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Immunology and Microbiology April 2025

Application of Metagenomic Long-Read Sequencing for the Diagnosis of Herpetic Uveitis

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Yoshito Koyanagi; Ai Fujita Sajiki; Kenya Yuki; Hiroaki Ushida; Kenichi Kawano; Kosuke Fujita; Hideyuki Shimizu; Daishi Okuda; Mitsuki Kosaka; Kazuhisa Yamada; Ayana Suzumura; Shu Kachi; Hiroki Kaneko; Hiroyuki Komatsu; Yoshihiko Usui; Hiroshi Goto; Koji M. Nishiguchi
TAGS: reading (activity), uveitis, metagenomic sequencing, nanopores, fluid flow
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):50. https://doi.org/10.1167/iovs.66.4.50

Includes: Supplemental Content

Glaucoma April 2025

Comparison of the Humphrey Field Analyzer and MP-3 Microperimeter in Patients With Glaucoma, Classified by Severity and Misalignment of Test Points

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Taiga Inooka; Ryo Tomita; Taro Kominami; Marie Mochizuki; Koji M. Nishiguchi; Kenya Yuki
TAGS: glaucoma, open-angle glaucoma, eye, reliability
Trans. Vis. Sci. Tech.. 2025; 14(4):6. https://doi.org/10.1167/tvst.14.4.6

Retina March 2025

Quantitative Evaluation of Changes in Retinal and Choroidal Blood Flow Following Strabismus Surgery

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Sayuri Yasuda; Yoshiko Takai; Yuma Yasuda; Takanori Yamamoto; Ryo Tomita; Takeshi Iwase; Norie Nonobe; Jun Takeuchi; Taiki Kojima; Koji M. Nishiguchi; Hiroki Kaneko
TAGS: strabismus, surgical procedures, operative, vascular flow
Trans. Vis. Sci. Tech.. 2025; 14(3):12. https://doi.org/10.1167/tvst.14.3.12

Glaucoma October 2024

A Novel Approach To Predict Glaucomatous Impairment in the Central 10° Visual Field, Excluding the Effect of Cataract

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Ryo Tomita; Ryo Asaoka; Kazunori Hirasawa; Yuri Fujino; Tetsuro Omura; Tsutomu Inatomi; Akira Obana; Koji M. Nishiguchi; Masaki Tanito
TAGS: cataract, glaucoma, impairment, visual fields, maximum tolerated dose, preoperative care
Trans. Vis. Sci. Tech.. 2024; 13(10):35. https://doi.org/10.1167/tvst.13.10.35

Retina September 2024

Aqueous Humor Cytokine Analysis in Age-Related Macular Degeneration After Switching From Aflibercept to Faricimab

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Takahito Todoroki; Jun Takeuchi; Hikaru Ota; Yuyako Nakano; Ai Fujita Sajiki; Koichi Nakamura; Hiroki Kaneko; Koji M. Nishiguchi
TAGS: aflibercept, age-related macular degeneration, aqueous humor, cytokine, faricimab, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):15. https://doi.org/10.1167/iovs.65.11.15

ARVO Annual Meeting Abstract June 2024

Retinal arterial lumen diameter is reduced and wall thickness is not altered in eyes with retinitis pigmentosa

Junya Ota; Taiga Inooka; Ryo Tomita; Taro Kominami; Yoshito Koyanagi; Yasuki Ito; Hiroko Terasaki; Koji Miura Nishiguchi; Shinji Ueno

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3087.

ARVO Annual Meeting Abstract June 2024

A survey of Initial electroretinogram (ERG) examination for Acute Retinal Necrosis (ARN) in multi-center study

Kazuichi Maruyama; Shunichi Fukuyama; Masaaki Yoshida; Hiroaki Ushida; Kazuki Hashimoto; Noriyasu Hashida; Toru Nakazawa; Koji Miura Nishiguchi; Kohji Nishida

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5394.

ARVO Annual Meeting Abstract June 2024

Silicone oil endotamponade induces retinal ferroptosis

Hiroki Kaneko; Hideyuki Shimizu; Hiroshi Tanaka; Kazuhisa Yamada; Shinya Toyokuni; Koji Miura Nishiguchi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6431.

ARVO Annual Meeting Abstract June 2023

Genetic characteristics of retinitis pigmentosa and allied diseases in 2063 Japanese patients

Koji Miura Nishiguchi; Yoshito Koyanagi; Masato Akiyama; Yusuke Murakami; Hanae Iijima; Mikiko Endo; Shinji Ueno; Takaaki Hayashi; Yoshihiro Hotta; Akira Murakami; Yuko Wada; Toshiaki Abe; Toru Nakazawa; Yasuhiro Ikeda; Koh-Hei Sonoda; Kensuke Goto

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4646.

Retina May 2022

Ablation of Ctrp9 , Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina

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Daiki Inooka; Yoshihiro Omori; Noriyuki Ouchi; Koji Ohashi; Yuto Kawakami; Yoshito Koyanagi; Chieko Koike; Hiroko Terasaki; Koji M. Nishiguchi; Shinji Ueno
TAGS: ligands, mice, retina, retinal cone, ablation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):14. https://doi.org/10.1167/iovs.63.5.14

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Micro-homology-mediated end joining allows precise excision-insertion genome editing by a single adeno-associated virus vector to restore visual function in blind mice

Koji M Nishiguchi; Kosuke Fujita; Shota Katayama; Toru Nakazawa

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4225.

Genetics March 2019

Macular Dystrophy and Cone-Rod Dystrophy Caused by Mutations in the RP1 Gene: Extending the RP1 Disease Spectrum

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Sanne K. Verbakel; Ramon A. C. van Huet; Anneke I. den Hollander; Maartje J. Geerlings; Eveline Kersten; B. Jeroen Klevering; Caroline C. W. Klaver; Astrid S. Plomp; Nieneke L. Wesseling; Arthur A. B. Bergen; Konstantinos Nikopoulos; Carlo Rivolta; Yasuhiro Ikeda; Koh-Hei Sonoda; Yuko Wada; Camiel J. F. Boon; Toru Nakazawa; Carel B. Hoyng; Koji M. Nishiguchi
TAGS: age-related macular degeneration, genes, macular dystrophy, mutation, retinitis pigmentosa, phenotype, family, genetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1192-1203. https://doi.org/10.1167/iovs.18-26084

Includes: Supplemental Content

Retinal Cell Biology August 2018

Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina

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Kota Sato; Yukihiro Shiga; Yurika Nakagawa; Kosuke Fujita; Koji M. Nishiguchi; Hiroshi Tawarayama; Namie Murayama; Shigeto Maekawa; Takeshi Yabana; Kazuko Omodaka; Shota Katayama; Qiwei Feng; Satoru Tsuda; Toru Nakazawa
TAGS: mice, optic nerve, retina, optic nerve injuries
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3943-3951. https://doi.org/10.1167/iovs.18-23784

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Refractory glaucoma treated with endolaser cyclophotocoagulation during pars plana vitrectomy

Nana Takahashi; Yu Yokoyama; Hiroshi Kunikata; Koji M NIshiguchi; Fumihiko Nitta; Takayuki Takeshita; Toru Nakazawa

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6105.

ARVO Annual Meeting Abstract July 2018

Ecel1 expression is promoted by damage to axonal flow and protects retinal ganglion cells after optic nerve crush in mice

Kota Sato; Yurika Nakagawa; Hiroshi Tawarayama; Namie Murayama; Yukihiro shiga; Kosuke Fujita; Koji M NIshiguchi; Toru Nakazawa

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6138.

Retina February 2018

Discovery of a Cynomolgus Monkey Family With Retinitis Pigmentosa

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Yasuhiro Ikeda; Koji M. Nishiguchi; Fuyuki Miya; Nobuhiro Shimozawa; Jun Funatsu; Shunji Nakatake; Kohta Fujiwara; Takashi Tachibana; Yusuke Murakami; Toshio Hisatomi; Shigeo Yoshida; Yasuhiro Yasutomi; Tatsuhiko Tsunoda; Toru Nakazawa; Tatsuro Ishibashi; Koh-Hei Sonoda
TAGS: cercopithecidae, family, macaca fascicularis, retinitis pigmentosa, eye, fundus photography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):826-830. https://doi.org/10.1167/iovs.17-22958

ARVO Annual Meeting Abstract June 2017

The effect of timing on visual restoration of Gnat1/Pde6c double-knockout mouse through AAV-mediated gene supplementation

Koji M Nishiguchi; Kosuke Fujita; Yukihiro Shiga; Toru Nakazawa

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4479.

ARVO Annual Meeting Abstract June 2017

Inherited retinal degeneration in the cynomolgus monkey (Macaca fascicularis)

Yasuhiro Ikeda; Nobuhiro Shimozawa; Koji M Nishiguchi; Jun Funatsu; Shunji Nakatake; Kohta Fujiwara; Takashi Tachibana; Yusuke Murakami; Toshio Hisatomi; Shigeo Yoshida; Tatsuro Ishibashi; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):283.

ARVO Annual Meeting Abstract September 2016

Lentiviral gene transfer of E2F2 induces regeneration of retinal pigment epithelium in situ

Daniel Kampik; Ulrich F O Luhmann; Koji Miura Nishiguchi; Mark Basche; Alexander J Smith; Hong Han; Jennifer Williams; John Greenwood; Stephen E Moss; Frank Larkin; Robin R Ali

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2128.

ARVO Annual Meeting Abstract April 2014

Relative preservation of foveal outer retinal structure in infants with AIPL1 associated Leber’s Congenital Amaurosis: implications for gene therapy

Jonathan Aboshiha; Adam M Dubis; Koji Miura Nishiguchi; Edward W Cheeseman; Carmen Ayuso; James W B Bainbridge; Michel Michaelides

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1416.

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Application of Metagenomic Long-Read Sequencing for the Diagnosis of Herpetic Uveitis

Comparison of the Humphrey Field Analyzer and MP-3 Microperimeter in Patients With Glaucoma, Classified by Severity and Misalignment of Test Points

Quantitative Evaluation of Changes in Retinal and Choroidal Blood Flow Following Strabismus Surgery

A Novel Approach To Predict Glaucomatous Impairment in the Central 10° Visual Field, Excluding the Effect of Cataract

Aqueous Humor Cytokine Analysis in Age-Related Macular Degeneration After Switching From Aflibercept to Faricimab

Retinal arterial lumen diameter is reduced and wall thickness is not altered in eyes with retinitis pigmentosa

A survey of Initial electroretinogram (ERG) examination for Acute Retinal Necrosis (ARN) in multi-center study

Silicone oil endotamponade induces retinal ferroptosis

Genetic characteristics of retinitis pigmentosa and allied diseases in 2063 Japanese patients

Ablation of Ctrp9 , Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina

Micro-homology-mediated end joining allows precise excision-insertion genome editing by a single adeno-associated virus vector to restore visual function in blind mice

Macular Dystrophy and Cone-Rod Dystrophy Caused by Mutations in the RP1 Gene: Extending the RP1 Disease Spectrum

Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina

Refractory glaucoma treated with endolaser cyclophotocoagulation during pars plana vitrectomy

Ecel1 expression is promoted by damage to axonal flow and protects retinal ganglion cells after optic nerve crush in mice

Discovery of a Cynomolgus Monkey Family With Retinitis Pigmentosa

The effect of timing on visual restoration of Gnat1/Pde6c double-knockout mouse through AAV-mediated gene supplementation

Inherited retinal degeneration in the cynomolgus monkey (Macaca fascicularis)

Lentiviral gene transfer of E2F2 induces regeneration of retinal pigment epithelium in situ

Relative preservation of foveal outer retinal structure in infants with AIPL1 associated Leber’s Congenital Amaurosis: implications for gene therapy

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