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Retina February 2025

Targeted Microperimetry Grids for Focal Lesions in Intermediate AMD: PINNACLE Study Report 7

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Stefan Futterknecht; Philipp Anders; Julia Mai; Sophie Riedl; Ursula Hall; Chrysoula Gabrani; Kristina Pfau; Martin J. Menten; Daniel Rueckert; A. Toby Prevost; Hrvoje Bogunovic; Lars G. Fritsche; Ursula Schmidt-Erfurth; Sobha Sivaprasad; Andrew Lotery; Hendrik P. N. Scholl; Maximilian Pfau
TAGS: drusen, study report, vision, eye, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):6. https://doi.org/10.1167/iovs.66.2.6

Includes: Supplemental Content

Retina December 2024

Real-World Outcomes After Switch From Aflibercept to Faricimab in Eyes With Diabetic Macular Edema

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Kim Lien Huber; Heiko Stino; Irene Steiner; Philipp Fuchs; Felix Goldbach; Julia Mai; Bianca S. Gerendas; Katharina Kriechbaum; Ursula Schmidt-Erfurth; Andreas Pollreisz
TAGS: aflibercept, diabetic macular edema, eye, faricimab, injections, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):46. https://doi.org/10.1167/iovs.65.14.46

Includes: Supplemental Content

Retina July 2024

Sequence of Morphological Changes Preceding Atrophy in Intermediate AMD Using Deep Learning

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Sophie Riedl; Ursula Schmidt-Erfurth; Antoine Rivail; Klaudia Birner; Julia Mai; Wolf-Dieter Vogl; Zhichao Wu; Robyn H. Guymer; Hrvoje Bogunović; Gregor S. Reiter
TAGS: atrophy, cohort studies, deep learning, drusen, diagnostic imaging, eye, atrophic condition of skin
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):30. https://doi.org/10.1167/iovs.65.8.30

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Rate of response to treatment in eyes with geographic atrophy treated with Pegcetacoplan in a within-patient comparison using automated AI-based OCT biomarker quantifications in OAKS and DERBY

Gregor Sebastian Reiter; Julia Mai; Alex McKeown; Emma Foos; Amir Sadeghipour; Hrvoje Bogunovic; Ursula Schmidt-Erfurth

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6488.

ARVO Annual Meeting Abstract June 2024

Patient-tailored Microperimetry Grids for Focal Lesions in Intermediate AMD: A PINNACLE Study Report

Stefan Futterknecht; Maximilian Pfau; Philipp Anders; Julia Mai; Ursula Hall; Hrvoje Bogunovic; Lars Fritsche; Daniel Rueckert; Ursula Schmidt-Erfurth; Sobha Sivaprasad; Andrew Lotery; Hendrik P Scholl

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4386.

ARVO Annual Meeting Abstract June 2024

OCT-based AI-assisted phenotyping of intermediate AMD in the prospective PINNACLE trial

Sophie Riedl; Julia Mai; Simon Schürer-Waldheim; Georg Faustmann; Hrvoje Bogunovic; Lars Fritsche; Toby Prevost; Daniel Rueckert; Hendrik P Scholl; Sobha Sivaprasad; Andrew Lotery; Ursula Schmidt-Erfurth

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):980.

ARVO Annual Meeting Abstract June 2024

Variability of perilesional FAF patterns associated with automated OCT-based PR/RPE loss ratios in GA progression in the phase 3 OAKS/DERBY trials

Julia Mai; Gregor Sebastian Reiter; Sophie Riedl; Wolf-Dieter Vogl; Amir Sadeghipour; Alex McKeown; Hrvoje Bogunovic; Ursula Schmidt-Erfurth

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):981.

ARVO Annual Meeting Abstract June 2024

Evaluating the distribution of fundus autofluorescence phenotypes in a large, European intermediate AMD cohort and describing a novel phenotype (A PINNACLE Study Report)

Tom Taylor; Rebecca Anne Kaye; Julia Mai; Lars Fritsche; Toby Prevost; Daniel Rueckert; Hrvoje Bogunovic; Hendrik P Scholl; Ursula Schmidt-Erfurth; Sobha Sivaprasad; Andrew Lotery

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2266.

ARVO Annual Meeting Abstract June 2024

Using adaptive optics to assess hyporeflective clumps as a biomarker for progression to cRORA in the PINNACLE study

Christopher Holmes; Naomi Wijesingha; Syed Ahmer Raza; Tom Taylor; Ahmed Hagag; Sophie Riedl; Julia Mai; Daniel Rueckert; Hrvoje Bogunovic; Hendrik P Scholl; Ursula Schmidt-Erfurth; Lars Fritsche; Andrew Lotery; Sobha Sivaprasad

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3264.

ARVO Annual Meeting Abstract June 2024

Predictive value of the photoreceptor/RPE loss ratio on OCT in the management of geographic atrophy (GA) for patient selection and monitoring of therapeutic efficacy

Ursula Schmidt-Erfurth; Julia Mai; Gregor Sebastian Reiter; Sophie Riedl; Wolf-Dieter Vogl; Amir Sadeghipour; Alex McKeown; Hrvoje Bogunovic

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3263.

Artificial Intelligence June 2024

Deep Neural Networks for Automated Outer Plexiform Layer Subsidence Detection on Retinal OCT of Patients With Intermediate AMD

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Guilherme Aresta; Teresa Araujo; Gregor S. Reiter; Julia Mai; Sophie Riedl; Christoph Grechenig; Robyn H. Guymer; Zhichao Wu; Ursula Schmidt-Erfurth; Hrvoje Bogunovic
TAGS: biological markers, datasets, lead, volume, eye, deep learning
Trans. Vis. Sci. Tech.. 2024; 13(6):7. https://doi.org/10.1167/tvst.13.6.7

Retina August 2023

Comparison of Novel Volumetric Microperimetry Metrics in Intermediate Age-Related Macular Degeneration: PINNACLE Study Report 3

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Philipp Anders; Ghislaine L. Traber; Maximilian Pfau; Sophie Riedl; Ahmed M. Hagag; Hanna Camenzind; Julia Mai; Rebecca Kaye; Hrvoje Bogunović; Lars G. Fritsche; Daniel Rueckert; Ursula Schmidt-Erfurth; Sobha Sivaprasad; Andrew J. Lotery; Hendrik P. N. Scholl
TAGS: age-related macular degeneration, study report, visual acuity, software
Trans. Vis. Sci. Tech.. 2023; 12(8):21. https://doi.org/10.1167/tvst.12.8.21

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Comparison of artificial intelligence-based OCT and manual fundus autofluorescence measurements of geographic atrophy in the phase III OAKS/DERBY trials

Julia Mai; Gregor Sebastian Reiter; Wolf-Dieter Vogl; Amir Sadeghipour; Emma Foos; Hrvoje Bogunovic; Ursula Schmidt-Erfurth

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1875.

ARVO Annual Meeting Abstract June 2023

Regional Variation of Retinal Sensitivity in Intermediate AMD in the PINNACLE study

Philipp Anders; Ghislaine L Traber; Maximilian Pfau; Sophie Riedl; Julia Mai; Hanna Camenzind; Chrysoula Gabrani; Rebecca Kaye; Toby Prevost; Hrvoje Bogunovic; Lars G Fritsche; Daniel Rueckert; Ursula Schmidt-Erfurth; Sobha Sivaprasad; Andrew J Lotery; Hendrik P Scholl

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4328.

ARVO Annual Meeting Abstract June 2023

Self-supervised machine learning for individual prediction of conversion to neovascular AMD in PINNACLE study

Arunava Chakravarty; Taha Emre; Oliver Leingang; Sophie Riedl; Julia Mai; Hendrik P Scholl; Sobha Sivaprasad; Lars G Fritsche; Daniel Rueckert; Andrew J Lotery; Ursula Schmidt-Erfurth; Hrvoje Bogunovic

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):545.

ARVO Annual Meeting Abstract June 2023

Label-efficient retinal OCT classification and segmentation using image restoration-based self-supervised learning

Hrvoje Bogunovic; Antoine Rivail; Botond Fazekas; Dmitrii Lachinov; Julia Mai; Ursula Schmidt-Erfurth

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5447.

ARVO Annual Meeting Abstract June 2023

Disease activity of geographic atrophy in fellow eyes of the pegcetacoplan phase III studies measured by automated AI-based OCT biomarker quantifications

Gregor Sebastian Reiter; Julia Mai; Sophie Frank; Oliver Leingang; Wolf-Dieter Vogl; Amir Sadeghipour; Hrvoje Bogunovic; Ursula Schmidt-Erfurth

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):317.

ARVO Annual Meeting Abstract June 2023

Therapeutic effect of pegcetacoplan on retinal pigment epithelium (RPE) and photoreceptor (PR) integrity in geographic atrophy (GA) in the phase III OAKS and DERBY trials

Ursula Schmidt-Erfurth; Julia Mai; Gregor Sebastian Reiter; Wolf-Dieter Vogl; Amir Sadeghipour; Alex Scott McKeown; Hrvoje Bogunovic

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):919.

ARVO Annual Meeting Abstract June 2023

Deciphering hypereflective foci in age related macular degeneration using adaptive optics in the PINNACLE Study

Christopher Holmes; Syed Ahmer Raza; Ahmed M Hagag; Thomas Taylor; Sophie Riedl; Julia Mai; Toby Prevost; Daniel Rueckert; Hrvoje Bogunovic; Hendrik P Scholl; Ursula Schmidt-Erfurth; Lars G Fritsche; Andrew J Lotery; Sobha Sivaprasad

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2171.

ARVO Annual Meeting Abstract June 2022

GA area measured by SD-OCT shows good correspondence with FAF-based measurements in patients enrolled in the FILLY trial

Julia Mai; Dmitrii Lachinov; Sophie Riedl; Gregor Sebastian Reiter; Wolf-Dieter Vogl; Hrvoje Bogunovic; Ursula Schmidt-Erfurth

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1015 – F0262.

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Targeted Microperimetry Grids for Focal Lesions in Intermediate AMD: PINNACLE Study Report 7

Real-World Outcomes After Switch From Aflibercept to Faricimab in Eyes With Diabetic Macular Edema

Sequence of Morphological Changes Preceding Atrophy in Intermediate AMD Using Deep Learning

Rate of response to treatment in eyes with geographic atrophy treated with Pegcetacoplan in a within-patient comparison using automated AI-based OCT biomarker quantifications in OAKS and DERBY

Patient-tailored Microperimetry Grids for Focal Lesions in Intermediate AMD: A PINNACLE Study Report

OCT-based AI-assisted phenotyping of intermediate AMD in the prospective PINNACLE trial

Variability of perilesional FAF patterns associated with automated OCT-based PR/RPE loss ratios in GA progression in the phase 3 OAKS/DERBY trials

Evaluating the distribution of fundus autofluorescence phenotypes in a large, European intermediate AMD cohort and describing a novel phenotype (A PINNACLE Study Report)

Using adaptive optics to assess hyporeflective clumps as a biomarker for progression to cRORA in the PINNACLE study

Predictive value of the photoreceptor/RPE loss ratio on OCT in the management of geographic atrophy (GA) for patient selection and monitoring of therapeutic efficacy

Deep Neural Networks for Automated Outer Plexiform Layer Subsidence Detection on Retinal OCT of Patients With Intermediate AMD

Comparison of Novel Volumetric Microperimetry Metrics in Intermediate Age-Related Macular Degeneration: PINNACLE Study Report 3

Comparison of artificial intelligence-based OCT and manual fundus autofluorescence measurements of geographic atrophy in the phase III OAKS/DERBY trials

Regional Variation of Retinal Sensitivity in Intermediate AMD in the PINNACLE study

Self-supervised machine learning for individual prediction of conversion to neovascular AMD in PINNACLE study

Label-efficient retinal OCT classification and segmentation using image restoration-based self-supervised learning

Disease activity of geographic atrophy in fellow eyes of the pegcetacoplan phase III studies measured by automated AI-based OCT biomarker quantifications

Therapeutic effect of pegcetacoplan on retinal pigment epithelium (RPE) and photoreceptor (PR) integrity in geographic atrophy (GA) in the phase III OAKS and DERBY trials

Deciphering hypereflective foci in age related macular degeneration using adaptive optics in the PINNACLE Study

GA area measured by SD-OCT shows good correspondence with FAF-based measurements in patients enrolled in the FILLY trial

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