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Genetics June 2025

Investigating the Immunogenic Potential of Variations in Host Cell Protein Levels in Clinical-Grade AAV8 Products

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Immanuel P. Seitz; Eduardo Rodríguez-Bocanegra; Kirsten Bucher; Felix F. Reichel; Stylianos Michalakis; Dimitri Romanovsky; Martin Biel; Bernd Wissinger; Karl-Ulrich Bartz-Schmidt; Tobias Peters; Manuel D. Fischer; on behalf of the RD-CURE Consortium
TAGS: disease vectors, proteins, spatial vectors, cytokine, thp-1 cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):38. https://doi.org/10.1167/iovs.66.6.38

Includes: Supplemental Content

Retina January 2025

Ocular Safety and Toxicology of Subretinal Gene Therapy With rAAV.hPDE6A in Nonhuman Primates

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Immanuel P. Seitz; Fabian Wozar; Guy Alex Ochakovski; Felix F. Reichel; Sven Korte; Birgit Korbmacher; Barbara Wilhelm; Daniela Süsskind; Karl-Ulrich Bartz-Schmidt; M. Dominik Fischer; Tobias Peters; for the RD Cure Consortium
TAGS: electroretinography, eye, gene therapy, histology, ophthalmic examination and evaluation, primates, safety, surgical procedures, operative, toxicology, intraocular pressure
Trans. Vis. Sci. Tech.. 2025; 14(1):29. https://doi.org/10.1167/tvst.14.1.29

ARVO Annual Meeting Abstract June 2024

Haptic force feedback input device for robotic surgeries

Marvin Bende; Thomas Bende; Karl-Ulrich Bartz-Schmidt

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2087.

ARVO Annual Meeting Abstract June 2024

Surgical approach for the implantation of a capsular ring electrode into the posterior chamber

Friederike Charlotte Kortuem; Sebastian Kaltenstadler; Sven Schumayer; Bishesh Sigdel; Immanuel Philipp Seitz; Tobias Peters; Albrecht Rothermel; Volker Bucher; Eberhart Zrenner; Karl-Ulrich Bartz-Schmidt; Torsten Strasser

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2086.

ARVO Annual Meeting Abstract June 2024

Host cell protein impurities are not a relevant driver of gene therapy-associated immune response

Immanuel Philipp Seitz; Eduardo Bocanegra; Felix Reichel; Stylianos Michalakis; Martin Biel; Karl Ulrich Bartz-Schmidt; Tobias Peters; M Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5345.

ARVO Annual Meeting Abstract June 2024

REVISION – Early Reperfusion Therapy with Alteplase for Recovery of Vision in Acute Central Retinal Artery Occlusion: A Phase III Double-Blind Randomized Placebo-Controlled Trial

Daniel A. Wenzel; Caroline J. Gassel; Sven Poli; Karl Ulrich Bartz-Schmidt; Spyridon Dimopoulos; Maximilian Schultheiss; Martin Stephan Spitzer

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1738.

ARVO Annual Meeting Abstract June 2024

Long-Term Efficacy and Impact on Corneal Endothelial Cells of PRESERFLO® MicroShunt

Caroline Julia Gassel; Daniel A. Wenzel; Torsten Strasser; Karl Ulrich Bartz-Schmidt; Bogomil Voykov

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3510.

Anatomy and Pathology/Oncology June 2024

Radiation-Induced DNA Damage in Uveal Melanoma Is Influenced by Dose Delivery and Chromosome 3 Status

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Aysegül Tura; Yingda Zhu; Siranush Vardanyan; Michelle Prasuhn; Vinodh Kakkassery; Julia Lüke; Hartmut Merz; Frank Paulsen; Dirk Rades; Florian Cremers; Karl-Ulrich Bartz-Schmidt; Salvatore Grisanti
TAGS: chromosomes, human, pair 3, dna damage, intraocular melanoma, neoplasms, stereotactic radiotherapy, neoplasm metastasis, in situ nick-end labeling, radiation induced dna damage, radiation therapy, monosomy
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):7. https://doi.org/10.1167/iovs.65.6.7

ARVO Annual Meeting Abstract June 2023

Cataract surgery using a 3D camera guided robotic arm

Marvin Bende; Thomas Bende; Karl-Ulrich Bartz-Schmidt

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3328.

ARVO Annual Meeting Abstract June 2023

Safety and Vision Outcomes of subretinal gene supplementation therapy in PDE6A -associated Retinitis pigmentosa

Felix Friedrich Lambert Reichel; Stylianos Michalakis; Dominik M Fischer; laura kuehlewein; Tobias Peters; Susanne Kohl; Karl-Ulrich Bartz-Schmidt; Marius Ueffing; Eberhart Zrenner; Martin Biel; Katarina Stingl; Bernd Wissinger

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):782.

ARVO Annual Meeting Abstract June 2023

Pathogen identification in endophthalmitis: FRES (Freiburg Endophthalmitis Set) versus standard procedure; a retrospective multicenter comparative study

Thomas Ness; Karl Ulrich Bartz-Schmidt; Florian Gekeler; Albrecht Bartz-Schmidt

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):615.

ARVO Annual Meeting Abstract June 2023

Evidence of potential early-stage ocular tertiary lymphoid tissue formation following high dose retinal AAV8 gene therapy

Kirsten Bucher; Daniela Süsskind; Martin Biel; Stylianos Michalakis; Karl-Ulrich Bartz-Schmidt; Tobias Peters; M Dominik Fischer; Simon J Clark

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3911.

ARVO Annual Meeting Abstract June 2022

Neural plasticity of the human visual system reflects treatment effect in gene therapy for Achromatopsia

Immanuel Philipp Seitz; Michael Erb; Thomas Ethofer; Andriani Rina; Georgios Keliris; M Dominik Fischer; Karl-Ulrich Bartz-Schmidt

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):452.

Articles July 2021

CT Assessment of Intraorbital Cable Movement of Electronic Subretinal Prosthesis in Three Different Surgical Approaches

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Hanna Faber; Ulrike Ernemann; Helmut Sachs; Florian Gekeler; Søren Danz; Assen Koitschev; Dorothea Besch; Karl-Ulrich Bartz-Schmidt; Eberhart Zrenner; Katarina Stingl; Christoph Kernstock
TAGS: implants, prostheses, surgical procedures, operative, retina, eye movement
Trans. Vis. Sci. Tech.. 2021; 10(8):16. https://doi.org/10.1167/tvst.10.8.16

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract July 2019

Outcomes after Descemet Membrane Endothelial Keratoplasty (DMEK) in a German multicenter study

Klara Charlotte Borgardts; Kristina Spaniol; Björn Bachmann; Martin Hellmich; Gerd Geerling; Philip Maier; Peter MH Wiedemann; Karl Ulrich Bartz-Schmidt; Max Pattmoeller; Anna-Karina Maier-Wenzel

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2224.

ARVO Annual Meeting Abstract July 2019

Effects of Subretinal AAV8 Gene Therapy on Microperimetry in CNGA3 Achromatopsia Patients

G. Alex Ochakovski; Ahmad Zhour; Laura Kuehlewein; Susanne Kohl; Andrea Rindtorff; Karl Ulrich Bartz-Schmidt; Marius Ueffing; Eberhart Zrenner; Stylianos Michalakis; Martin Biel; Bernd Wissinger; Tobias Peters; Barbara Wilhelm; M. Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2921.

ARVO Annual Meeting Abstract July 2019

Descemet’s Membrane Endothelial Keratoplasty: Long-term development of color and contrast in Fuchs' endothelial corneal dystrophy patients

Tarek Bayyoud; Helmut Wilhelm; Manfred Zierhut; Sebastian Thaler; Karl Ulrich Bartz-Schmidt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3812.

ARVO Annual Meeting Abstract July 2019

Potential therapy of neurodegenerative retinopathies via activation of the BDNF-TrkB signaling pathway by a specific aptamer

Marina Löscher; Evangelia Lilou; Karl Ulrich Bartz-Schmidt; Sven Schnichels; José Hurst

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5708.

ARVO Annual Meeting Abstract July 2019

Evaluation of pupil responses to local stimuli in Patients with retinitis pigmentosa caused by USH2A mutations

Tobias Peters; Krunoslav Stingl; Karl Ulrich Bartz-Schmidt; Laura Kuehlewein; Carina Kelbsch; Melanie Kempf; Eberhart Zrenner; Barbara Wilhelm; Katarina Stingl

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1829.

ARVO Annual Meeting Abstract July 2018

Safety study in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

Tobias Peters; Barbara Wilhelm; Birgit Korbmacher; Sven Korte; Karl Ulrich Bartz-Schmidt; Stylianos Michalakis; Guy Alex Ochakovski; M Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2658.

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Investigating the Immunogenic Potential of Variations in Host Cell Protein Levels in Clinical-Grade AAV8 Products

Ocular Safety and Toxicology of Subretinal Gene Therapy With rAAV.hPDE6A in Nonhuman Primates

Haptic force feedback input device for robotic surgeries

Surgical approach for the implantation of a capsular ring electrode into the posterior chamber

Host cell protein impurities are not a relevant driver of gene therapy-associated immune response

REVISION – Early Reperfusion Therapy with Alteplase for Recovery of Vision in Acute Central Retinal Artery Occlusion: A Phase III Double-Blind Randomized Placebo-Controlled Trial

Long-Term Efficacy and Impact on Corneal Endothelial Cells of PRESERFLO® MicroShunt

Radiation-Induced DNA Damage in Uveal Melanoma Is Influenced by Dose Delivery and Chromosome 3 Status

Cataract surgery using a 3D camera guided robotic arm

Safety and Vision Outcomes of subretinal gene supplementation therapy in PDE6A -associated Retinitis pigmentosa

Pathogen identification in endophthalmitis: FRES (Freiburg Endophthalmitis Set) versus standard procedure; a retrospective multicenter comparative study

Evidence of potential early-stage ocular tertiary lymphoid tissue formation following high dose retinal AAV8 gene therapy

Neural plasticity of the human visual system reflects treatment effect in gene therapy for Achromatopsia

CT Assessment of Intraorbital Cable Movement of Electronic Subretinal Prosthesis in Three Different Surgical Approaches

Outcomes after Descemet Membrane Endothelial Keratoplasty (DMEK) in a German multicenter study

Effects of Subretinal AAV8 Gene Therapy on Microperimetry in CNGA3 Achromatopsia Patients

Descemet’s Membrane Endothelial Keratoplasty: Long-term development of color and contrast in Fuchs' endothelial corneal dystrophy patients

Potential therapy of neurodegenerative retinopathies via activation of the BDNF-TrkB signaling pathway by a specific aptamer

Evaluation of pupil responses to local stimuli in Patients with retinitis pigmentosa caused by USH2A mutations

Safety study in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

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