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Biochemistry and Molecular Biology April 2019

PH20 Inhibits TGFβ1-Induced Differentiation of Perimysial Orbital Fibroblasts via Hyaluronan-CD44 Pathway in Thyroid-Associated Ophthalmopathy

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Ruiqi Ma; Hui Ren; Binbin Xu; Yun Cheng; Lu Gan; Rui Zhang; Jihong Wu; Jiang Qian
TAGS: fibroblasts, graves' ophthalmopathy, cd44 antigens, ovarian failure, premature, hyaluronan, homing-associated cell adhesion molecule
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1431-1441. doi: 10.1167/iovs.18-26268

Includes: Supplemental Content

Glaucoma October 2018

Decreased d -Serine Levels Prevent Retinal Ganglion Cell Apoptosis in a Glaucomatous Animal Model

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Xuejin Zhang; Rong Zhang; Xujiao Zhou; Jihong Wu
TAGS: apoptosis, glaucoma, animal model, retinal ganglion cells, serine, eye, retina, d-serine
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5045-5052. doi: 10.1167/iovs.18-24691

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Genetic deletion of NOS3 gene in CAV1 -/- mice decreases drug sensitivity to nitric oxide donor and nitric oxide synthase inhibitor

Yuan Lei; Maomao Song; Jihong Wu; Xing-Huai Sun

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1651. doi:

Glaucoma September 2017

Genetic Deletion of the NOS3 Gene in CAV1 −/− Mice Restores Aqueous Humor Outflow Function

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Maomao Song; Jihong Wu; Yuan Lei; Xinghuai Sun
TAGS: genes, aqueous humor, eye, genetics, intraocular pressure, mice
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):4976-4987. doi: 10.1167/iovs.16-21072

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

High pressure induces mtDNA damage and mutations and mitochondrial dysfunction in primary cultured retinal ganglion cells

Jihong Wu; Fengjuan Gao; Feng Gao; Yi Zhang; Xinghuai Sun

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6021. doi:

Glaucoma May 2016

eNOS Activity in CAV1 Knockout Mouse Eyes

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Yuan Lei; Maomao Song; Jihong Wu; Chao Xing; Xinghuai Sun
TAGS: mice, knockout, nitric oxide synthase, eye, intraocular pressure, mice, donors
Invest. Ophthalmol. Vis. Sci.. 2016; 57(6):2805-2813. doi: 10.1167/iovs.15-18841

Retinal Cell Biology February 2016

Interleukin-17A Induces IL-1β Secretion From RPE Cells Via the NLRP3 Inflammasome

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Shujie Zhang; Ning Yu; Rong Zhang; Shenghai Zhang; Jihong Wu
TAGS: bodily secretions, interleukin-17, interleukins, inflammasomes, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2016; 57(2):312-319. doi: 10.1167/iovs.15-17578

Glaucoma July 2015

Aqueous Humor Outflow Physiology in NOS3 Knockout Mice

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Yuan Lei; Xuejin Zhang; Maomao Song; Jihong Wu; Xinghuai Sun

Invest. Ophthalmol. Vis. Sci.. 2015; 56(8):4891-4898. doi: 10.1167/iovs.15-16564

ARVO Annual Meeting Abstract June 2015

Aqueous humour outflow physiology in NOS3 knockout mice

Yuan Lei; Xuejin Zhang; Jihong Wu; Xing-Huai Sun

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4849. doi:

Glaucoma December 2014

Endothelial Nitric Oxide Synthase–Related Mechanotransduction Changes in Aged Porcine Angular Aqueous Plexus Cells

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Yuan Lei; William Daniel Stamer; Jihong Wu; Xinghuai Sun
TAGS: aging, nitric oxide synthase, suidae, shear stress, mechanotransduction, cellular
Invest. Ophthalmol. Vis. Sci.. 2014; 55(12):8402-8408. doi: 10.1167/iovs.14-14992

Glaucoma April 2014

Cell Senescence Reduced the Mechanotransduction Sensitivity of Porcine Angular Aqueous Plexus Cells to Elevation of Pressure

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Yuan Lei; William D. Stamer; Jihong Wu; Xinghuai Sun
TAGS: aging, oxidative stress, western blotting, cadherins, cell aging, hydrostatic pressure, suidae, proteins, mechanotransduction, cellular
Invest. Ophthalmol. Vis. Sci.. 2014; 55(4):2324-2328. doi: 10.1167/iovs.13-13317

Glaucoma July 2013

Oxidative Stress Impact on Barrier Function of Porcine Angular Aqueous Plexus Cell Monolayers

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Yuan Lei; William D. Stamer; Jihong Wu; Xinghuai Sun
TAGS: aging, oxidative stress, endothelial cells, cadherins, dna damage, galactosidase, hyperoxia, suidae
Invest. Ophthalmol. Vis. Sci.. 2013; 54(7):4827-4835. doi: 10.1167/iovs.12-11435

ARVO Annual Meeting Abstract June 2013

Oxidative Stress Impacts On Barrier Function of Porcine Angular Aqueous Plexus Cell Monolayers

Yuan Lei; W Daniel Stamer; Jihong Wu; Xinghuai Sun

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3567. doi:

ARVO Annual Meeting Abstract June 2013

IL17A inhibits expression of POMC gene in RPE cells

Shujie Zhang; Jihong Wu; Research Center

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):143. doi:

ARVO Annual Meeting Abstract June 2013

Somatic Epigenetic Memory in iPSC-drived from Adult RPE

Shenghai Zhang; Jihong Wu

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2224. doi:

ARVO Annual Meeting Abstract June 2013

Accumulated Increase of mtDNA Damage Contribute to Progressive Loss of RGC in a Rat Model of Glaucoma

Jihong Wu; Shenghai Zhang

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):284. doi:

Biochemistry and Molecular Biology May 2012

Enhancement of rAAV2-Mediated Transgene Expression in Retina Cells In Vitro and In Vivo by Coadministration of Low-Dose Chemotherapeutic Drugs

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Shenghai Zhang; Jihong Wu; Xiaobing Wu; Ping Xu; Yuhua Tian; Miaoying Yi; Xinjian Liu; Xiaoyan Dong; Frank Wolf; Chuanyuan Li; Qian Huang
TAGS: antineoplastic agents, transgenes, infection, retina
Invest. Ophthalmol. Vis. Sci.. 2012; 53(6):2675-2684. doi: 10.1167/iovs.11-8856

ARVO Annual Meeting Abstract March 2012

Royal jelly Peptide Promotes Retinal Ganglion Cell Survival in Experimental Model of Glaucoma Through Up-regulating BDNF and GDNF

Jihong Wu; Xinghuai Sun; Shenghai Zhang

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6581. doi:

ARVO Annual Meeting Abstract March 2012

Valproate Exerts Pleiotropic Neuroprotective Effects on Retinal Ganglion Cells in vivo Through Epigenetic Modulation in an Experimental Model of Glaucoma

Shenghai Zhang; Xinghuai Sun; Jihong Wu

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6583. doi:

Glaucoma June 2010

Neuroprotective Effect of Upregulated Sonic Hedgehog in Retinal Ganglion Cells Following Chronic Ocular Hypertension

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Jihong Wu; Shenghai Zhang; Xinghuai Sun
TAGS: ocular hypertension, retinal ganglion cells, shh gene, neuroprotective effect
Invest. Ophthalmol. Vis. Sci.. 2010; 51(6):2986-2992. doi: 10.1167/iovs.09-4151

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PH20 Inhibits TGFβ1-Induced Differentiation of Perimysial Orbital Fibroblasts via Hyaluronan-CD44 Pathway in Thyroid-Associated Ophthalmopathy

Decreased d -Serine Levels Prevent Retinal Ganglion Cell Apoptosis in a Glaucomatous Animal Model

Genetic deletion of NOS3 gene in CAV1 -/- mice decreases drug sensitivity to nitric oxide donor and nitric oxide synthase inhibitor

Genetic Deletion of the NOS3 Gene in CAV1 −/− Mice Restores Aqueous Humor Outflow Function

High pressure induces mtDNA damage and mutations and mitochondrial dysfunction in primary cultured retinal ganglion cells

eNOS Activity in CAV1 Knockout Mouse Eyes

Interleukin-17A Induces IL-1β Secretion From RPE Cells Via the NLRP3 Inflammasome

Aqueous Humor Outflow Physiology in NOS3 Knockout Mice

Aqueous humour outflow physiology in NOS3 knockout mice

Endothelial Nitric Oxide Synthase–Related Mechanotransduction Changes in Aged Porcine Angular Aqueous Plexus Cells

Cell Senescence Reduced the Mechanotransduction Sensitivity of Porcine Angular Aqueous Plexus Cells to Elevation of Pressure

Oxidative Stress Impact on Barrier Function of Porcine Angular Aqueous Plexus Cell Monolayers

Oxidative Stress Impacts On Barrier Function of Porcine Angular Aqueous Plexus Cell Monolayers

IL17A inhibits expression of POMC gene in RPE cells

Somatic Epigenetic Memory in iPSC-drived from Adult RPE

Accumulated Increase of mtDNA Damage Contribute to Progressive Loss of RGC in a Rat Model of Glaucoma

Enhancement of rAAV2-Mediated Transgene Expression in Retina Cells In Vitro and In Vivo by Coadministration of Low-Dose Chemotherapeutic Drugs

Royal jelly Peptide Promotes Retinal Ganglion Cell Survival in Experimental Model of Glaucoma Through Up-regulating BDNF and GDNF

Valproate Exerts Pleiotropic Neuroprotective Effects on Retinal Ganglion Cells in vivo Through Epigenetic Modulation in an Experimental Model of Glaucoma

Neuroprotective Effect of Upregulated Sonic Hedgehog in Retinal Ganglion Cells Following Chronic Ocular Hypertension

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