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Artificial Intelligence June 2025

Development of Deep Learning Models to Screen Posterior Staphylomas in Highly Myopic Eyes Using UWF-OCT Images

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Yining Wang; Changyu Chen; Ziye Wang; Yijin Wu; Hongshuang Lu; Jianping Xiong; Keigo Sugisawa; Koju Kamoi; Kyoko Ohno-Matsui
TAGS: datasets, deep learning, eye, staphyloma, retina, specialism
Trans. Vis. Sci. Tech.. 2025; 14(6):25. https://doi.org/10.1167/tvst.14.6.25

Includes: Supplemental Content

Lens June 2025

Novel Subclassification of Presbyopia Based on Lens Functional and Structural Features

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Xiangjia Zhu; Xin Liu; Wenwen He; Kaiwen Cheng; Jiaqi Meng; Jiao Qi; Jing Zhao; Yi Lu; Xingtao Zhou
TAGS: lens (device), lens, crystalline, presbyopia, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(6):26. https://doi.org/10.1167/tvst.14.6.26

Retina June 2025

Ocular Characteristics and Genotype-Oriented Disease Spectrum of Alström Syndrome in Taiwan

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Chien-Chien Cheng; Chien-Yu Lin; Ting-Chieh Ko; Yu-Shu Huang; Chu-Hsuan Huang; Chang-Hao Yang; Tzyy-Chang Ho; Pei-Lung Chen; Ta-Ching Chen
TAGS: alstrom syndrome, genotype, taiwan, obesity, electroretinography, massively-parallel genome sequencing, visual impairment
Trans. Vis. Sci. Tech.. 2025; 14(6):22. https://doi.org/10.1167/tvst.14.6.22

Includes: Supplemental Content

Artificial Intelligence June 2025

Machine Learning Applied to Visual Fields of Dominant Optic Atrophy Patients

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Catarina P. Coutinho; Ferdinando Zanchetta; Michele Carbonelli; Marco Battista; Alice Galzignato; Chiara La Morgia; Giulia Amore; Martina Romagnoli; Giacomo Savini; Luigi Brotto; Paolo Nucci; Leonardo Caporali; Francesco Bandello; Valerio Carelli; Maria Lucia Cascavilla; Rita Fioresi; Piero Barboni
TAGS: antithymoglobulin, arterial tortuosity syndrome, dead on arrival, optic atrophy, autosomal dominant, periodic paralysis, potassium-sensitive cardiodysrhythmic type, visual fields, mutation, machine learning
Trans. Vis. Sci. Tech.. 2025; 14(6):20. https://doi.org/10.1167/tvst.14.6.20

Includes: Supplemental Content

Retina June 2025

Short-Chain Fatty Acids Are Potential Biomarkers of Immune Regulation in Diabetic Retinopathy

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Xinran Qin; Jiaqi Sun; Yi Xu; Lina Lu; Yingyan Ma; Fangzhou Lou; Haidong Zou
TAGS: acetates, biological markers, diabetic retinopathy, plasma, regulation, volatile fatty acids, diabetes mellitus, retina, cytokine, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):23. https://doi.org/10.1167/iovs.66.6.23

Includes: Supplemental Content

Glaucoma June 2025

Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study

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Louay Almidani; Jasdeep Sabharwal; Anoush Shahidzadeh; Ana Collazo Martinez; Shu Jie Ting; Brinda Vaidya; Xuejuan Jiang; Tim Kowalczyk; Alexa Beiser; Lucia Sobrin; Sudha Seshadri; Pradeep Ramulu; Amir H. Kashani
TAGS: eye, framingham heart study, glaucoma, retinal nerve fiber layer, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(6):7. https://doi.org/10.1167/tvst.14.6.7

Includes: Supplemental Content

Low Vision Rehabilitation May 2025

Using ChatGPT To Generate Walking Directions—Could It Potentially Help Visually Impaired With Micronavigation?

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Junxian He; Shrinivas Pundlik; Gang Luo
TAGS: chatgpt, datasets, gait, walking (activity)
Trans. Vis. Sci. Tech.. 2025; 14(5):28. https://doi.org/10.1167/tvst.14.5.28

Refractive Intervention May 2025

Distance of Corneal Vertex and Effective Optical Zone Margin Following Keratorefractive Lenticule Extraction in Myopic Astigmatism

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Xuyun Meng; Hui Ding; Hong He; Zhenduo Yang; Xiaodan Chen; Shisi Hu; Anzhen Li; Xingxing Wang; Yuhan Luo; Xingwu Zhong
TAGS: astigmatism, cornea, crown of head, optics, postoperative care, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(5):21. https://doi.org/10.1167/tvst.14.5.21

Visual Psychophysics and Physiological Optics May 2025

Monocular Contrast Sensitivity Visual Perceptual Learning Rebalances Adult Amblyopes’ Two Eyes

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Wenman Lin; Zhifen He; Shiqi Zhou; Liuqing Weng; Liying Zou; Renhao Ye; Jinli Zhu; Fan Lu; Jiawei Zhou
TAGS: amblyopia, contrast sensitivity, eye, perceptual learning, spatial frequency, vision, adult, balance, device, equilibrium, training
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):25. https://doi.org/10.1167/iovs.66.5.25

Includes: Supplemental Content

Anatomy and Pathology/Oncology May 2025

SOX4 as a Key Oncogene Driving Tumor Invasion in Retinoblastoma

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Jiahe Nie; Junjie Tang; Zhihui Zhang; Hetian Sun; Xinyue Wang; Longxiang Wang; Meng Wang; Weifeng Huang; Yang Gao; Jinmiao Li; Chao Cheng; Shicai Su; Shuxia Chen; Siming Ai; Yuxiang Mao; Ping Zhang; Yaoming Liu; Rong Lu
TAGS: oncogenes, retinoblastoma, tumor cell invasion, genes, cell lines, transplantation, heterologous
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):24. https://doi.org/10.1167/iovs.66.5.24

Includes: Supplemental Content

Review May 2025

Protein Acetylation in Age-Related Macular Degeneration: Mechanisms, Roles, and Therapeutic Perspectives

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Tianyi Luo; Cunzi Li; Lan Zhou; Hongyan Sun; Ming Ming Yang
TAGS: acetylation, age-related macular degeneration, proteins, oxidative stress, histone deacetylase inhibitors, choroidal neovascularization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):30. https://doi.org/10.1167/iovs.66.5.30

Uveitis May 2025

Associations Between the Gut Microbiota and Its Related Metabolic Pathways and Uveitis: A Bidirectional Two-Sample Mendelian Randomization Study

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Maomei Luo; Zhen Xing; Yanhao Gou; Xianlin Yang; Xinran Zhang; Wei Yu; Hongbin Lv
TAGS: gastrointestinal microbiome, uveitis, mendelian randomization analysis
Trans. Vis. Sci. Tech.. 2025; 14(5):15. https://doi.org/10.1167/tvst.14.5.15

Retina May 2025

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

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Weifeng Huang; Yaoming Liu; Jinmiao Li; Yang Gao; Junjie Tang; Siuhang Yip; Xinyue Wang; Hongwei Zhang; Yujun Ma; Shicai Su; Jiahe Nie; Rong Lu
TAGS: endoplasmic reticulum stress, lipocalin-2 protein, microglia, neuroinflammatory diseases, optic nerve injuries, up-regulation (physiology), inflammation, lcn2 gene, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):12. https://doi.org/10.1167/iovs.66.5.12

Includes: Supplemental Content

Immunology and Microbiology May 2025

Contribution of Leukocidin ED to the Pathogenesis of Staphylococcus aureus Endophthalmitis

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Luis Longoria-Gonzalez; Phillip S. Coburn; Roger Astley; Yan Chen; Michelle C. Callegan
TAGS: endophthalmitis, eye, infections, mice, pathogenesis, staphylococcus aureus
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):11. https://doi.org/10.1167/iovs.66.5.11

Retina April 2025

AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway

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Yijie Yang; Jiawei Shen; Yanting Li; Xinzhu Chen; Gaoqin Liu; Peirong Lu
TAGS: 1-phosphatidylinositol 3-kinase, akt signaling pathway, choroid, epithelial to mesenchymal transition, fibrosis, mice, lasers, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):83. https://doi.org/10.1167/iovs.66.4.83

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2025

Conjunctival MicroRNA Expression Signature in Primary Sjögren's Syndrome Dry Eye: A NanoString-Based Bioinformatic Analysis

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Francesca Giovannetti; Paola Pontecorvi; Francesca Megiorni; Marta Armentano; Ludovico Alisi; Enrico Romano; Cinzia Marchese; Alessandro Lambiase; Alice Bruscolini
TAGS: dry eye syndromes, micrornas, peeling skin syndrome, systemic scleroderma, sjogren's syndrome, bioinformatics, eye, conjunctiva, molecular profiling
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):80. https://doi.org/10.1167/iovs.66.4.80

Retina April 2025

Radiomics Analysis Based on Optical Coherence Tomography to Prognose the Efficacy of Anti-VEGF Therapy of Retinal Vein Occlusion-Related Macular Edema

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Biying Chen; Jianing Qiu; Yongan Meng; Youling Liang; Dan Liu; Yuqian Hu; Zhishang Meng; Jing Luo
TAGS: anti-vascular endothelial growth factor therapy, central retinal vein, macular edema, optical coherence tomography, radiomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):74. https://doi.org/10.1167/iovs.66.4.74

Includes: Supplemental Content

Article April 2025

Violated predictions enhance the representational fidelity of visual features in perception

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Reuben Rideaux; Phuong Dang; Luke Jackel-David; Zak Buhmann; Dragan Rangelov; Jason B. Mattingley
TAGS: perception, precision, reaction time
Journal of Vision. 2025; 25(4):14. https://doi.org/10.1167/jov.25.4.14

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging April 2025

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

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Yan-Jie Li; Zeng-Yu Zhang; Tian-Yue Liu; Hai-Yan Liu; Lu-Lu Shi; Rong-Xia Cao; Chao-Ran Lv; Zeng-Hui Zhang
TAGS: angiogram, fluid flow, microcirculation, optical coherence tomography, retina, thyroid carcinoma, papillary, carcinoma, perfusion, inflammation, inspection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):73. https://doi.org/10.1167/iovs.66.4.73

Glaucoma April 2025

New Threshold for Large Optic Discs in Children Using Bruch's Membrane Opening Area

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Julia V. Stingl; Cordula Braun; Sara Walter; Jasmin Rezapour; Felix M. Wagner; Lucy Shen; Alicja Strzalkowska; Irene Schmidtmann; Alexander K. Schuster; Esther M. Hoffmann
TAGS: bruch's basal membrane, child, optics, glaucoma, optic disk
Trans. Vis. Sci. Tech.. 2025; 14(4):24. https://doi.org/10.1167/tvst.14.4.24

Includes: Supplemental Content

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Development of Deep Learning Models to Screen Posterior Staphylomas in Highly Myopic Eyes Using UWF-OCT Images

Novel Subclassification of Presbyopia Based on Lens Functional and Structural Features

Ocular Characteristics and Genotype-Oriented Disease Spectrum of Alström Syndrome in Taiwan

Machine Learning Applied to Visual Fields of Dominant Optic Atrophy Patients

Short-Chain Fatty Acids Are Potential Biomarkers of Immune Regulation in Diabetic Retinopathy

Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study

Using ChatGPT To Generate Walking Directions—Could It Potentially Help Visually Impaired With Micronavigation?

Distance of Corneal Vertex and Effective Optical Zone Margin Following Keratorefractive Lenticule Extraction in Myopic Astigmatism

Monocular Contrast Sensitivity Visual Perceptual Learning Rebalances Adult Amblyopes’ Two Eyes

SOX4 as a Key Oncogene Driving Tumor Invasion in Retinoblastoma

Protein Acetylation in Age-Related Macular Degeneration: Mechanisms, Roles, and Therapeutic Perspectives

Associations Between the Gut Microbiota and Its Related Metabolic Pathways and Uveitis: A Bidirectional Two-Sample Mendelian Randomization Study

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

Contribution of Leukocidin ED to the Pathogenesis of Staphylococcus aureus Endophthalmitis

AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway

Conjunctival MicroRNA Expression Signature in Primary Sjögren's Syndrome Dry Eye: A NanoString-Based Bioinformatic Analysis

Radiomics Analysis Based on Optical Coherence Tomography to Prognose the Efficacy of Anti-VEGF Therapy of Retinal Vein Occlusion-Related Macular Edema

Violated predictions enhance the representational fidelity of visual features in perception

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

New Threshold for Large Optic Discs in Children Using Bruch's Membrane Opening Area

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