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Clinical and Epidemiologic Research April 2025

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

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Zi Xuan Lin; Xiu Juan Zhang; Fang Yao Tang; Yuzhou Zhang; Ka Wai Kam; Alvin L. Young; Patrick Ip; Carol Y. Cheung; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Kyoko Ohno-Matsui; Jason C. Yam
TAGS: child, eye, myopia, retinal vasculature, hong kong
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):64. https://doi.org/10.1167/iovs.66.4.64

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank

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Yu Peng; Yuzhou Zhang; Ka Wai Kam; Gavin Wong; Mary Ho; Simon Sezto; Sunny Au; Xiujuan Zhang; Mandy P. H. Ng; Patrick Ip; Alvin Young; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Jason C. Yam
TAGS: health, macular disorders, uk biobank, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):63. https://doi.org/10.1167/iovs.66.4.63

Includes: Supplemental Content

Retina April 2025

The Exponential Constriction Model of the Ellipsoid Zone in Taiwanese Individuals With RPGR-Related X-Linked Retinitis Pigmentosa

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Yi-Han Huang; Yu-Shu Huang; Chien-Yu Lin; Ying-Ju Lai; Chang-Hao Yang; Tzzy-Chang Ho; Yi-Ting Hsieh; Po-Ting Yeh; Tso-Ting Lai; Chao-Wen Lin; Chung-May Yang; Pei-Lung Chen; Ta-Ching Chen
TAGS: constriction procedure, disease progression, retinitis pigmentosa, taiwanese, x-linked inheritance, eye, phenotype, exons
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):59. https://doi.org/10.1167/iovs.66.4.59

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

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Wei-Qi Song; Wen-Fang Zhong; Zhi-Hao Li; Dan Liu; Jiao-Jiao Ren; Dong Shen; Jian Gao; Pei-Liang Chen; Jin Yang; Xiao-Meng Wang; Fang-Fei You; Chuan Li; Huan Chen; Jia-Hao Xie; Chen Mao
TAGS: glaucoma, genetic predisposition to disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):47. https://doi.org/10.1167/iovs.66.4.47

Includes: Supplemental Content

Retina April 2025

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

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Kao-Jung Chang; Ching-Yun Wang; Hsin-Yu Wu; Pei-Yu Weng; Chia-Hsin Lu; Wei Chiu; Wei-Chieh Fang; Chong-En Kao; Cheng-Yi Li; Yi-Ting Chung; Yu-Chun Chen; Ai-Ru Hsieh; Shih-Hwa Chiou; Chih-Chien Hsu; Tai-Chi Lin; Shih-Jen Chen; De-Kuang Hwang
TAGS: biological markers, polygenic risk score, retinal detachment, screening, ultrasonography, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(4):16. https://doi.org/10.1167/tvst.14.4.16

Includes: Supplemental Content

Visual Neuroscience April 2025

Astrocyte-Derived Extracellular Vesicles Alleviate Optic Nerve Injury Through Remodeling of Retinal Microenvironmental Homeostasis

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Lili Chen; Zhonghao Yu; Senmiao Zhu; Shihan Song; Guanwen He; Zai-Long Chi; Wencan Wu
TAGS: astrocytes, extracellular vesicles, micrornas, optic nerve injuries, rna, messenger, homeostasis, phosphate-buffered saline, wounds and injuries, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):16. https://doi.org/10.1167/iovs.66.4.16

Includes: Supplemental Content

Cornea March 2025

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

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Shiding Li; Hao Sun; Fei Fang; Siyi Zhang; Junzhao Chen; Chunyi Shao; Yao Fu; Liangbo Chen
TAGS: body tissue, cell communication, cornea, epithelial stem cells, epithelium, fluorescent antibody technique, genes, rna, small cytoplasmic, transcriptomics, melanocytes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):52. https://doi.org/10.1167/iovs.66.3.52

Includes: Supplemental Content

Artificial Intelligence March 2025

An Intelligent Grading Model for Myopic Maculopathy Based on Long-Tailed Learning

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Bo Zheng; Chen Wang; Maotao Zhang; Shaojun Zhu; Maonian Wu; Tao Wu; Weihua Yang; Lu Chen
TAGS: learning, macular disorders, fundus photography, color, datasets
Trans. Vis. Sci. Tech.. 2025; 14(3):4. https://doi.org/10.1167/tvst.14.3.4

Includes: Supplemental Content

Refractive Intervention March 2025

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

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Hongwei Qin; Xin Yang; Rui He; Yaowen Song; Junchao Wei; Xiaona Liu; Chenyan Wang; Ce Wu; Jie Hou; Zhipeng Gao; Lingfeng Chen; Xiaona Li; Weiyi Chen
TAGS: cornea, oryctolagus cuniculus, biomechanics, stress, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(3):3. https://doi.org/10.1167/tvst.14.3.3

Includes: Supplemental Content

Glaucoma February 2025

Lung Function as a Biomarker for Glaucoma: The UK Biobank Study

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Jun Yu; Yuzhou Zhang; Ka Wai Kam; Mary Ho; Alvin L. Young; Chi Pui Pang; Clement C. Tham; Jason C. Yam; Li Jia Chen
TAGS: glaucoma, pulmonary function, pulmonary function tests, respiratory physiology, uk biobank, biological markers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):48. https://doi.org/10.1167/iovs.66.2.48

Includes: Supplemental Content

Retina February 2025

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

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Xiaoyan Ding; Xiaodi Zhou; Xinyu Liu; Yanting Lai; Wenjia Yan; Yizhe Cheng; Aohan Hou; Limei Chen; Limei Sun
TAGS: angiogenesis, hypoxia, mice, neovascularization, pathologic, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):40. https://doi.org/10.1167/iovs.66.2.40

Includes: Supplemental Content

Retina February 2025

Preconception Paternal Alcohol Consumption Elicits Postnatal Changes in Neural Retinas of the Offspring

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Kofi Owusu-Ansah; Kara N. Thomas; Kelsey Cox; Dylan L. Pham; Wei-Lin Chen; Michael Lee Ko; Michael C. Golding; Gladys Yi-Ping Ko
TAGS: alcohol drinking, ethanol, neural retina, offspring, retina, mice, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):16. https://doi.org/10.1167/iovs.66.2.16

Anatomy and Pathology/Oncology February 2025

Hepatic Satellite Cell Activation and Alteration of Vitamin A Status Are Relevant to the Aggravation of Retinopathy by T2DM

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Min-Chun Chang; David Pei-Cheng Lin; Han-Hsin Chang
TAGS: diabetes mellitus, type 2, vitamin a, liver injuries
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):7. https://doi.org/10.1167/iovs.66.2.7

Includes: Supplemental Content

Retina January 2025

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

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Ines D. Nagel; Anna Heinke; Akshay P. Agnihotri; Shaden Yassin; Lingyun Cheng; Andrew S. Camp; Nathan L. Scott; Fritz Gerald P. Kalaw; Shyamanga Borooah; Dirk-Uwe G. Bartsch; Arthur J. Mueller; Nehal Mehta; William R. Freeman
TAGS: color, diagnostic imaging, lasers, minimal cognitive impairment, ophthalmoscopes, retinal imaging
Trans. Vis. Sci. Tech.. 2025; 14(1):11. https://doi.org/10.1167/tvst.14.1.11

Retina December 2024

Association of Metabolomics With Incidence of Age-Related Macular Degeneration: The UK Biobank Study

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Jun Yu; Yuzhou Zhang; Mary Ho; Xiu Juan Zhang; Ka Wai Kam; Alvin L. Young; Chi Pui Pang; Clement C. Tham; Jason C. Yam; Li Jia Chen
TAGS: age-related macular degeneration, incidence, metabolites, metabolomics, uk biobank, biological markers, polygenic risk score, lipids
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):43. https://doi.org/10.1167/iovs.65.14.43

Includes: Supplemental Content

Retina December 2024

Effects of Physical Activity and Inactivity on Microvasculature in Children: The Hong Kong Children Eye Study

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Xiu Juan Zhang; Vincent L. Yuen; Yuzhou Zhang; Ka Wai Kam; Jason Wong; Fang Yao Tang; Alvin Young; Patrick Ip; Li Jia Chen; Tien Y. Wong; Chi Pui Pang; Clement C. Tham; Carol Y. Cheung; Jason C. Yam
TAGS: child, eye, hong kong, lack of exercise, microvascular network, physical activity
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):7. https://doi.org/10.1167/iovs.65.14.7

Includes: Supplemental Content

Retina November 2024

Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury

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David A. Antonetti; Cheng-Mao Lin; Sumathi Shanmugam; Heather Hager; Manjing Cao; Xuwen Liu; Alyssa Dreffs; Adam Habash; Steven F. Abcouwer
TAGS: diabetes mellitus, wounds and injuries, mice, retina, photoreceptors, reperfusion injury, streptozocin
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):46. https://doi.org/10.1167/iovs.65.13.46

Includes: Supplemental Content

Retinal Cell Biology October 2024

Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs

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Mei-Ling Gao; Tong-Yu Wang; Xin Lin; Chun Tang; Mengyao Li; Zhan-Pei Bai; Zhi-Cong Liu; Li-Jun Chen; Qing-Ran Kong; Shao-Hui Pan; Shan-Shan Zeng; Ya Guo; Jian-Qi Cai; Xiu-Feng Huang; Jun Zhang
TAGS: foreign medical graduates, microglia, organoids, coculture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):19. https://doi.org/10.1167/iovs.65.12.19

Includes: Supplemental Content

Cornea & External Disease September 2024

Drug-Related Keratitis: A Real-World FDA Adverse Event Reporting System Database Study

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Shi-Nan Wu; Xiao-Dong Chen; Qing-He Zhang; Yu-Qian Wang; Dan Yan; Chang-Sheng Xu; Shao-Pan Wang; Linfangzi Zhu; Dan-Yi Qin; Shu-Jia Guo; Lin Chen; Yu-Wen Liu; Caihong Huang; Jiaoyue Hu; Zuguo Liu
TAGS: keratitis, united states food and drug administration, incident reporting
Trans. Vis. Sci. Tech.. 2024; 13(9):17. https://doi.org/10.1167/tvst.13.9.17

Includes: Supplemental Content

Vision Sciences Society Annual Meeting Abstract September 2024

The Role of Spatial Reference Frame in Implicit Distractor Location Learning

Litian Chen; Freek van Ede; Heleen Slagter

Journal of Vision. 2024; 24(10):586. https://doi.org/10.1167/jov.24.10.586

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Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank

The Exponential Constriction Model of the Ellipsoid Zone in Taiwanese Individuals With RPGR-Related X-Linked Retinitis Pigmentosa

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

Astrocyte-Derived Extracellular Vesicles Alleviate Optic Nerve Injury Through Remodeling of Retinal Microenvironmental Homeostasis

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

An Intelligent Grading Model for Myopic Maculopathy Based on Long-Tailed Learning

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

Lung Function as a Biomarker for Glaucoma: The UK Biobank Study

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

Preconception Paternal Alcohol Consumption Elicits Postnatal Changes in Neural Retinas of the Offspring

Hepatic Satellite Cell Activation and Alteration of Vitamin A Status Are Relevant to the Aggravation of Retinopathy by T2DM

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

Association of Metabolomics With Incidence of Age-Related Macular Degeneration: The UK Biobank Study

Effects of Physical Activity and Inactivity on Microvasculature in Children: The Hong Kong Children Eye Study

Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury

Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs

Drug-Related Keratitis: A Real-World FDA Adverse Event Reporting System Database Study

The Role of Spatial Reference Frame in Implicit Distractor Location Learning

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