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Visual Neuroscience June 2025

Associations Between Myopia and Brain Volumes: An Observational and Genetic Analysis

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Selena Wei Zhang; Jingze Guo; Yanxian Chen; Jiahao Liu; Yu Huang; Xianwen Shang; Mingguang He
TAGS: brain volume, myopia, genetic analysis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):57. https://doi.org/10.1167/iovs.66.6.57

Includes: Supplemental Content

Cornea June 2025

Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus –Induced Fungal Keratitis

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Jingze Kan; Shiqi Song; Mengzhu Liu; Qiang Xu; Jieun Lee; Jintao Sun; Shasha Xue; Xiaoyan Sun; Chengye Che
TAGS: aspergillus fumigatus, caspase-3, cornea, fungal keratitis, infections, inflammation, keratitis, mice, pyroptosis, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):52. https://doi.org/10.1167/iovs.66.6.52

Lens June 2025

Novel Subclassification of Presbyopia Based on Lens Functional and Structural Features

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Xiangjia Zhu; Xin Liu; Wenwen He; Kaiwen Cheng; Jiaqi Meng; Jiao Qi; Jing Zhao; Yi Lu; Xingtao Zhou
TAGS: lens (device), lens, crystalline, presbyopia, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(6):26. https://doi.org/10.1167/tvst.14.6.26

Retina June 2025

Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis

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Mariko Sasaki; Kai Xiong Cheong; Crystal Chun Yuen Chong; Marco Yu; Akiko Hanyuda; Kenya Yuki; Kazuno Negishi; Sawako Hashimoto; Kohta Fujiwara; Kohei Sonoda; Ya Xing Wang; Fei Gao; Anyarak Amornpetchsathaporn; Methaphon Chainakul; Ramyaa Srinivasan; Rehana Khan; Rajiv Raman; Paisan Ruamviboonsuk; Sung Ho Kim; Su Jeong Song; Mohammad Hassan Emamian; Hassan Hashemi; Akbar Fotouhi; Juping Liu; Xiaorong Li; Jost B. Jonas; Chui Ming Gemmy Cheung; Tien Yin Wong; Ching-Yu Cheng; Yih Chung Tham; Yasuo Yanagi; Anna Cheng Sim Tan
TAGS: age-related macular degeneration, asian, epidemiology, eye, meta-analysis, choroid, smoking
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):36. https://doi.org/10.1167/iovs.66.6.36

Includes: Supplemental Content

Clinical and Epidemiologic Research June 2025

Prevalence of Myopia and Axial Length Distribution in China: The Wuhu Children and Adolescents Eye Study

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Li Dong; Wen-Da Zhou; Ya-Bin Hu; Li Wei; Wei Cao; Ning-Hong Chen; Di Liu; Cheng Zhen; Yu-Chun Zheng; Jost B. Jonas; Wen-Bin Wei
TAGS: adolescent, child, china, eye, myopia, prevalence, refractive errors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):33. https://doi.org/10.1167/iovs.66.6.33

Includes: Supplemental Content

Cornea June 2025

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

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Hua Yang; Mengzhu Liu; Shiqi Song; Qiang Xu; Jieun Lee; Jintao Sun; Shasha Xue; Xiaoyan Sun; Chengye Che
TAGS: aspergillus fumigatus, caspase-8, cornea, inflammatory response, keratitis, macrophages, mice, pyroptosis, infections, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):32. https://doi.org/10.1167/iovs.66.6.32

Retina June 2025

Retinal Vessel Geometry and Retinal Abnormalities in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

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Wenbo Zhang; Xuecong Zhou; Jiacheng Liu; Tian Tian; Yu Guo; Chen Ling; Jingjing Xu; Qijie Wei; Yang Liu; Yuan Wu
TAGS: arterial disease, brain, cadasil, infarction, leukoencephalopathies, retinal vessels, subcortical
Trans. Vis. Sci. Tech.. 2025; 14(6):17. https://doi.org/10.1167/tvst.14.6.17

Review June 2025

Current Applications of Artificial Intelligence for Fuchs Endothelial Corneal Dystrophy: A Systematic Review

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Siyin Liu; Lynn Kandakji; Aleksander Stupnicki; Dayyanah Sumodhee; Marcello T. Leucci; Scott Hau; Shafi Balal; Arthur Okonkwo; Ismail Moghul; Sandor P. Kanda; Bruce D. Allan; Dan M. Gore; Kirithika Muthusamy; Alison J. Hardcastle; Alice E. Davidson; Petra Liskova; Nikolas Pontikos
TAGS: artificial intelligence, cornea, corneal edema, corneal endothelium, datasets, diagnostic imaging, endothelium, eye, hereditary corneal dystrophy, systematic reviews
Trans. Vis. Sci. Tech.. 2025; 14(6):12. https://doi.org/10.1167/tvst.14.6.12

Includes: Supplemental Content

Immunology and Microbiology June 2025

Alterations of the Enteric Virome in Vogt-Koyanagi-Harada Disease

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Mingzhu Liu; Jiawei Geng; Siyan Jin; Ping Hu; Xia Wang; Xiaoli Liu
TAGS: uveomeningoencephalitic syndrome, virome, viruses
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):15. https://doi.org/10.1167/iovs.66.6.15

Includes: Supplemental Content

Low Vision June 2025

The Efficiency and Safety of Oxygen-Supplemented Accelerated Scleral Cross-Linking in Rabbits

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Lingling Yan; Ce Wu; Xiaona Liu; Pengfei Han; Jie Zhang; Zhipeng Gao; Xiaona Li; Weiyi Chen
TAGS: cross-linking, oryctolagus cuniculus, oxygen, sclera, safety
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):10. https://doi.org/10.1167/iovs.66.6.10

Includes: Supplemental Content

Glaucoma June 2025

Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography

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Jie Wang; Karine D. Bojikian; Aiyin Chen; Ping Wei; Liang Liu; Yali Jia; David Huang
TAGS: angiogram, ganglia, optical coherence tomography, nerve fibers
Trans. Vis. Sci. Tech.. 2025; 14(6):5. https://doi.org/10.1167/tvst.14.6.5

Physiology and Pharmacology May 2025

Potential Application of Bendazac L-Lysine for Controlling Myopia Progression, as Demonstrated in Two Experimental Guinea Pig Myopia Models

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Zhenqi Guan; Shiming Jiao; Xingxing Yang; Shengcong Liu; Wenting Li; Le Yu; Jia Qu; Xiangtian Zhou; Miaozhen Pan
TAGS: lysine, myopia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):46. https://doi.org/10.1167/iovs.66.5.46

Includes: Supplemental Content

Review May 2025

Recent Advances in Stem Cells of Corneal Epithelia

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Yijian Li; Yong Liu
TAGS: cornea, corneal epithelium, epithelium, heterogeneity, stem cells, mice, adult stem cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):45. https://doi.org/10.1167/iovs.66.5.45

Retina May 2025

Clofarabine Enhances the Transduction Efficiency of Recombinant AAV2 in the Retina

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Yuyao Diao; Xuewei Xiong; Jiayan Liu; Xingbo Teng; Qi Shi; Shangli Jin; Yahui Lei; Shisi Ma; Guei-Sheung Liu; Lian Liu; Guocheng Yu; Jiang-Hui Wang; Jingxiang Zhong; Leilei Tu
TAGS: clofarabine, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):42. https://doi.org/10.1167/iovs.66.5.42

Includes: Supplemental Content

Glaucoma May 2025

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

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Huiwen Ye; Yanlin Feng; Wu Xiang; Zihao Lin; Yue Li; Wen Hu; Keyu Liu; Shuya Tao; Qinmeng Shu; Jiawei Wang; Fan Xu; Yue Xu; Yantao Wei; Jingjing Huang
TAGS: ferroptosis, mice, glutamate, glutamates, excitotoxicity, low tension glaucoma, lipid peroxidation, retina, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):26. https://doi.org/10.1167/iovs.66.5.26

Includes: Supplemental Content

Visual Neuroscience May 2025

Single-Cell RNA Sequencing of the Primary Visual Cortex in Mice With Optic Nerve Injury

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Deling Li; Bin Zou; Qinyuan Hu; Xinyi Zhang; Weiting Zeng; Liling Liu; Minbin Yu
TAGS: astrocytes, mice, optic nerve injuries, primary visual cortex, sequence analysis, rna, single-cell rna-seq, genes, microglia, alpha-crystallin b chain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):31. https://doi.org/10.1167/iovs.66.5.31

Includes: Supplemental Content

Cornea & External Disease May 2025

Unraveling the Link Between Obesity and Keratoconus Risk Based on Genetic Evidence

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Yuke Huang; Jiejie Zhuang; Chang Liu; Shiji Liu; Huanhuan Ren; Qitong Zhang; Yan Li; Jin Qiu; Na Yu; Keming Yu; Xi Chen; Jing Zhuang
TAGS: genetics, keratoconus, obesity
Trans. Vis. Sci. Tech.. 2025; 14(5):20. https://doi.org/10.1167/tvst.14.5.20

Includes: Supplemental Content

Artificial Intelligence May 2025

Grading of Foveal Hypoplasia Using Deep Learning on Retinal Fundus Images

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Tsung-Ying Tsai; Ying-Feng Chang; Eugene Yu-Chuan Kang; Kuan-Jen Chen; Nan-Kai Wang; Laura Liu; Yih-Shiou Hwang; Chi-Chun Lai; Sin-You Chen; Jenhui Chen; Chao-Sung Lai; Wei-Chi Wu
TAGS: deep learning, foveal hypoplasia, datasets, clinicians
Trans. Vis. Sci. Tech.. 2025; 14(5):18. https://doi.org/10.1167/tvst.14.5.18

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics May 2025

Monocular Contrast Sensitivity Visual Perceptual Learning Rebalances Adult Amblyopes’ Two Eyes

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Wenman Lin; Zhifen He; Shiqi Zhou; Liuqing Weng; Liying Zou; Renhao Ye; Jinli Zhu; Fan Lu; Jiawei Zhou
TAGS: amblyopia, contrast sensitivity, eye, perceptual learning, spatial frequency, vision, adult, balance, device, equilibrium, training
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):25. https://doi.org/10.1167/iovs.66.5.25

Includes: Supplemental Content

Anatomy and Pathology/Oncology May 2025

SOX4 as a Key Oncogene Driving Tumor Invasion in Retinoblastoma

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Jiahe Nie; Junjie Tang; Zhihui Zhang; Hetian Sun; Xinyue Wang; Longxiang Wang; Meng Wang; Weifeng Huang; Yang Gao; Jinmiao Li; Chao Cheng; Shicai Su; Shuxia Chen; Siming Ai; Yuxiang Mao; Ping Zhang; Yaoming Liu; Rong Lu
TAGS: oncogenes, retinoblastoma, tumor cell invasion, genes, cell lines, transplantation, heterologous
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):24. https://doi.org/10.1167/iovs.66.5.24

Includes: Supplemental Content

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Associations Between Myopia and Brain Volumes: An Observational and Genetic Analysis

Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus –Induced Fungal Keratitis

Novel Subclassification of Presbyopia Based on Lens Functional and Structural Features

Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis

Prevalence of Myopia and Axial Length Distribution in China: The Wuhu Children and Adolescents Eye Study

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

Retinal Vessel Geometry and Retinal Abnormalities in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Current Applications of Artificial Intelligence for Fuchs Endothelial Corneal Dystrophy: A Systematic Review

Alterations of the Enteric Virome in Vogt-Koyanagi-Harada Disease

The Efficiency and Safety of Oxygen-Supplemented Accelerated Scleral Cross-Linking in Rabbits

Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography

Potential Application of Bendazac L-Lysine for Controlling Myopia Progression, as Demonstrated in Two Experimental Guinea Pig Myopia Models

Recent Advances in Stem Cells of Corneal Epithelia

Clofarabine Enhances the Transduction Efficiency of Recombinant AAV2 in the Retina

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

Single-Cell RNA Sequencing of the Primary Visual Cortex in Mice With Optic Nerve Injury

Unraveling the Link Between Obesity and Keratoconus Risk Based on Genetic Evidence

Grading of Foveal Hypoplasia Using Deep Learning on Retinal Fundus Images

Monocular Contrast Sensitivity Visual Perceptual Learning Rebalances Adult Amblyopes’ Two Eyes

SOX4 as a Key Oncogene Driving Tumor Invasion in Retinoblastoma

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