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ARVO Annual Meeting Abstract June 2022

Recombinant Human MMP-3 Increases Outflow Facility In Vivo in Non-Human Primates and Ex Vivo in Human Cadaver Eyes

Jeffrey O'Callaghan; Matthew Lawrence; Merissa O'Connor; Joseph Sherwood; Annahita Keravala; Christopher Stanley; Thomas Walter Chalberg; Matthew Campbell

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2826 – A0342. doi:

ARVO Annual Meeting Abstract June 2022

The relationship between pressure-dependent changes in outflow facility and dimensional changes in the anterior segment during perfusion of enucleated mouse eyes

Ester Reina-Torres; Joseph van Batenburg-Sherwood; Darryl R Overby

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3301 – A0401. doi:

Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. doi: https://doi.org/10.1167/iovs.63.2.12

Physiology and Pharmacology January 2022

Anterior Segment Anatomy and Conventional Outflow Physiology of the Tree Shrew ( Tupaia belangeri )

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Jessica V. Jasien; A. Thomas Read; Joseph van Batenburg-Sherwood; Kristin M. Perkumas; C. Ross Ethier; W. Daniel Stamer; Brian C. Samuels
TAGS: eye, physiology, tupaia, tupaiidae, immunohistochemistry
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):21. doi: https://doi.org/10.1167/iovs.63.1.21

ARVO Annual Meeting Abstract June 2021

TRPV4-mediated oscillatory calcium signaling in TM cells requires internal stores

David Krizaj; Sarah N Redmon; Jackson M Baumann; Joseph M Sherwood; Darryl R Overby; Oleg Yarishkin

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2749. doi:

ARVO Annual Meeting Abstract June 2021

Vasoregulator Effects on Outflow Resistance, Flow Patterns and Distal Vessels in the Conventional Outflow Pathway of Mouse and Human Eyes

Fiona S McDonnell; Todd Fleming; Megan Kuhn; Heather Schmitt; Kristin Perkumas; Joseph van Batenburg-Sherwood; Alex S Huang; Darryl R Overby; Daniel W Stamer

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):469. doi:

ARVO Annual Meeting Abstract June 2021

Elevated IOP stimulates NO-mediated IOP homeostasis in mice

Ester Reina Torres; Jason YH Chang; Joseph van Batenburg-Sherwood; Daniel W Stamer; Darryl R Overby

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2781. doi:

Glaucoma August 2020

Aqueous Humor Outflow Requires Active Cellular Metabolism in Mice

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Ester Reina-Torres; Alexandra Boussommier-Calleja; Joseph M. Sherwood; Darryl R. Overby
TAGS: aqueous humor, body temperature, eye, metabolism, mice, temperature
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):45. doi: https://doi.org/10.1167/iovs.61.10.45

ARVO Annual Meeting Abstract June 2020

Visualization of Vasoregulator Effects on Distal Outflow Vessels in Human Anterior Segments

Fiona McDonnell; Heather Schmitt; Alex Huang; Joseph Sherwood; Darryl Overby; Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2718. doi:

ARVO Annual Meeting Abstract June 2020

Effects of Endothelin-1 on Resistance and Flow Patterns in Conventional Outflow Pathway of Perfused Mouse Eyes

Todd Fleming; Fiona McDonnell; Joseph Sherwood; Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4626. doi:

Glaucoma May 2020

Age and Menopause Effects on Ocular Compliance and Aqueous Outflow

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Andrew J. Feola; Joseph M. Sherwood; Machelle T. Pardue; Darryl R. Overby; C. Ross Ethier
TAGS: glaucoma, menopause
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):16. doi: https://doi.org/10.1167/iovs.61.5.16

Glaucoma March 2020

The β 4 -Subunit of the Large-Conductance Potassium Ion Channel K Ca 1.1 Regulates Outflow Facility in Mice

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Jacques A. Bertrand; Martin Schicht; W. Daniel Stamer; David Baker; Joseph M. Sherwood; Elke Lütjen-Drecoll; David L. Selwood; Darryl R. Overby
TAGS: mice, potassium channel, eye
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):41. doi: https://doi.org/10.1167/iovs.61.3.41

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Elevated IOP increases Shear Stress in Schlemm’s Canal

Fiona McDonnell; Kristin Marie Perkumas; Nicole E. Ashpole; Joan Kalnitsky; Joseph M Sherwood; Darryl R Overby; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3181. doi:

ARVO Annual Meeting Abstract July 2019

Aqueous humour outflow requires active cellular metabolism

Ester Reina Torres; Joseph M Sherwood; Darryl R Overby

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5155. doi:

ARVO Annual Meeting Abstract July 2019

In vivo measurement of TM stiffness: proof-of-principle in mice

C Ross Ethier; Guorong Li; Chanyoung Lee; Ke Wang; Iris D Navarro; Joseph M Sherwood; Karen Crews; Sina Farsiu; Cheng-Wen Lin; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5213. doi:

ARVO Annual Meeting Abstract July 2019

Blockade of the BK- a / β 4 potassium ion channel reduces outflow facility in mice

Jacques Alexander Bertrand; Joseph M Sherwood; Martin Schicht; Elke Lütjen-Drecoll; David Selwood; William D Stamer; Darryl R Overby

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5214. doi:

ARVO Annual Meeting Abstract July 2019

Actomyosin contractility and the vimentin cytoskeleton influence giant vacuole life-cycle in Schlemm’s canal endothelial cells

Darryl R Overby; Alice Spenlehauer; Andrea Cairoli; Joseph M Sherwood; Amir Vahabikashi; W Daniel Stamer; Chiu Fan Lee

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5122. doi:

ARVO Annual Meeting Abstract July 2018

Modulation of outflow facility by the ocular pulse

Darryl R Overby; Michael Madekurozwa; W Daniel Stamer; Joseph Sherwood

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3971. doi:

ARVO Annual Meeting Abstract July 2018

INDUCIBLE MMP-3 EXPRESSION IN A STEROID-INDUCED MURINE MODEL OF GLAUCOMA

Jeffrey O'Callaghan; Paul S. Cassidy; Ester Reina-Torres; Joseph Sherwood; Marian M Humphries; Matthew Campbell; Colm J O'Brien; Elke Lütjen-Drecoll; W Daniel Stamer; Darryl R Overby; Peter Humphries

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3505. doi:

ARVO Annual Meeting Abstract July 2018

Impact of Estrogen Deficiency on Outflow Facility and Ocular Biomechanics in Rats

Andrew Feola; Joseph Sherwood; Darryl R Overby; Machelle T Pardue; C Ross Ethier

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1217. doi:

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Recombinant Human MMP-3 Increases Outflow Facility In Vivo in Non-Human Primates and Ex Vivo in Human Cadaver Eyes

The relationship between pressure-dependent changes in outflow facility and dimensional changes in the anterior segment during perfusion of enucleated mouse eyes

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Anterior Segment Anatomy and Conventional Outflow Physiology of the Tree Shrew ( Tupaia belangeri )

TRPV4-mediated oscillatory calcium signaling in TM cells requires internal stores

Vasoregulator Effects on Outflow Resistance, Flow Patterns and Distal Vessels in the Conventional Outflow Pathway of Mouse and Human Eyes

Elevated IOP stimulates NO-mediated IOP homeostasis in mice

Aqueous Humor Outflow Requires Active Cellular Metabolism in Mice

Visualization of Vasoregulator Effects on Distal Outflow Vessels in Human Anterior Segments

Effects of Endothelin-1 on Resistance and Flow Patterns in Conventional Outflow Pathway of Perfused Mouse Eyes

Age and Menopause Effects on Ocular Compliance and Aqueous Outflow

The β 4 -Subunit of the Large-Conductance Potassium Ion Channel K Ca 1.1 Regulates Outflow Facility in Mice

Elevated IOP increases Shear Stress in Schlemm’s Canal

Aqueous humour outflow requires active cellular metabolism

In vivo measurement of TM stiffness: proof-of-principle in mice

Blockade of the BK- a / β 4 potassium ion channel reduces outflow facility in mice

Actomyosin contractility and the vimentin cytoskeleton influence giant vacuole life-cycle in Schlemm’s canal endothelial cells

Modulation of outflow facility by the ocular pulse

INDUCIBLE MMP-3 EXPRESSION IN A STEROID-INDUCED MURINE MODEL OF GLAUCOMA

Impact of Estrogen Deficiency on Outflow Facility and Ocular Biomechanics in Rats

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