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Biochemistry and Molecular Biology April 2021

Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell–Derived RPE

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Srinivasa R. Sripathi; Ming-Wen Hu; Melissa M. Liu; Jun Wan; Jie Cheng; Yukan Duan; Joseph L. Mertz; Karl J. Wahlin; Julien Maruotti; Cynthia A. Berlinicke; Jiang Qian; Donald J. Zack
TAGS: epithelial to mesenchymal transition, dissociation, tumor necrosis factors, gene expression profiling
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):1. doi: https://doi.org/10.1167/iovs.62.4.1

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Meysam Yazdankhah; Emily G. Boxi; Stacey L Hose; Nadezda A Stepicheva; Joseph Weiss; Sayan Ghosh; Peng Shang; Haitao Liu; Christopher Scott Fitting; Ming-Wen Hu; Jiang Qian; Peter Calabresi; J. Samuel Zigler; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2791. doi:

ARVO Annual Meeting Abstract June 2020

Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinas

Thanh Hoang; Jie Wang; Patrick Boyd; Fang Wang; Clayton Santiago; John D Ash; Andy J Fischer; David R Hyde; Jiang Qian; Seth Blackshaw

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3220. doi:

ARVO Annual Meeting Abstract June 2020

Nuclear Factor I Regulates the Switch from Neurogenesis to Gliogenesis in the Developing Retina

Clayton Santiago; Thanh Hoang; David F Espinoza; Patrick Leavey; Jie Wang; Jiang Qian; Richard M Gronostajski; Seth Blackshaw

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4017. doi:

ARVO Annual Meeting Abstract July 2019

Inhibition of NF-kB signaling modulates epithelial to mesenchymal transition in human stem cell-derived retinal pigment epithelial cells

Srinivas Rao Sripathi; Ming-Wen Hu; Jie Cheng; Melissa Liu; Yukan Duan; Jun Wan; Xue Yang; Joseph L Mertz; Cynthia Berlinicke; Julien Maruotti; Karl J Wahlin; Noriko Esumi; Jiang Qian; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1738. doi:

ARVO Annual Meeting Abstract July 2019

Nuclear Factor I Regulates Proliferation and Specification of Müller glial and Bipolar Cells

Clayton Santiago; Thanh Hoang; David F Espinoza; Jie Wang; Jiang Qian; Richard M Gronostajski; Brian Clark; Seth Blackshaw

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3842. doi:

ARVO Annual Meeting Abstract July 2019

Single-cell transcriptomic analysis of human NRL null retinal organoids

Donald J Zack; Alyssa Kallman; Elizabeth E. Capowski; Anu Kaushik; Liben Chen; Melissa Liu; Alex Jansen; Kim Edwards; Cindy Berlinicke; Ming-Wen Hu; Jiang Qian; Eric A Pierce; Jeff Wang; David M Gamm

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4766. doi:

ARVO Annual Meeting Abstract July 2019

Gene regulation dynamics induced by the protein kinase inhibitor, SBJ-051 associated with neuroprotection in light-induced photoreceptor cell death

Byung-Jin Kim; Jie Wang; Tomohiro Masuda; Melissa Liu; Reji Nair; Jiang Qian; Derek Stuart Welsbie; Thomas Bannister; Timothy Spicer; Louis Scampavia; George Trainor; Amy Trainor; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4863. doi:

Biochemistry and Molecular Biology April 2019

PH20 Inhibits TGFβ1-Induced Differentiation of Perimysial Orbital Fibroblasts via Hyaluronan-CD44 Pathway in Thyroid-Associated Ophthalmopathy

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Ruiqi Ma; Hui Ren; Binbin Xu; Yun Cheng; Lu Gan; Rui Zhang; Jihong Wu; Jiang Qian
TAGS: cd44 antigens, fibroblasts, graves' ophthalmopathy, homing-associated cell adhesion molecule, hyaluronan, ovarian failure, premature
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1431-1441. doi: https://doi.org/10.1167/iovs.18-26268

Includes: Supplemental Content

Special Issue July 2018

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

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Sayan Ghosh; Peng Shang; Hiroto Terasaki; Nadezda Stepicheva; Stacey Hose; Meysam Yazdankhah; Joseph Weiss; Taiji Sakamoto; Imran A. Bhutto; Shuli Xia; J. Samuel Zigler, Jr; Ram Kannan; Jiang Qian; James T. Handa; Debasish Sinha
TAGS: crystallins, epithelial to mesenchymal transition, retinal pigment cell, age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD104-AMD113. doi: https://doi.org/10.1167/iovs.18-24132

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Single-cell transcriptomic analysis of human and murine NRL-null retinas

Alyssa Kallman; Elizabeth E Capowski; Aniruddha M. Kaushik; Melissa Liu; Baranda S. Hansen; Liben Chen; Jie Cheng; Karl Wahlin; Ming-Wen Hu; Loyal A Goff; Jiang Qian; Cynthia Berlinicke; Jeff (Tza-Huei) Wang; David M Gamm; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3105. doi:

ARVO Annual Meeting Abstract July 2018

Large-scale Whole-organism Phenotypic Screen Identifies Rod Cell Neuroprotectants Effective in Zebrafish and Mouse Models of Retinitis Pigmentosa

Liyun Zhang; Conan Chen; Jiang Qian; Hongkai Ji; Donald J Zack; Justin Hanes; David Ackerley; Baerbel Rohrer; Jeff S Mumm

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):980. doi:

ARVO Annual Meeting Abstract July 2018

Comparative transcriptomic and epigenomic analysis identifes regulators of neurogenic competence in retinal Müller glia.

Seth Blackshaw; Thanh Hoang; Jie Wang; Manuela Lahne; Levi Todd; Clayton Santiago; Nathalie Squires; Patrick Boyd; John D Ash; Andrew J Fischer; Jiang Qian; David R Hyde

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):991. doi:

ARVO Annual Meeting Abstract July 2018

Transcriptomics analysis of Muller glia in response to different damage paradigms in the adult zebrafish retina

David R Hyde; Patrick Boyd; Manuela Lahne; Thanh Hoang; Jie Wang; Clayton Santiago; Seth Blackshaw; Jiang Qian; John D Ash; Andy Fischer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):992. doi:

ARVO Annual Meeting Abstract July 2018

Müller cell transcriptional unit to regulate stress induced LIF expression

Clayton Santiago; Marcus Hooper; Thanh Hoang; Jie Wang; Jiang Qian; Seth Blackshaw; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2511. doi:

ARVO Annual Meeting Abstract July 2018

Epithelial to mesenchymal transition of human stem cell-derived retinal pigment epithelium cells modulates expression of axonal guidance molecules

Srinivas Rao Sripathi; Melissa M Liu; Ming-Wen Hu; Jun Wan; Jie Cheng; Joseph L Mertz; Cynthia Berlinicke; Julien Maruotti; Karl Wahlin; Jiang Qian; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4002. doi:

Cornea June 2018

Integrated Stress Response and Decreased ECM in Cultured Stromal Cells From Keratoconus Corneas

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James W. Foster; Vishal Shinde; Uri S. Soiberman; Gajanan Sathe; Sheng Liu; Julius Wan; Jiang Qian; Yassine Dauoud; Akhilesh Pandey; Albert S. Jun; Shukti Chakravarti
TAGS: collagen, cornea, keratoconus, keratocytes, proteins, stress response, stromal cells, peptides, cell culture techniques
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2977-2986. doi: https://doi.org/10.1167/iovs.18-24367

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

βA3/A1-Crystallin/SLC36A4/V-ATPase complex in the RPE is a novel therapeutic target for AMD

Peng Shang; Mallika Valapala; Stacey L Hose; Jun Wan; Jiang Qian; Yuri V Sergeev; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3384. doi:

ARVO Annual Meeting Abstract June 2017

Molecular insights into ECM and collagen assembly disruptions in keratoconus

James William Foster; Vishal Shinde; Uri Soiberman; Yassine Jamil Daoud; Fares Alsaleh; Gajanan Sathe; Jun Wan; Jiang Qian; Albert S Jun; Akhilesh Pandey; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3904. doi:

ARVO Annual Meeting Abstract June 2017

Single cell RNA-seq provides insights into mechanisms driving photoreceptor development and degeneration

Melissa M Liu; Ming-Wen Hu; Cynthia A Berlinicke; Jiang Qian; Loyal Goff; Donald J Zack

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4775. doi:

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Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell–Derived RPE

Mitochondrial abnormality in astrocytes leads to optic nerve degeneration: a mechanism mediated by CXCL14

Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinas

Nuclear Factor I Regulates the Switch from Neurogenesis to Gliogenesis in the Developing Retina

Inhibition of NF-kB signaling modulates epithelial to mesenchymal transition in human stem cell-derived retinal pigment epithelial cells

Nuclear Factor I Regulates Proliferation and Specification of Müller glial and Bipolar Cells

Single-cell transcriptomic analysis of human NRL null retinal organoids

Gene regulation dynamics induced by the protein kinase inhibitor, SBJ-051 associated with neuroprotection in light-induced photoreceptor cell death

PH20 Inhibits TGFβ1-Induced Differentiation of Perimysial Orbital Fibroblasts via Hyaluronan-CD44 Pathway in Thyroid-Associated Ophthalmopathy

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

Single-cell transcriptomic analysis of human and murine NRL-null retinas

Large-scale Whole-organism Phenotypic Screen Identifies Rod Cell Neuroprotectants Effective in Zebrafish and Mouse Models of Retinitis Pigmentosa

Comparative transcriptomic and epigenomic analysis identifes regulators of neurogenic competence in retinal Müller glia.

Transcriptomics analysis of Muller glia in response to different damage paradigms in the adult zebrafish retina

Müller cell transcriptional unit to regulate stress induced LIF expression

Epithelial to mesenchymal transition of human stem cell-derived retinal pigment epithelium cells modulates expression of axonal guidance molecules

Integrated Stress Response and Decreased ECM in Cultured Stromal Cells From Keratoconus Corneas

βA3/A1-Crystallin/SLC36A4/V-ATPase complex in the RPE is a novel therapeutic target for AMD

Molecular insights into ECM and collagen assembly disruptions in keratoconus

Single cell RNA-seq provides insights into mechanisms driving photoreceptor development and degeneration

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