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Glaucoma October 2017

Tunneling Nanotubes are Novel Cellular Structures That Communicate Signals Between Trabecular Meshwork Cells

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Kate E. Keller; John M. Bradley; Ying Ying Sun; Yong-Feng Yang; Ted S. Acott
TAGS: actins, mitochondria, cd44 antigens, cellular structures, dimethyl sulfoxide, microscopy, confocal, software, body tissue, trabecular meshwork, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5298-5307. doi: 10.1167/iovs.17-22732

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Novel extracellular protein kinases Fam20A and Fam20C differentially distribute with MMP14 at PILS in TM cells

Mini Aga; Samuel J Berk; John M Bradley; Ted S Acott

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4701. doi:

ARVO Annual Meeting Abstract June 2015

Unidirectional transfer of cellular cargo between trabecular meshwork cells via novel actin-based filopodia

Kate E Keller; John M Bradley; Ted S Acott

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3265. doi:

ARVO Annual Meeting Abstract June 2015

Matrix metalloproteinase-14 dimerization orchestrates matrix degradation at podosome- or invadopodia-like structures (PILS) in trabecular meshwork.

Mini Aga; John M Bradley; Ted S Acott

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3283. doi:

Glaucoma September 2014

Differential Effects of Caveolin-1 and -2 Knockdown on Aqueous Outflow and Altered Extracellular Matrix Turnover in Caveolin-Silenced Trabecular Meshwork Cells

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Mini Aga; John M. Bradley; Rohan Wanchu; Yong-feng Yang; Ted S. Acott; Kate E. Keller
TAGS: extracellular matrix, fibronectins, caveolins, genes, lentivirus, matrix metalloproteinases, perfusion, trabecular meshwork, proteins, catabolism
Invest. Ophthalmol. Vis. Sci.. 2014; 55(9):5497-5509. doi: 10.1167/iovs.14-14519

Includes: Supplemental Content

Glaucoma July 2012

Perturbation of Hyaluronan Synthesis in the Trabecular Meshwork and the Effects on Outflow Facility

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Kate E. Keller; Ying Ying Sun; Yong-Feng Yang; John M. Bradley; Ted S. Acott
TAGS: western blotting, enzyme-linked immunosorbent assay, gene silencing, genes, lentivirus, perfusion, rna, messenger, suidae, body tissue, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2012; 53(8):4616-4625. doi: 10.1167/iovs.12-9500

ARVO Annual Meeting Abstract March 2012

Dynasore - A Dynamin Inhibitor Alters Outflow Facility and Endosomal Uptake in Trabecular Meshwork Cells

John M. Bradley; Mini Aga; Ted S. Acott

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3238. doi:

ARVO Annual Meeting Abstract March 2012

Gleevec Alters Endosomal Arrangement at PILS and Inhibits Extracellular Matrix (ECM) Degradation in Trabecular Meshwork Cells

Mini Aga; John M. Bradley; Mary J. Kelley; Ted S. Acott

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3251. doi:

Glaucoma September 2011

Molecular Chaperone Function for Myocilin

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Ann Marie Anderssohn; Kalani Cox; Kevin O'Malley; Scott Dees; Mojgan Hosseini; Lacey Boren; Anthony Wagner; John M. Bradley; Mary J. Kelley; Ted S. Acott
TAGS: citrate (si)-synthase, molecular chaperones, myoc gene
Invest. Ophthalmol. Vis. Sci.. 2011; 52(10):7548-7555. doi: 10.1167/iovs.11-7723

Glaucoma July 2011

Segmental Versican Expression in the Trabecular Meshwork and Involvement in Outflow Facility

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Kate E. Keller; John M. Bradley; Janice A. Vranka; Ted S. Acott
TAGS: immunohistochemistry, fluorescent antibody technique, glycosaminoglycans, lentivirus, microscopy, confocal, perfusion, proteoglycan, rna, messenger, suidae, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2011; 52(8):5049-5057. doi: 10.1167/iovs.10-6948

ARVO Annual Meeting Abstract April 2011

Stem Cell Repopulation of Trabecular Meshwork Following Cellular Loss

Mary J. Kelley; Eileen P. Ryan; John M. Bradley; Ted S. Acott

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4629. doi:

ARVO Annual Meeting Abstract April 2011

Perturbation Of Hyaluronan Synthesis By HAS Gene Silencing In The Trabecular Meshwork And The Effects On Outflow Facility

Kate E. Keller; John M. Bradley; Ying Ying Sun; Ted S. Acott

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4633. doi:

ARVO Annual Meeting Abstract April 2011

Effects Of Gleevec And Nilotinib On Trabecular Meshwork PILS And Outflow Facility

Mini Aga; John M. Bradley; Kaili Song; Mary J. Kelley; Ted Acott

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4644. doi:

Glaucoma December 2009

Differential Effects of ADAMTS-1, -4, and -5 in the Trabecular Meshwork

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Kate E. Keller; John M. Bradley; Ted S. Acott
TAGS: perfusion, rna, messenger, trabecular meshwork, adamts proteins
Invest. Ophthalmol. Vis. Sci.. 2009; 50(12):5769-5777. doi: 10.1167/iovs.09-3673

Glaucoma December 2008

Specialized Podosome- or Invadopodia-like Structures (PILS) for Focal Trabecular Meshwork Extracellular Matrix Turnover

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Mini Aga; John M. Bradley; Kate E. Keller; Mary J. Kelley; Ted S. Acott
TAGS: actins, immunohistochemistry, extracellular matrix, integrins, cdc42 gtp-binding protein, collagen, fluorescein-5-isothiocyanate, gelatinase a, matrix metalloproteinases, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2008; 49(12):5353-5365. doi: 10.1167/iovs.07-1666

Includes: Multimedia, Supplemental Content

Glaucoma June 2008

Effects of Modifiers of Glycosaminoglycan Biosynthesis on Outflow Facility in Perfusion Culture

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Kate E. Keller; John M. Bradley; Mary J. Kelley; Ted S. Acott
TAGS: immunohistochemistry, tenascin, fibronectins, chlorates, fluorescent antibody technique, glycosaminoglycans, microscopy, confocal, perfusion, suidae, eye
Invest. Ophthalmol. Vis. Sci.. 2008; 49(6):2495-2505. doi: 10.1167/iovs.07-0903

Glaucoma June 2007

Synergism of TNF and IL-1 in the Induction of Matrix Metalloproteinase-3 in Trabecular Meshwork

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Mary J. Kelley; Anastasia Y. Rose; Kaili Song; Yanwen Chen; John M. Bradley; Derek Rookhuizen; Ted S. Acott
TAGS: tumor necrosis factors, interleukin-1, stromelysin 1
Invest. Ophthalmol. Vis. Sci.. 2007; 48(6):2634-2643. doi: 10.1167/iovs.06-1445

Glaucoma December 2003

Signaling Pathways Used in Trabecular Matrix Metalloproteinase Response to Mechanical Stretch

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John M. B. Bradley; Mary J. Kelley; Anastasia Rose; Ted S. Acott
TAGS: rapamycin, gelatinase a, matrix metalloproteinases, peptide initiation factors, phosphorylation, protein structure, secondary, ribosomal protein s6 kinase, intraocular pressure, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2003; 44(12):5174-5181. doi: 10.1167/iovs.03-0213

Glaucoma June 2001

Effects of Mechanical Stretching on Trabecular Matrix Metalloproteinases

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John M. B. Bradley; Mary J. Kelley; XiangHong Zhu; Ann Marie Anderssohn; J. Preston Alexander; Ted S. Acott
TAGS: cell culture techniques, immunohistochemistry, gelatinase a, matrix metalloproteinases, tissue membrane, organ culture techniques, timp2 protein, human, intraocular pressure, stretching exercises, unit of flow rate
Invest. Ophthalmol. Vis. Sci.. 2001; 42(7):1505-1513. doi:

Glaucoma February 2000

Mediation of Laser Trabeculoplasty–Induced Matrix Metalloproteinase Expression by IL-1β and TNFα

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John M. B. Bradley; Ann Marie Anderssohn; Christine M. Colvis; Dorothy E. Parshley; XiangHong Zhu; Michael S. Ruddat; John R. Samples; Ted S. Acott
TAGS: cytokine, immunohistochemistry, cell growth, conditioning (psychology), culture media, conditioned, immunoblotting, matrix metalloproteinases, stromelysin 1, trabecular meshwork, antibodies
Invest. Ophthalmol. Vis. Sci.. 2000; 41(2):422-430. doi:

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Tunneling Nanotubes are Novel Cellular Structures That Communicate Signals Between Trabecular Meshwork Cells

Novel extracellular protein kinases Fam20A and Fam20C differentially distribute with MMP14 at PILS in TM cells

Unidirectional transfer of cellular cargo between trabecular meshwork cells via novel actin-based filopodia

Matrix metalloproteinase-14 dimerization orchestrates matrix degradation at podosome- or invadopodia-like structures (PILS) in trabecular meshwork.

Differential Effects of Caveolin-1 and -2 Knockdown on Aqueous Outflow and Altered Extracellular Matrix Turnover in Caveolin-Silenced Trabecular Meshwork Cells

Perturbation of Hyaluronan Synthesis in the Trabecular Meshwork and the Effects on Outflow Facility

Dynasore - A Dynamin Inhibitor Alters Outflow Facility and Endosomal Uptake in Trabecular Meshwork Cells

Gleevec Alters Endosomal Arrangement at PILS and Inhibits Extracellular Matrix (ECM) Degradation in Trabecular Meshwork Cells

Molecular Chaperone Function for Myocilin

Segmental Versican Expression in the Trabecular Meshwork and Involvement in Outflow Facility

Stem Cell Repopulation of Trabecular Meshwork Following Cellular Loss

Perturbation Of Hyaluronan Synthesis By HAS Gene Silencing In The Trabecular Meshwork And The Effects On Outflow Facility

Effects Of Gleevec And Nilotinib On Trabecular Meshwork PILS And Outflow Facility

Differential Effects of ADAMTS-1, -4, and -5 in the Trabecular Meshwork

Specialized Podosome- or Invadopodia-like Structures (PILS) for Focal Trabecular Meshwork Extracellular Matrix Turnover

Effects of Modifiers of Glycosaminoglycan Biosynthesis on Outflow Facility in Perfusion Culture

Synergism of TNF and IL-1 in the Induction of Matrix Metalloproteinase-3 in Trabecular Meshwork

Signaling Pathways Used in Trabecular Matrix Metalloproteinase Response to Mechanical Stretch

Effects of Mechanical Stretching on Trabecular Matrix Metalloproteinases

Mediation of Laser Trabeculoplasty–Induced Matrix Metalloproteinase Expression by IL-1β and TNFα

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