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ARVO Annual Meeting Abstract June 2024

Exploring the Effects of 1-Deoxysphingolipids on Human Macula: Insights from the Macula-on-a-Chip (MoaC) System

Yue Zeng; Ting Zhang; Michelle Yam; So-Ra Lee; Jialing Zhang; Shaoxue Zeng; Yingying Chen; Meidong Zhu; Meixia Zhang; Kevin Thomas Eade; Ling Zhu; Mark C Gillies

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1697.

ARVO Annual Meeting Abstract June 2024

ELOVL4 Knock-out Retinal Organoids show VLC-PUFA Elongation Dysfunction

Sarah Giles; Sarah Ruth Harkins-Perry; Aruna Gorusupudi; Uzoamaka Nwagbo; Arunkumar Ranganathan; Martin Friedlander; Jon Rainier; Paul S Bernstein; Kevin Thomas Eade

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4548.

ARVO Annual Meeting Abstract June 2024

Reconstruction of a human blood-retina barrier to investigate the role of APOE variants in age-related macular degeneration

Rikki Rooklin; Abigail Uchitelev; Sarah Giles; Kevin Thomas Eade; Joel W Blanchard; Louise Mesentier-Louro

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4507.

ARVO Annual Meeting Abstract June 2023

Impaired ceramide metabolism is associated with retinal changes in a model of tamoxifen retinopathy

Simone Tzaridis; Courtney R Green; Elena Diaz Rubio; Caleb Bates; Yoichiro Ideguchi; Regis Fallon; Sarah Giles; Elizabeth Mills; Kevin Eade; Christian M Metallo; Martin Friedlander; Marin Gantner

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3773.

ARVO Annual Meeting Abstract June 2022

Patient iPSC-RPE implicate mitochondrial defects in Macular Telangiectasia

Sarah Giles; Brendan Ansell; Sarah Harkins-Perry; Martina Wallace; Marin Gantner; Regis Fallon; Alec Johnson; Barbara Hart; Melanie Bahlo; Rando Allikmets; Christian Metallo; Paul S Bernstein; Martin Friedlander; Kevin Thomas Eade

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2449 – F0393.

ARVO Annual Meeting Abstract June 2022

Deoxysphingolipids mediate toxicity though the Unfolded Protein Response (UPR)

Kevin Thomas Eade; Jessica Rosarda; Sarah Giles; Sarah Harkins-Perry; R. Luke Wiseman; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2436 – F0380.

ARVO Annual Meeting Abstract June 2022

New co-culture system of human iPSC induced retinal organoid and microglia

Ayumi Ouchi; Sarah Giles; Nobuyuki Ebihara; Kevin Thomas Eade; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3723 – F0329.

ARVO Annual Meeting Abstract June 2021

A synthetic very-long-chain polyunsaturated fatty acid (VLC-PUFA) enhances photoreceptor development in ELOVL4 knockout retinal organoids

Aruna Gorusupudi; Kevin Eade; Sarah Harkins-Perry; Sarah Giles; Jon D Rainier; Paul S Bernstein

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2600.

ARVO Annual Meeting Abstract July 2019

Reduced serine synthesis in patient-derived retinal pigmented epithelium leads to localized lipid dysfunction in MacTel

Kevin Eade; sarah giles; Sarah Harkins-Perry; Regis Fallon; Marin Gantner; michelle baldini; Martina Wallace; Rando Allikmets; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3852.

ARVO Annual Meeting Abstract July 2019

Reduced systemic serine levels lead to retinal defects in a mouse model of MacTel

Marin Gantner; Martina Wallace; Regis Fallon; Michal Handzlik; Kevin Eade; Ilham Polis; Alex Ideguchi; Maki Kitano; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4954.

ARVO Annual Meeting Abstract July 2019

MacTel patients carry rare phosphoglycerate dehydrogenase (PHGDH) variants with reduced enzymatic activity

Regis Fallon; Rebecca Berlow; Jana Zernant; Takayuki Nagasaki; Marin Gantner; Sarah Harkins-Perry; Kevin Eade; Rando Allikmets; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5994.

ARVO Annual Meeting Abstract July 2018

Modeling the cell specific origins of MacTel using a large patient iPSC-RPE library

Kevin Eade; Marin Gantner; sarah Victor; Regis Fallon; sarah harkins-perry; Alec Johnson; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4584.

ARVO Annual Meeting Abstract July 2018

Rare variants in the phosphoglycerate dehydrogenase (PHGDH) gene in MacTel patients lead to decreased enzymatic activity

Regis Fallon; Jana Zernant; Takayuki Nagasaki; Marin Gantner; sarah harkins-perry; Kevin Eade; Rando Allikmets; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5409.

ARVO Annual Meeting Abstract June 2017

CNTF treatment prevents development of pathological tuft formation in VLDLR -/- mice

Edith Aguilar; Felicitas Bucher; Mauricio Rosenfeld; Susumu Sakimoto; Salome Murinello; Marin Gantner; kevin eade; Sophia Diaz-Aguilar; Maki Kitano; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):189.

ARVO Annual Meeting Abstract June 2017

Mitochondrial activity in the retina relies on glycolysis independent of substrate availability

Marin Gantner; kevin eade; Edith Aguilar; Mitchell Prins; Alec Johnson; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3013.

ARVO Annual Meeting Abstract September 2016

Implications for iPS-based disease modeling: significant variability is observed in RPE cells differentiated from identical sources

Marin L Gantner; Jennifer Hazen; Valentina Lo Sardo; Kevin Eade; Mitchell Prins; Peter D Westenskow; Ashley Barnett; Alec Johnson; Kristin Baldwin; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6061.

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