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Journal Articles (11)
Meeting Abstract (6)

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Investigative Ophthalmology & Visual Science (17)

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Cornea (7)
ARVO Annual Meeting Abstract (6)
Biochemistry and Molecular Biology (4)

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Eye Anatomy and Disorders (10)
Cornea (7)
Biochemistry and Molecular Biology (5)
Genetics (4)
Immunology and Microbiology (2)
Pharmacology (2)
Imaging (1)
Multidisciplinary Ophthalmic Imaging (1)
Surgery (1)

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lipids (7)
cornea (4)
tear film finding (4)
water (4)
esters (3)
evaporation (3)
cold sensation (2)
cold temperature (2)
common cold (2)
heat (physical force) (2)

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Biochemistry and Molecular Biology January 2017

The Effect of Phospholipids on Tear Film Lipid Layer Surface Activity

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Antti H. Rantamäki; Juha M. Holopainen *
TAGS: phospholipids, lipids, water, tear film finding
Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):149-154. doi: 10.1167/iovs.16-20468

ARVO Annual Meeting Abstract September 2016

Toxicity of glaucoma drugs on corneal epithelial cells

Alexandra Robciuc; Suvi Ruokonen; Joanna Witos; Antti H Rantamaki; Susanne Wiedmer; Juha M. Holopainen

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4384. doi:

ARVO Annual Meeting Abstract September 2016

Contrast sensitivity and aberrations in good and supranormal visual acuity

Jukka Ari Olavi Moilanen; Essi Peltomaa; Juha M. Holopainen

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):212. doi:

Biochemistry and Molecular Biology December 2015

The Effect of Ambient Ozone on Unsaturated Tear Film Wax Esters

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Riku O. Paananen; Antti H. Rantamäki; Jevgeni Parshintsev; Juha M. Holopainen
TAGS: esters, ozone, lipids, water, tear film finding, whole exome sequencing
Invest. Ophthalmol. Vis. Sci.. 2015; 56(13):8054-8062. doi: 10.1167/iovs.15-18398

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2014

Surface Properties of Artificial Tear Film Lipid Layers: Effects of Wax Esters

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Pipsa Kulovesi; Antti H. Rantamäki; Juha M. Holopainen
TAGS: esters, surface properties, lipids, tear film finding, evaporation
Invest. Ophthalmol. Vis. Sci.. 2014; 55(7):4448-4454. doi: 10.1167/iovs.14-14122

Cornea January 2014

Lipid-Modifying Enzymes in Human Tear Fluid and Corneal Epithelial Stress Response

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Alexandra Robciuc; Antti H. Rantamäki; Matti Jauhiainen; Juha M. Holopainen
TAGS: stress response, epithelium, bodily secretions, phospholipase, sphingolipids, cornea, enzymes, lipids, proteins, stress, vesicle
Invest. Ophthalmol. Vis. Sci.. 2014; 55(1):16-24. doi: 10.1167/iovs.13-12577

Cornea August 2013

Melting Points—The Key to the Anti-Evaporative Effect of the Tear Film Wax Esters

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Antti H. Rantamäki; Susanne K. Wiedmer; Juha M. Holopainen
TAGS: esters, lipids, temperature, water, tear film finding, evaporation, compression, liquids, melting point, whole exome sequencing
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5211-5217. doi: 10.1167/iovs.13-12408

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2012

Do Lipids Retard the Evaporation of the Tear Fluid?

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Antti H. Rantamäki; Matti Javanainen; Ilpo Vattulainen; Juha M. Holopainen
TAGS: lipids, water, evaporation
Invest. Ophthalmol. Vis. Sci.. 2012; 53(10):6442-6447. doi: 10.1167/iovs.12-10487

Cornea June 2012

Pro-Inflammatory Cytokines and Gelatinases in Climatic Droplet Keratopathy

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Juha M. Holopainen; Alexandra Robciuc; Thamara A. Cafaro; Maria F. Suarez; Yrjö T. Konttinen; Hind M. Alkatan; Khalid F. Tabbara; Taina Tervahartiala; Timo Sorsa; Julio A. Urrets-Zavalia; Horacio M. Serra
TAGS: cytokine, inflammation, gelatinase a, gelatinase b, gelatinases, matrix metalloproteinases, cornea, proteins, ultraviolet b radiation, labrador keratopathy
Invest. Ophthalmol. Vis. Sci.. 2012; 53(7):3527-3535. doi: 10.1167/iovs.12-9441

ARVO Annual Meeting Abstract March 2012

Evaporation Rate of Artificial Tear Fluid

Antti H. Rantamaki; Juha M. Holopainen

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4252. doi:

ARVO Annual Meeting Abstract March 2012

Corneal Sensitivity To Selective Stimulation In Iritis Patients

Waldir Neira; Timo T. Tervo; M.Carmen Acosta; Juha M. Holopainen; Carlos Belmonte; Juana Gallar

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1790. doi:

Cornea July 2011

Corneal Sensitivity in Diabetic Patients Subjected to Retinal Laser Photocoagulation

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Waldir Neira-Zalentein; Juha M. Holopainen; Timo M. T. Tervo; Fernando Borrás; M. Carmen Acosta; Carlos Belmonte; Juana Gallar
TAGS: diabetes mellitus, common cold, heat (physical force), lasers, light coagulation, cold temperature, cold sensation, cornea, sensory perception, myotonic dystrophy type 2
Invest. Ophthalmol. Vis. Sci.. 2011; 52(8):6043-6049. doi: 10.1167/iovs.10-7054

ARVO Annual Meeting Abstract April 2011

Human Tear Fluid Lipidome: from Composition to Function

Antti Rantamaki; Tuulikki Seppanen-Laakso; Matej Oresic; Matti Jauhiainen; Juha M. Holopainen

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3728. doi:

ARVO Annual Meeting Abstract April 2011

Treatment Of Subepithelial Limbal Fibrosis

Timo M. Tervo; Petri Järventausta; Waldir Neira; Marja-Liisa Lokki; Juha M. Holopainen

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5779. doi:

Cornea September 2010

Selective Changes in Human Corneal Sensation Associated with Herpes Simplex Virus Keratitis

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Juana Gallar; Timo M. T. Tervo; Waldir Neira; Juha M. Holopainen; Maria E. Lamberg; Fernando Miñana; M. Carmen Acosta; Carlos Belmonte
TAGS: simplexvirus, common cold, heat (physical force), keratitis, keratitis, herpetic, cold temperature, cold sensation, cornea, eye, sensory perception
Invest. Ophthalmol. Vis. Sci.. 2010; 51(9):4516-4522. doi: 10.1167/iovs.10-5225

Cornea October 2005

Interaction of Purified Tear Lipocalin with Lipid Membranes

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Heikki Saaren-Seppälä; Matti Jauhiainen; Timo M. T. Tervo; Bernhard Redl; Paavo K. J. Kinnunen; Juha M. Holopainen
TAGS: fluorescence, liposomes, tissue membrane, phospholipids, lipids
Invest. Ophthalmol. Vis. Sci.. 2005; 46(10):3649-3656. doi: 10.1167/iovs.05-0176

Cornea June 2003

Activation of Matrix Metalloproteinase-8 by Membrane Type 1-MMP and Their Expression in Human Tears after Photorefractive Keratectomy

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Juha M. Holopainen; Jukka A. O. Moilanen; Timo Sorsa; Marjo Kivelä-Rajamäki; Taina Tervahartiala; Minna H. Vesaluoma; Timo M. T. Tervo
TAGS: tissue membrane, neutrophil collagenase
Invest. Ophthalmol. Vis. Sci.. 2003; 44(6):2550-2556. doi: 10.1167/iovs.02-1190

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Online ISSN: 1552-5783

Investigative Ophthalmology & Visual Science
Journal of Vision
Translational Vision Science & Technology

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