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Cornea May 2022

Comprehensive Analysis Identified the Circadian Clock and Global Circadian Gene Expression in Human Corneal Endothelial Cells

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Hiroko Nakai; Yoshiki Tsuchiya; Nobuya Koike; Taiki Asano; Morio Ueno; Yasuhiro Umemura; Yuh Sasawaki; Ryutaro Ono; Junji Hamuro; Chie Sotozono; Kazuhiro Yagita
TAGS: circadian clocks, cornea, endothelial cells, gene expression, chronic exertional compartment syndrome, genes, rhythm, bioluminescence
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):16. doi: https://doi.org/10.1167/iovs.63.5.16

Includes: Multimedia, Supplemental Content

Cornea April 2022

Repressed miR-34a Expression Dictates the Cell Fate to Corneal Endothelium Failure

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Junji Hamuro; Kazuko Asada; Morio Ueno; Tomoko Yamashita; Atsushi Mukai; Tomoko Fujita; Eiko Ito; Nao Hiramoto; Munetoyo Toda; Chie Sotozono; Shigeru Kinoshita
TAGS: cd44 antigens, cells, corneal endothelium, gelatinase a, homing-associated cell adhesion molecule, micrornas, mitochondria, patient simulation, prostate health index, protected health information
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):22. doi: https://doi.org/10.1167/iovs.63.4.22

Includes: Supplemental Content

Cornea December 2020

Mitochondria as a Platform for Dictating the Cell Fate of Cultured Human Corneal Endothelial Cells

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Kohsaku Numa; Morio Ueno; Tomoko Fujita; Koji Ueda; Nao Hiramoto; Atushi Mukai; Yuichi Tokuda; Masakazu Nakano; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro

Invest. Ophthalmol. Vis. Sci.. 2020; 61(14):10. doi: https://doi.org/10.1167/iovs.61.14.10

Includes: Supplemental Content

Physiology and Pharmacology May 2020

Polarized Expression of Ion Channels and Solute Carrier Family Transporters on Heterogeneous Cultured Human Corneal Endothelial Cells

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Junji Hamuro; Hideto Deguchi; Tomoko Fujita; Koji Ueda; Yuichi Tokuda; Nao Hiramoto; Kohsaku Numa; Masakazu Nakano; John Bush; Morio Ueno; Chie Sotozono; Shigeru Kinoshita
TAGS: cornea, endothelial cells, family, heterogeneity, ion channels, membrane transport proteins, slc transporters, solutes, proteins, metabolism
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):47. doi: https://doi.org/10.1167/iovs.61.5.47

Includes: Supplemental Content

Cornea February 2020

Metabolites Interrogation in Cell Fate Decision of Cultured Human Corneal Endothelial Cells

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Junji Hamuro; Kohsaku Numa; Tomoko Fujita; Munetoyo Toda; Koji Ueda; Yuichi Tokuda; Atushi Mukai; Masakazu Nakano; Morio Ueno; Shigeru Kinoshita; Chie Sotozono
TAGS: cornea, endothelial cells, lactic acid, metabolites, pyruvic acid, small patella syndrome, sodium polystyrene sulfonate, stiff-person syndrome, enzymes
Invest. Ophthalmol. Vis. Sci.. 2020; 61(2):10. doi: https://doi.org/10.1167/iovs.61.2.10

Includes: Supplemental Content

Physiology and Pharmacology September 2019

In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots

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Munetoyo Toda; Hiroshi Yukawa; Jun Yamada; Morio Ueno; Shigeru Kinoshita; Yoshinobu Baba; Junji Hamuro
TAGS: anterior chamber of eye, cornea, endothelial cells, eye, fluorescence, mice, quantum dots, diagnostic imaging, injections
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):4008-4020. doi: https://doi.org/10.1167/iovs.19-27788

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Ten-Year of Glaucoma Transition Rate on the Basis of Optic Nerve Morphology in Normal Japanese Subjects

Yoko Ikeda; Kazuhiko Mori; Morio Ueno; Yuko Maruyama; Kengo Yoshii; Junji Hamuro; Chie Sotozono; Shigeru Kinoshita

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1968. doi:

ARVO Annual Meeting Abstract July 2019

A Non-Invasive Physical Biomarker for Evaluation of Corneal Endothelial Cells

Hiroshi Tanaka; Akihisa Yamamoto; Munetoyo Toda; Chie Sotozono; Junji Hamuro; Shigeru Kinoshita; Morio Ueno; Motomu Tanaka

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2156. doi:

ARVO Annual Meeting Abstract July 2019

Factors influencing the health and longevity of donor corneal endothelial cells

Munetoyo Toda; Koji Kitazawa; Morio Ueno; Yuko Maruyama; Asako Uehara; Chie Sotozono; Junji Hamuro; Shigeru Kinoshita

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3819. doi:

Retina December 2018

Association of Upregulated Angiogenic Cytokines With Choroidal Abnormalities in Chronic Central Serous Chorioretinopathy

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Nobuhiro Terao; Hideki Koizumi; Kentaro Kojima; Tetsuya Yamagishi; Kenji Nagata; Koji Kitazawa; Yuji Yamamoto; Kengo Yoshii; Asako Hiraga; Munetoyo Toda; Shigeru Kinoshita; Chie Sotozono; Junji Hamuro
TAGS: central serous chorioretinopathy, cytokine, hypertension, angiogenesis, choroid
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5924-5931. doi: https://doi.org/10.1167/iovs.18-25517

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

In vivo corneal endothelial cell findings after the infusion of cultivated HCECs into the anterior chamber with a slit-scanning wide-field contact specular microscope

Hiroshi Tanaka; Morio Ueno; Yuji Yamamoto; Naoki Okumura; Noriko Koizumi; Kojiro Imai; Michio Hagiya; Junji Hamuro; Chie Sotozono; Shigeru Kinoshita

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1456. doi:

ARVO Annual Meeting Abstract June 2017

Investigation of the interactions between macrophages and retinal pigment epithelium (RPE) cells in AMD

Takahiro Yamawaki; Eiko Ito; Jun Yamada; Shigeru Kinoshita; Chie Sotozono; Junji Hamuro

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5737. doi:

Cornea April 2017

Production of Homogeneous Cultured Human Corneal Endothelial Cells Indispensable for Innovative Cell Therapy

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Munetoyo Toda; Morio Ueno; Asako Hiraga; Kazuko Asada; Monty Montoya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
TAGS: cd44 antigens, cell therapy, cornea, endothelial cells, homing-associated cell adhesion molecule, homogeneity, donors, small patella syndrome, sodium polystyrene sulfonate, stiff-person syndrome
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2011-2020. doi: https://doi.org/10.1167/iovs.16-20703

Retina November 2016

The Ingenious Interactions Between Macrophages and Functionally Plastic Retinal Pigment Epithelium Cells

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Takahiro Yamawaki; Eiko Ito; Atsushi Mukai; Morio Ueno; Jun Yamada; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
TAGS: coculture techniques, cytokine, interleukin-6, macrophages, massively-parallel genome sequencing, monocyte chemoattractant protein-1, mucopolysaccharidoses, retinal pigment cell, vascular endothelial growth factor a, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2016; 57(14):5945-5953. doi: https://doi.org/10.1167/iovs.16-20604

Includes: Supplemental Content

Cornea October 2016

MicroRNA Profiles Qualify Phenotypic Features of Cultured Human Corneal Endothelial Cells

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Morio Ueno; Kazuko Asada; Munetoyo Toda; Asako Hiraga; Monty Montoya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
TAGS: cornea, endothelial cells, micrornas, phenotype, small patella syndrome, sodium polystyrene sulfonate, stiff-person syndrome, cd44 antigens, homing-associated cell adhesion molecule, patient simulation
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5509-5517. doi: https://doi.org/10.1167/iovs.16-19804

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Profiles of cytokines in the aqueous humor and serum of bullous keratopathy patients

Morio Ueno; Munetoyo Toda; Asako Hiraga; Koichi Wakimasu; Noriko Koizumi; Naoki Okumura; Kazuko Asada; Chie Sotozono; Junji Hamuro; Shigeru Kinoshita

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):898. doi:

ARVO Annual Meeting Abstract September 2016

Regulation of mitochondrial respiration under cell culture stress in human corneal endothelial cells

Shigeru Kinoshita; Morio Ueno; Kazuko Asada; Munetoyo Toda; Kazue Nagata; Chie Sotozono; Nobuyoshi Kosaka; Takahiro Ochiya; Junji Hamuro

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Allogeneic sensitization and tolerance induction post corneal endothelial cell injection into the anterior chamber

Jun Yamada; Morio Ueno; Munetoyo Toda; Katsuhiko Shinomiya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

The role of dysregulated expression of miRs in the pathogenesis of bullous keratopathy and Fuchs’ endothelial corneal dystrophy

Kazuko Asada; Morio Ueno; Munetoyo Toda; Asako Hiraga; Monty Montoya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4927. doi:

ARVO Annual Meeting Abstract September 2016

The high expression of C1q and tumor necrosis factor- related protein (CTRP) 6, a new complement regulatory factor, in the drusen of age-related macular degeneration eyes

Katsuhiko Shinomiya; Atsushi Mukai; Kazuhito Yoneda; Morio Ueno; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5013. doi:

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Comprehensive Analysis Identified the Circadian Clock and Global Circadian Gene Expression in Human Corneal Endothelial Cells

Repressed miR-34a Expression Dictates the Cell Fate to Corneal Endothelium Failure

Mitochondria as a Platform for Dictating the Cell Fate of Cultured Human Corneal Endothelial Cells

Polarized Expression of Ion Channels and Solute Carrier Family Transporters on Heterogeneous Cultured Human Corneal Endothelial Cells

Metabolites Interrogation in Cell Fate Decision of Cultured Human Corneal Endothelial Cells

In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots

Ten-Year of Glaucoma Transition Rate on the Basis of Optic Nerve Morphology in Normal Japanese Subjects

A Non-Invasive Physical Biomarker for Evaluation of Corneal Endothelial Cells

Factors influencing the health and longevity of donor corneal endothelial cells

Association of Upregulated Angiogenic Cytokines With Choroidal Abnormalities in Chronic Central Serous Chorioretinopathy

In vivo corneal endothelial cell findings after the infusion of cultivated HCECs into the anterior chamber with a slit-scanning wide-field contact specular microscope

Investigation of the interactions between macrophages and retinal pigment epithelium (RPE) cells in AMD

Production of Homogeneous Cultured Human Corneal Endothelial Cells Indispensable for Innovative Cell Therapy

The Ingenious Interactions Between Macrophages and Functionally Plastic Retinal Pigment Epithelium Cells

MicroRNA Profiles Qualify Phenotypic Features of Cultured Human Corneal Endothelial Cells

Profiles of cytokines in the aqueous humor and serum of bullous keratopathy patients

Regulation of mitochondrial respiration under cell culture stress in human corneal endothelial cells

Allogeneic sensitization and tolerance induction post corneal endothelial cell injection into the anterior chamber

The role of dysregulated expression of miRs in the pathogenesis of bullous keratopathy and Fuchs’ endothelial corneal dystrophy

The high expression of C1q and tumor necrosis factor- related protein (CTRP) 6, a new complement regulatory factor, in the drusen of age-related macular degeneration eyes

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