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ARVO Annual Meeting Abstract June 2025

Age-related retinal ganglion cell changes in a nonhuman primate model of autosomal dominant optic atrophy

Jaegook Lim; Ana Cláudia Santos Raposo; Michaela Dunn; Ana Ripolles-Garcia; Monica Motta; Karen Anderson; Glenn Yiu; Ala Moshiri; Brad Fortune; Brian Leonard; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1072.

ARVO Annual Meeting Abstract June 2025

Reference data on optic nerve flavoprotein fluorescence in normal rhesus macaques

Ana Ripolles-Garcia; Ana Cláudia Santos Raposo; Jaegook Lim; Monica Motta; Carol Villafuerte-Trisolini; Karen Anderson; Nadeen Habbas-Nimer; Collin Rich; Glenn Yiu; Ala Moshiri; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4776.

ARVO Annual Meeting Abstract June 2024

Retinal ganglion cell dysfunction demonstrated in a nonhuman primate model of autosomal dominant optic atrophy

Ana Cláudia Santos Raposo; Paige Karpinen; Michelle Ferneding; Monica Motta; Karen Anderson; Michaela Dunn; Brad Fortune; Ala Moshiri; Brian Leonard; Sara Thomasy

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5392.

ARVO Annual Meeting Abstract June 2022

STK-002, an Antisense Oligonucleotide (ASO) for the Treatment of Autosomal Dominant Optic Atrophy (ADOA), is Taken Up by Retinal Ganglion Cells (RGC) and Upregulates OPA-1 Protein Expression After Intravitreal Administration to Non-human Primates (NHPs)

Karen Anderson; Aditya Venkatesh; Taylor McKenty; Deidre Slate; Qian Lin; Shobha Ravipaty; Sarah Jacobson; Anne Christiansen; Radhia Benmohamed; Jeff Hoger; Gene Liau

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1111.

Physiology and Pharmacology June 2021

Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

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John T. Demirs; Junzheng Yang; Maura A. Crowley; Michael Twarog; Omar Delgado; Yubin Qiu; Stephen Poor; Dennis S. Rice; Thaddeus P. Dryja; Karen Anderson; Sha-Mei Liao
TAGS: complement system proteins, eye, rna, messenger, age-related macular degeneration, choroid, neural retina, donors
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):26. https://doi.org/10.1167/iovs.62.7.26

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Characterization of a model of chronic IOP elevation induced by a photopolymerizable biomatrix

Jie Ma; Kai Chen; Arogya Khadka; Lauren Bazinet; Karen Anderson

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1167.

ARVO Annual Meeting Abstract July 2019

Complement factor B is necessary for sub-RPE deposit formation in Efemp1 R345W /R345W knock-in mice

Maura Crowley; Donita Garland; Rosario Fernandez-Godino; Tomas Rejtar; Natasha Buchanan; Karen Anderson; Holger Sellner; Muneto Mogi; Y. Karen Wang; Bruce Jaffee; Stephen H Poor; Thaddeus Dryja; Eric A Pierce; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1241.

ARVO Annual Meeting Abstract July 2018

Retinal degeneration and subretinal Iba1 + accumulation in complement factor H-deficient mice are associated with increased gene expression of phagocytic markers

Natasha Buchanan; Erika Queiroz; John Demirs; Junzheng Yang; Barrett Leehy; Nalini Rangaswamy; Ivana Arellano; Maura Crowley; Chad E Bigelow; Karen Anderson; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):990.

Physiology and Pharmacology February 2018

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

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Maura A. Crowley; Omar Delgado; Adrian Will-Orrego; Natasha M. Buchanan; Karen Anderson; Bruce D. Jaffee; Thaddeus P. Dryja; Sha-Mei Liao
TAGS: animal model, complement activation, complement factor d, complement system proteins, eye, mice, proteins, plasma, body tissue
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):940-951. https://doi.org/10.1167/iovs.17-22605

ARVO Annual Meeting Abstract June 2017

Deletion of complement factor H is associated with accumulation of subretinal Iba-1-positive cells and retinal degeneration in aged mice

Sha-Mei Liao; Natasha Buchanan; John Demirs; Barrett Leehy; Casey Lewis; Junzheng Yang; Vanessa Davis; Nalini V Rangaswamy; Maura Crowley; Karen Anderson; Chad E Bigelow; Thaddeus P Dryja; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1625.

ARVO Annual Meeting Abstract September 2016

Ocular complement activation and inhibition in rodent models of endotoxin-induced uveitis

Maura Crowley; Omar Delgado; Karen Anderson; Wei Zheng; Holger Sellner; Nello Mainolfi; Muneto Mogi; Bruce D Jaffee; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):482.

ARVO Annual Meeting Abstract September 2016

A novel oral small molecule Factor D inhibitor blocks complement activation in the blood and ocular tissues

Karen Anderson; Sha-Mei Liao; Juergen Maibaum; Frederic Cumin; Omar Delgado; Andrea De Erkenez; Fang Liu; Upendra Argikar; Ron Newton; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4440.

ARVO Annual Meeting Abstract June 2015

Systemic Inhibition of the EGF Receptor Reduces Leukostasis and Retinal Vascular Leakage in Streptozotocin Induced-Diabetic Rats

Steve Louie; Karen Anderson; Hui Li; Debby Long; Sha-Mei Liao; Bruce D Jaffee; Michael Stefanidakis

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4700.

ARVO Annual Meeting Abstract April 2014

Differential inflammatory stages in the eyes and kidneys of aged complement factor H-deficient mice

Sha-Mei Liao; Natasha M Buchanan; John T Demirs; Karen L Anderson; Shawn M Hanks; Chad E Bigelow; Melinda Hubbard; Wei Zheng; Kathryn H McAllister; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):71.

ARVO Annual Meeting Abstract June 2013

EphA2 Stimulation of Angiogenesis is Dependent on VEGFR2

Luciana Ferrara; Andrea De Erkenez; Elizabeth Fassbender; Siyuan Shen; Amber Woolfenden; Yubin Qiu; Stephen Poor; Karen Anderson; Bruce Jaffee

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):5613.

ARVO Annual Meeting Abstract June 2013

Validation and Characterization of Murine Oxygen-induced Retinopathy of Prematurity Model

Yubin Qiu; Amber Woolfenden; Wei Zheng; Karen Anderson; Melinda Hubbard; John Demirs; Joseph Loureiro; Joy Ghosh; Stephen Poor; Bruce Jaffee

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):617.

ARVO Annual Meeting Abstract March 2012

Complement Play A Minor Role In Mouse Laser-induced Choroidal Neovascularization

Stephen H. Poor; Elizabeth Fassbender; Siyuan Shen; Yubin Qiu; Amber Woolfenden; John Demirs; Karen Anderson; Bruce D. Jaffee

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1642.

ARVO Annual Meeting Abstract April 2011

Different FTY720 (fingolimod) Treatment Regimens Can Suppress Autoimmune Uveoretinitis

David A. Copland; Volker Brinkmann; Karen Anderson; Jian Liu; Lindsay B. Nicholson; Andrew D. Dick

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4301.

ARVO Annual Meeting Abstract April 2011

Low-grade Ocular Inflammation Is Chronically Present In Complement Factor H-deficient Mice

Natasha Buchanan; John Demirs; Steve Louie; Sassan Azarian; Karen Anderson; Bruce Jaffee; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):978.

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Age-related retinal ganglion cell changes in a nonhuman primate model of autosomal dominant optic atrophy

Reference data on optic nerve flavoprotein fluorescence in normal rhesus macaques

Retinal ganglion cell dysfunction demonstrated in a nonhuman primate model of autosomal dominant optic atrophy

STK-002, an Antisense Oligonucleotide (ASO) for the Treatment of Autosomal Dominant Optic Atrophy (ADOA), is Taken Up by Retinal Ganglion Cells (RGC) and Upregulates OPA-1 Protein Expression After Intravitreal Administration to Non-human Primates (NHPs)

Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

Characterization of a model of chronic IOP elevation induced by a photopolymerizable biomatrix

Complement factor B is necessary for sub-RPE deposit formation in Efemp1 R345W /R345W knock-in mice

Retinal degeneration and subretinal Iba1 + accumulation in complement factor H-deficient mice are associated with increased gene expression of phagocytic markers

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

Deletion of complement factor H is associated with accumulation of subretinal Iba-1-positive cells and retinal degeneration in aged mice

Ocular complement activation and inhibition in rodent models of endotoxin-induced uveitis

A novel oral small molecule Factor D inhibitor blocks complement activation in the blood and ocular tissues

Systemic Inhibition of the EGF Receptor Reduces Leukostasis and Retinal Vascular Leakage in Streptozotocin Induced-Diabetic Rats

Differential inflammatory stages in the eyes and kidneys of aged complement factor H-deficient mice

EphA2 Stimulation of Angiogenesis is Dependent on VEGFR2

Validation and Characterization of Murine Oxygen-induced Retinopathy of Prematurity Model

Complement Play A Minor Role In Mouse Laser-induced Choroidal Neovascularization

Different FTY720 (fingolimod) Treatment Regimens Can Suppress Autoimmune Uveoretinitis

Low-grade Ocular Inflammation Is Chronically Present In Complement Factor H-deficient Mice

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