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Cornea June 2025

Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene

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Yuki Oyama; Suguru Ito; Taichi Yuasa; Mizuki Ueda; Satoshi Chiba; Tatsuya Nakagawa; Ayaka Izumi; Masahito Ikawa; Noriko Koizumi; Naoki Okumura
TAGS: endothelium, genes, hereditary corneal dystrophy, mice, trinucleotide repeat expansion, cornea, sequence analysis, rna
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):18. https://doi.org/10.1167/iovs.66.6.18

Includes: Supplemental Content

Cornea April 2025

Heterozygous Tcf4 Deficiency Mitigates Fuchs Endothelial Corneal Dystrophy Progression in a Mouse Model

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Suguru Ito; Yuki Oyama; Taichi Yuasa; Koki Amano; Kotaro Onishi; Ayaka Izumi; Albert S. Jun; Masahito Ikawa; Noriko Koizumi; Naoki Okumura
TAGS: cornea, endothelium, hereditary corneal dystrophy, heterozygote, mice, endothelial cells, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):19. https://doi.org/10.1167/iovs.66.4.19

Includes: Supplemental Content

Cornea March 2025

The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

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Tatsuya Nakagawa; Tetsuro Honda; Taichi Yuasa; Go Nishiuchi; Masakazu Sato; Ayumi Tokunaga; Makiko Nakahara; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Prema Padmanabhan; Amit Chatterjee; Gajanan Sathe; Vivek Ghose; Narayanan Janakiraman; Derek J. Blake; Noriko Koizumi; Sailaja Elchuri; Naoki Okumura
TAGS: apoptosis, cornea, endothelial cells, endothelium, genes, hereditary corneal dystrophy, pathogenesis, proteins, western blotting, liquid chromatography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):16. https://doi.org/10.1167/iovs.66.3.16

Includes: Supplemental Content

Cornea June 2024

Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy

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Tetsuro Honda; Tatsuya Nakagawa; Taichi Yuasa; Yuichi Tokuda; Masakazu Nakano; Kei Tashiro; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Koji Yamamoto; Noriko Koizumi; Naoki Okumura
TAGS: hereditary corneal dystrophy, protein isoforms, rna-seq, exons, cornea, endothelial cells, endothelium, datasets
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):27. https://doi.org/10.1167/iovs.65.6.27

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Investigation of the feasibility of long-term cryopreservation of cultured human corneal endothelial cells for manufacturing cellular products

Sora Tanaka; Naoki Okumura; Yuna Miyawaki; Yu Shima; Chieri Izumi; Makiko Nakahara; Yasushi Matsuoka; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4163.

ARVO Annual Meeting Abstract June 2024

Corneal Endothelial Cell Density of Cytomegalovirus Corneal Endotheliitis Cases

Toshihide Ikeda; Hideki Fukuoka; Koji Kitazawa; Tsutomu Inatomi; Noriko Koizumi; Chie Sotozono

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4142.

ARVO Annual Meeting Abstract June 2024

Investigation of the TCF4 Aberrant Splicing in the Corneal Endothelial Cells of Patients with Fuchs Endothelial Corneal Dystrophy

Taichi Yuasa; Naoki Okumura; Tatsuya Nakagawa; Tetsuro Honda; Ayana Tateishi; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Yuichi Tokuda; Masakazu Nakano; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5814.

ARVO Annual Meeting Abstract June 2024

Evaluation of the feasibility of caspase inhibitor eye drops as a treatment for Fuchs endothelial corneal dystrophy in a mouse model

Sohya Fujimoto; Naoki Okumura; Hirotaka Haraguchi; Ayaka Izumi; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5812.

ARVO Annual Meeting Abstract June 2024

Feasibility of using a novel endoplasmic reticulum stress inhibitor as potential therapy for Fuchs endothelial corneal dystrophy

Kanna Hasegawa; Naoki Okumura; Ryo Hirota; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Masahiro Abo; Motonari Uesugi; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5810.

ARVO Annual Meeting Abstract June 2024

Evaluation of the effect of mTOR signaling inhibition on Fuchs endothelial corneal dystrophy by generating an mTOR conditional knock-out mouse model

Suguru Ito; Naoki Okumura; Koki Amano; Yuki Oyama; Ayaka Izumi; Masahito Ikawa; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5809.

ARVO Annual Meeting Abstract June 2024

Establishment of cellular models of Fuchs endothelial corneal dystrophy with and without the expansion of a trinucleotide repeat in TCF4

Keita Miyadai; Naoki Okumura; Mari Yasunaga; Tatsuya Nakagawa; Renya Kamada; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Makiko Nakahara; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5806.

ARVO Annual Meeting Abstract June 2024

Association between subjective symptoms and severities in patients with Fuchs endothelial corneal dystrophy

Yo Koizumi; Yoshinori Oie; Kazunori Miyata; Akira Kobayashi; Chie Sotozono; Masakazu Yamada; takahiko hayashi; Takefumi Yamaguchi; Atsushi Shiraishi; Masahiro Yamaguchi; Tomohiko Usui; Masatoshi Hirayama; Ryo Kawasaki; Kohji Nishida

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5782.

ARVO Annual Meeting Abstract June 2023

Investigation of the TCF4 Splicing and Isoform Expressions in the Corneal Endothelial Cells of Patients with Fuchs Endothelial Corneal Dystrophy

Tetsuro Honda; Naoki Okumura; Tatsuya Nakagawa; Ayana Tateishi; Koji Yamamoto; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E. Kruse; Yuichi Tokuda; Masakazu Nakano; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):OD23.

ARVO Annual Meeting Abstract June 2023

Feasibility of injection of cryopreserved cultured human corneal endothelial cells for the treatment of corneal endothelial decompensation by using a rabbit model

Riko Hadano; Naoki Okumura; Kayoko Yamaguchi; Shuhei Kitayama; Reo Shibazaki; Kanta Ueda; Ayaka Izumi; Yasushi Matsuoka; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):654.

ARVO Annual Meeting Abstract June 2023

Generation and RNA Sequencing Analysis of Potential Mouse Model for Fuchs Endothelial Corneal Dystrophy Harboring CTG Trinucleotide Intronic Repeat Expansion in Tcf4

Mizuki Ueda; Naoki Okumura; Tatsuya Nakagawa; Yuki Oyama; Satoshi Chiba; Ayana Tateishi; Koki Amano; Ayaka Izumi; Masahito Ikawa; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):653.

ARVO Annual Meeting Abstract June 2023

Identification of Sex-Biased Genes in the Human Corneal Endothelial Cells by using RNA Sequencing Analysis

Soichiro Inagaki; Naoki Okumura; Tatsuya Nakagawa; Ayana Tateishi; Yuya Komori; Naoya Hanada; Yuichi Tokuda; Masakazu Nakano; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):649.

ARVO Annual Meeting Abstract June 2023

A Feasibility of Computational Drug Screening for Fuchs Endothelial Corneal Dystrophy

Itsuki Oka; Naoki Okumura; Tatsuya Nakagawa; Kota Imai; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E. Kruse; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):648.

ARVO Annual Meeting Abstract June 2023

RNA Sequencing Analysis of Corneal Endothelial Cells Derived from Fuchs Endothelial Corneal Dystrophy Patients with and without Trinucleotide Repeat Expansion in TCF4

Yoshiaki Toyokawa; Naoki Okumura; Tatsuya Nakagawa; Ayana Tateishi; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E. Kruse; Yuichi Tokuda; Masakazu Nakano; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):640.

ARVO Annual Meeting Abstract June 2023

The Relationship between Triplet Repeats in the TCF4 Gene and Progression of Fuchs Endothelial Corneal Dystrophy over One Year

Oliver Dorado Cortez; Emmanuel Crouzet; Marie Caroline Trone; Philippe Gain; Zhiguo HE; Hanielle Vaitinadapoule; Marielle Mentek; Frédéric Mascarelli; Sylvain POINARD; Go Nishiuchi; Mari Yasunaga; Noriko Koizumi; Naoki Okumura; Gilles Thuret

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):619.

ARVO Annual Meeting Abstract June 2023

AI model for predicting the diagnosis of infectious keratitis

Takaki Sato; Naoki Okumura; Takuya Matsumura; Sangavi Saravana; Meena Lakshmipathy; Rachapalle Sudhir; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2392.

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Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene

Heterozygous Tcf4 Deficiency Mitigates Fuchs Endothelial Corneal Dystrophy Progression in a Mouse Model

The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy

Investigation of the feasibility of long-term cryopreservation of cultured human corneal endothelial cells for manufacturing cellular products

Corneal Endothelial Cell Density of Cytomegalovirus Corneal Endotheliitis Cases

Investigation of the TCF4 Aberrant Splicing in the Corneal Endothelial Cells of Patients with Fuchs Endothelial Corneal Dystrophy

Evaluation of the feasibility of caspase inhibitor eye drops as a treatment for Fuchs endothelial corneal dystrophy in a mouse model

Feasibility of using a novel endoplasmic reticulum stress inhibitor as potential therapy for Fuchs endothelial corneal dystrophy

Evaluation of the effect of mTOR signaling inhibition on Fuchs endothelial corneal dystrophy by generating an mTOR conditional knock-out mouse model

Establishment of cellular models of Fuchs endothelial corneal dystrophy with and without the expansion of a trinucleotide repeat in TCF4

Association between subjective symptoms and severities in patients with Fuchs endothelial corneal dystrophy

Investigation of the TCF4 Splicing and Isoform Expressions in the Corneal Endothelial Cells of Patients with Fuchs Endothelial Corneal Dystrophy

Feasibility of injection of cryopreserved cultured human corneal endothelial cells for the treatment of corneal endothelial decompensation by using a rabbit model

Generation and RNA Sequencing Analysis of Potential Mouse Model for Fuchs Endothelial Corneal Dystrophy Harboring CTG Trinucleotide Intronic Repeat Expansion in Tcf4

Identification of Sex-Biased Genes in the Human Corneal Endothelial Cells by using RNA Sequencing Analysis

A Feasibility of Computational Drug Screening for Fuchs Endothelial Corneal Dystrophy

RNA Sequencing Analysis of Corneal Endothelial Cells Derived from Fuchs Endothelial Corneal Dystrophy Patients with and without Trinucleotide Repeat Expansion in TCF4

The Relationship between Triplet Repeats in the TCF4 Gene and Progression of Fuchs Endothelial Corneal Dystrophy over One Year

AI model for predicting the diagnosis of infectious keratitis

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