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Biochemistry and Molecular Biology September 2024

Metabolic Phenotyping of Healthy and Diseased Human RPE Cells

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Saira Rizwan; Beverly Toothman; Bo Li; Abbi L. Engel; Rayne R. Lim; Sheldon Niernberger; Jinyu Lu; Cloe Ratliff; Yinxiao Xiang; Mark Eminhizer; Jennifer R. Chao; Jianhai Du
TAGS: glutamine, nutrients, phenotype determination, retinal pigment cell, sugars, induced pluripotent stem cells, amino acids
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):5. https://doi.org/10.1167/iovs.65.11.5

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Media nutrient composition alters RPE metabolism

Rayne Lim; Yekai Wang; Emily Zhao; Sheldon Niernberger; Jianhai Du; Jennifer R Chao

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):192.

ARVO Annual Meeting Abstract June 2024

Early metabolic signature of the eye and brain in Alzheimer’s disease

Yinxiao Xiang; Rachel McNeel; Tuan Ngo; Meghashri Saravanan; Yekai Wang; Mark Eminhizer; Saira Rizwan; Audrey Anderson; Jianhai Du

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):190.

ARVO Annual Meeting Abstract June 2024

Sacrificing Adaptability for Functionality: The Ivory Tower of Macular Müller Cells

Ling Zhu; Ting Zhang; Kaiyu Jin; Shaoxue Zeng; Penghui Yang; Meidong Zhu; Jialing Zhang; Yingying Chen; So-Ra Lee; Michelle Yam; Yue Zeng; Andrew Chang; Jianhai Du; Xiaohui Fan; Mark C Gillies; Xiaoyan Lu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1679.

ARVO Annual Meeting Abstract June 2024

Photoreceptor mitochondrial pyruvate is essential for aspartate metabolism and visual function

Jiancheng Huang; Rong Xu; Siyan Zhu; Yekai Wang; Chen Zhao; Jianhai Du

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1331.

ARVO Annual Meeting Abstract June 2024

Enhancing Photoreceptor Resilience: The Impact of Regulating Aerobic Glycolysis Enzymes

Raju V S Rajala; Jianhai Du; Ammaji Rajala

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1285.

ARVO Annual Meeting Abstract June 2024

CFH (Y402H) polymorphism sensitizes mitochondria to oxidative stress in RPE cells

Peng Shang; Helena Ambrosino; Johnson Hoang; Zhaohui Geng; Shichen Shen; Mark Eminhizer; Yekai Wang; Jun Qu; Jianhai Du; Sandra Montezuma; James Dutton; Deborah A Ferrington

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2550.

ARVO Annual Meeting Abstract June 2024

Disease associated mutations in inosine monophosphate dehydrogenase 1 (IMPDH1) cause aberrant steady state metabolism in zebrafish retina

Kaitlyn Michelle Rutter; Whitney M Cleghorn; Michelle Giarmarco; John Calise; Anika L Burrell; Mark Eminhizer; Yekai Wang; Justin M Kollman; Jianhai Du; Susan E Brockerhoff

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4708.

ARVO Annual Meeting Abstract June 2023

Metabolic alterations in the JR5558 mouse model of subretinal fibrosis

Yue Zeng; Ting Zhang; Ling Zhu; So-Ra Lee; Shaoxue Zeng; Michelle Yam; Jianhai Du; Mark Gillies

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2969.

ARVO Annual Meeting Abstract June 2023

Nutrient environments influence retinal pigment epithelium phenotype and metabolic profile.

Rayne Lim; YeKai Wang; Marcos Nazario; Aspen-Marie S Tong; Jianhai Du; Jennifer R Chao

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3192.

Biochemistry and Molecular Biology March 2023

Tissue-Specific Sex Difference in Mouse Eye and Brain Metabolome Under Fed and Fasted States

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Meghashri Saravanan; Rong Xu; Olivia Roby; Yekai Wang; Siyan Zhu; Amy Lu; Jianhai Du
TAGS: body tissue, brain, eye, metabolism, metabolites, mice, sex characteristics, metabolome, lens, crystalline, retina
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):18. https://doi.org/10.1167/iovs.64.3.18

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Complement dysregulation in an iPSC-RPE model with CFH/FHL-1 haploinsufficiency.

Rayne Lim; Sharlene Shirali; Jessica Rowlan; Abbi Engel; Marcos Nazario; Jianhai Du; Maureen Neitz; Jay Neitz; Jennifer R Chao

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1473.

ARVO Annual Meeting Abstract June 2022

Rod photoreceptor-specific deletion of MPC1 impairs visual function with age-dependent retinal degeneration

Rong Xu; Jiancheng Huang; Yekai Wang; Siyan Zhu; James B Hurley; Jianhai Du

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1788 – F0337.

ARVO Annual Meeting Abstract June 2022

Sorsby Fundus Dystrophy (SFD)-associated mutations in Tissue Inhibitor of Metalloproteinase 3 ( Timp3 ) leads to metabolic dysfunction in the RPE and Retina.

Allison B Grenell; Charandeep Singh; Andrew Dale Benos; Jianhai Du; Henri Brunengraber; Bela Anand-Apte

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2487 – F0194.

ARVO Annual Meeting Abstract June 2022

RPE utilizes proline through proline dehydrogenase to support retinal metabolism

Siyan Zhu; Rong Xu; Yekai Wang; Jianhai Du

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2481 – F0188.

ARVO Annual Meeting Abstract June 2022

GLUT1 is Required for the Anabolic Metabolism of Photoreceptor Cells

John Yeong Se Han; Lauren L Daniele; Ravikiran Komirisetty; Nikhil Mehta; Yekai Wang; Jianhai Du; Neal S Peachey; Ivy S Samuels; Nancy Philp

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2479 – F0186.

ARVO Annual Meeting Abstract June 2022

Sex matters in eye and brain metabolism: targeted metabolomics reveals tissue-specific sex difference in metabolism in fasted vs. fed state

Olivia Roby; Saravanan Meghashr; Rong Xu; Yekai Wang; Jianhai Du

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4290.

ARVO Annual Meeting Abstract June 2021

Disruption of the pentose phosphate pathway in Müller cells makes them more susceptible to light stress by interfering with the oxidative stress-induced NRF2 response

Yingying Chen; Ting Zhang; Shaoxue Zeng; Kaiyu Jin; Rong Xu; Xiaohui Fan; Meixia Zhang; Jianhai Du; Mark C Gillies; Ling Zhu

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1667.

ARVO Annual Meeting Abstract June 2021

RPE utilizes proline to enhance nutrient availability to the retina

Siyan Zhu; Abbi L Engel; Yekai Wang; Rong Xu; Jennifer R Chao; Jianhai Du

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2231.

ARVO Annual Meeting Abstract June 2021

A novel CFH mutation affects FHL-1 expression and metabolism in EOMD patient derived iPSC-RPE.

Rayne Ruiyi Lim; Abbi Engel; Jessica Rowlan; Yekai Wang; Kelie Gonzalez; Sharlene Shirali; Jay Neitz; Maureen Neitz; Jianhai Du; Jennifer R Chao

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3112.

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Metabolic Phenotyping of Healthy and Diseased Human RPE Cells

Media nutrient composition alters RPE metabolism

Early metabolic signature of the eye and brain in Alzheimer’s disease

Sacrificing Adaptability for Functionality: The Ivory Tower of Macular Müller Cells

Photoreceptor mitochondrial pyruvate is essential for aspartate metabolism and visual function

Enhancing Photoreceptor Resilience: The Impact of Regulating Aerobic Glycolysis Enzymes

CFH (Y402H) polymorphism sensitizes mitochondria to oxidative stress in RPE cells

Disease associated mutations in inosine monophosphate dehydrogenase 1 (IMPDH1) cause aberrant steady state metabolism in zebrafish retina

Metabolic alterations in the JR5558 mouse model of subretinal fibrosis

Nutrient environments influence retinal pigment epithelium phenotype and metabolic profile.

Tissue-Specific Sex Difference in Mouse Eye and Brain Metabolome Under Fed and Fasted States

Complement dysregulation in an iPSC-RPE model with CFH/FHL-1 haploinsufficiency.

Rod photoreceptor-specific deletion of MPC1 impairs visual function with age-dependent retinal degeneration

Sorsby Fundus Dystrophy (SFD)-associated mutations in Tissue Inhibitor of Metalloproteinase 3 ( Timp3 ) leads to metabolic dysfunction in the RPE and Retina.

RPE utilizes proline through proline dehydrogenase to support retinal metabolism

GLUT1 is Required for the Anabolic Metabolism of Photoreceptor Cells

Sex matters in eye and brain metabolism: targeted metabolomics reveals tissue-specific sex difference in metabolism in fasted vs. fed state

Disruption of the pentose phosphate pathway in Müller cells makes them more susceptible to light stress by interfering with the oxidative stress-induced NRF2 response

RPE utilizes proline to enhance nutrient availability to the retina

A novel CFH mutation affects FHL-1 expression and metabolism in EOMD patient derived iPSC-RPE.

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