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ARVO Annual Meeting Abstract June 2022

Cell-Penetrable Protease-Resistant Amphiphilic Minichaperones for Treating Protein Misfolding Diseases

Puttur Santhoshkumar; Goutham Shankar; Swati Srivastava; SUNDARARAJAN MAHALINGAM; Gina Broitman-Maduro; Morris Maduro; Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):67 – A0040. doi:

ARVO Annual Meeting Abstract June 2022

Consequences of eliminating 52 LFRTVL 57 residues from the N-terminal domain of αA-crystallin on structure and function of the protein

SUNDARARAJAN MAHALINGAM; Goutham Shankar; Puttur Santhoshkumar; Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4048 – F0012. doi:

ARVO Annual Meeting Abstract June 2021

Cell-penetrable, protease-resistant αA-crystallin-derived peptide chaperone triggers cell stress response pathways and alleviates β-amyloid engendered toxicity in Caenorhabditis elegans

Puttur Santhoshkumar; Swati Srivastava; SUNDARARAJAN MAHALINGAM; Gina Broitman-Maduro; Madhu Sudhana Saddala; Akash Verma; Anil Bhatia; Jay S Kirkwood; Morris F Maduro; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):226. doi:

ARVO Annual Meeting Abstract June 2021

αB-crystallin super chaperone for treating protein aggregation diseases

SUNDARARAJAN MAHALINGAM; Swati Srivastava; Puttur Santhoshkumar; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2061. doi:

ARVO Annual Meeting Abstract June 2020

Molecular basis for the activation of αB-crystallin chaperone-like function after deletion of the 54-61 sequence (αBΔ54-61)

SUNDARARAJAN MAHALINGAM; Srabani Karmakar; Puttur Santhoshkumar; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):783. doi:

ARVO Annual Meeting Abstract June 2020

A cell-penetrable mini-chaperone extends the lifespan of Caenorhabditis elegans and alleviates β amyloid-induced toxicity

Puttur Santhoshkumar; Swati Srivastava; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4488. doi:

ARVO Annual Meeting Abstract July 2019

Cell-Penetrable and in vivo activatable mini-chaperones for stabilizing misfolded proteins

Puttur Santhoshkumar; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3424. doi:

ARVO Annual Meeting Abstract July 2019

Minichaperones inhibit the hemolytic activity of Mellitin

K Krishna Sharma; Puttur Santhoshkumar

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5696. doi:

ARVO Annual Meeting Abstract June 2017

Intracellular expression of mini-chaperone confers resistance to apoptosis from oxidative and thermal stress in cos7 cells

Puttur Santhoshkumar; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4502. doi:

ARVO Annual Meeting Abstract June 2017

αA-crystallin derived mini chaperone stabilizes bovine γ-crystallin aggregation by affecting its zeta (ζ) potential.

Ashutosh Phadte; Puttur Santhoshkumar; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5299. doi:

ARVO Annual Meeting Abstract June 2017

Synthesis and Characterization of Cell-penetrating Peptide Chaperone

K Krishna Sharma; Murugesan Raju; Puttur Santhoshkumar

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5598. doi:

ARVO Annual Meeting Abstract September 2016

LOSS OF FUNCTION IN αA-CRYSTALLIN MUTANT G98R IS RESCUED BY A COMPENSATORY MUTATION IN THE N-TERMINAL OF THE PROTEIN.

Ashutosh Phadte; Puttur Santhoshkumar; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):728. doi:

ARVO Annual Meeting Abstract September 2016

Mini-chaperone peptide binding sites in mutant αA-G98R protein and its efficacy to stabilize mutant protein in HLE-B3 cells

Murugesan Raju; Puttur Santhoshkumar; Ashutosh Phadte; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):732. doi:

ARVO Annual Meeting Abstract September 2016

Intraocular lens loaded with anti-EMT drug combinations a feasible strategy for long-term suppression of Posterior Cataract Opacification

Puttur Santhoshkumar; Murugesan Raju; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2020. doi:

ARVO Annual Meeting Abstract June 2015

Structural and Functional Studies of Substrate Recognition by Alpha Crystallin and N terminal deletion mutant αBΔ54-61

Srabani Karmakar; Tommi White; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5588. doi:

ARVO Annual Meeting Abstract June 2015

Characterization of a of αA crystallin mutant αAR21Q implicated in congenital cataract

Ashutosh S Phadte; Puttur Santhoshkumar; K Krishna Sharma

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5589. doi:

Lens August 2014

Histone Deacetylase Inhibitors Trichostatin A and Vorinostat Inhibit TGFβ2-Induced Lens Epithelial-to-Mesenchymal Cell Transition

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Leike Xie; Puttur Santhoshkumar; Lixing W. Reneker; K. Krishna Sharma
TAGS: epithelium, histone deacetylase, lens (device), lens, crystalline, vorinostat, histone deacetylase inhibitors, epithelial to mesenchymal transition
Invest. Ophthalmol. Vis. Sci.. 2014; 55(8):4731-4740. doi: https://doi.org/10.1167/iovs.14-14109

ARVO Annual Meeting Abstract April 2014

Addition of αA-Crystallin Sequence 163-173 to αA-Mini-chaperone, DFVIFLDVKHFSPEDLT Alters The Conformation But Retains The Chaperone Activity

Krishna Sharma; Raju Murugesan; Puttur Santhoshkumar

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5725. doi:

ARVO Annual Meeting Abstract June 2013

Histone Deacetylase Inhibitors Trichostatin A and Vorinostat Inhibit TGF-β2 -Induced Epithelial to Mesenchymal Cell Transition of Lens Epithelium

K Krishna Sharma; Leike Xie; Puttur Santhoshkumar; Lixing Reneker

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2953. doi:

Physiology and Pharmacology April 2013

Antiapoptotic Properties of α-Crystallin–Derived Peptide Chaperones and Characterization of Their Uptake Transporters in Human RPE Cells

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Parameswaran G. Sreekumar; Paresh Chothe; Krishna K. Sharma; Rinku Baid; Uday Kompella; Christine Spee; Nandini Kannan; Christina Manh; Stephen J. Ryan; Vadivel Ganapathy; Ram Kannan; David R. Hinton
TAGS: crystallins, molecular chaperones, peptides, retinal pigment cell, membrane transport proteins, antiapoptotic agents
Invest. Ophthalmol. Vis. Sci.. 2013; 54(4):2787-2798. doi: https://doi.org/10.1167/iovs.12-11571

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Cell-Penetrable Protease-Resistant Amphiphilic Minichaperones for Treating Protein Misfolding Diseases

Consequences of eliminating 52 LFRTVL 57 residues from the N-terminal domain of αA-crystallin on structure and function of the protein

Cell-penetrable, protease-resistant αA-crystallin-derived peptide chaperone triggers cell stress response pathways and alleviates β-amyloid engendered toxicity in Caenorhabditis elegans

αB-crystallin super chaperone for treating protein aggregation diseases

Molecular basis for the activation of αB-crystallin chaperone-like function after deletion of the 54-61 sequence (αBΔ54-61)

A cell-penetrable mini-chaperone extends the lifespan of Caenorhabditis elegans and alleviates β amyloid-induced toxicity

Cell-Penetrable and in vivo activatable mini-chaperones for stabilizing misfolded proteins

Minichaperones inhibit the hemolytic activity of Mellitin

Intracellular expression of mini-chaperone confers resistance to apoptosis from oxidative and thermal stress in cos7 cells

αA-crystallin derived mini chaperone stabilizes bovine γ-crystallin aggregation by affecting its zeta (ζ) potential.

Synthesis and Characterization of Cell-penetrating Peptide Chaperone

LOSS OF FUNCTION IN αA-CRYSTALLIN MUTANT G98R IS RESCUED BY A COMPENSATORY MUTATION IN THE N-TERMINAL OF THE PROTEIN.

Mini-chaperone peptide binding sites in mutant αA-G98R protein and its efficacy to stabilize mutant protein in HLE-B3 cells

Intraocular lens loaded with anti-EMT drug combinations a feasible strategy for long-term suppression of Posterior Cataract Opacification

Structural and Functional Studies of Substrate Recognition by Alpha Crystallin and N terminal deletion mutant αBΔ54-61

Characterization of a of αA crystallin mutant αAR21Q implicated in congenital cataract

Histone Deacetylase Inhibitors Trichostatin A and Vorinostat Inhibit TGFβ2-Induced Lens Epithelial-to-Mesenchymal Cell Transition

Addition of αA-Crystallin Sequence 163-173 to αA-Mini-chaperone, DFVIFLDVKHFSPEDLT Alters The Conformation But Retains The Chaperone Activity

Histone Deacetylase Inhibitors Trichostatin A and Vorinostat Inhibit TGF-β2 -Induced Epithelial to Mesenchymal Cell Transition of Lens Epithelium

Antiapoptotic Properties of α-Crystallin–Derived Peptide Chaperones and Characterization of Their Uptake Transporters in Human RPE Cells

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