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ARVO Annual Meeting Abstract June 2021

A disease-modifying therapy for retinal degenerations by drug repurposing

Henri Olavi Leinonen; Jianye Zhang; Fangyuan Gao; Elliot H Choi; Elliott E Einstein; David E Einstein; Laurence Mireille Occelli; Luis Felipe Marinho; Alexander V Kolesnikov; Vladimir Kefalov; Dorota Skowronska-Krawczyk; Seth Blackshaw; Simon M Petersen-Jones; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3157. doi:

ARVO Annual Meeting Abstract June 2021

Dissecting lipid contents in the distinct regions of native retinal rod disk membranes

Christopher Sander; Avery Sears; Antonio F. M. Pinto; Elliot H Choi; Shirin Kahremany; Hui Grace Jin; Els Pardon; Susie Suh; Zhiqian Dong; Jan Steyaert; Alan Saghatelian; Dorota Skowronska-Krawczyk; Philip David Kiser; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):529. doi:

ARVO Annual Meeting Abstract June 2021

Base editing restores retinal and visual function in the mouse model of Leber congenital amaurosis

Susie Suh; Elliot H Choi; Henri Leinonen; Andrzej Foik; Gregory A Newby; Philip David Kiser; David R Liu; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1480. doi:

ARVO Annual Meeting Abstract June 2021

An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease

Elliot H Choi; Susie Suh; Henri Leinonen; David Einstein; Zhiqian Dong; Steven J. Fliesler; Seth Blackshaw; Neal S Peachey; Krzysztof Palczewski; Philip David Kiser

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1524. doi:

Articles July 2020

Clinical Application of Infrared-Light Microperimetry in the Assessment of Scotopic-Eye Sensitivity

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Grzegorz Łabuz; Asu Rayamajhi; Julia Usinger; Katarzyna Komar; Patrick Merz; Ramin Khoramnia; Grazyna Palczewska; Krzysztof Palczewski; Gerd U. Auffarth
TAGS: eye, infrared rays
Trans. Vis. Sci. Tech.. 2020; 9(8):7. doi: https://doi.org/10.1167/tvst.9.8.7

ARVO Annual Meeting Abstract June 2020

Light-driven regeneration of 11- cis -retinal in the retinal pigment epithelium

Elliot H Choi; Jianye Zhang; Aleksander Tworak; David Salom; Grazyna Palczewska; Philip David Kiser; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1519. doi:

ARVO Annual Meeting Abstract June 2020

Maintained scotopic contrast sensitivity is associated with increased rod to rod-bipolar cell signal transmission in retinitis pigmentosa

Nguyen Cao Pham; Henri Leinonen; Taylor Boyd; Johanes Santoso; Krzysztof Palczewski; Frans Vinberg

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4513. doi:

ARVO Annual Meeting Abstract June 2020

An Image-Based High Throughput Screening Assay for Compounds Mitigating the Effect of All- Trans- Retinal Toxicity in Photoreceptor Degeneration

Susie Suh; Tamar Getter; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4941. doi:

ARVO Annual Meeting Abstract July 2019

New large animal model for RDH5 -associated retinopathies

Simon M Petersen-Jones; Laurence Occelli; Paige Winkler; Andrea Minella; Kelian Sun; Leslie Lyons; Anahita Daruwalla; Philip Kiser; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):458. doi:

ARVO Annual Meeting Abstract July 2019

Modulation of mouse rod signaling by llama-derived transducin nanobody

Guhan Iyer; Sahil Gulati; Krzysztof Palczewski; Vladimir Kefalov

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):568. doi:

ARVO Annual Meeting Abstract July 2019

Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones

Philip Kiser; Alexander V Kolesnikov; Jianying Kiser; Zhiqian Dong; Bhagirath Chaurasia; Liping Wang; Scott Summers; Thanh Hoang; Seth Blackshaw; Neal S Peachey; Vladimir Kefalov; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2369. doi:

ARVO Annual Meeting Abstract July 2019

Novel AAV Capsids Demonstrate Strong Retinal Expression in Non-Human Primates After Intravitreal Administration

Brian Kevany; Susie Suh; Jennings Lu; Linas Padegimas; Krzysztof Palczewski; Timothy Miller

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2900. doi:

ARVO Annual Meeting Abstract July 2019

Small molecules selectively reduce the misfolded rhodopsin that causes retinitis pigmentosa

Yuanyuan Chen; Krzysztof Palczewski; Xujie Liu

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):43. doi:

ARVO Annual Meeting Abstract July 2019

The phagocytic function of Müller glia in a mouse model of retinitis pigmentosa

Sanae Sakami; Yoshikazu Imanishi; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):444. doi:

ARVO Annual Meeting Abstract July 2019

Efficient Non-viral Gene Therapy for Stargardt’s Disease with pH-Sensitive Multifunctional Lipid ECO Plasmid DNA Nanoparticles

Da Sun; Rebecca Schur; Avery Sears; Songqi Gao; Rui Xin; Akiko Maeda; Krzysztof Palczewski; Zheng-Rong Lu

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2915. doi:

Retina April 2019

Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy

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Haitao Liu; Jie Tang; Yunpeng Du; Aicha Saadane; Ivy Samuels; Alex Veenstra; Jianying Z. Kiser; Krzysztof Palczewski; Timothy S. Kern
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, mice, phototransduction, photoreceptors, retina, vision, rod photoreceptors, tissue degeneration
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1538-1546. doi: https://doi.org/10.1167/iovs.18-26433

Physiology and Pharmacology April 2019

A Mixture of U.S. Food and Drug Administration–Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness

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Henri Leinonen; Elliot H. Choi; Anthony Gardella; Vladimir J. Kefalov; Krzysztof Palczewski
TAGS: disease models, mice, night blindness, retina, retinal cone, united states food and drug administration, disease susceptibility, diagnostic imaging, eye, transducin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1442-1453. doi: https://doi.org/10.1167/iovs.19-26560

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ARVO Annual Meeting Abstract July 2018

Protective effect of unbleachable retinal chromophore analogue against light-induced retinal degeneration in mice

Beata Jastrzebska; Songqi Gao; Grazyna Palczewska; Marcin Golczak; Zhigian Dong; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):369. doi:

ARVO Annual Meeting Abstract July 2018

Prevention of photoreceptor degeneration with FDA-accepted compounds

Henri O Leinonen; Tivadar Orban; Zhiqian Dong; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1591. doi:

ARVO Annual Meeting Abstract July 2018

Inner Retina Signaling and Well-Preserved Vision during Photoreceptor Degeneration in the P23H Retinitis Pigmentosa Model

Frans Vinberg; Henri O Leinonen; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1869. doi:

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A disease-modifying therapy for retinal degenerations by drug repurposing

Dissecting lipid contents in the distinct regions of native retinal rod disk membranes

Base editing restores retinal and visual function in the mouse model of Leber congenital amaurosis

An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease

Clinical Application of Infrared-Light Microperimetry in the Assessment of Scotopic-Eye Sensitivity

Light-driven regeneration of 11- cis -retinal in the retinal pigment epithelium

Maintained scotopic contrast sensitivity is associated with increased rod to rod-bipolar cell signal transmission in retinitis pigmentosa

An Image-Based High Throughput Screening Assay for Compounds Mitigating the Effect of All- Trans- Retinal Toxicity in Photoreceptor Degeneration

New large animal model for RDH5 -associated retinopathies

Modulation of mouse rod signaling by llama-derived transducin nanobody

Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones

Novel AAV Capsids Demonstrate Strong Retinal Expression in Non-Human Primates After Intravitreal Administration

Small molecules selectively reduce the misfolded rhodopsin that causes retinitis pigmentosa

The phagocytic function of Müller glia in a mouse model of retinitis pigmentosa

Efficient Non-viral Gene Therapy for Stargardt’s Disease with pH-Sensitive Multifunctional Lipid ECO Plasmid DNA Nanoparticles

Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy

A Mixture of U.S. Food and Drug Administration–Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness

Protective effect of unbleachable retinal chromophore analogue against light-induced retinal degeneration in mice

Prevention of photoreceptor degeneration with FDA-accepted compounds

Inner Retina Signaling and Well-Preserved Vision during Photoreceptor Degeneration in the P23H Retinitis Pigmentosa Model

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