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Glaucoma May 2025

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

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Yu-Ting Tsao; Hung-Chi Chen; Yi-Jen Hsueh; Yu-Chun Cheng; Eugene Yu-Chuan Kang; Chu-Yen Huang; Yung-Sung Lee
TAGS: antioxidants, aqueous humor, glaucoma, intraocular pressure, teller acuity cards, total arterial compliance, trigeminal autonomic cephalalgias, prospective studies, drug usage
Trans. Vis. Sci. Tech.. 2025; 14(5):7. https://doi.org/10.1167/tvst.14.5.7

Includes: Supplemental Content

Retinal Cell Biology March 2025

Targeted siRNA Delivery Against RUNX1 Via tFNA: Inhibiting Retinal Neovascularization and Restoring Vessels Through Dll4/Notch1 Signaling

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Xiaodi Zhou; Xiaoxiao Xu; Qiong Wang; Yanting Lai; Linyan Zhang; Yunfeng Lin; Xiaoyan Ding; Limei Sun
TAGS: endothelial cells, hypoxia, notch1 gene, retinal neovascularization, rna, small interfering, signal transduction, proteins, neovascularization, pathologic, ischemia, fluorescence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):39. https://doi.org/10.1167/iovs.66.3.39

Retina February 2025

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

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Xiaoyan Ding; Xiaodi Zhou; Xinyu Liu; Yanting Lai; Wenjia Yan; Yizhe Cheng; Aohan Hou; Limei Chen; Limei Sun
TAGS: angiogenesis, hypoxia, mice, neovascularization, pathologic, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):40. https://doi.org/10.1167/iovs.66.2.40

Includes: Supplemental Content

Visual Neuroscience November 2024

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

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Zhonghao Yu; Yue Guan; Tian Xia; Xuanwen Li; Mingyue Liu; Yujia Huo; Zhuowei Wang; Zhirong Liu; Yuting Luo; Wentao Yan; Lanfang Sun; Wencan Wu; Baoguo Shen; Yikui Zhang
TAGS: optic nerve, rna, rna, messenger, white matter
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):25. https://doi.org/10.1167/iovs.65.13.25

Includes: Multimedia, Supplemental Content

Cornea September 2024

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys

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Ming Zhou; Zhuo-Xing Shi; Zhong Liu; Shu-Rui Ke; Chao-Yang Wang; Xiao-Lin Liang; Qiu-Ling Hu; Qi-Kai Zhang; Dong-Liang Wang; Li Sun; Yu-Heng Lin; Qi Dai; Ying-Feng Zheng
TAGS: cornea, corneal epithelium, genes, macaca fascicularis, wound healing, epithelium, transcription, genetic, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):43. https://doi.org/10.1167/iovs.65.11.43

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Genetic duplication found in strabismus patients leads to decreased synaptic formation in iPSC-derived cortical neurons

Mayra Martinez Sanchez; Ashish Jain; William Skarnes; Liang Sun; Mary Whitman

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1153.

ARVO Annual Meeting Abstract June 2024

ARMMs as non-viral vehicles for the delivery of genome editors to treat Stargardt disease

Jinling Yang; Chou-Wei Chang; Qiyu Wang; Wendy Zhao; Adam Miller; Shu-Lin Liu; Lucy (Yumei) Sun; Alysia Bryant; Steven Greenway; Adam Francoeur; Leah Gens; Kristin Luther; Gary Hao; Yashodhan Chinchore; Qin Yu; Joseph Nabhan

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2227.

ARVO Annual Meeting Abstract June 2024

Trigeminal denervation induces disruption of corneal endothelial cell junctions and inflammation in the mouse eye

Hsin Yu Liu; Yi Lan Tsai; Yueh Feng Wu; Sung Jan Lin; Fung Rong Hu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4158.

ARVO Annual Meeting Abstract June 2024

Dynamics of MicroRNA Secreted via Extracellular Vesicles During the Aging of Embryonic Stem Cell-Derived Retinal Pigment Epithelium

Dimitrios Pollalis; Gopa Kumar Gopinadhan Nair; Justin Leung; Clarisa Marie Bloemhof; Jeffrey K. Bailey; Britney O. Pennington; Amir I. Khan; Kaitlin R. Kelly; Ashley K. Yeh; Kartik S. Sundaram; Dennis O Clegg; Chen-Ching Peng; Liya Xu; Constantin Georgescu; Jonathan Wren; Sun Young Lee

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):728.

ARVO Annual Meeting Abstract June 2024

Müller Glia-Derived Small Extracellular Vesicles as Potential Therapy of Early-Stage Diabetic Retinopathy

Clarisa Marie Bloemhof; Gopa Kumar Gopinadhan Nair; Dimitrios Pollalis; Justin Leung; Kayla Mahboubi; Sun Young Lee

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4442.

Clinical and Epidemiologic Research June 2024

Use of Sodium-Glucose Co-Transporter 2 Inhibitors in Patients With Type 2 Diabetes and the Incidence of Retinal Vein Occlusion in Taiwan

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Hou-Ren Tsai; Yu-Jie Lin; Jih-I Yeh; Shu-Man Lin; Peter Pin-Sung Liu; Yung-Ching Chang; Yuan-Chieh Lee; Ching-Hui Loh; Huei-Kai Huang
TAGS: diabetes mellitus, type 2, retinal vein occlusion, sodium-glucose transport proteins, taiwan, sodium-glucose transporter 2 inhibitors, incidence
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):19. https://doi.org/10.1167/iovs.65.6.19

Includes: Supplemental Content

Genetics May 2024

Association of Novel Loci With Keratoconus Susceptibility in a Chinese Genome-Wide Association Study

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Liyan Xu; Xiaodong Zheng; Shanshan Yin; Kaili Yang; Qi Fan; Yuwei Gu; Yi Yuan; Chenchen Yin; Yonghao Zang; Chenjiu Pang; Liangdan Sun; Shengwei Ren
TAGS: chinese (other dialects), chinese people, disease susceptibility, genome-wide association study, keratoconus, cornea, genome, study population, single nucleotide polymorphism
Invest. Ophthalmol. Vis. Sci.. 2024; 65(5):29. https://doi.org/10.1167/iovs.65.5.29

Includes: Supplemental Content

Retina March 2024

Genotype-Phenotype of CRB1-Associated Early-Onset Retinal Dystrophy: Novel Insights on Retinal Architecture and Therapeutic Window for Clinical Trials

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Yili Jin; Songshan Li; Zhaoxin Jiang; Limei Sun; Li Huang; Ting Zhang; Xinyu Liu; Xiaoyan Ding
TAGS: genotype, phenotype, retinal dystrophies, therapeutic index, child, genetics, signs and symptoms
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):11. https://doi.org/10.1167/iovs.65.3.11

Biochemistry and Molecular Biology March 2024

Isolation and Characterization of Extracellular Vesicles Through Orthogonal Approaches for the Development of Intraocular EV Therapy

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Justin Leung; Dimitrios Pollalis; Gopa K. G. Nair; Jeffrey K. Bailey; Britney O. Pennington; Amir I. Khan; Kaitlin R. Kelly; Ashley K. Yeh; Kartik S. Sundaram; Dennis O. Clegg; Chen-Ching Peng; Liya Xu; Sun Young Lee
TAGS: extracellular vesicles, mass or substance concentration per volume, particle, patient isolation, proteins, social isolation, pan-hematopoietic expression protein, biophysics, recovery of function, microscopes, transmission electron
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):6. https://doi.org/10.1167/iovs.65.3.6

Includes: Supplemental Content

Cornea October 2023

Single-Cell Transcriptomics Reveals Cellular Heterogeneity and Complex Cell–Cell Communication Networks in the Mouse Cornea

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Yueh-Feng Wu; Nai-Wen Chang; Li-An Chu; Hsin-Yu Liu; Yu-Xian Zhou; Yun-Lin Pai; Yu-Sheng Yu; Chen-Hsiang Kuan; Yu-Ching Wu; Sung-Jan Lin; Hsin-Yuan Tan
TAGS: cell communication, cornea, heterogeneity, mice, rna, small cytoplasmic
Invest. Ophthalmol. Vis. Sci.. 2023; 64(13):5. https://doi.org/10.1167/iovs.64.13.5

Includes: Multimedia, Supplemental Content

Cornea July 2023

Corneal Biomechanical Properties Demonstrate Anisotropy and Correlate With Axial Length in Myopic Eyes

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Lingfeng Chen; Yangyi Huang; Xiaoyu Zhang; Yike Shi; Zhipeng Gao; Bingqing Sun; Yang Shen; Ling Sun; Yifan Cao; Qianqian Zhang; Jiqiang Guo; Fen Li; Weiyi Chen; Xiaona Li; Xingtao Zhou
TAGS: cornea, eye, anisotropy, stress
Invest. Ophthalmol. Vis. Sci.. 2023; 64(10):27. https://doi.org/10.1167/iovs.64.10.27

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Cellular and molecular mechanisms governing myelin integrity in the visual system

Daniela Barbosa; Katherine J. Wert; Lu Sun

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1598.

ARVO Annual Meeting Abstract June 2023

OCT Macular Ganglion Cell Layer Step Patterns and Their Relationship to Visual Field Nasal Step Defects and Other Parameters in Glaucoma and Glaucoma Suspect Patients

Soo Jung Lee; Kipp Beyerle; Lirong Sun; Christina Morettin; Anne Rozwat; Daniel K Roberts

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2021.

ARVO Annual Meeting Abstract June 2023

Vutiglabridin, a mitochondrial paraoxonase-2 modulator, attenuates laser-induced choroidal neovascularization in mice in a manner comparable and complementary to anti-VEGF

Chul-Woo Park; Leo Sungwong Choi; Jae-Byoung Chae; Jaejin Shin; Jaemin Lee; Sun Kyung Park; Hyung Soon Park; Hyewon Chung

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3238.

ARVO Annual Meeting Abstract June 2023

Distinct rod and cone precursor transcriptomic responses to pRB loss reveals a metabolic predisposition to retinoblastoma initiation

Zachary Fouladian; Sunhye Lee; Kevin Stachelek; Martin Triska; Hardeep Singh; Matthew Thornton; Brendan Grubbs; David Cobrinik

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3744.

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Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

Targeted siRNA Delivery Against RUNX1 Via tFNA: Inhibiting Retinal Neovascularization and Restoring Vessels Through Dll4/Notch1 Signaling

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys

Genetic duplication found in strabismus patients leads to decreased synaptic formation in iPSC-derived cortical neurons

ARMMs as non-viral vehicles for the delivery of genome editors to treat Stargardt disease

Trigeminal denervation induces disruption of corneal endothelial cell junctions and inflammation in the mouse eye

Dynamics of MicroRNA Secreted via Extracellular Vesicles During the Aging of Embryonic Stem Cell-Derived Retinal Pigment Epithelium

Müller Glia-Derived Small Extracellular Vesicles as Potential Therapy of Early-Stage Diabetic Retinopathy

Use of Sodium-Glucose Co-Transporter 2 Inhibitors in Patients With Type 2 Diabetes and the Incidence of Retinal Vein Occlusion in Taiwan

Association of Novel Loci With Keratoconus Susceptibility in a Chinese Genome-Wide Association Study

Genotype-Phenotype of CRB1-Associated Early-Onset Retinal Dystrophy: Novel Insights on Retinal Architecture and Therapeutic Window for Clinical Trials

Isolation and Characterization of Extracellular Vesicles Through Orthogonal Approaches for the Development of Intraocular EV Therapy

Single-Cell Transcriptomics Reveals Cellular Heterogeneity and Complex Cell–Cell Communication Networks in the Mouse Cornea

Corneal Biomechanical Properties Demonstrate Anisotropy and Correlate With Axial Length in Myopic Eyes

Cellular and molecular mechanisms governing myelin integrity in the visual system

OCT Macular Ganglion Cell Layer Step Patterns and Their Relationship to Visual Field Nasal Step Defects and Other Parameters in Glaucoma and Glaucoma Suspect Patients

Vutiglabridin, a mitochondrial paraoxonase-2 modulator, attenuates laser-induced choroidal neovascularization in mice in a manner comparable and complementary to anti-VEGF

Distinct rod and cone precursor transcriptomic responses to pRB loss reveals a metabolic predisposition to retinoblastoma initiation

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