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ARVO Annual Meeting Abstract June 2022

Genetic variants in ANO2 may be predictive for treatment response to anti-VEGF in neovascular age-related macular degeneration

Robyn H Guymer; Rufino Silva; Mercedeh Ghadessi; Sergio Leal; Isabella Gashaw; Amy Damask; Charles Paulding; Kay D. Rittenhouse

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1495. doi:

Articles April 2021

Durability of VEGF Suppression With Intravitreal Aflibercept and Brolucizumab: Using Pharmacokinetic Modeling to Understand Clinical Outcomes

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Thomas Eissing; Michael W. Stewart; Cynthia X. Qian; Kay D. Rittenhouse
TAGS: aflibercept, anti-vascular endothelial growth factor therapy, brolucizumab, vascular endothelial growth factor a, treatment outcome, vitreous body, half-life, molar tooth
Trans. Vis. Sci. Tech.. 2021; 10(4):9. doi: https://doi.org/10.1167/tvst.10.4.9

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Pharmacokinetic Simulations of Intravitreal Aflibercept and Brolucizumab to Explore Results from Clinical Trials

Cynthia Qian; Kay D Rittenhouse; Thomas Eissing; Samia Ezzine; Todd A Katz; Jean Daniel Arbour

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4206. doi:

ARVO Annual Meeting Abstract June 2017

Impact of baseline retinal nonperfusion on best corrected visual acuity in eyes with central retinal vein occlusion: post hoc analyses of COPERNICUS and GALILEO

David M Brown; Yuichiro Ogura; Francesco Boscia; Frank G Holz; Jean-Francois Korobelnik; Jeffrey Heier; Kay D Rittenhouse; Friedrich Asmus; Christiane Ahlers; Florian Hiemeyer; Chengxing Lu; Robert Vitti; Namrata Saroj; Nicolas Feltgen

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1559. doi:

ARVO Annual Meeting Abstract April 2014

A High Fat Western Diet Accelerates Progression of Drusen in Japanese Macaques with Dominantly Inherited Maculopathy

Martha Neuringer; Laurie Renner; Trevor J McGill; Mark E Pennesi; Travis Smith; Kay D Rittenhouse; Marvin Sperling; Joachim Fruebis; Anda Cornea

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5240. doi:

Research Opportunities April 2014

Drug and Gene Delivery to the Back of the Eye: From Bench to Bedside

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Cheryl L. Rowe-Rendleman; Shelley A. Durazo; Uday B. Kompella; Kay D. Rittenhouse; Adriana Di Polo; Alan L. Weiner; Hans E. Grossniklaus; Muna I. Naash; Alfred S. Lewin; Alan Horsager; Henry F. Edelhauser
TAGS: drug delivery systems, eye, genes, animal model, gene therapy, proteins, nanoparticles, hydrogels, retina, molecule
Invest. Ophthalmol. Vis. Sci.. 2014; 55(4):2714-2730. doi: https://doi.org/10.1167/iovs.13-13707

Retina March 2014

RTP801 Gene Expression Is Differentially Upregulated in Retinopathy and Is Silenced by PF-04523655, a 19-Mer siRNA Directed Against RTP801

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Kay D. Rittenhouse; Theodore R. Johnson; Paolo Vicini; Brad Hirakawa; Dalia Kalabat; Amy H. Yang; Wenhu Huang; Anthony S. Basile
TAGS: choroidal neovascularization, diabetes mellitus, gene expression, pharmacodynamics, rats, retina, retinal diseases, rna, small interfering, streptozocin, lasers
Invest. Ophthalmol. Vis. Sci.. 2014; 55(3):1232-1240. doi: https://doi.org/10.1167/iovs.13-13449

Clinical Trials July 2012

Evaluations of Tear Protein Markers in Dry Eye Disease: Repeatability of Measurement and Correlation with Disease

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Jing-Feng Huang; Yi Zhang; Kay D. Rittenhouse; Eve H. Pickering; Michael T. McDowell
TAGS: dry eye syndromes, proteins, interleukin-8, eye
Invest. Ophthalmol. Vis. Sci.. 2012; 53(8):4556-4564. doi: https://doi.org/10.1167/iovs.11-9054

ARVO Annual Meeting Abstract March 2012

Molecular Bases for Multiple Subgroups of Dry Eye Patients?

Jing-Feng Huang; Yi Zhang; Jim Li; Kay D. Rittenhouse

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2317. doi:

ARVO Annual Meeting Abstract April 2011

Retinal Microcirculation As A Predictor For Retinal And Optic Nerve Structural Changes In Patients With Primary Open Angle Glaucoma

Brent A. Siesky; Alon Harris; Kay D. Rittenhouse; Yochai Z. Shoshani; Mohammadali Shoja; Yoel Arieli; Barbara M. Wirostko; Chris Jonescu; Rita Ehrlich; George Eckert

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3475. doi:

ARVO Annual Meeting Abstract April 2011

Decreasing Retrobulbar Blood Flow is Predictive of OCT Structural Changes in Patients with Primary Open Angle Glaucoma

Yochai Z. Shoshani; Alon Harris; Kay D. Rittenhouse; Brent A. Siesky; Mohammadali M. Shoja; Yoel Arieli; Barbara M. Wirostko; Christian Jonescu; Rita Ehrlich; George Eckert

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3478. doi:

ARVO Annual Meeting Abstract April 2011

Modulation of HLA-DR On Conjunctival Cells And Inflammatory Mediators In Tears In Dry Eye Patients By CP-690,550, A Selective Inhibitor of The JAK Family

Jing-Feng Huang; Rolla Yafawi; Yi Zhang; Min H. Zhang; Kay D. Rittenhouse; Michael McDowell; S-H M. Liew; Scott R. Cooper; Eve H. Pickering

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3824. doi:

ARVO Annual Meeting Abstract April 2011

Characterization of Regional RTP801 Gene Expression Within the Retina and the Concentration-Effect Relationship of PF-655, an RTP801-silencing siRNA, Following Intravitreous Administration to Diabetic Rats

Kay D. Rittenhouse; Dalia Kalabat; Amy Yang; Paolo Vicini; Theodore R. Johnson; Wenhu Huang; Brad Hirakawa; Anthony S. Basile; Ronald A. Schachar

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5641. doi:

ARVO Annual Meeting Abstract April 2011

PF655 (Human) and Dharmacon (Murine) siRNAs Against the Stress Protein Response Gene RTP801 Enhances RGC-5 Cell Survival in Culture Caused by Insults of Blue Light or Cobalt Chloride

Alberto Garcia-Manso; Dan Ji; Kay D. Rittenhouse; Neville N. Osborne

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1424. doi:

ARVO Annual Meeting Abstract April 2011

Rabbit Retina Expression And Cross-species Validation Of Gene Suppression By PF-655, a siRNA Against RTP801

Dong U. Lee; Wenhu Huang; Kay D. Rittenhouse; Bart Jessen

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1427. doi:

Research Opportunities November 2010

Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications

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Henry F. Edelhauser; Cheryl L. Rowe-Rendleman; Michael R. Robinson; Daniel G. Dawson; Gerald J. Chader; Hans E. Grossniklaus; Kay D. Rittenhouse; Clive G. Wilson; David A. Weber; Baruch D. Kuppermann; Karl G. Csaky; Timothy W. Olsen; Uday B. Kompella; V. Michael Holers; Gregory S. Hageman; Brian C. Gilger; Peter A. Campochiaro; Scott M. Whitcup; Wai T. Wong
TAGS: drug clearance, drug delivery systems, eye, ophthalmic agents, retinal diseases, retina, body tissue, vitreous body, permeability, basic science research
Invest. Ophthalmol. Vis. Sci.. 2010; 51(11):5403-5420. doi: https://doi.org/10.1167/iovs.10-5392

Includes: Supplemental Content

Glaucoma July 2009

Expression of Prostaglandin PGE 2 Receptors under Conditions of Aging and Stress and the Protective Effect of the EP2 Agonist Butaprost on Retinal Ischemia

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Neville N. Osborne; Guang-Yu Li; Dan Ji; Belmira L. Andrade da Costa; Rebecca J. Fawcett; Kui Dong Kang; Kay D. Rittenhouse
TAGS: aging, agonists, ischemia, physiologic reperfusion, prostaglandins e, reperfusion therapy, retina, retinal ischemia, stress, rats
Invest. Ophthalmol. Vis. Sci.. 2009; 50(7):3238-3248. doi: https://doi.org/10.1167/iovs.08-3185

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Genetic variants in ANO2 may be predictive for treatment response to anti-VEGF in neovascular age-related macular degeneration

Durability of VEGF Suppression With Intravitreal Aflibercept and Brolucizumab: Using Pharmacokinetic Modeling to Understand Clinical Outcomes

Pharmacokinetic Simulations of Intravitreal Aflibercept and Brolucizumab to Explore Results from Clinical Trials

Impact of baseline retinal nonperfusion on best corrected visual acuity in eyes with central retinal vein occlusion: post hoc analyses of COPERNICUS and GALILEO

A High Fat Western Diet Accelerates Progression of Drusen in Japanese Macaques with Dominantly Inherited Maculopathy

Drug and Gene Delivery to the Back of the Eye: From Bench to Bedside

RTP801 Gene Expression Is Differentially Upregulated in Retinopathy and Is Silenced by PF-04523655, a 19-Mer siRNA Directed Against RTP801

Evaluations of Tear Protein Markers in Dry Eye Disease: Repeatability of Measurement and Correlation with Disease

Molecular Bases for Multiple Subgroups of Dry Eye Patients?

Retinal Microcirculation As A Predictor For Retinal And Optic Nerve Structural Changes In Patients With Primary Open Angle Glaucoma

Decreasing Retrobulbar Blood Flow is Predictive of OCT Structural Changes in Patients with Primary Open Angle Glaucoma

Modulation of HLA-DR On Conjunctival Cells And Inflammatory Mediators In Tears In Dry Eye Patients By CP-690,550, A Selective Inhibitor of The JAK Family

Characterization of Regional RTP801 Gene Expression Within the Retina and the Concentration-Effect Relationship of PF-655, an RTP801-silencing siRNA, Following Intravitreous Administration to Diabetic Rats

PF655 (Human) and Dharmacon (Murine) siRNAs Against the Stress Protein Response Gene RTP801 Enhances RGC-5 Cell Survival in Culture Caused by Insults of Blue Light or Cobalt Chloride

Rabbit Retina Expression And Cross-species Validation Of Gene Suppression By PF-655, a siRNA Against RTP801

Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications

Expression of Prostaglandin PGE 2 Receptors under Conditions of Aging and Stress and the Protective Effect of the EP2 Agonist Butaprost on Retinal Ischemia

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