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ARVO Annual Meeting Abstract June 2024

In Search of Mouse Model for Exfoliation Syndrome

Samuel Insignares; Sharon Yang; John Kuchtey; Rachel W Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6137.

ARVO Annual Meeting Abstract June 2024

Targeted genetic defects in elastic fibers cause biomechanical weakening of mouse sclera during physiological dynamic intraocular pressure changes

Gianfranco Bianco; Samuel Insignares; Massimo A. Fazio; John Kuchtey; Rachel Wang Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2508.

ARVO Annual Meeting Abstract June 2022

Investigation of fibrillin-1 and LOXL1 in ocular health and disease

Rachel W Kuchtey; Lauren wareham; Hangjing Wu; Evan Krystofiak; Yusheng Wu; Cynthia Reinhart-King; Vijaykrishna Raghunathan; Elena Pokidysheva; Sergei Budko; John Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1923 – A0069.

ARVO Annual Meeting Abstract June 2022

Optic neuropathy associated with TGFβ dysregulation in mice with a glaucoma-causative mutation of Adamts10

Hangjing Wu; Rachel W Kuchtey; John Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1914 – A0060.

Glaucoma August 2021

Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10

PDF

Hang-Jing Wu; Douglas P. Mortlock; Rachel W. Kuchtey; John Kuchtey
TAGS: fibrillin-2, fibrillins, glaucoma, mice, microfibrils, mutation, fibrillin-1, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):26. https://doi.org/10.1167/iovs.62.10.26

Glaucoma August 2020

Increased Susceptibility to Glaucomatous Damage in Microfibril Deficient Mice

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Hang-Jing Wu; John Kuchtey; Rachel W. Kuchtey
TAGS: axon, disease susceptibility, fibrillin-1, glaucoma, injections, mice, microspheres, optic nerve, microfibrils, eye
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):28. https://doi.org/10.1167/iovs.61.10.28

Includes: Supplemental Content

Glaucoma May 2020

Telmisartan Reduces Axon Degeneration in Mice With Experimental Glaucoma

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Ralph J. Hazlewood; John Kuchtey; Hang-Jing Wu; Rachel W. Kuchtey
TAGS: axon, glaucoma, mice, neuroprotective effect, telmisartan, tissue degeneration, microspheres, intraocular pressure, injections
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):51. https://doi.org/10.1167/iovs.61.5.51

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Telmisartan, an angiotensin II type 1 receptor blocker, reduces IOP and prevents axon loss in mice with experimental glaucoma

Ralph J Hazlewood; John Kuchtey; Rachel W Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):627.

ARVO Annual Meeting Abstract July 2019

Reduced number and caliber of optic nerve axons and smaller optic nerves in mice homozygous for a glaucoma-causing mutation in Adamts10

Hangjing Wu; Rachel W Kuchtey; John Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2851.

ARVO Annual Meeting Abstract July 2018

Increased susceptibility to glaucomatous optic nerve damage in microfibril deficient mice

Hangjing Wu; Abudi Nashabi; Frances Clark; Samyukta Reddy; John Kuchtey; Rachel W Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3705.

ARVO Annual Meeting Abstract June 2017

Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma

Michelle Drewry; John Kuchtey; Iris Navarro; Shruti Sharma; W Daniel Stamer; Ashok Sharma; Pratap Challa; Rachel W Kuchtey; Yutao Liu

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2142.

ARVO Annual Meeting Abstract June 2017

Angiotensin II type 1 receptor blockers lower IOP in mice and reduce TGFβ signaling in retinal ganglion cells

Ralph J Hazlewood; John Kuchtey; Rachel W Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4917.

ARVO Annual Meeting Abstract June 2017

Glaucomatous retinal dysfunction and optic nerve phenotype in microfibril deficient mice

Hang Jing Wu; George Naratadam; Ralph Hazelwood; Abudi Nashabi; John Kuchtey; Rachel W Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5854.

ARVO Annual Meeting Abstract September 2016

The glaucoma-causative gene adamts10 is required for normal retinal ganglion cell development in zebrafish

John Kuchtey; Shu-Yu Wu; Frances K. Clark; Hassane S Mchaourab; Rachel W Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):810.

ARVO Annual Meeting Abstract September 2016

Pharmacological investigations of angiotensin II type 1 receptor antagonists reveal effective physiological concentrations in the eye after administration via drinking water

Ralph J Hazlewood; George Naratadam; Sayan Paria; John Kuchtey; Rachel W Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1189.

ARVO Annual Meeting Abstract September 2016

Inner Retina Dysfunction in Microfibril Deficient Mice with Low Tension Glaucoma

Hang-Jing Wu; Sayan Paria; George Naratadam; John Kuchtey; Rachel W Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2540.

Genetics August 2016

A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium

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Yutao Liu; Jessica Cooke Bailey; Inas Helwa; W. Michael Dismuke; Jingwen Cai; Michelle Drewry; Murray H. Brilliant; Donald L. Budenz; William G. Christen; Daniel I. Chasman; John H. Fingert; Douglas Gaasterland; Terry Gaasterland; Mae O. Gordon; Robert P. Igo, Jr; Jae H. Kang; Michael A. Kass; Peter Kraft; Richard K. Lee; Paul Lichter; Sayoko E. Moroi; Anthony Realini; Julia E. Richards; Robert Ritch; Joel S. Schuman; William K. Scott; Kuldev Singh; Arthur J. Sit; Yeunjoo E. Song; Douglas Vollrath; Robert Weinreb; Felipe Medeiros; Gadi Wollstein; Donald J. Zack; Kang Zhang; Margaret A. Pericak-Vance; Pedro Gonzalez; W. Daniel Stamer; John Kuchtey; Rachel W. Kuchtey; R. Rand Allingham; Michael A. Hauser; Louis R. Pasquale; Jonathan L. Haines; Janey L. Wiggs
TAGS: micrornas, neighborhood, open-angle glaucoma, glaucoma, body tissue, hypertension, exosomes
Invest. Ophthalmol. Vis. Sci.. 2016; 57(10):4528-4535. https://doi.org/10.1167/iovs.16-19688

Includes: Supplemental Content

Glaucoma July 2015

Metabolome-Wide Association Study of Primary Open Angle Glaucoma

PDF

L. Goodwin Burgess; Karan Uppal; Douglas I. Walker; Rachel M. Roberson; ViLinh Tran; Megan B. Parks; Emily A. Wade; Alexandra T. May; Allison C. Umfress; Kelli L. Jarrell; Brooklyn O. C. Stanley; John Kuchtey; Rachel W. Kuchtey; Dean P. Jones; Milam A. Brantley, Jr
TAGS: metabolomics, open-angle glaucoma, metabolites
Invest. Ophthalmol. Vis. Sci.. 2015; 56(8):5020-5028. https://doi.org/10.1167/iovs.15-16702

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

In search of novel CYP1B1 mutations that cause primary congenital glaucoma.

Varun Reddy; Sharon Freedman; Shelby Strickland; Yu Chen-Hsin; Rachel W Kuchtey; John Kuchtey; R Rand Allingham; Michael A Hauser

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2540.

Glaucoma August 2014

Elevated Transforming Growth Factor β1 in Plasma of Primary Open-Angle Glaucoma Patients

PDF

John Kuchtey; Jessica Kunkel; L. Goodwin Burgess; Megan B. Parks; Milam A. Brantley, Jr; Rachel W. Kuchtey
TAGS: open-angle glaucoma, plasma, transforming growth factor alpha, transforming growth factors, thrombospondin 1
Invest. Ophthalmol. Vis. Sci.. 2014; 55(8):5291-5297. https://doi.org/10.1167/iovs.14-14578

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In Search of Mouse Model for Exfoliation Syndrome

Targeted genetic defects in elastic fibers cause biomechanical weakening of mouse sclera during physiological dynamic intraocular pressure changes

Investigation of fibrillin-1 and LOXL1 in ocular health and disease

Optic neuropathy associated with TGFβ dysregulation in mice with a glaucoma-causative mutation of Adamts10

Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10

Increased Susceptibility to Glaucomatous Damage in Microfibril Deficient Mice

Telmisartan Reduces Axon Degeneration in Mice With Experimental Glaucoma

Telmisartan, an angiotensin II type 1 receptor blocker, reduces IOP and prevents axon loss in mice with experimental glaucoma

Reduced number and caliber of optic nerve axons and smaller optic nerves in mice homozygous for a glaucoma-causing mutation in Adamts10

Increased susceptibility to glaucomatous optic nerve damage in microfibril deficient mice

Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma

Angiotensin II type 1 receptor blockers lower IOP in mice and reduce TGFβ signaling in retinal ganglion cells

Glaucomatous retinal dysfunction and optic nerve phenotype in microfibril deficient mice

The glaucoma-causative gene adamts10 is required for normal retinal ganglion cell development in zebrafish

Pharmacological investigations of angiotensin II type 1 receptor antagonists reveal effective physiological concentrations in the eye after administration via drinking water

Inner Retina Dysfunction in Microfibril Deficient Mice with Low Tension Glaucoma

A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium

Metabolome-Wide Association Study of Primary Open Angle Glaucoma

In search of novel CYP1B1 mutations that cause primary congenital glaucoma.

Elevated Transforming Growth Factor β1 in Plasma of Primary Open-Angle Glaucoma Patients

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