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Glaucoma April 2025

Association Between Cup-to-Disc Ratio and Structural and Functional Damage Parameters in Glaucoma: Insights From Multiparametric Modeling

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Aliah McCalla; Mengyu Wang; Mohammad Eslami; Saber Kazeminasab; Yan Luo; Hannah Rana; Sajib Saha; Min Shi; Yu Tian; Nazlee Zebardast; Tobias Elze
TAGS: glaucoma, clinicians, optic disk
Trans. Vis. Sci. Tech.. 2025; 14(4):17. https://doi.org/10.1167/tvst.14.4.17

Includes: Supplemental Content

Retina March 2025

Addressing Multiplicity in Retinal Sensitivity Analysis: An Alternative Approach to Assessing Gene Therapy Efficacy in Inherited Retinal Diseases

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Antonio Yaghy; David G. Birch; Yunchan Hwang; Edmund Luo; JungAh Jung; Darin Curtiss; Nadia K. Waheed
TAGS: gene therapy, retinal diseases, sensitivity analysis, treatment effect
Trans. Vis. Sci. Tech.. 2025; 14(3):25. https://doi.org/10.1167/tvst.14.3.25

Biochemistry and Molecular Biology March 2025

Epigenetic ALYREF/UHRF1/RHOB Axis in Corneal Wound Healing and Implications for Epithelial Tumorigenesis

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Hua Zhang; Shuning Lan; Disuo Ren; Xiaoyan Chen; Yong Lin; Qiongjie Cao; Weiwei Xu; Jiao Wang; Peter Sol Reinach; Dongsheng Yan; Guangying Luo
TAGS: cornea, dna methylation, epigenetics, epithelium, genes, rna, tumorigenesis, wound healing, neoplasms, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):54. https://doi.org/10.1167/iovs.66.3.54

Includes: Supplemental Content

Lens March 2025

Changes in Lens Thickness and Power Before and After Myopia Onset

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Jiaqing Zhang; Ling Jin; Qianyun Chen; Decai Wang; Xiang Chen; Yuting Li; Yabin Qu; Rong Lin; Mingguang He; Ian G. Morgan; Lixia Luo; Yangfa Zeng; Xiaotong Han
TAGS: lens, crystalline, myopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):36. https://doi.org/10.1167/iovs.66.3.36

Includes: Supplemental Content

Cornea & External Disease March 2025

Enhanced Riboflavin Stromal Delivery Using Microchannel-Assisted Iontophoresis for Corneal Crosslinking

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Rohan Joshi; Samantha Bradford; Shangbang Luo; Emily Farrah; Yilu Xie; Donald J. Brown; Tibor Juhasz; James V. Jester
TAGS: corneal collagen cross-linking, iontophoresis, riboflavin, mass or substance concentration per volume, eye, oryctolagus cuniculus, cornea
Trans. Vis. Sci. Tech.. 2025; 14(3):18. https://doi.org/10.1167/tvst.14.3.18

Public Health March 2025

Visual Deficits in Type 2 Diabetes Mellitus Without Retinopathy: From Retinal Structure to Higher-Level Visual Functions

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Sha Luo; Lin Xia; Yue Wang; Yong Tang; Jiong Dong; Rong Liu; Lixia Feng
TAGS: diabetes mellitus, diabetes mellitus, type 2, retina, retinal diseases, vision, vision disorders
Trans. Vis. Sci. Tech.. 2025; 14(3):10. https://doi.org/10.1167/tvst.14.3.10

Includes: Supplemental Content

Retina March 2025

Fibronectin Mediates Endothelial-to-Mesenchymal Transition in Retina Angiogenesis

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Dan Liu; Zhishang Meng; Chen Jin; Fang Chen; Li Pu; Ze Wu; Qi Zeng; Jing Luo; Wenyi Wu
TAGS: angiogenesis, fibronectins, retina, genes, endothelium, vascular endothelial growth factor a, epithelial to mesenchymal transition, rna, small interfering, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):10. https://doi.org/10.1167/iovs.66.3.10

Includes: Supplemental Content

Cornea February 2025

IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression

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Yanxiao Li; Zan Luo; Zihao Liu; Xinhao Zhu; Peter S. Reinach; Ling Li; Wei Chen
TAGS: dry eye syndromes, interleukin-23, conjunctiva, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):10. https://doi.org/10.1167/iovs.66.2.10

Includes: Supplemental Content

Glaucoma January 2025

SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression

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Qian Ying; Hongdou Luo; Zhi Xie; Yi Huang; Haijian Hu; Ming Jin; Ke Xu; Yulian Pang; Yuning Song; Xu Zhang
TAGS: glutamate, glutamates, mitochondria, neuroglia, optic atrophy, autosomal dominant, proteins, retina, wounds and injuries, n-methylaspartate, retinal injuries
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):62. https://doi.org/10.1167/iovs.66.1.62

Lens January 2025

Influence of Lens Power on IOL/Posterior Lens Capsule Interactions and IOL's PCO Potential

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Amjad Chatila; Vicki Ea; Samira Izuagbe; Le Quynh Hoang; Bhavya Vaish; Cynthia M. Co; Trinh M. Luong; Liping Tang
TAGS: adhesions, diopters, incidence, lens (device), lens capsule, crystalline, lens, crystalline, myopia, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):41. https://doi.org/10.1167/iovs.66.1.41

Includes: Supplemental Content

Biochemistry and Molecular Biology January 2025

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3

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Qiongjie Cao; Wenji Xu; Xiaoyan Chen; Guangying Luo; Peter S. Reinach; Dongsheng Yan
TAGS: arginine, cornea, epigenetics, epithelium, methylation, wound healing, regulation, mice, western blotting, histones
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):22. https://doi.org/10.1167/iovs.66.1.22

Includes: Supplemental Content

Physiology and Pharmacology December 2024

Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome

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Ameya Belamkar; Qianyi Luo; Neha Mahajan; Surabhi Abhyankar; Bryce A. Jones; Rupinder Kaur Sodhi; Padmanabhan P. Pattabiraman; Moshe Levi; Ashay D. Bhatwadekar
TAGS: collagen, cornea, eye, eye diseases, fluorescent antibody technique, hereditary nephritis, lens (device), mice, mice, knockout, phenotype
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):29. https://doi.org/10.1167/iovs.65.14.29

Includes: Supplemental Content

Retina December 2024

Multi-Omics Integration With Machine Learning Identified Early Diabetic Retinopathy, Diabetic Macula Edema and Anti-VEGF Treatment Response

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Yuhui Pang; Chaokun Luo; Qingruo Zhang; Xiongze Zhang; Nanying Liao; Yuying Ji; Lan Mi; Yuhong Gan; Yongyue Su; Feng Wen; Hui Chen
TAGS: anti-vascular endothelial growth factor therapy, diabetes mellitus, diabetic retinopathy, edema, machine learning, multiomics, macula lutea, hypertension, nonproliferative diabetic retinopathy, metabolomics
Trans. Vis. Sci. Tech.. 2024; 13(12):23. https://doi.org/10.1167/tvst.13.12.23

Includes: Supplemental Content

Clinical Trials November 2024

A Comparative and Prospective Study of Corneal Consumption and Corneal Biomechanics After SMILE and FS-LASIK Performed on the Contralateral Eyes With High Myopic Astigmatism

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Xiangtao Hou; Pei Chen; Na Yu; Yiqi Luo; Han Wei; Jing Zhuang; Keming Yu
TAGS: astigmatism, biomechanics, cardiac ct, cornea, eye, keratomileusis, laser in situ, laser surgery, prospective studies, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2024; 13(11):29. https://doi.org/10.1167/tvst.13.11.29

Visual Neuroscience November 2024

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

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Zhonghao Yu; Yue Guan; Tian Xia; Xuanwen Li; Mingyue Liu; Yujia Huo; Zhuowei Wang; Zhirong Liu; Yuting Luo; Wentao Yan; Lanfang Sun; Wencan Wu; Baoguo Shen; Yikui Zhang
TAGS: optic nerve, rna, rna, messenger, white matter
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):25. https://doi.org/10.1167/iovs.65.13.25

Includes: Multimedia, Supplemental Content

Cornea & External Disease October 2024

In Vivo Femtosecond Laser Machined Transepithelial Nonlinear Optical Corneal Crosslinking Compared to Ultraviolet Corneal Crosslinking

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Samantha Bradford; Rohan Joshi; Shangbang Luo; Emily Farrah; Yilu Xie; Donald J. Brown; Tibor Juhasz; James V. Jester
TAGS: corneal collagen cross-linking, ultraviolet a radiation, epithelium, cornea, femtosecond pulsed lasers, optics, riboflavin
Trans. Vis. Sci. Tech.. 2024; 13(10):9. https://doi.org/10.1167/tvst.13.10.9

Artificial Intelligence September 2024

Generating Synthesized Fluorescein Angiography Images From Color Fundus Images by Generative Adversarial Networks for Macular Edema Assessment

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Xiaoling Xie; Danba Jiachu; Chang Liu; Meng Xie; Jinming Guo; Kebo Cai; Xiangbo Li; Wei Mi; Hehua Ye; Li Luo; Jianlong Yang; Mingzhi Zhang; Ce Zheng
TAGS: color, datasets, fluorescein angiography, macular edema, specialism
Trans. Vis. Sci. Tech.. 2024; 13(9):26. https://doi.org/10.1167/tvst.13.9.26

Artificial Intelligence September 2024

A Meta-Learning Approach for Classifying Multimodal Retinal Images of Retinal Vein Occlusion With Limited Data

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Danba Jiachu; Li Luo; Meng Xie; Xiaoling Xie; Jinming Guo; Hehua Ye; Kebo Cai; Lingling Zhou; Gang Song; Feng Jiang; Danqing Huang; Mingzhi Zhang; Ce Zheng
TAGS: datasets, learning, retinal vein occlusion, training
Trans. Vis. Sci. Tech.. 2024; 13(9):22. https://doi.org/10.1167/tvst.13.9.22

Retina September 2024

Characterization of Vortex Vein Drainage System in Healthy Individuals Imaged by Ultra-Widefield Optical Coherence Tomography Angiography

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Zhonghua Luo; Yue Xu; Xiaomei Xiong; Shengsong Huang; Subinuer Alimu; Jinli Cui; Kun Xu; Ching-Kit Tsui; Shuxin Fan; Kaixuan Cui; Shanshan Yu; Xiaoling Liang
TAGS: angiogram, discharge, body substance, drainage procedure, eye, optical coherence tomography, cortical blindness, cardiovascular imaging, venous anastomosis
Trans. Vis. Sci. Tech.. 2024; 13(9):19. https://doi.org/10.1167/tvst.13.9.19

Includes: Supplemental Content

Article September 2024

Bistable perception of symbolic numbers

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Junxiang Luo; Isao Yokoi; Serge O. Dumoulin; Hiromasa Takemura
TAGS: numbers, perception, semantics, shape, visual processing
Journal of Vision. 2024; 24(9):12. https://doi.org/10.1167/jov.24.9.12

Includes: Multimedia, Supplemental Content

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Association Between Cup-to-Disc Ratio and Structural and Functional Damage Parameters in Glaucoma: Insights From Multiparametric Modeling

Addressing Multiplicity in Retinal Sensitivity Analysis: An Alternative Approach to Assessing Gene Therapy Efficacy in Inherited Retinal Diseases

Epigenetic ALYREF/UHRF1/RHOB Axis in Corneal Wound Healing and Implications for Epithelial Tumorigenesis

Changes in Lens Thickness and Power Before and After Myopia Onset

Enhanced Riboflavin Stromal Delivery Using Microchannel-Assisted Iontophoresis for Corneal Crosslinking

Visual Deficits in Type 2 Diabetes Mellitus Without Retinopathy: From Retinal Structure to Higher-Level Visual Functions

Fibronectin Mediates Endothelial-to-Mesenchymal Transition in Retina Angiogenesis

IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression

SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression

Influence of Lens Power on IOL/Posterior Lens Capsule Interactions and IOL's PCO Potential

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3

Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome

Multi-Omics Integration With Machine Learning Identified Early Diabetic Retinopathy, Diabetic Macula Edema and Anti-VEGF Treatment Response

A Comparative and Prospective Study of Corneal Consumption and Corneal Biomechanics After SMILE and FS-LASIK Performed on the Contralateral Eyes With High Myopic Astigmatism

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

In Vivo Femtosecond Laser Machined Transepithelial Nonlinear Optical Corneal Crosslinking Compared to Ultraviolet Corneal Crosslinking

Generating Synthesized Fluorescein Angiography Images From Color Fundus Images by Generative Adversarial Networks for Macular Edema Assessment

A Meta-Learning Approach for Classifying Multimodal Retinal Images of Retinal Vein Occlusion With Limited Data

Characterization of Vortex Vein Drainage System in Healthy Individuals Imaged by Ultra-Widefield Optical Coherence Tomography Angiography

Bistable perception of symbolic numbers

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