by first corneal allografts and produce a permanent loss of immune privilege in both eyes

Penetrating keratoplasty to one eye abolishes immune privilege and promotes corneal allograft rejection in the opposite eye, even to grafts from unrelated donors

Epigenetic Regulation of CXCR4 Expression by the Ocular Microenvironment

Epigenetic Regulation of Corneal Endothelial Cell Proliferation

NKT Cell Exacerbation of Liver Metastases Arising from Melanomas Transplanted into Either the Eyes or Spleens of Mice

Expression and Possible Function of IL-2 and IL-15 Receptors on Human Uveal Melanoma Cells

Role of Tumor Necrosis Factor Receptor Expression in Anterior Chamber-Associated Immune Deviation (ACAID) and Corneal Allograft Survival

Fate of MHC-Matched Corneal Allografts in Th1-Deficient Hosts

Effect of Alloantibodies on Corneal Allograft Survival

Inhibition of Intraocular Tumor Growth by Topical Application of the Angiostatic Steroid Anecortave Acetate

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