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ARVO Annual Meeting Abstract June 2025

A Novel AAV Gene Therapy Complement Inhibitor: KRIYA-825 Exhibits Dose-Dependent Murine Efficacy and NHP Biodistribution

Rachel Eclov; Pilar Prentiss; Angela Ambakhutwala; Michael Engles; Jessica Raubenolt; William Chappell; Robert Damitz; Yoreh Barak; Hagay Drori; Jiewu Liu; Kara Shumansky; Angela Yang; Lauren Parker; Benjamin Johnson; James Coyne; David Ryan Lally; Andrew Murphy; Nancy Bordelon; Ashlyn Bassiri; Michele Stone

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):5577.

Cornea February 2025

HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis

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Xiaojuan Hu; Jiayao Feng; Chengjie Pan; Zhenzhen Sun; Jiechen Liu; Shuang Xie; Decheng Xiao; Xiaoyin Ma; Qinxiang Zheng; Wei Chen
TAGS: dry eye syndromes, hmgb1 protein, lysosomes, borderline neoplasms, apoptosis, homeostasis, cell death, stress, date of last normal period, cytoplasm
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):5. https://doi.org/10.1167/iovs.66.2.5

ARVO Annual Meeting Abstract June 2024

Liquid biopsy for proliferative diabetic retinopathy: single-cell transcriptomics (scRNA-seq) of human vitreous reveals inflammatory T cell signature

Rachana Haliyur; David Parkinson; Jing Xu; Qiang Li; Yuanhao Huang; Jie Liu; Feiyang Ma; Johann Gudjonsson; Rajesh Rao

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):935.

ARVO Annual Meeting Abstract June 2024

Monocytes undergo transcriptional and biochemical changes, allowing expression of microglia markers P2ry12, TMEM119, FCRLS and Iba1 upon engraftment into the retina.

Jie Liu; Fengyang Lei; Naiwen Cui; Bin Yan; Jyoti Sharma; Victor S.M.C. Correa; Savvas Nicolaou; Kristen Pitts; Lara Roach; Milica Margeta; Demetrios G. Vavvas; Raul Mostoslavsky; Huidan Zhang; David Weitz; Eleftherios I Paschalis

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1688.

ARVO Annual Meeting Abstract June 2024

Non-viral gene delivery of crystallin gamma S protects retinal cells and increases their proliferation during inflammation

Jyoti Sharma; Fengyang Lei; Mohammad Mirazul Islam; Pedro De La Torre Marquez; Bin Yan; Toshio Narimatsu; Da Sun; Jie Liu; James Chodosh; Demetrios G. Vavvas; Graeme J Wistow; Artur Indzhykulian; zheng rong lu; Eleftherios I Paschalis

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4452.

ARVO Annual Meeting Abstract June 2024

Necroptosis pathway activation in the retina after ocular alkali burn

Bin Yan; Jie Liu; Victor S.M.C. Correa; Toshio Narimatsu; Lara Roach; Raul Mostoslavsky; Demetrios G. Vavvas; Eleftherios I Paschalis

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6432.

ARVO Annual Meeting Abstract June 2024

Investigating the Efficacy of AAV Mediated Expression of CR2-CR1 fusion protein, a Complement Inhibitor, in Ameliorating Retinal Degeneration in Mice

Michael Engles; Rachel Eclov; Pilar Prentiss; Jessica Raubenolt; William Chappell; Jiewu Liu; Kara Shumansky; Angela Yang; Ashlyn Bassiri; Angela Ambakhutwala; Andrew Murphy; Lauren Parker; Benjamin Johnson

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3808.

ARVO Annual Meeting Abstract June 2024

Evaluation of AAV2 biodistribution after suprachoroidal injection in NHPs using a novel suprachoroidal delivery device system

Rachel Eclov; Michael Engles; Pilar Prentiss; Will Quinn; Dawn Fellner; Hagay Drori; Rob Damitz; Jiewu Liu; Ashlyn Bassiri; Yoreh Barak; Michele Stone

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5325.

ARVO Annual Meeting Abstract June 2023

Single-cell RNAseq reveals a dynamic shift in the transcriptome of peripheral monocytes upon engraftment into the neuroretina which resembles that of microlgia and leads to expression of microlgia “specific” markers P2ry12, TMEM119, and FCRLS.

Jie Liu; Fengyang Lei; Bin Yan; Jyoti Sharma; Eleftherios I Paschalis

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5233.

ARVO Annual Meeting Abstract June 2023

Minimally invasive keratoprosthesis (mi-KPro) for vision restoration after severe chemical injury.

Jyoti Sharma; Thomas H Dohlman; Chengxin Zhou; Peter York; Fengyang Lei; Jie Liu; Robert Woods; Claes Dohlman; James Chodosh; Roberto Pineda; Eleftherios I Paschalis

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5136.

Pediatric Ophthalmology & Strabismus December 2022

The Cumulative Effect of Multilevel Factors on Myopia Prevalence, Incidence, and Progression Among Children and Adolescents in China During the COVID-19 Pandemic

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Yanhui Dong; Catherine Jan; Li Chen; Tao Ma; Jieyu Liu; Yi Zhang; Qi Ma; Panliang Zhong; Yi Song; Jun Ma; George C. Patton; Susan M. Sawyer
TAGS: adolescent, child, coronavirus pandemic, incidence, myopia, prevalence, china, school (environment)
Trans. Vis. Sci. Tech.. 2022; 11(12):9. https://doi.org/10.1167/tvst.11.12.9

Includes: Supplemental Content

Retinal Cell Biology March 2021

The Long Non-Coding RNA HOTAIR Is a Critical Epigenetic Mediator of Angiogenesis in Diabetic Retinopathy

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Saumik Biswas; Biao Feng; Shali Chen; Jieting Liu; Erfan Aref-Eshghi; John Gonder; Vy Ngo; Bekim Sadikovic; Subrata Chakrabarti
TAGS: angiogenesis, diabetes mellitus, diabetic retinopathy, epigenetics, glucose, rna, vascular endothelial growth factor a, molecule, methylation, histones
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):20. https://doi.org/10.1167/iovs.62.3.20

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Mechanical-sensitive hemichannels regulated by integrins mediates the delivery of glucose and glutathione into lens fiber cells

Jie Liu; Manuel Riquelme; Zhen Li; Sumin Gu; Jean X Jiang

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4794.

ARVO Annual Meeting Abstract July 2018

CTGF Contributes to the Development of Posterior Capsule Opacification: an in vitro and in vivo study

Ruihua Jing; Bo Ma; Jie Liu; Cheng Pei

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5632.

ARVO Annual Meeting Abstract June 2017

A role for the focal adhesion kinase in TGF-β2 induced cell migration in human lens epithelial cells

Jie Liu; Jingming Li; Dan Xu; Yongping Shao; Cheng Pei

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3189.

Visual Psychophysics and Physiological Optics April 2013

Optimizing Chinese Character Displays Improves Recognition and Reading Performance of Simulated Irregular Phosphene Maps

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Yanyu Lu; Han Kan; Jie Liu; Jing Wang; Chen Tao; Yao Chen; Qiushi Ren; Jie Hu; Xinyu Chai
TAGS: accommodation phosphene, chief complaint, chinese (other dialects), maps, reading (activity)
Invest. Ophthalmol. Vis. Sci.. 2013; 54(4):2918-2926. https://doi.org/10.1167/iovs.12-11039

Anatomy and Pathology/Oncology October 2004

Pathogenesis of Persistent Hyperplastic Primary Vitreous in Mice Lacking the Arf Tumor Suppressor Gene

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Amy C. Martin; J. Derek Thornton; Jiewiu Liu; XiaoFei Wang; Jian Zuo; Monica M. Jablonski; Edward Chaum; Frederique Zindy; Stephen X. Skapek
TAGS: eye, mice, pathogenesis, persistent hyperplastic primary vitreous, tumor suppressor genes
Invest. Ophthalmol. Vis. Sci.. 2004; 45(10):3387-3396. https://doi.org/10.1167/iovs.04-0349

Biochemistry and Molecular Biology January 2004

Catalase and Peroxiredoxin 5 Protect Xenopus Embryos against Alcohol-Induced Ocular Anomalies

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Ying Peng; Pai-Hao Yang; Yan Guo; Samuel S. M. Ng; Jie Liu; P. C. W. Fung; David Tay; Jian Ge; Ming-Liang He; Hsiang-fu Kung; Marie C. Lin
TAGS: catalase, embryo, ethanol, xenopus, eye
Invest. Ophthalmol. Vis. Sci.. 2004; 45(1):23-29. https://doi.org/10.1167/iovs.03-0550

Glaucoma July 2003

Differential Dendritic Shrinkage of α and β Retinal Ganglion Cells in Cats with Chronic Glaucoma

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Tiande Shou; Jie Liu; Wei Wang; Yifeng Zhou; Kanxing Zhao
TAGS: adaptive testing, cats, dendrites, glaucoma, retina, retinal ganglion cells, eye
Invest. Ophthalmol. Vis. Sci.. 2003; 44(7):3005-3010. https://doi.org/10.1167/iovs.02-0620

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A Novel AAV Gene Therapy Complement Inhibitor: KRIYA-825 Exhibits Dose-Dependent Murine Efficacy and NHP Biodistribution

HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis

Liquid biopsy for proliferative diabetic retinopathy: single-cell transcriptomics (scRNA-seq) of human vitreous reveals inflammatory T cell signature

Monocytes undergo transcriptional and biochemical changes, allowing expression of microglia markers P2ry12, TMEM119, FCRLS and Iba1 upon engraftment into the retina.

Non-viral gene delivery of crystallin gamma S protects retinal cells and increases their proliferation during inflammation

Necroptosis pathway activation in the retina after ocular alkali burn

Investigating the Efficacy of AAV Mediated Expression of CR2-CR1 fusion protein, a Complement Inhibitor, in Ameliorating Retinal Degeneration in Mice

Evaluation of AAV2 biodistribution after suprachoroidal injection in NHPs using a novel suprachoroidal delivery device system

Single-cell RNAseq reveals a dynamic shift in the transcriptome of peripheral monocytes upon engraftment into the neuroretina which resembles that of microlgia and leads to expression of microlgia “specific” markers P2ry12, TMEM119, and FCRLS.

Minimally invasive keratoprosthesis (mi-KPro) for vision restoration after severe chemical injury.

The Cumulative Effect of Multilevel Factors on Myopia Prevalence, Incidence, and Progression Among Children and Adolescents in China During the COVID-19 Pandemic

The Long Non-Coding RNA HOTAIR Is a Critical Epigenetic Mediator of Angiogenesis in Diabetic Retinopathy

Mechanical-sensitive hemichannels regulated by integrins mediates the delivery of glucose and glutathione into lens fiber cells

CTGF Contributes to the Development of Posterior Capsule Opacification: an in vitro and in vivo study

A role for the focal adhesion kinase in TGF-β2 induced cell migration in human lens epithelial cells

Optimizing Chinese Character Displays Improves Recognition and Reading Performance of Simulated Irregular Phosphene Maps

Pathogenesis of Persistent Hyperplastic Primary Vitreous in Mice Lacking the Arf Tumor Suppressor Gene

Catalase and Peroxiredoxin 5 Protect Xenopus Embryos against Alcohol-Induced Ocular Anomalies

Differential Dendritic Shrinkage of α and β Retinal Ganglion Cells in Cats with Chronic Glaucoma

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