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ARVO Annual Meeting Abstract June 2024

Proteome dynamics of aging retinal pigment epithelium

Steffi Daniel; John Hulleman

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):762.

ARVO Annual Meeting Abstract June 2024

Longitudinal BLamD quantification analyses reveal a critical window for disease pathophysiology in R345W EFEMP1 mice

Antonio Ortega; John Hulleman

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4752.

ARVO Annual Meeting Abstract June 2023

Endogenous HiBiT tagging of CFH, HtrA1, and PEDF enables a sensitive and versatile approach for protein interrogation and high-throughput screening

Sophia DiCesare; Archishman Bhattacharyaa; Melissa McCoy; Bruce Posner; John Hulleman

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2104.

ARVO Annual Meeting Abstract June 2023

Nlrp3 deficiency protects mice from the development of sub-RPE basal laminar deposits in a macular degeneration (R345W Efemp1) model

Antonio J Ortega; Hasan Zaki; John Hulleman

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2992.

ARVO Annual Meeting Abstract June 2023

Optimizing primary porcine RPE cultures for genetic manipulation and high-throughput screening

Steffi Daniel; John Hulleman

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2983.

ARVO Annual Meeting Abstract June 2023

High-throughput screening detects pharmacologic compounds rescuing mutant myocilin secretion

Owen Duane Clinger; Bing Feng; Christian Kim; John Hulleman; Yiqin Du; Yuanyuan Chen

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3768.

ARVO Annual Meeting Abstract June 2023

Low level glycogen synthase kinase 3 (GSK3) inhibition broadly reduces extracellular matrix protein production and pathology associated with a juvenile macular dystrophy

John Hulleman; Sophia DiCesare; Antonio J Ortega; Gracen Collier; Steffi Daniel

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4435.

ARVO Annual Meeting Abstract June 2022

The effects of vimentin knockout on corneal fibroblast mechanical behavior in 3D collagen matrices

Miguel Miron Mendoza; Emi Nakahara; Meet Paresh Bhatt; John Hulleman; Matthew Petroll

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):105 – A0203.

ARVO Annual Meeting Abstract June 2022

HiBiT tagging of endogenously expressed retinal degeneration-associated proteins enables sensitive, unbiased chemical and genetic modulator screens.

Sophia DiCesare; Steffi Daniel; Melissa McCoy; Bruce Posner; John Hulleman

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3172 – F0446.

ARVO Annual Meeting Abstract June 2022

Ocular chemoproteomics for determining broad profiles of enzymatic activities

Steffi Daniel; John Hulleman

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4606 – F0398.

ARVO Annual Meeting Abstract June 2022

Molecular and ocular characterization of R345W EFEMP1 mice reveal new disease-related insights

John Hulleman; Marian Renwick; Steffi Daniel

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4605 – F0397.

ARVO Annual Meeting Abstract June 2021

Clinically-Identified C-terminal Mutations in Fibulin-3 are Prone to Misfolding and Destabilization

DaNae Woodard; Emi Nakahara; John Hulleman

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2947.

ARVO Annual Meeting Abstract June 2021

Species and age-related changes to fibulin-3 expression in the retina and RPE of a series of mammals

Steffi Daniel; John Hulleman

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2716.

Articles August 2020

Trinucleotide Repeat-Targeting dCas9 as a Therapeutic Strategy for Fuchs’ Endothelial Corneal Dystrophy

PDF

Ziye Rong; Xin Gong; John D. Hulleman; David R. Corey; V. Vinod Mootha
TAGS: endothelium, hereditary corneal dystrophy, rna, dna, endothelial cells
Trans. Vis. Sci. Tech.. 2020; 9(9):47. https://doi.org/10.1167/tvst.9.9.47

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

The R345W-Fibulin-3 point mutation induces RPE cell epithelial-mesenchymal transition and alters the content of their extracellular vesicles

Mi Zhou; Stephanie Grillo; Sarah Weber; Yuanjun Zhao; Han Chen; John Hulleman; Jeffrey Sundstrom

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1502.

ARVO Annual Meeting Abstract July 2019

A destabilized domain-based approach to control protein abundance in aged mice and models of retinal degeneration

Shyamtanu Datta; Bo Chen; Marian Renwick; Hui Peng; Rafael Ufret-Vincenty; John Hulleman

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3392.

ARVO Annual Meeting Abstract July 2019

Versatile, non-antibiotic control of an ocular DHFR-based destabilizing domain

John Hulleman; Viet Q Chau; Shyamtanu Datta; Hui Peng; Marian Renwick

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3393.

Retina October 2018

A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye – Implications for Ocular Gene Therapy

PDF

Shyamtanu Datta; Marian Renwick; Viet Q. Chau; Fang Zhang; Emily R. Nettesheim; Daniel M. Lipinski; John D. Hulleman
TAGS: dihydrofolate reductase, eye, gene therapy, mice, proteins, retina, potable water, regulation, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4909-4920. https://doi.org/10.1167/iovs.18-24987

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

A generalizable destabilized domain-based approach to quickly and reversibly control gene therapies in the eye

John D Hulleman; Shyamtanu Datta; Fang Zhang; Wenzhi Feng

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4547.

Retinal Cell Biology August 2017

Conditional, Genetically Encoded, Small Molecule–Regulated Inhibition of NFκB Signaling in RPE Cells

PDF

Khiem T. Vu; Fang Zhang; John D. Hulleman
TAGS: dihydrofolate reductase, retinal pigment cell, signal transduction, small molecule, stabilization, cytokine, interleukin-6
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4126-4137. https://doi.org/10.1167/iovs.17-22133

Includes: Supplemental Content

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Proteome dynamics of aging retinal pigment epithelium

Longitudinal BLamD quantification analyses reveal a critical window for disease pathophysiology in R345W EFEMP1 mice

Endogenous HiBiT tagging of CFH, HtrA1, and PEDF enables a sensitive and versatile approach for protein interrogation and high-throughput screening

Nlrp3 deficiency protects mice from the development of sub-RPE basal laminar deposits in a macular degeneration (R345W Efemp1) model

Optimizing primary porcine RPE cultures for genetic manipulation and high-throughput screening

High-throughput screening detects pharmacologic compounds rescuing mutant myocilin secretion

Low level glycogen synthase kinase 3 (GSK3) inhibition broadly reduces extracellular matrix protein production and pathology associated with a juvenile macular dystrophy

The effects of vimentin knockout on corneal fibroblast mechanical behavior in 3D collagen matrices

HiBiT tagging of endogenously expressed retinal degeneration-associated proteins enables sensitive, unbiased chemical and genetic modulator screens.

Ocular chemoproteomics for determining broad profiles of enzymatic activities

Molecular and ocular characterization of R345W EFEMP1 mice reveal new disease-related insights

Clinically-Identified C-terminal Mutations in Fibulin-3 are Prone to Misfolding and Destabilization

Species and age-related changes to fibulin-3 expression in the retina and RPE of a series of mammals

Trinucleotide Repeat-Targeting dCas9 as a Therapeutic Strategy for Fuchs’ Endothelial Corneal Dystrophy

The R345W-Fibulin-3 point mutation induces RPE cell epithelial-mesenchymal transition and alters the content of their extracellular vesicles

A destabilized domain-based approach to control protein abundance in aged mice and models of retinal degeneration

Versatile, non-antibiotic control of an ocular DHFR-based destabilizing domain

A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye – Implications for Ocular Gene Therapy

A generalizable destabilized domain-based approach to quickly and reversibly control gene therapies in the eye

Conditional, Genetically Encoded, Small Molecule–Regulated Inhibition of NFκB Signaling in RPE Cells

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