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ARVO Annual Meeting Abstract June 2022

Blood-Retinal -Barrier 3D Model Using Microfabricated Porous Scaffolds

Karen Yud Torrejon; Andrea Unser; Hira Afzaal; Hunter Williams; Feryan Ahmed; Patricia A D'Amore

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3155 – F0429. doi:

Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. doi: https://doi.org/10.1167/iovs.63.2.12

ARVO Annual Meeting Abstract June 2021

Use of a Novel Potassium Channel Opener in a 3D-Glaucomatous Human Trabecular Meshwork/Schlemm’s Canal Tissue Model

Karen Yud Torrejon; Andrea Unser; Feryan Ahmed; Vandhana Chari; Thurein Htoo; Cynthia Steel; Barbara M Wirostko

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2758. doi:

ARVO Annual Meeting Abstract June 2021

Examining the Effects of Glaucoma Medications on the Trabecular Outflow Pathway Using Glauconix Bioscience’s 3D-HTM™ Tissue Constructs

Andrea Unser; Feryan Ahmed; Hira Afzaal; Hunter Williams; Karen Yud Torrejon

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):470. doi:

ARVO Annual Meeting Abstract June 2021

Human Trabecular Meshwork Cells Appear Healthier & More Viable in Contact with Titanium Stents Than in Contact with Nickel-Titanium Stents

Hal Heitzmann; Barbara M Wirostko; Feryan Ahmed; Andrea Unser; Vandhana Chari; Karen Yud Torrejon

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3421. doi:

Physiology and Pharmacology March 2021

NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFβ2-Induced Outflow in HTM/HSC Constructs

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Elena Bastia; Carol B. Toris; Stefania Brambilla; Corinna Galli; Nicoletta Almirante; Michael V. W. Bergamini; Emanuela Masini; Silvia Sgambellone; Andrea M. Unser; Feryan Ahmed; Karen Y. Torrejon; Tomas Navratil; Francesco Impagnatiello
TAGS: animal model, dog, domestic, intraocular pressure, ocular hypertension, oryctolagus cuniculus, nitric oxide, primates, donors, cyclic gmp
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):17. doi: https://doi.org/10.1167/iovs.62.3.17

ARVO Annual Meeting Abstract June 2020

3D Human Trabecular Meshwork model as a potential tool for gene screening

Karen Y Torrejon; Cula N Dautriche; Andrea Unser; Mathew Kerr; Feryan Ahmed; Abbey Van Alstyne-Ponce; Dan Stamer; Susan T Sharfstein; Yubing Xie; John Danias

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3441. doi:

ARVO Annual Meeting Abstract June 2020

Distinct pharmacological activities between cannabidiol (CBD) and cannabidiol analog (CBDVHS) in a 3D human trabecular meshwork model

Andrea Unser; Karen Y Torrejon; Feryan Ahmed; Abbey Van Alstyne-Ponce; Brian Murphy

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3463. doi:

ARVO Annual Meeting Abstract July 2019

Investigation of the Mechanism of Action and IOP Lowering Ability of CB1 Agonists using Glauconix Biosciences’ 3D-HTM TM Tissue Model

Andrea Unser; Aishwarya Panneerselvam; Feryan Ahmed; George Torrejon; Karen Yud Torrejon

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5159. doi:

ARVO Annual Meeting Abstract July 2018

Tandem-pore domain potassium channels are components of intracellular signaling pathways, determinants of pH sensitivity and mechanosensitivity of human trabecular meshwork cells.

Oleg Yarishkin; Tam Phuong; Jackson M Baumann; Alan S Crandall; Feryan Ahmed; Karen Yud Torrejon; David Krizaj

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1660. doi:

ARVO Annual Meeting Abstract July 2018

Nitric Oxide Induces Changes in the Cytoskeleton and ECM of TGFβ2-treated Trabecular Meshwork and Schlemm’s canal cells

Karen Yud Torrejon; Ellen L Papke; Andrea Unser; Matthew Kerr; W Daniel Stamer; Feryan Ahmed

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4708. doi:

Physiology and Pharmacology January 2018

Trabodenoson, an Adenosine Mimetic With A 1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice

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Guorong Li; Karen Y. Torrejon; Andrea M. Unser; Feryan Ahmed; Iris D. Navarro; Rudolf A. Baumgartner; David S. Albers; W. Daniel Stamer
TAGS: adenosine, eye, intraocular pressure, mice, gelatinase a, body tissue, proteins, placebos, fibronectins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):383-392. doi: https://doi.org/10.1167/iovs.17-23212

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ARVO Annual Meeting Abstract June 2017

Human microvascular endothelial cells (HMVECs) assume Schlemm’s canal (HSC) cell characteristics after co-culture with human trabecular meshwork (HTM) cells and can be used to model conventional outflow

Karen Y Torrejon; Ellen Papke; Dhruba J Bharali; Magnus Bergkvist; W Daniel Stamer; Susan T Sharfstein; Yubing Xie; Feryan Ahmed; John Danias

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3471. doi:

ARVO Annual Meeting Abstract June 2015

Recreation of a 3-D Physiological Model of Conventional Outflow Tract in vitro

Karen Yud Torrejon; Cula Dautriche; Ellen Papke; W Daniel Stamer; John Danias; Magnus Bergkvist; Susan T Sharfstein; Yubing Xie

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3544. doi:

ARVO Annual Meeting Abstract April 2014

Bioengineered 3D HTM is physiologically responsive to glucocorticoid

Karen Yud Torrejon; Adam Goodcoff; Cula Dautriche; Magnus Bergkvist; Yubing Xie; Susan Sharfstein; John Danias

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5654. doi:

ARVO Annual Meeting Abstract April 2014

3D-Bio-engineering of the Conventional Outflow Tract for High Throughput Glaucoma Drug Screening

Cula Dautriche; Karen Yud Torrejon; Magnus Bergkvist; Yubing Xie; Susan Sharfstein; John Danias

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5659. doi:

ARVO Annual Meeting Abstract March 2012

Bioengineering Human Trabecular Meshwork for Glaucoma Therapeutic Screening

Karen Y. Torrejon; Dennis Pu; Magnus Bergkvist; Susan Sharfstein; Yubing Xie; Natalya A. Tokranova; John Danias

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3272. doi:

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Blood-Retinal -Barrier 3D Model Using Microfabricated Porous Scaffolds

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Use of a Novel Potassium Channel Opener in a 3D-Glaucomatous Human Trabecular Meshwork/Schlemm’s Canal Tissue Model

Examining the Effects of Glaucoma Medications on the Trabecular Outflow Pathway Using Glauconix Bioscience’s 3D-HTM™ Tissue Constructs

Human Trabecular Meshwork Cells Appear Healthier & More Viable in Contact with Titanium Stents Than in Contact with Nickel-Titanium Stents

NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFβ2-Induced Outflow in HTM/HSC Constructs

3D Human Trabecular Meshwork model as a potential tool for gene screening

Distinct pharmacological activities between cannabidiol (CBD) and cannabidiol analog (CBDVHS) in a 3D human trabecular meshwork model

Investigation of the Mechanism of Action and IOP Lowering Ability of CB1 Agonists using Glauconix Biosciences’ 3D-HTM TM Tissue Model

Tandem-pore domain potassium channels are components of intracellular signaling pathways, determinants of pH sensitivity and mechanosensitivity of human trabecular meshwork cells.

Nitric Oxide Induces Changes in the Cytoskeleton and ECM of TGFβ2-treated Trabecular Meshwork and Schlemm’s canal cells

Trabodenoson, an Adenosine Mimetic With A 1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice

Human microvascular endothelial cells (HMVECs) assume Schlemm’s canal (HSC) cell characteristics after co-culture with human trabecular meshwork (HTM) cells and can be used to model conventional outflow

Recreation of a 3-D Physiological Model of Conventional Outflow Tract in vitro

Bioengineered 3D HTM is physiologically responsive to glucocorticoid

3D-Bio-engineering of the Conventional Outflow Tract for High Throughput Glaucoma Drug Screening

Bioengineering Human Trabecular Meshwork for Glaucoma Therapeutic Screening

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